Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8667
Gene name Gene Name - the full gene name approved by the HGNC.
Eukaryotic translation initiation factor 3 subunit H
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
EIF3H
Synonyms (NCBI Gene) Gene synonyms aliases
EIF3S3, eIF3-gamma, eIF3-p40
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q23.3-q24.11
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT031946 hsa-miR-16-5p Proteomics 18668040
MIRT539720 hsa-miR-3609 PAR-CLIP 21572407
MIRT539719 hsa-miR-548ah-5p PAR-CLIP 21572407
MIRT539718 hsa-miR-3664-5p PAR-CLIP 21572407
MIRT539717 hsa-miR-520g-3p PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001732 Process Formation of cytoplasmic translation initiation complex IEA
GO:0001732 Process Formation of cytoplasmic translation initiation complex NAS 16920360
GO:0002183 Process Cytoplasmic translational initiation IEA
GO:0003723 Function RNA binding HDA 22658674
GO:0003743 Function Translation initiation factor activity IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603912 3273 ENSG00000147677
Protein
UniProt ID O15372
Protein name Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit)
Protein function Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40
PDB 3J8B , 3J8C , 6YBD , 6ZMW , 6ZON , 6ZP4 , 6ZVJ , 7A09 , 7QP6 , 7QP7 , 8OZ0 , 8PJ1 , 8PJ2 , 8PJ3 , 8PJ4 , 8PJ5 , 8PJ6 , 8PPL , 8RG0 , 8XXN , 9BLN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01398 JAB 34 146 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Family
Sequence
MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGT
EVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWY
QSTYYGSFVTRALLDSQFSYQHAIEE
SVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEK
DFSPEALKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLG
KNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEED
LSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN
Sequence length 352
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Measles   L13a-mediated translational silencing of Ceruloplasmin expression
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Colorectal Cancer Colorectal cancer, Colorectal cancer (PheCode 153), ICD10 C18, C19, C20: colorectal cancer, Early onset colorectal cancer N/A N/A GWAS
Endometriosis Endometriosis N/A N/A GWAS
Otosclerosis Otosclerosis N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 34038061
Adenomatous Polyposis Coli Associate 32170005
Alzheimer Disease Associate 34367470
Breast Neoplasms Associate 10362802, 24927736
Breast Neoplasms Stimulate 14997205
Carcinogenesis Associate 37559097
Carcinoma Hepatocellular Associate 37559097, 40069645
Carcinoma Non Small Cell Lung Associate 19204574
Cerebellar Ataxia and Hypogonadotropic Hypogonadism Associate 10362802
Colorectal Neoplasms Associate 20862326, 22367214, 32170005, 37527660