Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8660
Gene name	Insulin receptor substrate 2
Gene symbol	IRS2
Synonyms (NCBI Gene)	IRS-2
Chromosome	13
Chromosome location	13q34
Summary	This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstr

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1805097	C>G,T	Risk-factor	Coding sequence variant, missense variant
rs137852740	G>A,C	Risk-factor	Missense variant, synonymous variant, coding sequence variant

529

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miRTarBase ID	miRNA	Experiments	Reference
MIRT003808	hsa-miR-7-5p	Reporter assayWestern blot	18483236
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT007355	hsa-miR-33a-5p	ImmunofluorescenceLuciferase reporter assayWestern blot	23547260
MIRT007355	hsa-miR-33a-5p	ImmunofluorescenceLuciferase reporter assayWestern blot	23547260
MIRT016052	hsa-miR-374b-5p	Sequencing	20371350
MIRT003808	hsa-miR-7-5p	Reporter assay;Western blot	18483236
MIRT027863	hsa-miR-98-5p	Microarray	19088304
MIRT052219	hsa-let-7b-5p	CLASH	23622248
MIRT051561	hsa-let-7e-5p	CLASH	23622248
MIRT041990	hsa-miR-484	CLASH	23622248
MIRT437827	hsa-miR-135a-5p	Luciferase reporter assay	23579070
MIRT437827	hsa-miR-135a-5p	Luciferase reporter assay	23579070
MIRT437827	hsa-miR-135a-5p	Luciferase reporter assay	23579070
MIRT437827	hsa-miR-135a-5p	Luciferase reporter assay	23579070
MIRT052219	hsa-let-7b-5p	FlowLuciferase reporter assayqRT-PCRWestern blot	24810113
MIRT052219	hsa-let-7b-5p	FlowLuciferase reporter assayqRT-PCRWestern blot	24810113
MIRT052219	hsa-let-7b-5p	FlowLuciferase reporter assayqRT-PCRWestern blot	24810113
MIRT052219	hsa-let-7b-5p	FlowLuciferase reporter assayqRT-PCRWestern blot	24810113
MIRT248936	hsa-miR-4501	HITS-CLIP	23313552
MIRT702681	hsa-miR-4793-5p	HITS-CLIP	23313552
MIRT702680	hsa-miR-3607-5p	HITS-CLIP	23313552
MIRT702679	hsa-miR-146a-3p	HITS-CLIP	23313552
MIRT702678	hsa-miR-301a-5p	HITS-CLIP	23313552
MIRT702677	hsa-miR-301b-5p	HITS-CLIP	23313552
MIRT702675	hsa-miR-3921	HITS-CLIP	23313552
MIRT702676	hsa-miR-4653-5p	HITS-CLIP	23313552
MIRT702674	hsa-miR-6730-3p	HITS-CLIP	23313552
MIRT702673	hsa-miR-3660	HITS-CLIP	23313552
MIRT702672	hsa-miR-4526	HITS-CLIP	23313552
MIRT702671	hsa-miR-6719-3p	HITS-CLIP	23313552
MIRT702670	hsa-miR-4299	HITS-CLIP	23313552
MIRT702669	hsa-miR-3913-3p	HITS-CLIP	23313552
MIRT702668	hsa-miR-4504	HITS-CLIP	23313552
MIRT702667	hsa-miR-542-3p	HITS-CLIP	23313552
MIRT702666	hsa-miR-489-3p	HITS-CLIP	23313552
MIRT732366	hsa-miR-338-3p	Luciferase reporter assayqRT-PCRWestern blot	28123847
MIRT732366	hsa-miR-338-3p	Luciferase reporter assayqRT-PCRWestern blot	28123847
MIRT735563	hsa-miR-181d-5p	ELISALuciferase reporter assayqRT-PCRWestern blotting	34155619
MIRT051561	hsa-let-7e-5p	qRT-PCR	32710190
MIRT248936	hsa-miR-4501	HITS-CLIP	23313552
MIRT702681	hsa-miR-4793-5p	HITS-CLIP	23313552
MIRT702680	hsa-miR-3607-5p	HITS-CLIP	23313552
MIRT702679	hsa-miR-146a-3p	HITS-CLIP	23313552
MIRT702678	hsa-miR-301a-5p	HITS-CLIP	23313552
MIRT702677	hsa-miR-301b-5p	HITS-CLIP	23313552
MIRT702675	hsa-miR-3921	HITS-CLIP	23313552
MIRT702676	hsa-miR-4653-5p	HITS-CLIP	23313552
MIRT702674	hsa-miR-6730-3p	HITS-CLIP	23313552
MIRT702673	hsa-miR-3660	HITS-CLIP	23313552
MIRT702672	hsa-miR-4526	HITS-CLIP	23313552
MIRT702671	hsa-miR-6719-3p	HITS-CLIP	23313552
MIRT702670	hsa-miR-4299	HITS-CLIP	23313552
MIRT702669	hsa-miR-3913-3p	HITS-CLIP	23313552
MIRT702668	hsa-miR-4504	HITS-CLIP	23313552
MIRT702667	hsa-miR-542-3p	HITS-CLIP	23313552
MIRT702666	hsa-miR-489-3p	HITS-CLIP	23313552
MIRT1072121	hsa-let-7a	CLIP-seq
MIRT1072122	hsa-let-7b	CLIP-seq
MIRT1072123	hsa-let-7c	CLIP-seq
MIRT1072124	hsa-let-7d	CLIP-seq
MIRT1072125	hsa-let-7e	CLIP-seq
MIRT1072126	hsa-let-7f	CLIP-seq
MIRT1072127	hsa-let-7g	CLIP-seq
MIRT1072128	hsa-let-7i	CLIP-seq
MIRT1072129	hsa-miR-103a	CLIP-seq
MIRT1072130	hsa-miR-107	CLIP-seq
MIRT1072131	hsa-miR-1208	CLIP-seq
MIRT1072132	hsa-miR-126	CLIP-seq
MIRT1072133	hsa-miR-141	CLIP-seq
MIRT1072134	hsa-miR-145	CLIP-seq
MIRT1072135	hsa-miR-15a	CLIP-seq
MIRT1072136	hsa-miR-15b	CLIP-seq
MIRT1072137	hsa-miR-16	CLIP-seq
MIRT1072138	hsa-miR-181a	CLIP-seq
MIRT1072139	hsa-miR-181b	CLIP-seq
MIRT1072140	hsa-miR-181c	CLIP-seq
MIRT1072141	hsa-miR-181d	CLIP-seq
MIRT1072142	hsa-miR-188-3p	CLIP-seq
MIRT1072143	hsa-miR-1909	CLIP-seq
MIRT1072144	hsa-miR-1910	CLIP-seq
MIRT1072145	hsa-miR-1914	CLIP-seq
MIRT1072146	hsa-miR-195	CLIP-seq
MIRT1072147	hsa-miR-200a	CLIP-seq
MIRT1072148	hsa-miR-202	CLIP-seq
MIRT1072149	hsa-miR-2052	CLIP-seq
MIRT1072150	hsa-miR-2114	CLIP-seq
MIRT1072151	hsa-miR-223	CLIP-seq
MIRT1072152	hsa-miR-224	CLIP-seq
MIRT1072153	hsa-miR-23a	CLIP-seq
MIRT1072154	hsa-miR-23b	CLIP-seq
MIRT1072155	hsa-miR-23c	CLIP-seq
MIRT1072156	hsa-miR-3065-3p	CLIP-seq
MIRT1072157	hsa-miR-3117-3p	CLIP-seq
MIRT1072158	hsa-miR-3127-5p	CLIP-seq
MIRT1072159	hsa-miR-3143	CLIP-seq
MIRT1072160	hsa-miR-3169	CLIP-seq
MIRT1072161	hsa-miR-3177-5p	CLIP-seq
MIRT1072162	hsa-miR-3190	CLIP-seq
MIRT1072163	hsa-miR-3200-3p	CLIP-seq
MIRT1072164	hsa-miR-330-3p	CLIP-seq
MIRT1072165	hsa-miR-3545-3p	CLIP-seq
MIRT1072166	hsa-miR-3649	CLIP-seq
MIRT1072167	hsa-miR-3659	CLIP-seq
MIRT1072168	hsa-miR-3667-5p	CLIP-seq
MIRT1072169	hsa-miR-369-3p	CLIP-seq
MIRT1072170	hsa-miR-374a	CLIP-seq
MIRT1072171	hsa-miR-374b	CLIP-seq
MIRT1072172	hsa-miR-378g	CLIP-seq
MIRT1072173	hsa-miR-3910	CLIP-seq
MIRT1072174	hsa-miR-3925-3p	CLIP-seq
MIRT1072175	hsa-miR-3973	CLIP-seq
MIRT1072176	hsa-miR-3977	CLIP-seq
MIRT1072177	hsa-miR-409-5p	CLIP-seq
MIRT1072178	hsa-miR-423-3p	CLIP-seq
MIRT1072179	hsa-miR-424	CLIP-seq
MIRT1072180	hsa-miR-4258	CLIP-seq
MIRT1072181	hsa-miR-4262	CLIP-seq
MIRT1072182	hsa-miR-4269	CLIP-seq
MIRT1072183	hsa-miR-4270	CLIP-seq
MIRT1072184	hsa-miR-4272	CLIP-seq
MIRT1072185	hsa-miR-4291	CLIP-seq
MIRT1072186	hsa-miR-431	CLIP-seq
MIRT1072187	hsa-miR-4318	CLIP-seq
MIRT1072188	hsa-miR-4419a	CLIP-seq
MIRT1072189	hsa-miR-4437	CLIP-seq
MIRT1072190	hsa-miR-4441	CLIP-seq
MIRT1072191	hsa-miR-4458	CLIP-seq
MIRT1072192	hsa-miR-4459	CLIP-seq
MIRT1072193	hsa-miR-4461	CLIP-seq
MIRT1072194	hsa-miR-4468	CLIP-seq
MIRT1072195	hsa-miR-4477b	CLIP-seq
MIRT1072196	hsa-miR-4489	CLIP-seq
MIRT1072197	hsa-miR-4500	CLIP-seq
MIRT1072198	hsa-miR-4509	CLIP-seq
MIRT1072199	hsa-miR-4510	CLIP-seq
MIRT1072200	hsa-miR-4514	CLIP-seq
MIRT1072201	hsa-miR-452	CLIP-seq
MIRT1072202	hsa-miR-4530	CLIP-seq
MIRT1072203	hsa-miR-455-3p	CLIP-seq
MIRT1072204	hsa-miR-4648	CLIP-seq
MIRT1072205	hsa-miR-4653-3p	CLIP-seq
MIRT1072206	hsa-miR-4654	CLIP-seq
MIRT1072207	hsa-miR-4658	CLIP-seq
MIRT1072208	hsa-miR-4666-3p	CLIP-seq
MIRT1072209	hsa-miR-4674	CLIP-seq
MIRT1072210	hsa-miR-4676-3p	CLIP-seq
MIRT1072211	hsa-miR-4676-5p	CLIP-seq
MIRT1072212	hsa-miR-4683	CLIP-seq
MIRT1072213	hsa-miR-4692	CLIP-seq
MIRT1072214	hsa-miR-4697-3p	CLIP-seq
MIRT1072215	hsa-miR-4698	CLIP-seq
MIRT1072216	hsa-miR-4700-3p	CLIP-seq
MIRT1072217	hsa-miR-4723-5p	CLIP-seq
MIRT1072218	hsa-miR-4724-3p	CLIP-seq
MIRT1072219	hsa-miR-4733-5p	CLIP-seq
MIRT1072220	hsa-miR-4742-5p	CLIP-seq
MIRT1072221	hsa-miR-4744	CLIP-seq
MIRT1072222	hsa-miR-4758-5p	CLIP-seq
MIRT1072223	hsa-miR-4759	CLIP-seq
MIRT1072224	hsa-miR-4769-5p	CLIP-seq
MIRT1072225	hsa-miR-4795-3p	CLIP-seq
MIRT1072226	hsa-miR-4799-5p	CLIP-seq
MIRT1072227	hsa-miR-4800-3p	CLIP-seq
MIRT1072228	hsa-miR-487b	CLIP-seq
MIRT1072229	hsa-miR-497	CLIP-seq
MIRT1072230	hsa-miR-511	CLIP-seq
MIRT1072231	hsa-miR-513a-3p	CLIP-seq
MIRT1072232	hsa-miR-520d-5p	CLIP-seq
MIRT1072233	hsa-miR-520g	CLIP-seq
MIRT1072234	hsa-miR-520h	CLIP-seq
MIRT1072235	hsa-miR-524-5p	CLIP-seq
MIRT1072236	hsa-miR-539	CLIP-seq
MIRT1072237	hsa-miR-548ag	CLIP-seq
MIRT1072238	hsa-miR-548ai	CLIP-seq
MIRT1072239	hsa-miR-548an	CLIP-seq
MIRT1072240	hsa-miR-554	CLIP-seq
MIRT1072241	hsa-miR-561	CLIP-seq
MIRT1072242	hsa-miR-570	CLIP-seq
MIRT1072243	hsa-miR-574-5p	CLIP-seq
MIRT1072244	hsa-miR-575	CLIP-seq
MIRT1072245	hsa-miR-580	CLIP-seq
MIRT1072246	hsa-miR-619	CLIP-seq
MIRT1072247	hsa-miR-637	CLIP-seq
MIRT1072248	hsa-miR-660	CLIP-seq
MIRT1072249	hsa-miR-7	CLIP-seq
MIRT1072250	hsa-miR-766	CLIP-seq
MIRT1072251	hsa-miR-935	CLIP-seq
MIRT1072252	hsa-miR-944	CLIP-seq
MIRT1072253	hsa-miR-98	CLIP-seq
MIRT1072121	hsa-let-7a	CLIP-seq
MIRT1072122	hsa-let-7b	CLIP-seq
MIRT1072123	hsa-let-7c	CLIP-seq
MIRT1072124	hsa-let-7d	CLIP-seq
MIRT1072125	hsa-let-7e	CLIP-seq
MIRT1072126	hsa-let-7f	CLIP-seq
MIRT1072127	hsa-let-7g	CLIP-seq
MIRT1072128	hsa-let-7i	CLIP-seq
MIRT1550210	hsa-miR-1253	CLIP-seq
MIRT1072148	hsa-miR-202	CLIP-seq
MIRT1072149	hsa-miR-2052	CLIP-seq
MIRT1072157	hsa-miR-3117-3p	CLIP-seq
MIRT1072160	hsa-miR-3169	CLIP-seq
MIRT1072167	hsa-miR-3659	CLIP-seq
MIRT1072187	hsa-miR-4318	CLIP-seq
MIRT1072191	hsa-miR-4458	CLIP-seq
MIRT1072197	hsa-miR-4500	CLIP-seq
MIRT1072207	hsa-miR-4658	CLIP-seq
MIRT1072211	hsa-miR-4676-5p	CLIP-seq
MIRT1072222	hsa-miR-4758-5p	CLIP-seq
MIRT1072223	hsa-miR-4759	CLIP-seq
MIRT1072243	hsa-miR-574-5p	CLIP-seq
MIRT1072244	hsa-miR-575	CLIP-seq
MIRT1072253	hsa-miR-98	CLIP-seq
MIRT1072131	hsa-miR-1208	CLIP-seq
MIRT2017816	hsa-miR-1290	CLIP-seq
MIRT1072133	hsa-miR-141	CLIP-seq
MIRT1072138	hsa-miR-181a	CLIP-seq
MIRT1072139	hsa-miR-181b	CLIP-seq
MIRT1072140	hsa-miR-181c	CLIP-seq
MIRT1072141	hsa-miR-181d	CLIP-seq
MIRT1072145	hsa-miR-1914	CLIP-seq
MIRT1072147	hsa-miR-200a	CLIP-seq
MIRT2017817	hsa-miR-214	CLIP-seq
MIRT1072152	hsa-miR-224	CLIP-seq
MIRT2017818	hsa-miR-30a	CLIP-seq
MIRT2017819	hsa-miR-30b	CLIP-seq
MIRT2017820	hsa-miR-30c	CLIP-seq
MIRT2017821	hsa-miR-30d	CLIP-seq
MIRT2017822	hsa-miR-30e	CLIP-seq
MIRT2017823	hsa-miR-3138	CLIP-seq
MIRT1072159	hsa-miR-3143	CLIP-seq
MIRT2017824	hsa-miR-3171	CLIP-seq
MIRT1072161	hsa-miR-3177-5p	CLIP-seq
MIRT1072162	hsa-miR-3190	CLIP-seq
MIRT2017825	hsa-miR-323b-3p	CLIP-seq
MIRT2017826	hsa-miR-331-5p	CLIP-seq
MIRT2017827	hsa-miR-3611	CLIP-seq
MIRT2017828	hsa-miR-3619-5p	CLIP-seq
MIRT1072168	hsa-miR-3667-5p	CLIP-seq
MIRT2017829	hsa-miR-3911	CLIP-seq
MIRT1072177	hsa-miR-409-5p	CLIP-seq
MIRT1072181	hsa-miR-4262	CLIP-seq
MIRT1072182	hsa-miR-4269	CLIP-seq
MIRT1072184	hsa-miR-4272	CLIP-seq
MIRT1072185	hsa-miR-4291	CLIP-seq
MIRT2017830	hsa-miR-4328	CLIP-seq
MIRT1072192	hsa-miR-4459	CLIP-seq
MIRT2017831	hsa-miR-4477a	CLIP-seq
MIRT1072195	hsa-miR-4477b	CLIP-seq
MIRT1072196	hsa-miR-4489	CLIP-seq
MIRT1072200	hsa-miR-4514	CLIP-seq
MIRT2017832	hsa-miR-451b	CLIP-seq
MIRT1072201	hsa-miR-452	CLIP-seq
MIRT1072204	hsa-miR-4648	CLIP-seq
MIRT1072206	hsa-miR-4654	CLIP-seq
MIRT1072210	hsa-miR-4676-3p	CLIP-seq
MIRT2017833	hsa-miR-4679	CLIP-seq
MIRT1072212	hsa-miR-4683	CLIP-seq
MIRT1072213	hsa-miR-4692	CLIP-seq
MIRT1072215	hsa-miR-4698	CLIP-seq
MIRT1072216	hsa-miR-4700-3p	CLIP-seq
MIRT2017834	hsa-miR-4735-5p	CLIP-seq
MIRT1072220	hsa-miR-4742-5p	CLIP-seq
MIRT2017835	hsa-miR-4753-5p	CLIP-seq
MIRT1072224	hsa-miR-4769-5p	CLIP-seq
MIRT2017836	hsa-miR-4775	CLIP-seq
MIRT2017837	hsa-miR-4778-3p	CLIP-seq
MIRT2017838	hsa-miR-4793-3p	CLIP-seq
MIRT2017839	hsa-miR-4800-5p	CLIP-seq
MIRT2017840	hsa-miR-501-3p	CLIP-seq
MIRT2017841	hsa-miR-502-3p	CLIP-seq
MIRT1072231	hsa-miR-513a-3p	CLIP-seq
MIRT1072232	hsa-miR-520d-5p	CLIP-seq
MIRT1072235	hsa-miR-524-5p	CLIP-seq
MIRT2017842	hsa-miR-543	CLIP-seq
MIRT1072237	hsa-miR-548ag	CLIP-seq
MIRT1072238	hsa-miR-548ai	CLIP-seq
MIRT2017843	hsa-miR-548n	CLIP-seq
MIRT1072241	hsa-miR-561	CLIP-seq
MIRT1072242	hsa-miR-570	CLIP-seq
MIRT1072245	hsa-miR-580	CLIP-seq
MIRT2017844	hsa-miR-590-3p	CLIP-seq
MIRT2017845	hsa-miR-646	CLIP-seq
MIRT2017846	hsa-miR-659	CLIP-seq
MIRT1072249	hsa-miR-7	CLIP-seq
MIRT2017847	hsa-miR-761	CLIP-seq
MIRT2017848	hsa-miR-890	CLIP-seq
MIRT2017849	hsa-miR-922	CLIP-seq
MIRT1072144	hsa-miR-1910	CLIP-seq
MIRT2249653	hsa-miR-203	CLIP-seq
MIRT2249654	hsa-miR-2113	CLIP-seq
MIRT1072151	hsa-miR-223	CLIP-seq
MIRT1072161	hsa-miR-3177-5p	CLIP-seq
MIRT1072162	hsa-miR-3190	CLIP-seq
MIRT2017827	hsa-miR-3611	CLIP-seq
MIRT1072167	hsa-miR-3659	CLIP-seq
MIRT1072175	hsa-miR-3973	CLIP-seq
MIRT1072188	hsa-miR-4419a	CLIP-seq
MIRT1072193	hsa-miR-4461	CLIP-seq
MIRT1072194	hsa-miR-4468	CLIP-seq
MIRT2017831	hsa-miR-4477a	CLIP-seq
MIRT1072199	hsa-miR-4510	CLIP-seq
MIRT2017832	hsa-miR-451b	CLIP-seq
MIRT1072203	hsa-miR-455-3p	CLIP-seq
MIRT2249655	hsa-miR-4639-3p	CLIP-seq
MIRT1072207	hsa-miR-4658	CLIP-seq
MIRT1072211	hsa-miR-4676-5p	CLIP-seq
MIRT1072214	hsa-miR-4697-3p	CLIP-seq
MIRT1072216	hsa-miR-4700-3p	CLIP-seq
MIRT1072219	hsa-miR-4733-5p	CLIP-seq
MIRT1072233	hsa-miR-520g	CLIP-seq
MIRT1072234	hsa-miR-520h	CLIP-seq
MIRT1072236	hsa-miR-539	CLIP-seq
MIRT2017842	hsa-miR-543	CLIP-seq
MIRT1072241	hsa-miR-561	CLIP-seq
MIRT1072243	hsa-miR-574-5p	CLIP-seq
MIRT1072244	hsa-miR-575	CLIP-seq
MIRT1072245	hsa-miR-580	CLIP-seq
MIRT1072249	hsa-miR-7	CLIP-seq
MIRT2249656	hsa-miR-758	CLIP-seq
MIRT2389472	hsa-miR-1264	CLIP-seq
MIRT1072135	hsa-miR-15a	CLIP-seq
MIRT1072136	hsa-miR-15b	CLIP-seq
MIRT1072137	hsa-miR-16	CLIP-seq
MIRT1072146	hsa-miR-195	CLIP-seq
MIRT2389473	hsa-miR-3655	CLIP-seq
MIRT1072174	hsa-miR-3925-3p	CLIP-seq
MIRT1072179	hsa-miR-424	CLIP-seq
MIRT1072202	hsa-miR-4530	CLIP-seq
MIRT1072229	hsa-miR-497	CLIP-seq
MIRT1072249	hsa-miR-7	CLIP-seq
MIRT1072250	hsa-miR-766	CLIP-seq
MIRT1072121	hsa-let-7a	CLIP-seq
MIRT1072122	hsa-let-7b	CLIP-seq
MIRT1072123	hsa-let-7c	CLIP-seq
MIRT1072124	hsa-let-7d	CLIP-seq
MIRT1072125	hsa-let-7e	CLIP-seq
MIRT1072126	hsa-let-7f	CLIP-seq
MIRT1072127	hsa-let-7g	CLIP-seq
MIRT1072128	hsa-let-7i	CLIP-seq
MIRT1072131	hsa-miR-1208	CLIP-seq
MIRT2430088	hsa-miR-1273e	CLIP-seq
MIRT1072133	hsa-miR-141	CLIP-seq
MIRT2430089	hsa-miR-192	CLIP-seq
MIRT1072147	hsa-miR-200a	CLIP-seq
MIRT2430090	hsa-miR-200b	CLIP-seq
MIRT2430091	hsa-miR-200c	CLIP-seq
MIRT1072148	hsa-miR-202	CLIP-seq
MIRT1072149	hsa-miR-2052	CLIP-seq
MIRT2430092	hsa-miR-215	CLIP-seq
MIRT2430093	hsa-miR-3064-3p	CLIP-seq
MIRT1072156	hsa-miR-3065-3p	CLIP-seq
MIRT2017818	hsa-miR-30a	CLIP-seq
MIRT2017819	hsa-miR-30b	CLIP-seq
MIRT2017820	hsa-miR-30c	CLIP-seq
MIRT2017821	hsa-miR-30d	CLIP-seq
MIRT2017822	hsa-miR-30e	CLIP-seq
MIRT1072157	hsa-miR-3117-3p	CLIP-seq
MIRT1072159	hsa-miR-3143	CLIP-seq
MIRT1072160	hsa-miR-3169	CLIP-seq
MIRT2430094	hsa-miR-3173-3p	CLIP-seq
MIRT2430095	hsa-miR-320e	CLIP-seq
MIRT2430096	hsa-miR-33a	CLIP-seq
MIRT2430097	hsa-miR-33b	CLIP-seq
MIRT2430098	hsa-miR-3607-3p	CLIP-seq
MIRT2017827	hsa-miR-3611	CLIP-seq
MIRT2430099	hsa-miR-3616-3p	CLIP-seq
MIRT2389473	hsa-miR-3655	CLIP-seq
MIRT1072167	hsa-miR-3659	CLIP-seq
MIRT2430100	hsa-miR-3686	CLIP-seq
MIRT2430101	hsa-miR-3942-3p	CLIP-seq
MIRT2430102	hsa-miR-4267	CLIP-seq
MIRT2430103	hsa-miR-429	CLIP-seq
MIRT1072185	hsa-miR-4291	CLIP-seq
MIRT1072186	hsa-miR-431	CLIP-seq
MIRT1072187	hsa-miR-4318	CLIP-seq
MIRT2430104	hsa-miR-4428	CLIP-seq
MIRT1072191	hsa-miR-4458	CLIP-seq
MIRT1072195	hsa-miR-4477b	CLIP-seq
MIRT1072197	hsa-miR-4500	CLIP-seq
MIRT2430105	hsa-miR-4503	CLIP-seq
MIRT1072198	hsa-miR-4509	CLIP-seq
MIRT2430106	hsa-miR-450b-5p	CLIP-seq
MIRT1072201	hsa-miR-452	CLIP-seq
MIRT2430107	hsa-miR-4528	CLIP-seq
MIRT1072207	hsa-miR-4658	CLIP-seq
MIRT1072208	hsa-miR-4666-3p	CLIP-seq
MIRT1072210	hsa-miR-4676-3p	CLIP-seq
MIRT2430108	hsa-miR-4724-5p	CLIP-seq
MIRT2430109	hsa-miR-4729	CLIP-seq
MIRT1072221	hsa-miR-4744	CLIP-seq
MIRT1072222	hsa-miR-4758-5p	CLIP-seq
MIRT1072223	hsa-miR-4759	CLIP-seq
MIRT2430110	hsa-miR-4761-3p	CLIP-seq
MIRT2430111	hsa-miR-4766-3p	CLIP-seq
MIRT2430112	hsa-miR-4774-5p	CLIP-seq
MIRT2430113	hsa-miR-4778-5p	CLIP-seq
MIRT2430114	hsa-miR-4779	CLIP-seq
MIRT2430115	hsa-miR-4789-5p	CLIP-seq
MIRT1072226	hsa-miR-4799-5p	CLIP-seq
MIRT2430116	hsa-miR-4803	CLIP-seq
MIRT2430117	hsa-miR-507	CLIP-seq
MIRT1072230	hsa-miR-511	CLIP-seq
MIRT2017842	hsa-miR-543	CLIP-seq
MIRT2430118	hsa-miR-548p	CLIP-seq
MIRT2430119	hsa-miR-557	CLIP-seq
MIRT1072241	hsa-miR-561	CLIP-seq
MIRT1072242	hsa-miR-570	CLIP-seq
MIRT1072243	hsa-miR-574-5p	CLIP-seq
MIRT2430120	hsa-miR-603	CLIP-seq
MIRT2017846	hsa-miR-659	CLIP-seq
MIRT1072249	hsa-miR-7	CLIP-seq
MIRT1072253	hsa-miR-98	CLIP-seq
MIRT2437913	hsa-miR-1305	CLIP-seq
MIRT2017825	hsa-miR-323b-3p	CLIP-seq
MIRT2437914	hsa-miR-582-5p	CLIP-seq
MIRT2437915	hsa-miR-607	CLIP-seq
MIRT2017816	hsa-miR-1290	CLIP-seq
MIRT2430089	hsa-miR-192	CLIP-seq
MIRT2430090	hsa-miR-200b	CLIP-seq
MIRT2430091	hsa-miR-200c	CLIP-seq
MIRT2430092	hsa-miR-215	CLIP-seq
MIRT2553103	hsa-miR-2278	CLIP-seq
MIRT2430093	hsa-miR-3064-3p	CLIP-seq
MIRT2553104	hsa-miR-3121-3p	CLIP-seq
MIRT1072158	hsa-miR-3127-5p	CLIP-seq
MIRT1072159	hsa-miR-3143	CLIP-seq
MIRT2017824	hsa-miR-3171	CLIP-seq
MIRT2553105	hsa-miR-3200-5p	CLIP-seq
MIRT2389473	hsa-miR-3655	CLIP-seq
MIRT1072173	hsa-miR-3910	CLIP-seq
MIRT2430101	hsa-miR-3942-3p	CLIP-seq
MIRT1072177	hsa-miR-409-5p	CLIP-seq
MIRT2430102	hsa-miR-4267	CLIP-seq
MIRT1072183	hsa-miR-4270	CLIP-seq
MIRT2430103	hsa-miR-429	CLIP-seq
MIRT2553106	hsa-miR-4303	CLIP-seq
MIRT2553107	hsa-miR-4433	CLIP-seq
MIRT1072190	hsa-miR-4441	CLIP-seq
MIRT1072192	hsa-miR-4459	CLIP-seq
MIRT1072194	hsa-miR-4468	CLIP-seq
MIRT2430107	hsa-miR-4528	CLIP-seq
MIRT2017833	hsa-miR-4679	CLIP-seq
MIRT2430108	hsa-miR-4724-5p	CLIP-seq
MIRT2553108	hsa-miR-4768-3p	CLIP-seq
MIRT2430112	hsa-miR-4774-5p	CLIP-seq
MIRT2430116	hsa-miR-4803	CLIP-seq
MIRT2017840	hsa-miR-501-3p	CLIP-seq
MIRT2017841	hsa-miR-502-3p	CLIP-seq
MIRT2017842	hsa-miR-543	CLIP-seq
MIRT2553109	hsa-miR-548a-5p	CLIP-seq
MIRT2553110	hsa-miR-548aa	CLIP-seq
MIRT2553111	hsa-miR-548ab	CLIP-seq
MIRT2553112	hsa-miR-548ak	CLIP-seq
MIRT1072239	hsa-miR-548an	CLIP-seq
MIRT2553113	hsa-miR-548b-5p	CLIP-seq
MIRT2553114	hsa-miR-548c-3p	CLIP-seq
MIRT2553115	hsa-miR-548c-5p	CLIP-seq
MIRT2553116	hsa-miR-548d-5p	CLIP-seq
MIRT2553117	hsa-miR-548h	CLIP-seq
MIRT2553118	hsa-miR-548i	CLIP-seq
MIRT2553119	hsa-miR-548j	CLIP-seq
MIRT2017843	hsa-miR-548n	CLIP-seq
MIRT2553120	hsa-miR-548w	CLIP-seq
MIRT2553121	hsa-miR-548y	CLIP-seq
MIRT2553122	hsa-miR-559	CLIP-seq
MIRT2553123	hsa-miR-568	CLIP-seq
MIRT1072242	hsa-miR-570	CLIP-seq
MIRT2430120	hsa-miR-603	CLIP-seq
MIRT2017846	hsa-miR-659	CLIP-seq
MIRT2553124	hsa-miR-802	CLIP-seq
MIRT2017816	hsa-miR-1290	CLIP-seq
MIRT2430089	hsa-miR-192	CLIP-seq
MIRT2430090	hsa-miR-200b	CLIP-seq
MIRT2430091	hsa-miR-200c	CLIP-seq
MIRT2430092	hsa-miR-215	CLIP-seq
MIRT2553103	hsa-miR-2278	CLIP-seq
MIRT2430093	hsa-miR-3064-3p	CLIP-seq
MIRT2553104	hsa-miR-3121-3p	CLIP-seq
MIRT1072159	hsa-miR-3143	CLIP-seq
MIRT2017824	hsa-miR-3171	CLIP-seq
MIRT2553105	hsa-miR-3200-5p	CLIP-seq
MIRT2389473	hsa-miR-3655	CLIP-seq
MIRT1072173	hsa-miR-3910	CLIP-seq
MIRT2430101	hsa-miR-3942-3p	CLIP-seq
MIRT1072177	hsa-miR-409-5p	CLIP-seq
MIRT2430102	hsa-miR-4267	CLIP-seq
MIRT2430103	hsa-miR-429	CLIP-seq
MIRT2553106	hsa-miR-4303	CLIP-seq
MIRT2553107	hsa-miR-4433	CLIP-seq
MIRT1072192	hsa-miR-4459	CLIP-seq
MIRT1072194	hsa-miR-4468	CLIP-seq
MIRT2430107	hsa-miR-4528	CLIP-seq
MIRT2017833	hsa-miR-4679	CLIP-seq
MIRT2430108	hsa-miR-4724-5p	CLIP-seq
MIRT2553108	hsa-miR-4768-3p	CLIP-seq
MIRT2430112	hsa-miR-4774-5p	CLIP-seq
MIRT2430116	hsa-miR-4803	CLIP-seq
MIRT2017840	hsa-miR-501-3p	CLIP-seq
MIRT2017841	hsa-miR-502-3p	CLIP-seq
MIRT2017842	hsa-miR-543	CLIP-seq
MIRT2553109	hsa-miR-548a-5p	CLIP-seq
MIRT2553110	hsa-miR-548aa	CLIP-seq
MIRT2553111	hsa-miR-548ab	CLIP-seq
MIRT2553112	hsa-miR-548ak	CLIP-seq
MIRT1072239	hsa-miR-548an	CLIP-seq
MIRT2553113	hsa-miR-548b-5p	CLIP-seq
MIRT2553114	hsa-miR-548c-3p	CLIP-seq
MIRT2553115	hsa-miR-548c-5p	CLIP-seq
MIRT2553116	hsa-miR-548d-5p	CLIP-seq
MIRT2553117	hsa-miR-548h	CLIP-seq
MIRT2553118	hsa-miR-548i	CLIP-seq
MIRT2553119	hsa-miR-548j	CLIP-seq
MIRT2017843	hsa-miR-548n	CLIP-seq
MIRT2553120	hsa-miR-548w	CLIP-seq
MIRT2553121	hsa-miR-548y	CLIP-seq
MIRT2553122	hsa-miR-559	CLIP-seq
MIRT2553123	hsa-miR-568	CLIP-seq
MIRT1072242	hsa-miR-570	CLIP-seq
MIRT2430120	hsa-miR-603	CLIP-seq
MIRT2017846	hsa-miR-659	CLIP-seq

Show/Hide all (9)

Transcription factor	Regulation	Reference
DLX5	Activation	21045156
EIF2AK2	Unknown	20685959
FOXO1	Unknown	20685959
NFIC	Activation	19755487
PGR	Unknown	14534541
SP1	Activation	19755487
SP1	Unknown	19875459
SREBF1	Repression	15881188;16091421
ZNF148	Unknown	19875459

Show/Hide all (65)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002053	Process	Positive regulation of mesenchymal cell proliferation	IEA
GO:0002903	Process	Negative regulation of B cell apoptotic process	IEA
GO:0002903	Process	Negative regulation of B cell apoptotic process	ISS
GO:0005068	Function	Transmembrane receptor protein tyrosine kinase adaptor activity	IEA
GO:0005158	Function	Insulin receptor binding	IBA
GO:0005158	Function	Insulin receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	15161933, 15778465, 17901049, 21241768, 23617393, 26496610, 28514442, 33961781, 36931259
GO:0005737	Component	Cytoplasm	IDA	28320862
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006006	Process	Glucose metabolic process	TAS	9495343
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	7675087
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IEA
GO:0007420	Process	Brain development	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	NAS	17925406
GO:0008286	Process	Insulin receptor signaling pathway	IBA
GO:0008286	Process	Insulin receptor signaling pathway	IEA
GO:0008286	Process	Insulin receptor signaling pathway	IEA
GO:0008286	Process	Insulin receptor signaling pathway	ISS
GO:0009749	Process	Response to glucose	IEA
GO:0009749	Process	Response to glucose	ISS
GO:0010631	Process	Epithelial cell migration	IEA
GO:0010634	Process	Positive regulation of epithelial cell migration	IEA
GO:0010748	Process	Negative regulation of long-chain fatty acid import across plasma membrane	IMP	16814735
GO:0010907	Process	Positive regulation of glucose metabolic process	IMP	16814735
GO:0016477	Process	Cell migration	IEA
GO:0019216	Process	Regulation of lipid metabolic process	TAS	16814735
GO:0019901	Function	Protein kinase binding	IEA
GO:0019903	Function	Protein phosphatase binding	IEA
GO:0019904	Function	Protein domain specific binding	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IEA
GO:0030879	Process	Mammary gland development	IEA
GO:0030890	Process	Positive regulation of B cell proliferation	IEA
GO:0030890	Process	Positive regulation of B cell proliferation	ISS
GO:0032000	Process	Positive regulation of fatty acid beta-oxidation	IMP	16814735
GO:0032024	Process	Positive regulation of insulin secretion	IEA
GO:0032024	Process	Positive regulation of insulin secretion	ISS
GO:0032869	Process	Cellular response to insulin stimulus	IEA
GO:0032869	Process	Cellular response to insulin stimulus	IEA
GO:0032869	Process	Cellular response to insulin stimulus	IMP	16814735
GO:0035591	Function	Signaling adaptor activity	IDA	15316008
GO:0035591	Function	Signaling adaptor activity	IEA
GO:0043548	Function	Phosphatidylinositol 3-kinase binding	IBA
GO:0043548	Function	Phosphatidylinositol 3-kinase binding	IEA
GO:0044342	Process	Type B pancreatic cell proliferation	IEA
GO:0045725	Process	Positive regulation of glycogen biosynthetic process	IMP	16814735
GO:0045725	Process	Positive regulation of glycogen biosynthetic process	NAS	17925406
GO:0046326	Process	Positive regulation of D-glucose import	IMP	16814735
GO:0048009	Process	Insulin-like growth factor receptor signaling pathway	IDA	17827393
GO:0051050	Process	Positive regulation of transport	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0055088	Process	Lipid homeostasis	TAS	16814735
GO:0071333	Process	Cellular response to glucose stimulus	IEA
GO:0071889	Function	14-3-3 protein binding	IEA
GO:0141038	Function	Phosphatidylinositol 3-kinase activator activity	IEA
GO:1904692	Process	Positive regulation of type B pancreatic cell proliferation	IEA
GO:1990859	Process	Cellular response to endothelin	IEA

MIM	HGNC	e!Ensembl
600797	6126	ENSG00000185950

Q9Y4H2

Protein name

Insulin receptor substrate 2 (IRS-2)

Protein function

Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in de

PDB

3FQW , 3FQX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	31 → 144	PH domain	Domain
PF02174	IRS	194 → 296	PTB domain (IRS-1 type)	Domain

Sequence

MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEA
TAGGGSAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE
YFAVAAENEQEQEGWYRALTDLVSEGRAAAGDAPPAAAPAASCSASLPGALGGSAGAAGA
EDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTL
QLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEF
RPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCR
VRTASEGDGGAAAGAAAAGARPVSVAGSPLSPGPVRAPLSRSHTLSGGCGGRGSKVALLP
AGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPPLPHPLHHGPGQR
PSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGGGGGEFY
GYMTMDRPLSHCGRSYRRVSGDAAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTL
MRATFSGSAGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGA
ALAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAAVPSAGPAGPAPTSAAGRTF
PASGGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAVTTGTP
PDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTCGGDSDQYVLMSSPVGRILEEERLE
PQATPGPSQAASAFGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTRLSLEGLPS
LPSMHEYPLPPEPKSPGEYINIDFGEPGARLSPPAPPLLASAASSSSLLSASSPASSLGS
GTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEASSPYPPLPPR
PSASPSSSLQPPPPPPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVA
ATPPQPIAAPPKPEAARVASPTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAKVIRADP
QGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEP
PTSPRQLQPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYIAIDVRE
EPGLPPQPQPPPPPLPQPGDKSSWGRTRSLGGLISAVGVGSTGGGCGGPGPGALPPANTY
ASIDFLSHHLKEATIVKE

Sequence length

1338

Interactions

View interactions

	KEGG		Reactome
	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling Autophagy - animal AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Insulin signaling pathway Adipocytokine signaling pathway Regulation of lipolysis in adipocytes Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease Growth hormone synthesis, secretion and action Alzheimer disease MicroRNAs in cancer		PI3K Cascade IRS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates RAS

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
IRS2-related disorder	Benign; risk factor; Likely benign; Uncertain significance	rs1805097, rs950586821, rs4773092, rs12853546, rs3742210, rs2501619444, rs532810290, rs376586626, rs140229481, rs34412495, rs9583424, rs201499247, rs549588978	RCV003974814 RCV003964510 RCV003967367 RCV003979331 RCV003982242 RCV003911468 RCV003914117 RCV003931921 RCV003969128 RCV003972195 RCV003978164 RCV003975617 RCV003968117
Type 2 diabetes mellitus	Benign; risk factor	rs1805097, rs137852740	RCV004595475 RCV004595476

Show/Hide Text Mining Associations (74)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acute Coronary Syndrome	Associate	23535507
Adenocarcinoma	Associate	31393907
Adenocarcinoma of Lung	Associate	35844799
Adenoma	Associate	23594372
Asthma	Associate	28599074, 32512817
Atherosclerosis	Inhibit	21984580
Autism Spectrum Disorder	Associate	31009952
Autistic Disorder	Associate	31009952
Breast Neoplasms	Associate	18611262, 18819936, 21258861, 23562473, 23877285, 24811890, 26991655, 30229539, 30457165, 33432018, 35859293
Carcinogenesis	Associate	34104084, 35844799
Carcinoma Hepatocellular	Associate	23112878
Carcinoma Intraductal Noninfiltrating	Inhibit	23562473
Carcinoma Lobular	Associate	29669935
Carcinoma Non Small Cell Lung	Associate	24289561, 30988063, 31393907
Carcinoma Renal Cell	Associate	26018509
Carcinoma Small Cell	Associate	33888337
Colorectal Neoplasms	Associate	23594372, 24175768, 25557790, 28268248, 28369940, 31666286
Coronary Artery Disease	Associate	23216712
Diabetes Complications	Associate	39348384
Diabetes Gestational	Associate	24401133, 28846666
Diabetes Mellitus	Associate	14604996, 21771880, 23216712, 30457165, 34801581
Diabetes Mellitus	Inhibit	21984580
Diabetes Mellitus Insulin Dependent 19	Associate	25644968
Diabetes Mellitus Type 2	Associate	20184486, 24401133, 28049237, 32710190, 37234924
Diabetes Mellitus Type 2	Inhibit	21984580
Diabetes Mellitus Type 2	Stimulate	24289561
Diastrophic dysplasia	Associate	19878940
Endometrial Neoplasms	Associate	20184486, 35816477
Endometriosis	Associate	19878940
Epilepsy Temporal Lobe	Associate	25458098
Ganglioglioma	Associate	34355449
Gaucher Disease	Associate	19878940
Glioblastoma	Associate	32669109
Heart Diseases	Associate	23535507
Hyperglycemia	Associate	19259821
Infertility Male	Associate	31103287
Inflammation	Associate	37716291
Insulin Resistance	Associate	10973656, 15380067, 20184486, 23216712, 24401133, 27535281, 27857189, 29717275, 31996098
Insulin Resistance	Inhibit	21984580
Intracranial Aneurysm	Associate	28930970
Liver Diseases	Associate	27458792
Lymphatic Metastasis	Inhibit	24289561
Medulloblastoma	Associate	28303061
Melanoma Cutaneous Malignant	Associate	36631465
Metabolic Syndrome	Associate	25646961, 38181524
Neoplasm Metastasis	Associate	21258861, 28303061, 30229539
Neoplasms	Associate	14655756, 21258861, 23578105, 23594372, 26755644, 31393907, 32296029, 34355449, 35163645, 35844799, 36727938
Neoplasms	Stimulate	23562473
Neoplasms Adipose Tissue	Associate	26514561
Neoplasms Basal Cell	Associate	25921176
Neoplasms Neuroepithelial	Associate	34355449
Neuroblastoma	Associate	19259821, 21354306
Neurotoxicity Syndromes	Associate	21354306
Non alcoholic Fatty Liver Disease	Associate	29717275, 29749571, 32603046, 34449768
Non alcoholic Fatty Liver Disease	Inhibit	32603046
Obesity	Associate	18611262, 20184486, 21771880, 23193206, 24401133, 25310961, 32710190, 33761612, 35124585, 35816477
Osteoarthritis	Associate	34856957
Osteoporosis	Associate	31773671
Ovarian Diseases	Associate	22246450
Ovarian Neoplasms	Associate	34609082, 35163645, 36727938
Pancreatic Neoplasms	Associate	14604996, 19190347, 20416304
Pancreatitis	Associate	34155619
Parkinson Disease	Associate	34967697
Polycystic Ovary Syndrome	Associate	21300347, 24390626, 25310961, 35124585
Primary Ovarian Insufficiency	Associate	10973656
Prostatic Neoplasms	Associate	22844442, 23251408
Psoriasis	Associate	31996098
Rhabdomyosarcoma	Associate	23578105
Rufous oculocutaneous albinism	Associate	19878940
Sleep Apnea Obstructive	Associate	34449768
Soft Tissue Injuries	Associate	26514561
Stomach Neoplasms	Associate	16367923
Thyroid Cancer Papillary	Associate	34104084
Urinary Bladder Neoplasms	Associate	25921176, 36140796

IRS2 (insulin receptor substrate 2)