Gene Gene information from NCBI Gene database.
Entrez ID 8658
Gene name Tankyrase
Gene symbol TNKS
Synonyms (NCBI Gene)
ARTD5PARP-5aPARP5APARPLTIN1TINF1TNKS1pART5
Chromosome 8
Chromosome location 8p23.1
miRNA miRNA information provided by mirtarbase database.
666
miRTarBase ID miRNA Experiments Reference
MIRT028854 hsa-miR-26b-5p Microarray 19088304
MIRT043016 hsa-miR-324-5p CLASH 23622248
MIRT043012 hsa-miR-324-3p CLASH 23622248
MIRT037431 hsa-miR-744-5p CLASH 23622248
MIRT442718 hsa-miR-1277-5p PAR-CLIP 22100165
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
77
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000209 Process Protein polyubiquitination IDA 19759537, 21478859
GO:0000209 Process Protein polyubiquitination IEA
GO:0000242 Component Pericentriolar material IEA
GO:0000242 Component Pericentriolar material TAS 11454873
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603303 11941 ENSG00000173273
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95271
Protein name Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP
Protein function Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:236222
PDB 2RF5 , 3UDD , 3UH2 , 3UH4 , 4DVI , 4I9I , 4K4E , 4K4F , 4KRS , 4LI6 , 4LI7 , 4LI8 , 4MSG , 4MSK , 4MT9 , 4N3R , 4N4V , 4OA7 , 4TOR , 4TOS , 4U6A , 4UUH , 4UW1 , 4W5S , 4W6E , 5EBT , 5ECE , 5ETY , 5GP7 , 5JHQ , 5JTI , 5JU5 , 5KNI , 6QXU , 6URQ , 7KKM , 7KKN , 7KKO , 7KKP , 7KKQ , 7OCV , 8X5J
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00023 Ank 217 247 Ankyrin repeat Repeat
PF00023 Ank 248 280 Ankyrin repeat Repeat
PF00023 Ank 281 313 Ankyrin repeat Repeat
PF00023 Ank 369 400 Ankyrin repeat Repeat
PF00023 Ank 401 433 Ankyrin repeat Repeat
PF00023 Ank 434 466 Ankyrin repeat Repeat
PF00023 Ank 522 556 Ankyrin repeat Repeat
PF00023 Ank 557 589 Ankyrin repeat Repeat
PF00023 Ank 590 621 Ankyrin repeat Repeat
PF00023 Ank 685 715 Ankyrin repeat Repeat
PF12796 Ank_2 714 780 Ankyrin repeats (3 copies) Repeat
PF00023 Ank 837 868 Ankyrin repeat Repeat
PF00023 Ank 869 901 Ankyrin repeat Repeat
PF13637 Ank_4 905 945 Repeat
PF07647 SAM_2 1027 1087 SAM domain (Sterile alpha motif) Domain
PF00644 PARP 1115 1310 Poly(ADP-ribose) polymerase catalytic domain Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous; highest levels in testis.
Sequence
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPR
HGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNP
AGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA
NVHARDD
GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV
LLQHGADPNIRNT
DGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNV
NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL
LLKHGACVNAMDL
WQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL
RERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQV
TELLLRKGANVNEKNK
DFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAAL
AGHLQTCRLLLSYGSDPSIIS
LQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKA
GDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVP
LHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKN

RDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTP
LHLAAGYNNLEVAEYLLEHGADVNAQDK
GGLIPLHNAASYGHVDIAALLIKYNTCVNATD
K
WAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEA
LPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERK
EGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLI
KGVERLL
GGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGG
IFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDER
HAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSF
LQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQI
MKPEAPSQTA
TAAEQKT
Sequence length 1327
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    TCF dependent signaling in response to WNT
Degradation of AXIN
XAV939 inhibits tankyrase, stabilizing AXIN
Ub-specific processing proteases
Regulation of PTEN stability and activity
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
21
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTHMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CATARACT GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CERVICAL CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Associate 26617760
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Associate 27482906
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 23629941
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 26617760
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Associate 20937264
★☆☆☆☆
Found in Text Mining only
Cerebral Infarction Associate 20937264
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Inhibit 18026951
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 28615517
★☆☆☆☆
Found in Text Mining only
Coronary Disease Associate 36221106
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Associate 21665207
★☆☆☆☆
Found in Text Mining only