Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8654
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphodiesterase 5A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PDE5A
Synonyms (NCBI Gene) Gene synonyms aliases	CGB-PDE, CN5A, PDE5
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4q26
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5`-GMP. It is involved in the regulation of intracellular concentrations

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017190	hsa-miR-335-5p	Microarray	18185580
MIRT529328	hsa-miR-548ac	PAR-CLIP	22012620
MIRT529327	hsa-miR-548bb-3p	PAR-CLIP	22012620
MIRT529326	hsa-miR-548d-3p	PAR-CLIP	22012620
MIRT529325	hsa-miR-548h-3p	PAR-CLIP	22012620
MIRT529324	hsa-miR-548z	PAR-CLIP	22012620
MIRT529323	hsa-miR-548aa	PAR-CLIP	22012620
MIRT529322	hsa-miR-548ap-3p	PAR-CLIP	22012620
MIRT529321	hsa-miR-548t-3p	PAR-CLIP	22012620
MIRT529320	hsa-miR-5692a	PAR-CLIP	22012620
MIRT529319	hsa-miR-944	PAR-CLIP	22012620
MIRT529318	hsa-miR-570-3p	PAR-CLIP	22012620
MIRT529323	hsa-miR-548aa	PAR-CLIP	27292025
MIRT529328	hsa-miR-548ac	PAR-CLIP	27292025
MIRT529322	hsa-miR-548ap-3p	PAR-CLIP	27292025
MIRT529327	hsa-miR-548bb-3p	PAR-CLIP	27292025
MIRT529326	hsa-miR-548d-3p	PAR-CLIP	27292025
MIRT529325	hsa-miR-548h-3p	PAR-CLIP	27292025
MIRT529321	hsa-miR-548t-3p	PAR-CLIP	27292025
MIRT529324	hsa-miR-548z	PAR-CLIP	27292025
MIRT529320	hsa-miR-5692a	PAR-CLIP	27292025
MIRT529318	hsa-miR-570-3p	PAR-CLIP	27292025
MIRT529319	hsa-miR-944	PAR-CLIP	27292025
MIRT529328	hsa-miR-548ac	PAR-CLIP	22012620
MIRT529327	hsa-miR-548bb-3p	PAR-CLIP	22012620
MIRT529326	hsa-miR-548d-3p	PAR-CLIP	22012620
MIRT529325	hsa-miR-548h-3p	PAR-CLIP	22012620
MIRT529324	hsa-miR-548z	PAR-CLIP	22012620
MIRT529323	hsa-miR-548aa	PAR-CLIP	22012620
MIRT529322	hsa-miR-548ap-3p	PAR-CLIP	22012620
MIRT529321	hsa-miR-548t-3p	PAR-CLIP	22012620
MIRT529320	hsa-miR-5692a	PAR-CLIP	22012620
MIRT529319	hsa-miR-944	PAR-CLIP	22012620
MIRT529318	hsa-miR-570-3p	PAR-CLIP	22012620
MIRT1220685	hsa-miR-183	CLIP-seq
MIRT1220686	hsa-miR-2054	CLIP-seq
MIRT1220687	hsa-miR-3117-3p	CLIP-seq
MIRT1220688	hsa-miR-3163	CLIP-seq
MIRT1220689	hsa-miR-3169	CLIP-seq
MIRT1220690	hsa-miR-3613-3p	CLIP-seq
MIRT1220691	hsa-miR-371-5p	CLIP-seq
MIRT1220692	hsa-miR-371b-5p	CLIP-seq
MIRT1220693	hsa-miR-376a	CLIP-seq
MIRT1220694	hsa-miR-376b	CLIP-seq
MIRT1220695	hsa-miR-382	CLIP-seq
MIRT1220696	hsa-miR-3942-3p	CLIP-seq
MIRT1220697	hsa-miR-4470	CLIP-seq
MIRT1220698	hsa-miR-4668-3p	CLIP-seq
MIRT1220699	hsa-miR-4742-3p	CLIP-seq
MIRT1220700	hsa-miR-4753-3p	CLIP-seq
MIRT1220701	hsa-miR-4759	CLIP-seq
MIRT1220702	hsa-miR-4768-5p	CLIP-seq
MIRT1220703	hsa-miR-512-5p	CLIP-seq
MIRT1220704	hsa-miR-548g	CLIP-seq
MIRT1220705	hsa-miR-587	CLIP-seq
MIRT1220706	hsa-miR-1	CLIP-seq
MIRT1220707	hsa-miR-106a	CLIP-seq
MIRT1220708	hsa-miR-106b	CLIP-seq
MIRT1220709	hsa-miR-136	CLIP-seq
MIRT1220710	hsa-miR-17	CLIP-seq
MIRT1220711	hsa-miR-200b	CLIP-seq
MIRT1220712	hsa-miR-200c	CLIP-seq
MIRT1220713	hsa-miR-206	CLIP-seq
MIRT1220714	hsa-miR-20a	CLIP-seq
MIRT1220715	hsa-miR-20b	CLIP-seq
MIRT1220716	hsa-miR-3136-3p	CLIP-seq
MIRT1220717	hsa-miR-3164	CLIP-seq
MIRT1220718	hsa-miR-3545-5p	CLIP-seq
MIRT1220719	hsa-miR-3609	CLIP-seq
MIRT1220720	hsa-miR-3673	CLIP-seq
MIRT1220721	hsa-miR-374c	CLIP-seq
MIRT1220722	hsa-miR-3941	CLIP-seq
MIRT1220723	hsa-miR-4255	CLIP-seq
MIRT1220724	hsa-miR-4257	CLIP-seq
MIRT1220725	hsa-miR-4260	CLIP-seq
MIRT1220726	hsa-miR-429	CLIP-seq
MIRT1220727	hsa-miR-4326	CLIP-seq
MIRT1220728	hsa-miR-466	CLIP-seq
MIRT1220729	hsa-miR-4672	CLIP-seq
MIRT1220730	hsa-miR-4719	CLIP-seq
MIRT1220731	hsa-miR-4731-3p	CLIP-seq
MIRT1220732	hsa-miR-4790-3p	CLIP-seq
MIRT1220733	hsa-miR-4796-3p	CLIP-seq
MIRT1220734	hsa-miR-4801	CLIP-seq
MIRT1220735	hsa-miR-519d	CLIP-seq
MIRT1220736	hsa-miR-548ah	CLIP-seq
MIRT1220737	hsa-miR-613	CLIP-seq
MIRT1220738	hsa-miR-655	CLIP-seq
MIRT1220739	hsa-miR-93	CLIP-seq
MIRT1552152	hsa-miR-199a-3p	CLIP-seq
MIRT1552153	hsa-miR-199b-3p	CLIP-seq
MIRT1552154	hsa-miR-3129-5p	CLIP-seq
MIRT1220717	hsa-miR-3164	CLIP-seq
MIRT1220724	hsa-miR-4257	CLIP-seq
MIRT1552155	hsa-miR-4277	CLIP-seq
MIRT1220730	hsa-miR-4719	CLIP-seq
MIRT1552156	hsa-miR-501-5p	CLIP-seq
MIRT1552157	hsa-miR-640	CLIP-seq
MIRT1552158	hsa-miR-653	CLIP-seq
MIRT1552159	hsa-miR-936	CLIP-seq
MIRT1220717	hsa-miR-3164	CLIP-seq
MIRT1220722	hsa-miR-3941	CLIP-seq
MIRT1220696	hsa-miR-3942-3p	CLIP-seq
MIRT2063674	hsa-miR-4276	CLIP-seq
MIRT2063675	hsa-miR-4302	CLIP-seq
MIRT1220728	hsa-miR-466	CLIP-seq
MIRT1220729	hsa-miR-4672	CLIP-seq
MIRT2063676	hsa-miR-4697-3p	CLIP-seq
MIRT1220730	hsa-miR-4719	CLIP-seq
MIRT1220731	hsa-miR-4731-3p	CLIP-seq
MIRT1220734	hsa-miR-4801	CLIP-seq
MIRT1220711	hsa-miR-200b	CLIP-seq
MIRT1220712	hsa-miR-200c	CLIP-seq
MIRT2292138	hsa-miR-28-3p	CLIP-seq
MIRT2292139	hsa-miR-4264	CLIP-seq
MIRT2063674	hsa-miR-4276	CLIP-seq
MIRT1220726	hsa-miR-429	CLIP-seq
MIRT1220729	hsa-miR-4672	CLIP-seq
MIRT2292140	hsa-miR-4789-3p	CLIP-seq
MIRT2292141	hsa-miR-4797-3p	CLIP-seq
MIRT2292142	hsa-miR-513a-3p	CLIP-seq
MIRT2292143	hsa-miR-642b	CLIP-seq
MIRT2292144	hsa-miR-3117-5p	CLIP-seq
MIRT1552155	hsa-miR-4277	CLIP-seq
MIRT2292145	hsa-miR-4422	CLIP-seq
MIRT1220697	hsa-miR-4470	CLIP-seq
MIRT2292146	hsa-miR-543	CLIP-seq
MIRT2392274	hsa-miR-3127-5p	CLIP-seq
MIRT2392275	hsa-miR-3170	CLIP-seq
MIRT2392276	hsa-miR-3189-3p	CLIP-seq
MIRT2392277	hsa-miR-3670	CLIP-seq
MIRT2392278	hsa-miR-4270	CLIP-seq
MIRT2392279	hsa-miR-4441	CLIP-seq
MIRT2392280	hsa-miR-4448	CLIP-seq
MIRT2392281	hsa-miR-4760-3p	CLIP-seq
MIRT2392282	hsa-miR-522	CLIP-seq
MIRT2392283	hsa-miR-570	CLIP-seq
MIRT2392284	hsa-miR-615-5p	CLIP-seq
MIRT2431954	hsa-miR-1284	CLIP-seq
MIRT2431955	hsa-miR-1305	CLIP-seq
MIRT2431956	hsa-miR-1324	CLIP-seq
MIRT2431957	hsa-miR-181a	CLIP-seq
MIRT2431958	hsa-miR-181b	CLIP-seq
MIRT2431959	hsa-miR-181c	CLIP-seq
MIRT2431960	hsa-miR-181d	CLIP-seq
MIRT2431961	hsa-miR-300	CLIP-seq
MIRT2292144	hsa-miR-3117-5p	CLIP-seq
MIRT2431962	hsa-miR-381	CLIP-seq
MIRT2431963	hsa-miR-4262	CLIP-seq
MIRT2063675	hsa-miR-4302	CLIP-seq
MIRT2431964	hsa-miR-4666-3p	CLIP-seq
MIRT2442457	hsa-miR-1271	CLIP-seq
MIRT2431954	hsa-miR-1284	CLIP-seq
MIRT2431956	hsa-miR-1324	CLIP-seq
MIRT2292144	hsa-miR-3117-5p	CLIP-seq
MIRT1220722	hsa-miR-3941	CLIP-seq
MIRT2063675	hsa-miR-4302	CLIP-seq
MIRT1220728	hsa-miR-466	CLIP-seq
MIRT1220729	hsa-miR-4672	CLIP-seq
MIRT1220730	hsa-miR-4719	CLIP-seq
MIRT1220731	hsa-miR-4731-3p	CLIP-seq
MIRT2292140	hsa-miR-4789-3p	CLIP-seq
MIRT1220734	hsa-miR-4801	CLIP-seq
MIRT2442458	hsa-miR-509-3p	CLIP-seq
MIRT2442459	hsa-miR-520d-5p	CLIP-seq
MIRT2442460	hsa-miR-524-5p	CLIP-seq
MIRT2442461	hsa-miR-564	CLIP-seq
MIRT2292143	hsa-miR-642b	CLIP-seq
MIRT2442462	hsa-miR-96	CLIP-seq
MIRT2442457	hsa-miR-1271	CLIP-seq
MIRT2589889	hsa-miR-1273f	CLIP-seq
MIRT2589890	hsa-miR-143	CLIP-seq
MIRT2431957	hsa-miR-181a	CLIP-seq
MIRT2431958	hsa-miR-181b	CLIP-seq
MIRT2431959	hsa-miR-181c	CLIP-seq
MIRT2431960	hsa-miR-181d	CLIP-seq
MIRT2589891	hsa-miR-3115	CLIP-seq
MIRT2589892	hsa-miR-3132	CLIP-seq
MIRT2589893	hsa-miR-3134	CLIP-seq
MIRT2589894	hsa-miR-342-3p	CLIP-seq
MIRT1220719	hsa-miR-3609	CLIP-seq
MIRT2589895	hsa-miR-3622a-3p	CLIP-seq
MIRT2589896	hsa-miR-3622b-3p	CLIP-seq
MIRT1220722	hsa-miR-3941	CLIP-seq
MIRT1220696	hsa-miR-3942-3p	CLIP-seq
MIRT2431963	hsa-miR-4262	CLIP-seq
MIRT2589897	hsa-miR-4522	CLIP-seq
MIRT2589898	hsa-miR-4534	CLIP-seq
MIRT1220728	hsa-miR-466	CLIP-seq
MIRT1220729	hsa-miR-4672	CLIP-seq
MIRT2589899	hsa-miR-4708-5p	CLIP-seq
MIRT2589900	hsa-miR-4711-5p	CLIP-seq
MIRT1220730	hsa-miR-4719	CLIP-seq
MIRT2589901	hsa-miR-4724-5p	CLIP-seq
MIRT1220731	hsa-miR-4731-3p	CLIP-seq
MIRT2589902	hsa-miR-4770	CLIP-seq
MIRT1220734	hsa-miR-4801	CLIP-seq
MIRT2589903	hsa-miR-4802-5p	CLIP-seq
MIRT2442458	hsa-miR-509-3p	CLIP-seq
MIRT2589904	hsa-miR-5096	CLIP-seq
MIRT2292146	hsa-miR-543	CLIP-seq
MIRT2589905	hsa-miR-548a-5p	CLIP-seq
MIRT2589906	hsa-miR-548ab	CLIP-seq
MIRT1220736	hsa-miR-548ah	CLIP-seq
MIRT2589907	hsa-miR-548ak	CLIP-seq
MIRT2589908	hsa-miR-548b-5p	CLIP-seq
MIRT2589909	hsa-miR-548c-5p	CLIP-seq
MIRT2589910	hsa-miR-548d-5p	CLIP-seq
MIRT2589911	hsa-miR-548h	CLIP-seq
MIRT2589912	hsa-miR-548i	CLIP-seq
MIRT2589913	hsa-miR-548j	CLIP-seq
MIRT2589914	hsa-miR-548w	CLIP-seq
MIRT2589915	hsa-miR-548y	CLIP-seq
MIRT2589916	hsa-miR-559	CLIP-seq
MIRT2442461	hsa-miR-564	CLIP-seq
MIRT2589917	hsa-miR-765	CLIP-seq
MIRT2442462	hsa-miR-96	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
POU3F2	Repression	21215707

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004114	Function	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA
GO:0004114	Function	3',5'-cyclic-nucleotide phosphodiesterase activity	NAS	9714779
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IBA
GO:0005515	Function	Protein binding	IPI	18757735, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0008081	Function	Phosphoric diester hydrolase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030553	Function	CGMP binding	IEA
GO:0030553	Function	CGMP binding	TAS	15938621
GO:0046069	Process	CGMP catabolic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0047555	Function	3',5'-cyclic-GMP phosphodiesterase activity	IBA
GO:0047555	Function	3',5'-cyclic-GMP phosphodiesterase activity	IDA	14687666
GO:0047555	Function	3',5'-cyclic-GMP phosphodiesterase activity	IEA
GO:0141162	Process	Negative regulation of cAMP/PKA signal transduction	IBA

MIM	HGNC	e!Ensembl
603310	8784	ENSG00000138735

Protein

UniProt ID

O76074

Protein name

cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE)

Protein function

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:15489334, PubMed:9714779). Specifically regulates nitric-

PDB

1RKP , 1T9R , 1T9S , 1TBF , 1UDT , 1UDU , 1UHO , 1XOZ , 1XP0 , 2CHM , 2H40 , 2H42 , 2H44 , 2XSS , 3B2R , 3BJC , 3HC8 , 3HDZ , 3JWQ , 3JWR , 3LFV , 3MF0 , 3SHY , 3SHZ , 3SIE , 3TGE , 3TGG , 4G2W , 4G2Y , 4I9Z , 4IA0 , 4MD6 , 4OEW , 4OEX , 5JO3 , 5ZZ2 , 6ACB , 6IWI , 6L6E , 6VBI , 7FAQ , 7FAR , 8W4S , 8W4T , 8WKF , 8WKG , 8XWW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01590	GAF	164 → 314	GAF domain	Domain
PF01590	GAF	346 → 503	GAF domain	Domain
PF00233	PDEase_I	612 → 847		Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.

Sequence

MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN

Sequence length

875

Interactions

View interactions

	KEGG		Reactome
	Purine metabolism Metabolic pathways cGMP-PKG signaling pathway		cGMP effects

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Bipolar Disorder	Bipolar disorder	N/A	N/A	GWAS
Endometriosis	Endometriosis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (37)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	31433119
Aortic Aneurysm Thoracic	Inhibit	31434939
Aortic Dissection	Associate	31434939
Breast Neoplasms	Associate	21505183
Cardiomyopathies	Stimulate	22135403
Cardiomyopathy Dilated	Associate	22135403
Cerebrovascular Disorders	Associate	25247292
Colonic Neoplasms	Associate	22556201, 26299804, 38179743
Colorectal Neoplasms	Associate	22556201
Diabetes Mellitus	Associate	21297971
Drug Related Side Effects and Adverse Reactions	Associate	25103559
Epstein Barr Virus Infections	Associate	33741394
Erectile Dysfunction	Associate	16735511, 23916810, 31433119, 36401440, 38086555
Erectile Dysfunction	Inhibit	22578167
Familial Primary Pulmonary Hypertension	Stimulate	16980375
Familial Primary Pulmonary Hypertension	Associate	34981661
Glioblastoma	Associate	25103559, 28099939, 37175205
Glioma	Associate	25103559
Headache	Associate	25247292
Heart Failure	Associate	27427220
Heart Murmurs	Associate	38086555
Hypertension Pulmonary	Associate	16735511, 18591337
Hypertension Pulmonary	Stimulate	16980375
Hypertension Pulmonary	Inhibit	22578167
Hypertrophy Right Ventricular	Associate	18591337
Leukemia Myeloid Acute	Associate	23916810
Marfan Syndrome	Inhibit	31434939
Melanoma	Associate	23381931, 24710960, 27299522
Migraine Disorders	Associate	25247292
Mitochondrial Diseases	Associate	33087445
Neoplasms	Associate	27927168, 28099939, 31917403, 35764701, 37280069, 38179743
Neuroblastoma	Associate	25247292
Prostatic Hyperplasia	Associate	31433119
Prostatic Neoplasms	Associate	28700469, 31433119
Pulmonary Arterial Hypertension	Associate	18591337
Renal Insufficiency	Associate	22135403
Thyroid Cancer Papillary	Associate	36217175

PDE5A (phosphodiesterase 5A)