PDE5A (phosphodiesterase 5A)

Gene

• Entrez ID: 8654
• Gene name: Phosphodiesterase 5A
• Gene symbol: PDE5A
• Synonyms (NCBI Gene): CGB-PDE, CN5A, PDE5
• Chromosome: 4
• Chromosome location: 4q26
• Summary: This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5`-GMP. It is involved in the regulation of intracellular concentrations

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017190	hsa-miR-335-5p	Microarray	18185580
MIRT529328	hsa-miR-548ac	PAR-CLIP	22012620
MIRT529327	hsa-miR-548bb-3p	PAR-CLIP	22012620
MIRT529326	hsa-miR-548d-3p	PAR-CLIP	22012620
MIRT529325	hsa-miR-548h-3p	PAR-CLIP	22012620
MIRT529324	hsa-miR-548z	PAR-CLIP	22012620
MIRT529323	hsa-miR-548aa	PAR-CLIP	22012620
MIRT529322	hsa-miR-548ap-3p	PAR-CLIP	22012620
MIRT529321	hsa-miR-548t-3p	PAR-CLIP	22012620
MIRT529320	hsa-miR-5692a	PAR-CLIP	22012620
MIRT529319	hsa-miR-944	PAR-CLIP	22012620
MIRT529318	hsa-miR-570-3p	PAR-CLIP	22012620
MIRT529323	hsa-miR-548aa	PAR-CLIP	27292025
MIRT529328	hsa-miR-548ac	PAR-CLIP	27292025
MIRT529322	hsa-miR-548ap-3p	PAR-CLIP	27292025
MIRT529327	hsa-miR-548bb-3p	PAR-CLIP	27292025
MIRT529326	hsa-miR-548d-3p	PAR-CLIP	27292025
MIRT529325	hsa-miR-548h-3p	PAR-CLIP	27292025
MIRT529321	hsa-miR-548t-3p	PAR-CLIP	27292025
MIRT529324	hsa-miR-548z	PAR-CLIP	27292025
MIRT529320	hsa-miR-5692a	PAR-CLIP	27292025
MIRT529318	hsa-miR-570-3p	PAR-CLIP	27292025
MIRT529319	hsa-miR-944	PAR-CLIP	27292025
MIRT529328	hsa-miR-548ac	PAR-CLIP	22012620
MIRT529327	hsa-miR-548bb-3p	PAR-CLIP	22012620
MIRT529326	hsa-miR-548d-3p	PAR-CLIP	22012620
MIRT529325	hsa-miR-548h-3p	PAR-CLIP	22012620
MIRT529324	hsa-miR-548z	PAR-CLIP	22012620
MIRT529323	hsa-miR-548aa	PAR-CLIP	22012620
MIRT529322	hsa-miR-548ap-3p	PAR-CLIP	22012620
MIRT529321	hsa-miR-548t-3p	PAR-CLIP	22012620
MIRT529320	hsa-miR-5692a	PAR-CLIP	22012620
MIRT529319	hsa-miR-944	PAR-CLIP	22012620
MIRT529318	hsa-miR-570-3p	PAR-CLIP	22012620
MIRT1220685	hsa-miR-183	CLIP-seq
MIRT1220686	hsa-miR-2054	CLIP-seq
MIRT1220687	hsa-miR-3117-3p	CLIP-seq
MIRT1220688	hsa-miR-3163	CLIP-seq
MIRT1220689	hsa-miR-3169	CLIP-seq
MIRT1220690	hsa-miR-3613-3p	CLIP-seq
MIRT1220691	hsa-miR-371-5p	CLIP-seq
MIRT1220692	hsa-miR-371b-5p	CLIP-seq
MIRT1220693	hsa-miR-376a	CLIP-seq
MIRT1220694	hsa-miR-376b	CLIP-seq
MIRT1220695	hsa-miR-382	CLIP-seq
MIRT1220696	hsa-miR-3942-3p	CLIP-seq
MIRT1220697	hsa-miR-4470	CLIP-seq
MIRT1220698	hsa-miR-4668-3p	CLIP-seq
MIRT1220699	hsa-miR-4742-3p	CLIP-seq
MIRT1220700	hsa-miR-4753-3p	CLIP-seq
MIRT1220701	hsa-miR-4759	CLIP-seq
MIRT1220702	hsa-miR-4768-5p	CLIP-seq
MIRT1220703	hsa-miR-512-5p	CLIP-seq
MIRT1220704	hsa-miR-548g	CLIP-seq
MIRT1220705	hsa-miR-587	CLIP-seq
MIRT1220706	hsa-miR-1	CLIP-seq
MIRT1220707	hsa-miR-106a	CLIP-seq
MIRT1220708	hsa-miR-106b	CLIP-seq
MIRT1220709	hsa-miR-136	CLIP-seq
MIRT1220710	hsa-miR-17	CLIP-seq
MIRT1220711	hsa-miR-200b	CLIP-seq
MIRT1220712	hsa-miR-200c	CLIP-seq
MIRT1220713	hsa-miR-206	CLIP-seq
MIRT1220714	hsa-miR-20a	CLIP-seq
MIRT1220715	hsa-miR-20b	CLIP-seq
MIRT1220716	hsa-miR-3136-3p	CLIP-seq
MIRT1220717	hsa-miR-3164	CLIP-seq
MIRT1220718	hsa-miR-3545-5p	CLIP-seq
MIRT1220719	hsa-miR-3609	CLIP-seq
MIRT1220720	hsa-miR-3673	CLIP-seq
MIRT1220721	hsa-miR-374c	CLIP-seq
MIRT1220722	hsa-miR-3941	CLIP-seq
MIRT1220723	hsa-miR-4255	CLIP-seq
MIRT1220724	hsa-miR-4257	CLIP-seq
MIRT1220725	hsa-miR-4260	CLIP-seq
MIRT1220726	hsa-miR-429	CLIP-seq
MIRT1220727	hsa-miR-4326	CLIP-seq
MIRT1220728	hsa-miR-466	CLIP-seq
MIRT1220729	hsa-miR-4672	CLIP-seq
MIRT1220730	hsa-miR-4719	CLIP-seq
MIRT1220731	hsa-miR-4731-3p	CLIP-seq
MIRT1220732	hsa-miR-4790-3p	CLIP-seq
MIRT1220733	hsa-miR-4796-3p	CLIP-seq
MIRT1220734	hsa-miR-4801	CLIP-seq
MIRT1220735	hsa-miR-519d	CLIP-seq
MIRT1220736	hsa-miR-548ah	CLIP-seq
MIRT1220737	hsa-miR-613	CLIP-seq
MIRT1220738	hsa-miR-655	CLIP-seq
MIRT1220739	hsa-miR-93	CLIP-seq
MIRT1552152	hsa-miR-199a-3p	CLIP-seq
MIRT1552153	hsa-miR-199b-3p	CLIP-seq
MIRT1552154	hsa-miR-3129-5p	CLIP-seq
MIRT1220717	hsa-miR-3164	CLIP-seq
MIRT1220724	hsa-miR-4257	CLIP-seq
MIRT1552155	hsa-miR-4277	CLIP-seq
MIRT1220730	hsa-miR-4719	CLIP-seq
MIRT1552156	hsa-miR-501-5p	CLIP-seq
MIRT1552157	hsa-miR-640	CLIP-seq
MIRT1552158	hsa-miR-653	CLIP-seq
MIRT1552159	hsa-miR-936	CLIP-seq
MIRT1220717	hsa-miR-3164	CLIP-seq
MIRT1220722	hsa-miR-3941	CLIP-seq
MIRT1220696	hsa-miR-3942-3p	CLIP-seq
MIRT2063674	hsa-miR-4276	CLIP-seq
MIRT2063675	hsa-miR-4302	CLIP-seq
MIRT1220728	hsa-miR-466	CLIP-seq
MIRT1220729	hsa-miR-4672	CLIP-seq
MIRT2063676	hsa-miR-4697-3p	CLIP-seq
MIRT1220730	hsa-miR-4719	CLIP-seq
MIRT1220731	hsa-miR-4731-3p	CLIP-seq
MIRT1220734	hsa-miR-4801	CLIP-seq
MIRT1220711	hsa-miR-200b	CLIP-seq
MIRT1220712	hsa-miR-200c	CLIP-seq
MIRT2292138	hsa-miR-28-3p	CLIP-seq
MIRT2292139	hsa-miR-4264	CLIP-seq
MIRT2063674	hsa-miR-4276	CLIP-seq
MIRT1220726	hsa-miR-429	CLIP-seq
MIRT1220729	hsa-miR-4672	CLIP-seq
MIRT2292140	hsa-miR-4789-3p	CLIP-seq
MIRT2292141	hsa-miR-4797-3p	CLIP-seq
MIRT2292142	hsa-miR-513a-3p	CLIP-seq
MIRT2292143	hsa-miR-642b	CLIP-seq
MIRT2292144	hsa-miR-3117-5p	CLIP-seq
MIRT1552155	hsa-miR-4277	CLIP-seq
MIRT2292145	hsa-miR-4422	CLIP-seq
MIRT1220697	hsa-miR-4470	CLIP-seq
MIRT2292146	hsa-miR-543	CLIP-seq
MIRT2392274	hsa-miR-3127-5p	CLIP-seq
MIRT2392275	hsa-miR-3170	CLIP-seq
MIRT2392276	hsa-miR-3189-3p	CLIP-seq
MIRT2392277	hsa-miR-3670	CLIP-seq
MIRT2392278	hsa-miR-4270	CLIP-seq
MIRT2392279	hsa-miR-4441	CLIP-seq
MIRT2392280	hsa-miR-4448	CLIP-seq
MIRT2392281	hsa-miR-4760-3p	CLIP-seq
MIRT2392282	hsa-miR-522	CLIP-seq
MIRT2392283	hsa-miR-570	CLIP-seq
MIRT2392284	hsa-miR-615-5p	CLIP-seq
MIRT2431954	hsa-miR-1284	CLIP-seq
MIRT2431955	hsa-miR-1305	CLIP-seq
MIRT2431956	hsa-miR-1324	CLIP-seq
MIRT2431957	hsa-miR-181a	CLIP-seq
MIRT2431958	hsa-miR-181b	CLIP-seq
MIRT2431959	hsa-miR-181c	CLIP-seq
MIRT2431960	hsa-miR-181d	CLIP-seq
MIRT2431961	hsa-miR-300	CLIP-seq
MIRT2292144	hsa-miR-3117-5p	CLIP-seq
MIRT2431962	hsa-miR-381	CLIP-seq
MIRT2431963	hsa-miR-4262	CLIP-seq
MIRT2063675	hsa-miR-4302	CLIP-seq
MIRT2431964	hsa-miR-4666-3p	CLIP-seq
MIRT2442457	hsa-miR-1271	CLIP-seq
MIRT2431954	hsa-miR-1284	CLIP-seq
MIRT2431956	hsa-miR-1324	CLIP-seq
MIRT2292144	hsa-miR-3117-5p	CLIP-seq
MIRT1220722	hsa-miR-3941	CLIP-seq
MIRT2063675	hsa-miR-4302	CLIP-seq
MIRT1220728	hsa-miR-466	CLIP-seq
MIRT1220729	hsa-miR-4672	CLIP-seq
MIRT1220730	hsa-miR-4719	CLIP-seq
MIRT1220731	hsa-miR-4731-3p	CLIP-seq
MIRT2292140	hsa-miR-4789-3p	CLIP-seq
MIRT1220734	hsa-miR-4801	CLIP-seq
MIRT2442458	hsa-miR-509-3p	CLIP-seq
MIRT2442459	hsa-miR-520d-5p	CLIP-seq
MIRT2442460	hsa-miR-524-5p	CLIP-seq
MIRT2442461	hsa-miR-564	CLIP-seq
MIRT2292143	hsa-miR-642b	CLIP-seq
MIRT2442462	hsa-miR-96	CLIP-seq
MIRT2442457	hsa-miR-1271	CLIP-seq
MIRT2589889	hsa-miR-1273f	CLIP-seq
MIRT2589890	hsa-miR-143	CLIP-seq
MIRT2431957	hsa-miR-181a	CLIP-seq
MIRT2431958	hsa-miR-181b	CLIP-seq
MIRT2431959	hsa-miR-181c	CLIP-seq
MIRT2431960	hsa-miR-181d	CLIP-seq
MIRT2589891	hsa-miR-3115	CLIP-seq
MIRT2589892	hsa-miR-3132	CLIP-seq
MIRT2589893	hsa-miR-3134	CLIP-seq
MIRT2589894	hsa-miR-342-3p	CLIP-seq
MIRT1220719	hsa-miR-3609	CLIP-seq
MIRT2589895	hsa-miR-3622a-3p	CLIP-seq
MIRT2589896	hsa-miR-3622b-3p	CLIP-seq
MIRT1220722	hsa-miR-3941	CLIP-seq
MIRT1220696	hsa-miR-3942-3p	CLIP-seq
MIRT2431963	hsa-miR-4262	CLIP-seq
MIRT2589897	hsa-miR-4522	CLIP-seq
MIRT2589898	hsa-miR-4534	CLIP-seq
MIRT1220728	hsa-miR-466	CLIP-seq
MIRT1220729	hsa-miR-4672	CLIP-seq
MIRT2589899	hsa-miR-4708-5p	CLIP-seq
MIRT2589900	hsa-miR-4711-5p	CLIP-seq
MIRT1220730	hsa-miR-4719	CLIP-seq
MIRT2589901	hsa-miR-4724-5p	CLIP-seq
MIRT1220731	hsa-miR-4731-3p	CLIP-seq
MIRT2589902	hsa-miR-4770	CLIP-seq
MIRT1220734	hsa-miR-4801	CLIP-seq
MIRT2589903	hsa-miR-4802-5p	CLIP-seq
MIRT2442458	hsa-miR-509-3p	CLIP-seq
MIRT2589904	hsa-miR-5096	CLIP-seq
MIRT2292146	hsa-miR-543	CLIP-seq
MIRT2589905	hsa-miR-548a-5p	CLIP-seq
MIRT2589906	hsa-miR-548ab	CLIP-seq
MIRT1220736	hsa-miR-548ah	CLIP-seq
MIRT2589907	hsa-miR-548ak	CLIP-seq
MIRT2589908	hsa-miR-548b-5p	CLIP-seq
MIRT2589909	hsa-miR-548c-5p	CLIP-seq
MIRT2589910	hsa-miR-548d-5p	CLIP-seq
MIRT2589911	hsa-miR-548h	CLIP-seq
MIRT2589912	hsa-miR-548i	CLIP-seq
MIRT2589913	hsa-miR-548j	CLIP-seq
MIRT2589914	hsa-miR-548w	CLIP-seq
MIRT2589915	hsa-miR-548y	CLIP-seq
MIRT2589916	hsa-miR-559	CLIP-seq
MIRT2442461	hsa-miR-564	CLIP-seq
MIRT2589917	hsa-miR-765	CLIP-seq
MIRT2442462	hsa-miR-96	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
POU3F2	Repression	21215707

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004114	Function	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA
GO:0004114	Function	3',5'-cyclic-nucleotide phosphodiesterase activity	NAS	9714779
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IBA
GO:0005515	Function	Protein binding	IPI	18757735, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0008081	Function	Phosphoric diester hydrolase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030553	Function	CGMP binding	IEA
GO:0030553	Function	CGMP binding	TAS	15938621
GO:0046069	Process	CGMP catabolic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0047555	Function	3',5'-cyclic-GMP phosphodiesterase activity	IBA
GO:0047555	Function	3',5'-cyclic-GMP phosphodiesterase activity	IDA	14687666
GO:0047555	Function	3',5'-cyclic-GMP phosphodiesterase activity	IEA
GO:0141162	Process	Negative regulation of cAMP/PKA signal transduction	IBA

Other IDs

• MIM: 603310
• HGNC: 8784
• e!Ensembl: ENSG00000138735

Protein

• UniProt ID: O76074
• Protein name: cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE)
• Protein function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:15489334, PubMed:9714779). Specifically regulates nitric-
• PDB: 1RKP, 1T9R, 1T9S, 1TBF, 1UDT, 1UDU, 1UHO, 1XOZ, 1XP0, 2CHM, 2H40, 2H42, 2H44, 2XSS, 3B2R, 3BJC, 3HC8, 3HDZ, 3JWQ, 3JWR, 3LFV, 3MF0, 3SHY, 3SHZ, 3SIE, 3TGE, 3TGG, 4G2W, 4G2Y, 4I9Z, 4IA0, 4MD6, 4OEW, 4OEX, 5JO3, 5ZZ2, 6ACB, 6IWI, 6L6E, 6VBI, 7FAQ, 7FAR, 8W4S, 8W4T, 8WKF, 8WKG, 8XWW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01590	GAF	164 → 314	GAF domain	Domain
  PF01590	GAF	346 → 503	GAF domain	Domain
  PF00233	PDEase_I	612 → 847		Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.
• Sequence:

  MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
  RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
  TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
  SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
  NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
  KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
  FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
  PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
  VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
  QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
  SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
  NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
  LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
  LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
  PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN

• Sequence length: 875

Pathways

KEGG:

Purine metabolism
Metabolic pathways
cGMP-PKG signaling pathway

Reactome:

cGMP effects