Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8643
Gene name Gene Name - the full gene name approved by the HGNC.	Patched 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PTCH2
Synonyms (NCBI Gene) Gene synonyms aliases	PTC2, SLC65B2
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p34.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal

Show/Hide all(3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs56126236	GA>-	Pathogenic, conflicting-interpretations-of-pathogenicity, likely-benign	Stop gained, coding sequence variant
rs121434397	C>T	Pathogenic	Missense variant, coding sequence variant
rs587776628	G>A	Pathogenic	Intron variant

Show/Hide all(168)

miRTarBase ID	miRNA	Experiments	Reference
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	21572407
MIRT508529	hsa-miR-6074	PAR-CLIP	21572407
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	21572407
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	21572407
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	21572407
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	21572407
MIRT498817	hsa-miR-491-3p	PAR-CLIP	21572407
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	21572407
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	21572407
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	21572407
MIRT508529	hsa-miR-6074	PAR-CLIP	23446348
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	23446348
MIRT498821	hsa-miR-4484	PAR-CLIP	23446348
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	23446348
MIRT498817	hsa-miR-491-3p	PAR-CLIP	23446348
MIRT498821	hsa-miR-4484	PAR-CLIP	23446348
MIRT508529	hsa-miR-6074	PAR-CLIP	23446348
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	23446348
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	23446348
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	23446348
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	23446348
MIRT498817	hsa-miR-491-3p	PAR-CLIP	23446348
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	23446348
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	23446348
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	23446348
MIRT498821	hsa-miR-4484	PAR-CLIP	24398324
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	24398324
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	24398324
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	24398324
MIRT498817	hsa-miR-491-3p	PAR-CLIP	24398324
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	24398324
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	24398324
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	24398324
MIRT498821	hsa-miR-4484	PAR-CLIP	27292025
MIRT498821	hsa-miR-4484	PAR-CLIP	27292025
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	27292025
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	27292025
MIRT498817	hsa-miR-491-3p	PAR-CLIP	27292025
MIRT498817	hsa-miR-491-3p	PAR-CLIP	27292025
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	21572407
MIRT508529	hsa-miR-6074	PAR-CLIP	21572407
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	21572407
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	21572407
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	21572407
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	21572407
MIRT498817	hsa-miR-491-3p	PAR-CLIP	21572407
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	21572407
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	21572407
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	21572407
MIRT508529	hsa-miR-6074	PAR-CLIP	23446348
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	23446348
MIRT498821	hsa-miR-4484	PAR-CLIP	23446348
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	23446348
MIRT498817	hsa-miR-491-3p	PAR-CLIP	23446348
MIRT498821	hsa-miR-4484	PAR-CLIP	23446348
MIRT508529	hsa-miR-6074	PAR-CLIP	23446348
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	23446348
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	23446348
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	23446348
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	23446348
MIRT498817	hsa-miR-491-3p	PAR-CLIP	23446348
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	23446348
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	23446348
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	23446348
MIRT498821	hsa-miR-4484	PAR-CLIP	24398324
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	24398324
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	24398324
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	24398324
MIRT498817	hsa-miR-491-3p	PAR-CLIP	24398324
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	24398324
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	24398324
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	24398324
MIRT1272129	hsa-miR-1266	CLIP-seq
MIRT1272130	hsa-miR-141	CLIP-seq
MIRT1272131	hsa-miR-146a	CLIP-seq
MIRT1272132	hsa-miR-146b-5p	CLIP-seq
MIRT1272133	hsa-miR-200a	CLIP-seq
MIRT1272134	hsa-miR-3150a-5p	CLIP-seq
MIRT1272135	hsa-miR-3150b-5p	CLIP-seq
MIRT1272136	hsa-miR-3612	CLIP-seq
MIRT1272137	hsa-miR-3622a-5p	CLIP-seq
MIRT1272138	hsa-miR-3649	CLIP-seq
MIRT1272139	hsa-miR-4270	CLIP-seq
MIRT1272140	hsa-miR-4441	CLIP-seq
MIRT1272141	hsa-miR-4459	CLIP-seq
MIRT1272142	hsa-miR-4518	CLIP-seq
MIRT1272143	hsa-miR-4688	CLIP-seq
MIRT1272144	hsa-miR-4695-5p	CLIP-seq
MIRT1272145	hsa-miR-510	CLIP-seq
MIRT1272146	hsa-miR-513a-5p	CLIP-seq
MIRT1272147	hsa-miR-650	CLIP-seq
MIRT2306271	hsa-miR-3613-3p	CLIP-seq
MIRT2306272	hsa-miR-371b-5p	CLIP-seq
MIRT2306273	hsa-miR-873	CLIP-seq
MIRT2306271	hsa-miR-3613-3p	CLIP-seq
MIRT2393167	hsa-miR-3664-3p	CLIP-seq
MIRT2306272	hsa-miR-371b-5p	CLIP-seq
MIRT2306273	hsa-miR-873	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001558	Process	Regulation of cell growth	IMP	18285427
GO:0001709	Process	Cell fate determination	IEA
GO:0005119	Function	Smoothened binding	IBA	21873635
GO:0005119	Function	Smoothened binding	IPI	9811851
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0007224	Process	Smoothened signaling pathway	IBA	21873635
GO:0008158	Function	Hedgehog receptor activity	IBA	21873635
GO:0008158	Function	Hedgehog receptor activity	TAS	11001584
GO:0009957	Process	Epidermal cell fate specification	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0042633	Process	Hair cycle	IEA
GO:0043588	Process	Skin development	IEA
GO:0045606	Process	Positive regulation of epidermal cell differentiation	IEA
GO:0045879	Process	Negative regulation of smoothened signaling pathway	TAS	11001584
GO:0097108	Function	Hedgehog family protein binding	IBA	21873635
GO:0097108	Function	Hedgehog family protein binding	IPI	9811851
GO:0097108	Function	Hedgehog family protein binding	TAS	11001584

MIM	HGNC	e!Ensembl
603673	9586	ENSG00000117425

Protein

UniProt ID

Q9Y6C5

Protein name

Protein patched homolog 2 (PTC2)

Protein function

Plays a role in the control of cellular growth (PubMed:18285427). May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12349	Sterol-sensing	418 → 570	Sterol-sensing domain of SREBP cleavage-activation	Family
PF02460	Patched	903 → 1116	Patched family	Family

Sequence

MTRSPPLRELPPSYTPPARTAAPQILAGSLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLF
LGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTAR
QEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKL
FPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFASLEGFRELLDK
AQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLG
GMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFV
QLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRWDCAQ
SQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTE
ALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFV
AVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGDGTVPVGIAHLTATV
QAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTRDLLGQEEETRQKAACKS
LPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRG
TKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRT
WLHYYRNWLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLT
TRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGENLRIP
PAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGL
RRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVV
ILVASVGIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSH
FDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEVIQMYKESPEILSPPAPQGGG
LRWGASSSLPQSFARVTTSMTVAIHPPPLPGAYIHPAPDEPPWSPAATSSGNLSSRGPGP
ATG

Sequence length

1203

Interactions

View interactions

	KEGG
	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma

Show/Hide Causal Diseases (20)

Disease term	Disease name	dbSNP ID	References
Causal
Basal cell neoplasm	Basal Cell Nevus Syndrome	rs587776578, rs587776579, rs2117956624, rs2118419579, rs2118365442, rs2118041703, rs2136689212, rs2118336503, rs1587692888, rs267606984, rs878853849, rs1554695110, rs1064793921, rs1588605348, rs1588568813	16914743, 18285427, 8681379, 19533801, 23479190, 3986729
Brachydactyly	Brachydactyly	rs121908949, rs28937580, rs121909082, rs104894122, rs863223289, rs863223290, rs104894121, rs1587657302, rs863223292, rs74315386, rs74315387, rs28936397, rs753691079, rs121909348, rs121917852 View all (22 more)
Carcinoma	Carcinoma, Basal Cell	rs121912654, rs555607708, rs786202962, rs1564055259
Carcinoma, somatic	BASAL CELL CARCINOMA, SOMATIC	rs587776628, rs121918347, rs121918348, rs587776689, rs137853214, rs137853215, rs137853216
Cataract	Cataract	rs118203965, rs118203966, rs104893685, rs121908938, rs104894175, rs121909048, rs28937573, rs121909049, rs121909050, rs74315488, rs80358200, rs80358203, rs121434643, rs56141211, rs132630322 View all (150 more)
Cryptorchidism	Cryptorchidism	rs121912555, rs104894697, rs104894698, rs398122886
Gastrointestinal stromal tumor	Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Sarcoma	rs587776653, rs74315368, rs74315369, rs587776793, rs587776794, rs587776795, rs606231209, rs121908589, rs121913685, rs121913680, rs794726675, rs587776804, rs121913517, rs121913234, rs121913512 View all (59 more)	27793025
Glaucoma	Glaucoma	rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328 View all (29 more)
Gorlin syndrome	Gorlin syndrome	rs199476090, rs2118365442, rs2118336503, rs1587692888, rs267606984, rs786204056, rs786204167, rs863224443, rs863224442, rs863224485, rs863224484, rs863224444, rs863224487, rs863224486, rs863225055 View all (162 more)
Hydrocephalus	Hydrocephalus	rs387907320, rs369384363, rs387907321, rs372127610, rs770273135, rs797045095, rs797045707, rs769795916, rs781251438, rs922703465, rs376078512, rs1567043467, rs1587149916, rs1586841546
Hypogonadotropic hypogonadism	Hypogonadotropic hypogonadism	rs104894702, rs104893836, rs104893837, rs104893842, rs121909628, rs138249161, rs1601946139
Macrocephaly	Macrocephaly	rs786204854, rs764333096, rs1557739557
Medulloblastoma	Medulloblastoma, Childhood Medulloblastoma, Adult Medulloblastoma, Desmoplastic Medulloblastoma, Melanotic medulloblastoma	rs1589970134, rs587776578, rs587776579, rs17847577, rs111033171, rs80359604, rs80358785, rs80358814, rs863224925, rs1555950011, rs1554231278, rs926177767, rs759412460, rs1564032829, rs761911009
Mental retardation	Intellectual Disability	rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315 View all (1024 more)
Microphthalmos	Microphthalmos	rs794726862, rs1329285216
Oculodentodigital dysplasia	Oculo-dento-digital syndrome	rs104893961, rs104893962, rs104893963, rs104893964, rs1582558097, rs28931601, rs1582558666, rs104893966, rs121912969, rs1582558514, rs121912970, rs267606844, rs387906616, rs397518464, rs794729675 View all (9 more)	18285427, 23479190
Ovarian cancer	Malignant neoplasm of ovary	rs34424986, rs137853060, rs28934575, rs79658334, rs121913021, rs62625308, rs80356898, rs80357579, rs41293497, rs80356904, rs80357471, rs80357522, rs80357234, rs80357912, rs80357828 View all (31 more)
Ovarian carcinoma	Ovarian Carcinoma	rs62625308, rs137886232, rs397507192, rs80357609, rs397508926, rs80357223, rs80357678, rs587779243, rs587782861, rs747539984, rs876658381
Polydactyly	Polydactyly	rs1583729398, rs121917709, rs1583734240, rs121917714, rs397507422, rs398122899, rs587776959, rs386833752, rs1057518698, rs1060499558, rs755938967, rs1375768446, rs1309855392, rs1565601979, rs748321474 View all (3 more)
Scoliosis	Scoliosis, unspecified	rs1057518828, rs147296805, rs758163506, rs1555613564, rs1596852902, rs1596853067, rs1596853085

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text Mining
Arthritis Rheumatoid	Associate	37019382
Basal Cell Nevus Syndrome	Associate	23951062, 28915250, 33441926, 34170463
Carcinoma Basal Cell	Associate	11982765, 32319607, 33441926
Cartilage hair hypoplasia	Associate	24009312
Colorectal Neoplasms	Associate	34573430
Endometriosis	Stimulate	26059197
Neoplasms	Associate	11982765, 21666490, 23951062, 31588709, 34308104
Neoplasms Basal Cell	Associate	26059197
Odontogenic Tumors	Associate	23951062
Ovarian Neoplasms	Stimulate	26059197
Polycystic Ovary Syndrome	Associate	34873972
Rhabdomyosarcoma	Associate	29230040
Rhabdomyosarcoma Embryonal	Associate	29230040
Schwannomatosis	Associate	32281771
Thyroid Cancer Papillary	Associate	9528832
Uterine Cervical Neoplasms	Associate	22028038

PTCH2 (patched 2)