Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8643
Gene name	Patched 2
Gene symbol	PTCH2
Synonyms (NCBI Gene)	PTC2SLC65B2
Chromosome	1
Chromosome location	1p34.1
Summary	This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal

Show/Hide all (3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs56126236	GA>-	Pathogenic, conflicting-interpretations-of-pathogenicity, likely-benign	Stop gained, coding sequence variant
rs121434397	C>T	Pathogenic	Missense variant, coding sequence variant
rs587776628	G>A	Pathogenic	Intron variant

168

Show/Hide all (168)

miRTarBase ID	miRNA	Experiments	Reference
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	21572407
MIRT508529	hsa-miR-6074	PAR-CLIP	21572407
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	21572407
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	21572407
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	21572407
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	21572407
MIRT498817	hsa-miR-491-3p	PAR-CLIP	21572407
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	21572407
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	21572407
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	21572407
MIRT508529	hsa-miR-6074	PAR-CLIP	23446348
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	23446348
MIRT498821	hsa-miR-4484	PAR-CLIP	23446348
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	23446348
MIRT498817	hsa-miR-491-3p	PAR-CLIP	23446348
MIRT498821	hsa-miR-4484	PAR-CLIP	23446348
MIRT508529	hsa-miR-6074	PAR-CLIP	23446348
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	23446348
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	23446348
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	23446348
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	23446348
MIRT498817	hsa-miR-491-3p	PAR-CLIP	23446348
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	23446348
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	23446348
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	23446348
MIRT498821	hsa-miR-4484	PAR-CLIP	24398324
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	24398324
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	24398324
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	24398324
MIRT498817	hsa-miR-491-3p	PAR-CLIP	24398324
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	24398324
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	24398324
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	24398324
MIRT498821	hsa-miR-4484	PAR-CLIP	27292025
MIRT498821	hsa-miR-4484	PAR-CLIP	27292025
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	27292025
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	27292025
MIRT498817	hsa-miR-491-3p	PAR-CLIP	27292025
MIRT498817	hsa-miR-491-3p	PAR-CLIP	27292025
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	20371350
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	20371350
MIRT508529	hsa-miR-6074	PAR-CLIP	20371350
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	20371350
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	20371350
MIRT498817	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT498821	hsa-miR-4484	PAR-CLIP	21572407
MIRT508529	hsa-miR-6074	PAR-CLIP	21572407
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	21572407
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	21572407
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	21572407
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	21572407
MIRT498817	hsa-miR-491-3p	PAR-CLIP	21572407
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	21572407
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	21572407
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	21572407
MIRT508529	hsa-miR-6074	PAR-CLIP	23446348
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	23446348
MIRT498821	hsa-miR-4484	PAR-CLIP	23446348
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	23446348
MIRT498817	hsa-miR-491-3p	PAR-CLIP	23446348
MIRT498821	hsa-miR-4484	PAR-CLIP	23446348
MIRT508529	hsa-miR-6074	PAR-CLIP	23446348
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	23446348
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	23446348
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	23446348
MIRT508528	hsa-miR-4709-3p	PAR-CLIP	23446348
MIRT498817	hsa-miR-491-3p	PAR-CLIP	23446348
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	23446348
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	23446348
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	23446348
MIRT498821	hsa-miR-4484	PAR-CLIP	24398324
MIRT498820	hsa-miR-4787-3p	PAR-CLIP	24398324
MIRT498819	hsa-miR-6845-3p	PAR-CLIP	24398324
MIRT498818	hsa-miR-6873-3p	PAR-CLIP	24398324
MIRT498817	hsa-miR-491-3p	PAR-CLIP	24398324
MIRT191170	hsa-miR-4768-5p	PAR-CLIP	24398324
MIRT191173	hsa-miR-6833-3p	PAR-CLIP	24398324
MIRT191172	hsa-miR-6809-3p	PAR-CLIP	24398324
MIRT1272129	hsa-miR-1266	CLIP-seq
MIRT1272130	hsa-miR-141	CLIP-seq
MIRT1272131	hsa-miR-146a	CLIP-seq
MIRT1272132	hsa-miR-146b-5p	CLIP-seq
MIRT1272133	hsa-miR-200a	CLIP-seq
MIRT1272134	hsa-miR-3150a-5p	CLIP-seq
MIRT1272135	hsa-miR-3150b-5p	CLIP-seq
MIRT1272136	hsa-miR-3612	CLIP-seq
MIRT1272137	hsa-miR-3622a-5p	CLIP-seq
MIRT1272138	hsa-miR-3649	CLIP-seq
MIRT1272139	hsa-miR-4270	CLIP-seq
MIRT1272140	hsa-miR-4441	CLIP-seq
MIRT1272141	hsa-miR-4459	CLIP-seq
MIRT1272142	hsa-miR-4518	CLIP-seq
MIRT1272143	hsa-miR-4688	CLIP-seq
MIRT1272144	hsa-miR-4695-5p	CLIP-seq
MIRT1272145	hsa-miR-510	CLIP-seq
MIRT1272146	hsa-miR-513a-5p	CLIP-seq
MIRT1272147	hsa-miR-650	CLIP-seq
MIRT2306271	hsa-miR-3613-3p	CLIP-seq
MIRT2306272	hsa-miR-371b-5p	CLIP-seq
MIRT2306273	hsa-miR-873	CLIP-seq
MIRT2306271	hsa-miR-3613-3p	CLIP-seq
MIRT2393167	hsa-miR-3664-3p	CLIP-seq
MIRT2306272	hsa-miR-371b-5p	CLIP-seq
MIRT2306273	hsa-miR-873	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001558	Process	Regulation of cell growth	IMP	18285427
GO:0001709	Process	Cell fate determination	IEA
GO:0005119	Function	Smoothened binding	IBA
GO:0005119	Function	Smoothened binding	IEA
GO:0005119	Function	Smoothened binding	IPI	9811851
GO:0005886	Component	Plasma membrane	IBA
GO:0008158	Function	Hedgehog receptor activity	IBA
GO:0008158	Function	Hedgehog receptor activity	IEA
GO:0008158	Function	Hedgehog receptor activity	TAS	11001584
GO:0008544	Process	Epidermis development	IEA
GO:0009957	Process	Epidermal cell fate specification	IEA
GO:0016020	Component	Membrane	IEA
GO:0042633	Process	Hair cycle	IEA
GO:0043588	Process	Skin development	IEA
GO:0045606	Process	Positive regulation of epidermal cell differentiation	IEA
GO:0045879	Process	Negative regulation of smoothened signaling pathway	IBA
GO:0045879	Process	Negative regulation of smoothened signaling pathway	TAS	11001584
GO:0097108	Function	Hedgehog family protein binding	IBA
GO:0097108	Function	Hedgehog family protein binding	IEA
GO:0097108	Function	Hedgehog family protein binding	IPI	9811851
GO:0097108	Function	Hedgehog family protein binding	TAS	11001584

MIM	HGNC	e!Ensembl
603673	9586	ENSG00000117425

Q9Y6C5

Protein name

Protein patched homolog 2 (PTC2)

Protein function

Plays a role in the control of cellular growth (PubMed:18285427). May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12349	Sterol-sensing	418 → 570	Sterol-sensing domain of SREBP cleavage-activation	Family
PF02460	Patched	903 → 1116	Patched family	Family

Sequence

MTRSPPLRELPPSYTPPARTAAPQILAGSLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLF
LGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTAR
QEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKL
FPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFASLEGFRELLDK
AQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLG
GMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFV
QLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRWDCAQ
SQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTE
ALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFV
AVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGDGTVPVGIAHLTATV
QAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTRDLLGQEEETRQKAACKS
LPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRG
TKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRT
WLHYYRNWLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLT
TRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGENLRIP
PAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGL
RRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVV
ILVASVGIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSH
FDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEVIQMYKESPEILSPPAPQGGG
LRWGASSSLPQSFARVTTSMTVAIHPPPLPGAYIHPAPDEPPWSPAATSSGNLSSRGPGP
ATG

Sequence length

1203

Interactions

View interactions

	KEGG
	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma

1162

Show/Hide Causal Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Basal cell carcinoma, somatic	Pathogenic	rs587776628	RCV000006521
Basal cell carcinoma, susceptibility to, 1	Pathogenic	rs2521979430	RCV003992761
Familial cancer of breast	Likely pathogenic	rs771498368	RCV003315494
Gorlin syndrome	Pathogenic	rs2521979430	RCV003322681

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Adrenocortical carcinoma, hereditary	Benign	rs2295997	RCV005909586
Basal cell nevus syndrome 1	Uncertain significance; Benign; Likely benign; Conflicting classifications of pathogenicity	rs761307519, rs765876309, rs121434397, rs144193647, rs111471526, rs11573588, rs11573586, rs35851686, rs11573579, rs147627670, rs45573433, rs561781541, rs779438541, rs11573587, rs11573590 View all (13 more)	RCV005601844 RCV005055204 RCV005055058 RCV005601980 RCV005235163 RCV005235162 RCV005235161 RCV005235160 RCV005235159 RCV005235165 RCV005235166 RCV005235164 RCV004786956 RCV005235330 RCV005235328 RCV005235332 RCV005235331 RCV005235329 RCV005235333 RCV004787836 RCV005235374 RCV005860118 RCV005438367 RCV004788123 RCV005601617 RCV004773206 RCV005055153 RCV005055163
Breast carcinoma	Uncertain significance	rs757205202, rs145536878	RCV003233038 RCV003233042
Cholangiocarcinoma	Benign	rs3795719	RCV005916989
Colorectal cancer	Benign	rs2295997	RCV005909588
Diffuse midline glioma, H3 K27-altered	Uncertain significance	rs1052051090	RCV003313767
Gastric cancer	Likely benign; Uncertain significance	rs11573583, rs760548568	RCV005920879 RCV005891092
Malignant lymphoma, large B-cell, diffuse	Benign	rs2295997	RCV005909587
Medulloblastoma	Uncertain significance; Conflicting classifications of pathogenicity; Benign; Likely benign	rs376282577, rs201345708, rs752886480, rs765975927, rs779024571, rs2148874807, rs745653597, rs748846701, rs769826884, rs745450202, rs1557646078, rs56126236, rs200862802, rs34245589, rs45573433 View all (37 more)	RCV005014459 RCV005023159 RCV005016754 RCV005025622 RCV005016987 RCV005017018 RCV005016844 RCV002484628 RCV005019619 RCV005028297 RCV005021807 RCV000006520 RCV005019549 RCV002494644 RCV005396794 RCV005014751 RCV005014811 RCV005014896 RCV005030244 RCV002475914 RCV000765169 RCV005027621 RCV000765172 RCV000765170 RCV002507055 RCV005392190 RCV005021096 RCV005027852 RCV005027865 RCV000765171 RCV005021137 RCV005021238 RCV005029513 RCV005021227 RCV005029471 RCV005392428 RCV005029458 RCV002487739 RCV005392473 RCV002487887 RCV002495280 RCV005021368 RCV005021342 RCV005021521 RCV005021539 RCV005394827 RCV005029784 RCV005029752 RCV005029816 RCV005014301 RCV005394914 RCV005029877
Oromandibular-limb hypogenesis spectrum	Uncertain significance; Likely benign	rs760548568, rs775127172	RCV000239932 RCV000240145
Ovarian serous cystadenocarcinoma	Uncertain significance; Likely benign	rs369587910, rs200437527	RCV005924229 RCV005900104
PTCH2-related disorder	Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity	rs200049774, rs973768191, rs746328425, rs569864866, rs188437092, rs141511043, rs138668059, rs151287275, rs370819522, rs58079936, rs757205202, rs756770955, rs143348731, rs771080740, rs372723227 View all (54 more)	RCV004738259 RCV004548188 RCV004550091 RCV004550111 RCV004550198 RCV004738305 RCV004550255 RCV004738488 RCV004552111 RCV004738430 RCV004738458 RCV004553689 RCV004553655 RCV004550384 RCV004548315 RCV004548340 RCV004550339 RCV004550343 RCV004550342 RCV004547606 RCV004547605 RCV004547604 RCV004547603 RCV004547602 RCV004547621 RCV004548591 RCV004552628 RCV004552587 RCV004554112 RCV004554268 RCV004738768 RCV004550993 RCV004552738 RCV004552722 RCV004552835 RCV004554404 RCV004551559 RCV004737529 RCV004551558 RCV004551557 RCV004551556 RCV004551560 RCV004553169 RCV004737602 RCV004737603 RCV004553168 RCV004553167 RCV004553166 RCV004737906 RCV004547771 RCV004737902 RCV004547767 RCV004547766 RCV004547772 RCV004547769 RCV001824867 RCV004549883 RCV004549917 RCV004549924 RCV004549934 RCV004549921 RCV004549932 RCV004738034 RCV004549949 RCV004549954 RCV004549948 RCV004549953 RCV004549959 RCV004547975 RCV004726983
See cases	Uncertain significance	rs900911841	RCV002252220
Uterine carcinosarcoma	Benign	rs2295997, rs3795719	RCV005909589 RCV005916988

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Arthritis Rheumatoid	Associate	37019382
Basal Cell Nevus Syndrome	Associate	23951062, 28915250, 33441926, 34170463
Carcinoma Basal Cell	Associate	11982765, 32319607, 33441926
Cartilage hair hypoplasia	Associate	24009312
Colorectal Neoplasms	Associate	34573430
Endometriosis	Stimulate	26059197
Neoplasms	Associate	11982765, 21666490, 23951062, 31588709, 34308104
Neoplasms Basal Cell	Associate	26059197
Odontogenic Tumors	Associate	23951062
Ovarian Neoplasms	Stimulate	26059197
Polycystic Ovary Syndrome	Associate	34873972
Rhabdomyosarcoma	Associate	29230040
Rhabdomyosarcoma Embryonal	Associate	29230040
Schwannomatosis	Associate	32281771
Thyroid Cancer Papillary	Associate	9528832
Uterine Cervical Neoplasms	Associate	22028038

PTCH2 (patched 2)