Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8638
Gene name Gene Name - the full gene name approved by the HGNC.	2'-5'-oligoadenylate synthetase like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	OASL
Synonyms (NCBI Gene) Gene synonyms aliases	OASL1, OASLd, TRIP-14, TRIP14, p59 OASL, p59-OASL, p59OASL
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q24.31

Show/Hide all(106)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021250	hsa-miR-146a-5p	Microarray	18057241
MIRT022684	hsa-miR-124-3p	Microarray	18668037
MIRT023766	hsa-miR-1-3p	Microarray	18668037
MIRT1201245	hsa-miR-3934	CLIP-seq
MIRT1201246	hsa-miR-5095	CLIP-seq
MIRT1201247	hsa-miR-552	CLIP-seq
MIRT1201248	hsa-miR-610	CLIP-seq
MIRT2058150	hsa-miR-1224-3p	CLIP-seq
MIRT2058151	hsa-miR-1234	CLIP-seq
MIRT2058152	hsa-miR-1260	CLIP-seq
MIRT2058153	hsa-miR-1260b	CLIP-seq
MIRT2058154	hsa-miR-1280	CLIP-seq
MIRT2058155	hsa-miR-4268	CLIP-seq
MIRT2058156	hsa-miR-518e	CLIP-seq
MIRT2058157	hsa-miR-532-3p	CLIP-seq
MIRT2058150	hsa-miR-1224-3p	CLIP-seq
MIRT2058151	hsa-miR-1234	CLIP-seq
MIRT2584635	hsa-miR-1255a	CLIP-seq
MIRT2584636	hsa-miR-1255b	CLIP-seq
MIRT2058152	hsa-miR-1260	CLIP-seq
MIRT2058153	hsa-miR-1260b	CLIP-seq
MIRT2058154	hsa-miR-1280	CLIP-seq
MIRT2584637	hsa-miR-1299	CLIP-seq
MIRT2584638	hsa-miR-150	CLIP-seq
MIRT2584639	hsa-miR-1912	CLIP-seq
MIRT2584640	hsa-miR-3130-5p	CLIP-seq
MIRT2584641	hsa-miR-3176	CLIP-seq
MIRT2584642	hsa-miR-3192	CLIP-seq
MIRT2584643	hsa-miR-3545-3p	CLIP-seq
MIRT2584644	hsa-miR-3649	CLIP-seq
MIRT2584645	hsa-miR-3661	CLIP-seq
MIRT2584646	hsa-miR-3663-5p	CLIP-seq
MIRT2584647	hsa-miR-3919	CLIP-seq
MIRT2584648	hsa-miR-3922-3p	CLIP-seq
MIRT1201245	hsa-miR-3934	CLIP-seq
MIRT2058155	hsa-miR-4268	CLIP-seq
MIRT2584649	hsa-miR-4289	CLIP-seq
MIRT2584650	hsa-miR-4299	CLIP-seq
MIRT2584651	hsa-miR-4314	CLIP-seq
MIRT2584652	hsa-miR-4482	CLIP-seq
MIRT2584653	hsa-miR-4635	CLIP-seq
MIRT2584654	hsa-miR-4638-5p	CLIP-seq
MIRT2584655	hsa-miR-4646-5p	CLIP-seq
MIRT2584656	hsa-miR-4680-5p	CLIP-seq
MIRT2584657	hsa-miR-4713-5p	CLIP-seq
MIRT2584658	hsa-miR-4782-5p	CLIP-seq
MIRT2584659	hsa-miR-4797-5p	CLIP-seq
MIRT2584660	hsa-miR-4802-3p	CLIP-seq
MIRT1201246	hsa-miR-5095	CLIP-seq
MIRT2584661	hsa-miR-516b	CLIP-seq
MIRT2058156	hsa-miR-518e	CLIP-seq
MIRT2058157	hsa-miR-532-3p	CLIP-seq
MIRT2584662	hsa-miR-548a-3p	CLIP-seq
MIRT2584663	hsa-miR-548e	CLIP-seq
MIRT2584664	hsa-miR-548f	CLIP-seq
MIRT1201247	hsa-miR-552	CLIP-seq
MIRT2584665	hsa-miR-582-3p	CLIP-seq
MIRT1201248	hsa-miR-610	CLIP-seq
MIRT2584666	hsa-miR-631	CLIP-seq
MIRT2584667	hsa-miR-661	CLIP-seq
MIRT2584668	hsa-miR-936	CLIP-seq
MIRT2058150	hsa-miR-1224-3p	CLIP-seq
MIRT2058151	hsa-miR-1234	CLIP-seq
MIRT2584635	hsa-miR-1255a	CLIP-seq
MIRT2584636	hsa-miR-1255b	CLIP-seq
MIRT2058152	hsa-miR-1260	CLIP-seq
MIRT2058153	hsa-miR-1260b	CLIP-seq
MIRT2058154	hsa-miR-1280	CLIP-seq
MIRT2584637	hsa-miR-1299	CLIP-seq
MIRT2584638	hsa-miR-150	CLIP-seq
MIRT2584639	hsa-miR-1912	CLIP-seq
MIRT2584640	hsa-miR-3130-5p	CLIP-seq
MIRT2584641	hsa-miR-3176	CLIP-seq
MIRT2584642	hsa-miR-3192	CLIP-seq
MIRT2584643	hsa-miR-3545-3p	CLIP-seq
MIRT2584644	hsa-miR-3649	CLIP-seq
MIRT2584645	hsa-miR-3661	CLIP-seq
MIRT2584646	hsa-miR-3663-5p	CLIP-seq
MIRT2584647	hsa-miR-3919	CLIP-seq
MIRT2584648	hsa-miR-3922-3p	CLIP-seq
MIRT1201245	hsa-miR-3934	CLIP-seq
MIRT2058155	hsa-miR-4268	CLIP-seq
MIRT2584649	hsa-miR-4289	CLIP-seq
MIRT2584650	hsa-miR-4299	CLIP-seq
MIRT2584651	hsa-miR-4314	CLIP-seq
MIRT2584652	hsa-miR-4482	CLIP-seq
MIRT2584653	hsa-miR-4635	CLIP-seq
MIRT2584654	hsa-miR-4638-5p	CLIP-seq
MIRT2584655	hsa-miR-4646-5p	CLIP-seq
MIRT2584656	hsa-miR-4680-5p	CLIP-seq
MIRT2584657	hsa-miR-4713-5p	CLIP-seq
MIRT2584658	hsa-miR-4782-5p	CLIP-seq
MIRT2584659	hsa-miR-4797-5p	CLIP-seq
MIRT2584660	hsa-miR-4802-3p	CLIP-seq
MIRT1201246	hsa-miR-5095	CLIP-seq
MIRT2584661	hsa-miR-516b	CLIP-seq
MIRT2058156	hsa-miR-518e	CLIP-seq
MIRT2058157	hsa-miR-532-3p	CLIP-seq
MIRT2584662	hsa-miR-548a-3p	CLIP-seq
MIRT2584663	hsa-miR-548e	CLIP-seq
MIRT2584664	hsa-miR-548f	CLIP-seq
MIRT1201247	hsa-miR-552	CLIP-seq
MIRT2584665	hsa-miR-582-3p	CLIP-seq
MIRT1201248	hsa-miR-610	CLIP-seq
MIRT2584666	hsa-miR-631	CLIP-seq
MIRT2584667	hsa-miR-661	CLIP-seq

Show/Hide all(37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001730	Function	2'-5'-oligoadenylate synthetase activity	IDA	9826176
GO:0002376	Process	Immune system process	IEA
GO:0003677	Function	DNA binding	IDA	9826176
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IBA
GO:0003725	Function	Double-stranded RNA binding	IDA	9826176, 25925578
GO:0003725	Function	Double-stranded RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	30833792, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA	9826176
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA	9826176
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0009615	Process	Response to virus	IDA	18931074, 20074559
GO:0009615	Process	Response to virus	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0045071	Process	Negative regulation of viral genome replication	IBA
GO:0045071	Process	Negative regulation of viral genome replication	IDA	18931074, 20074559
GO:0045087	Process	Innate immune response	IEA
GO:0046966	Function	Nuclear thyroid hormone receptor binding	TAS	7776974
GO:0051607	Process	Defense response to virus	IDA	21478870
GO:0051607	Process	Defense response to virus	IEA
GO:0060337	Process	Type I interferon-mediated signaling pathway	IBA
GO:0070106	Process	Interleukin-27-mediated signaling pathway	IBA
GO:0070106	Process	Interleukin-27-mediated signaling pathway	IEA
GO:0070106	Process	Interleukin-27-mediated signaling pathway	IEP	32270034
GO:0098542	Process	Defense response to other organism	IEA
GO:0140374	Process	Antiviral innate immune response	IBA
GO:1900246	Process	Positive regulation of RIG-I signaling pathway	IDA	25925578

MIM	HGNC	e!Ensembl
603281	8090	ENSG00000135114

Protein

UniProt ID

Q15646

Protein name

2'-5'-oligoadenylate synthase-like protein (2'-5'-OAS-related protein) (2'-5'-OAS-RP) (59 kDa 2'-5'-oligoadenylate synthase-like protein) (Thyroid receptor-interacting protein 14) (TR-interacting protein 14) (TRIP-14) (p59 OASL) (p59OASL)

Protein function

Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMe

PDB

1WH3 , 4XQ7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10421	OAS1_C	168 → 351		Domain
PF00240	ubiquitin	436 → 507	Ubiquitin family	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.

Sequence

MALMQELYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFLRQEHFQGKRGLDQDVR
VLKVVKVGSFGNGTVLRSTREVELVAFLSCFHSFQEAAKHHKDVLRLIWKTMWQSQDLLD
LGLEDLRMEQRVPDALVFTIQTRGTAEPITVTIVPAYRALGPSLPNSQPPPEVYVSLIKA
CGGPGNFCPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVKARSPRANLPPLYALELLT
IYAWEMGTEEDENFMLDEGFTTVMDLLLEYEVICIYWTKYYTLHNAIIEDCVRKQLKKER
PIILDPADPTLNVAEGYRWDIVAQRASQCLKQDCCYDNRENPISSWNVKRARDIHLTVEQ
RGYPDFNLIVNPYEPIRKVKEKIRRTRGYSGLQRLSFQVPGSERQLLSSRCSLAKYGIFS
HTHIYLLETIPSEIQVFVKNPDGGSYAYAINPNSFILGLKQQIEDQQGLPKKQQQLEFQG
QVLQDWLGLGIYGIQDSDTLILSKKKGEALFPAS

Sequence length

514

Interactions

View interactions

	KEGG		Reactome
	Human papillomavirus infection		Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Diabetes	Type 2 diabetes, Type 2 diabetes mellitus adjusted for BMI or coronary artery disease (pleiotropy), Type 2 diabetes mellitus or coronary artery disease (pleiotropy)	N/A	N/A	GWAS

Show/Hide Text Mining Associations (26)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Arthritis Rheumatoid	Associate	29973208, 34079550
Asthma	Inhibit	38373824
Breast Neoplasms	Associate	32560641
Carcinoma Ductal	Associate	36765396
Carcinoma Pancreatic Ductal	Associate	32545414
Carcinoma Renal Cell	Associate	33229623
Condylomata Acuminata	Associate	35131475
COVID 19	Associate	34009691, 36072597, 36656015, 36911695
Dengue	Associate	14557666
Diabetes Gestational	Associate	29947923
Glioma	Associate	36007277
Infections	Stimulate	14557666
Influenza Human	Associate	36911695, 37631988, 39591472
Lupus Erythematosus Systemic	Associate	16947629, 32321151, 34079550, 35967341, 36765396
Microscopic Polyangiitis	Associate	23690996, 28569178
Mouth Neoplasms	Associate	36510962, 37174688
Neoplasms	Associate	37174688, 39286258
Netherton Syndrome	Associate	29803800
Prediabetic State	Associate	30629177
Scleroderma Systemic	Associate	33253099, 35183246
Sjogren's Syndrome	Associate	36189916
Squamous Cell Carcinoma of Head and Neck	Associate	36510962
Urinary Bladder Neoplasms	Associate	36162993
Uterine Cervical Neoplasms	Associate	37174688
Vascular Diseases	Associate	36333342
West Nile Fever	Associate	24865988

OASL (2'-5'-oligoadenylate synthetase like)