Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	8638
Gene name	2'-5'-oligoadenylate synthetase like
Gene symbol	OASL
Synonyms (NCBI Gene)	OASL1OASLdTRIP-14TRIP14p59 OASLp59-OASLp59OASL
Chromosome	12
Chromosome location	12q24.31

106

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021250	hsa-miR-146a-5p	Microarray	18057241
MIRT022684	hsa-miR-124-3p	Microarray	18668037
MIRT023766	hsa-miR-1-3p	Microarray	18668037
MIRT1201245	hsa-miR-3934	CLIP-seq
MIRT1201246	hsa-miR-5095	CLIP-seq
MIRT1201247	hsa-miR-552	CLIP-seq
MIRT1201248	hsa-miR-610	CLIP-seq
MIRT2058150	hsa-miR-1224-3p	CLIP-seq
MIRT2058151	hsa-miR-1234	CLIP-seq
MIRT2058152	hsa-miR-1260	CLIP-seq
MIRT2058153	hsa-miR-1260b	CLIP-seq
MIRT2058154	hsa-miR-1280	CLIP-seq
MIRT2058155	hsa-miR-4268	CLIP-seq
MIRT2058156	hsa-miR-518e	CLIP-seq
MIRT2058157	hsa-miR-532-3p	CLIP-seq
MIRT2058150	hsa-miR-1224-3p	CLIP-seq
MIRT2058151	hsa-miR-1234	CLIP-seq
MIRT2584635	hsa-miR-1255a	CLIP-seq
MIRT2584636	hsa-miR-1255b	CLIP-seq
MIRT2058152	hsa-miR-1260	CLIP-seq
MIRT2058153	hsa-miR-1260b	CLIP-seq
MIRT2058154	hsa-miR-1280	CLIP-seq
MIRT2584637	hsa-miR-1299	CLIP-seq
MIRT2584638	hsa-miR-150	CLIP-seq
MIRT2584639	hsa-miR-1912	CLIP-seq
MIRT2584640	hsa-miR-3130-5p	CLIP-seq
MIRT2584641	hsa-miR-3176	CLIP-seq
MIRT2584642	hsa-miR-3192	CLIP-seq
MIRT2584643	hsa-miR-3545-3p	CLIP-seq
MIRT2584644	hsa-miR-3649	CLIP-seq
MIRT2584645	hsa-miR-3661	CLIP-seq
MIRT2584646	hsa-miR-3663-5p	CLIP-seq
MIRT2584647	hsa-miR-3919	CLIP-seq
MIRT2584648	hsa-miR-3922-3p	CLIP-seq
MIRT1201245	hsa-miR-3934	CLIP-seq
MIRT2058155	hsa-miR-4268	CLIP-seq
MIRT2584649	hsa-miR-4289	CLIP-seq
MIRT2584650	hsa-miR-4299	CLIP-seq
MIRT2584651	hsa-miR-4314	CLIP-seq
MIRT2584652	hsa-miR-4482	CLIP-seq
MIRT2584653	hsa-miR-4635	CLIP-seq
MIRT2584654	hsa-miR-4638-5p	CLIP-seq
MIRT2584655	hsa-miR-4646-5p	CLIP-seq
MIRT2584656	hsa-miR-4680-5p	CLIP-seq
MIRT2584657	hsa-miR-4713-5p	CLIP-seq
MIRT2584658	hsa-miR-4782-5p	CLIP-seq
MIRT2584659	hsa-miR-4797-5p	CLIP-seq
MIRT2584660	hsa-miR-4802-3p	CLIP-seq
MIRT1201246	hsa-miR-5095	CLIP-seq
MIRT2584661	hsa-miR-516b	CLIP-seq
MIRT2058156	hsa-miR-518e	CLIP-seq
MIRT2058157	hsa-miR-532-3p	CLIP-seq
MIRT2584662	hsa-miR-548a-3p	CLIP-seq
MIRT2584663	hsa-miR-548e	CLIP-seq
MIRT2584664	hsa-miR-548f	CLIP-seq
MIRT1201247	hsa-miR-552	CLIP-seq
MIRT2584665	hsa-miR-582-3p	CLIP-seq
MIRT1201248	hsa-miR-610	CLIP-seq
MIRT2584666	hsa-miR-631	CLIP-seq
MIRT2584667	hsa-miR-661	CLIP-seq
MIRT2584668	hsa-miR-936	CLIP-seq
MIRT2058150	hsa-miR-1224-3p	CLIP-seq
MIRT2058151	hsa-miR-1234	CLIP-seq
MIRT2584635	hsa-miR-1255a	CLIP-seq
MIRT2584636	hsa-miR-1255b	CLIP-seq
MIRT2058152	hsa-miR-1260	CLIP-seq
MIRT2058153	hsa-miR-1260b	CLIP-seq
MIRT2058154	hsa-miR-1280	CLIP-seq
MIRT2584637	hsa-miR-1299	CLIP-seq
MIRT2584638	hsa-miR-150	CLIP-seq
MIRT2584639	hsa-miR-1912	CLIP-seq
MIRT2584640	hsa-miR-3130-5p	CLIP-seq
MIRT2584641	hsa-miR-3176	CLIP-seq
MIRT2584642	hsa-miR-3192	CLIP-seq
MIRT2584643	hsa-miR-3545-3p	CLIP-seq
MIRT2584644	hsa-miR-3649	CLIP-seq
MIRT2584645	hsa-miR-3661	CLIP-seq
MIRT2584646	hsa-miR-3663-5p	CLIP-seq
MIRT2584647	hsa-miR-3919	CLIP-seq
MIRT2584648	hsa-miR-3922-3p	CLIP-seq
MIRT1201245	hsa-miR-3934	CLIP-seq
MIRT2058155	hsa-miR-4268	CLIP-seq
MIRT2584649	hsa-miR-4289	CLIP-seq
MIRT2584650	hsa-miR-4299	CLIP-seq
MIRT2584651	hsa-miR-4314	CLIP-seq
MIRT2584652	hsa-miR-4482	CLIP-seq
MIRT2584653	hsa-miR-4635	CLIP-seq
MIRT2584654	hsa-miR-4638-5p	CLIP-seq
MIRT2584655	hsa-miR-4646-5p	CLIP-seq
MIRT2584656	hsa-miR-4680-5p	CLIP-seq
MIRT2584657	hsa-miR-4713-5p	CLIP-seq
MIRT2584658	hsa-miR-4782-5p	CLIP-seq
MIRT2584659	hsa-miR-4797-5p	CLIP-seq
MIRT2584660	hsa-miR-4802-3p	CLIP-seq
MIRT1201246	hsa-miR-5095	CLIP-seq
MIRT2584661	hsa-miR-516b	CLIP-seq
MIRT2058156	hsa-miR-518e	CLIP-seq
MIRT2058157	hsa-miR-532-3p	CLIP-seq
MIRT2584662	hsa-miR-548a-3p	CLIP-seq
MIRT2584663	hsa-miR-548e	CLIP-seq
MIRT2584664	hsa-miR-548f	CLIP-seq
MIRT1201247	hsa-miR-552	CLIP-seq
MIRT2584665	hsa-miR-582-3p	CLIP-seq
MIRT1201248	hsa-miR-610	CLIP-seq
MIRT2584666	hsa-miR-631	CLIP-seq
MIRT2584667	hsa-miR-661	CLIP-seq

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001730	Function	2'-5'-oligoadenylate synthetase activity	IDA	9826176
GO:0002376	Process	Immune system process	IEA
GO:0003677	Function	DNA binding	IDA	9826176
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IBA
GO:0003725	Function	Double-stranded RNA binding	IDA	9826176, 25925578
GO:0003725	Function	Double-stranded RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	30833792, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA	9826176
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA	9826176
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0009615	Process	Response to virus	IDA	18931074, 20074559
GO:0009615	Process	Response to virus	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0045071	Process	Negative regulation of viral genome replication	IBA
GO:0045071	Process	Negative regulation of viral genome replication	IDA	18931074, 20074559
GO:0045087	Process	Innate immune response	IEA
GO:0046966	Function	Nuclear thyroid hormone receptor binding	TAS	7776974
GO:0051607	Process	Defense response to virus	IDA	21478870
GO:0051607	Process	Defense response to virus	IEA
GO:0060337	Process	Type I interferon-mediated signaling pathway	IBA
GO:0070106	Process	Interleukin-27-mediated signaling pathway	IBA
GO:0070106	Process	Interleukin-27-mediated signaling pathway	IEA
GO:0070106	Process	Interleukin-27-mediated signaling pathway	IEP	32270034
GO:0098542	Process	Defense response to other organism	IEA
GO:0140374	Process	Antiviral innate immune response	IBA
GO:1900246	Process	Positive regulation of RIG-I signaling pathway	IDA	25925578

MIM	HGNC	e!Ensembl
603281	8090	ENSG00000135114

Q15646

Protein name

2'-5'-oligoadenylate synthase-like protein (2'-5'-OAS-related protein) (2'-5'-OAS-RP) (59 kDa 2'-5'-oligoadenylate synthase-like protein) (Thyroid receptor-interacting protein 14) (TR-interacting protein 14) (TRIP-14) (p59 OASL) (p59OASL)

Protein function

Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMe

PDB

1WH3 , 4XQ7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10421	OAS1_C	168 → 351		Domain
PF00240	ubiquitin	436 → 507	Ubiquitin family	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.

Sequence

MALMQELYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFLRQEHFQGKRGLDQDVR
VLKVVKVGSFGNGTVLRSTREVELVAFLSCFHSFQEAAKHHKDVLRLIWKTMWQSQDLLD
LGLEDLRMEQRVPDALVFTIQTRGTAEPITVTIVPAYRALGPSLPNSQPPPEVYVSLIKA
CGGPGNFCPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVKARSPRANLPPLYALELLT
IYAWEMGTEEDENFMLDEGFTTVMDLLLEYEVICIYWTKYYTLHNAIIEDCVRKQLKKER
PIILDPADPTLNVAEGYRWDIVAQRASQCLKQDCCYDNRENPISSWNVKRARDIHLTVEQ
RGYPDFNLIVNPYEPIRKVKEKIRRTRGYSGLQRLSFQVPGSERQLLSSRCSLAKYGIFS
HTHIYLLETIPSEIQVFVKNPDGGSYAYAINPNSFILGLKQQIEDQQGLPKKQQQLEFQG
QVLQDWLGLGIYGIQDSDTLILSKKKGEALFPAS

Sequence length

514

Interactions

View interactions

	KEGG		Reactome
	Human papillomavirus infection		Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling

OASL (2'-5'-oligoadenylate synthetase like)