SSNA1 (SS nuclear autoantigen 1)

Gene

• Entrez ID: 8636
• Gene name: SS nuclear autoantigen 1
• Gene symbol: SSNA1
• Synonyms (NCBI Gene): N14, NA-14, NA14
• Chromosome: 9
• Chromosome location: 9q34.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001330	hsa-miR-1-3p	pSILAC	18668040
MIRT022545	hsa-miR-124-3p	Microarray	18668037
MIRT001330	hsa-miR-1-3p	Proteomics;Other	18668040
MIRT041367	hsa-miR-193b-3p	CLASH	23622248
MIRT2117530	hsa-miR-22	CLIP-seq
MIRT2117531	hsa-miR-3126-5p	CLIP-seq
MIRT2117532	hsa-miR-3185	CLIP-seq
MIRT2117533	hsa-miR-3194-3p	CLIP-seq
MIRT2117534	hsa-miR-3663-3p	CLIP-seq
MIRT2117535	hsa-miR-3921	CLIP-seq
MIRT2117536	hsa-miR-4303	CLIP-seq
MIRT2117537	hsa-miR-4419a	CLIP-seq
MIRT2117538	hsa-miR-4510	CLIP-seq
MIRT2117539	hsa-miR-4653-5p	CLIP-seq
MIRT2117540	hsa-miR-4747-5p	CLIP-seq
MIRT2117541	hsa-miR-4786-5p	CLIP-seq
MIRT2117542	hsa-miR-603	CLIP-seq
MIRT2117543	hsa-miR-769-5p	CLIP-seq
MIRT2339687	hsa-miR-2467-3p	CLIP-seq
MIRT2339688	hsa-miR-3160-3p	CLIP-seq
MIRT2339689	hsa-miR-3661	CLIP-seq
MIRT2339690	hsa-miR-3678-3p	CLIP-seq
MIRT2339691	hsa-miR-4254	CLIP-seq
MIRT2339692	hsa-miR-619	CLIP-seq
MIRT2339693	hsa-miR-631	CLIP-seq
MIRT2633516	hsa-miR-1252	CLIP-seq
MIRT2633517	hsa-miR-1324	CLIP-seq
MIRT2633518	hsa-miR-146b-3p	CLIP-seq
MIRT2633519	hsa-miR-1827	CLIP-seq
MIRT2117530	hsa-miR-22	CLIP-seq
MIRT2633520	hsa-miR-2861	CLIP-seq
MIRT2633521	hsa-miR-296-5p	CLIP-seq
MIRT2633522	hsa-miR-3064-5p	CLIP-seq
MIRT2117531	hsa-miR-3126-5p	CLIP-seq
MIRT2633523	hsa-miR-3150b-3p	CLIP-seq
MIRT2633524	hsa-miR-3157-3p	CLIP-seq
MIRT2339688	hsa-miR-3160-3p	CLIP-seq
MIRT2633525	hsa-miR-3173-5p	CLIP-seq
MIRT2633526	hsa-miR-3184	CLIP-seq
MIRT2117532	hsa-miR-3185	CLIP-seq
MIRT2117533	hsa-miR-3194-3p	CLIP-seq
MIRT2633527	hsa-miR-339-5p	CLIP-seq
MIRT2633528	hsa-miR-3612	CLIP-seq
MIRT2117534	hsa-miR-3663-3p	CLIP-seq
MIRT2633529	hsa-miR-3907	CLIP-seq
MIRT2633530	hsa-miR-3909	CLIP-seq
MIRT2117535	hsa-miR-3921	CLIP-seq
MIRT2633531	hsa-miR-3940-5p	CLIP-seq
MIRT2633532	hsa-miR-423-5p	CLIP-seq
MIRT2633533	hsa-miR-4283	CLIP-seq
MIRT2633534	hsa-miR-4292	CLIP-seq
MIRT2117536	hsa-miR-4303	CLIP-seq
MIRT2117537	hsa-miR-4419a	CLIP-seq
MIRT2633535	hsa-miR-4421	CLIP-seq
MIRT2633536	hsa-miR-4428	CLIP-seq
MIRT2633537	hsa-miR-4464	CLIP-seq
MIRT2633538	hsa-miR-4487	CLIP-seq
MIRT2633539	hsa-miR-4489	CLIP-seq
MIRT2633540	hsa-miR-4507	CLIP-seq
MIRT2117538	hsa-miR-4510	CLIP-seq
MIRT2117539	hsa-miR-4653-5p	CLIP-seq
MIRT2633541	hsa-miR-4656	CLIP-seq
MIRT2633542	hsa-miR-4663	CLIP-seq
MIRT2633543	hsa-miR-4688	CLIP-seq
MIRT2633544	hsa-miR-4689	CLIP-seq
MIRT2633545	hsa-miR-4710	CLIP-seq
MIRT2633546	hsa-miR-4731-5p	CLIP-seq
MIRT2117540	hsa-miR-4747-5p	CLIP-seq
MIRT2633547	hsa-miR-4748	CLIP-seq
MIRT2633548	hsa-miR-4757-5p	CLIP-seq
MIRT2633549	hsa-miR-4761-5p	CLIP-seq
MIRT2633550	hsa-miR-4779	CLIP-seq
MIRT2633551	hsa-miR-4780	CLIP-seq
MIRT2633552	hsa-miR-4784	CLIP-seq
MIRT2117541	hsa-miR-4786-5p	CLIP-seq
MIRT2633553	hsa-miR-544b	CLIP-seq
MIRT2633554	hsa-miR-558	CLIP-seq
MIRT2633555	hsa-miR-589	CLIP-seq
MIRT2117542	hsa-miR-603	CLIP-seq
MIRT2633556	hsa-miR-623	CLIP-seq
MIRT2633557	hsa-miR-624	CLIP-seq
MIRT2633558	hsa-miR-650	CLIP-seq
MIRT2117543	hsa-miR-769-5p	CLIP-seq
MIRT2633559	hsa-miR-874	CLIP-seq
MIRT2633560	hsa-miR-940	CLIP-seq
MIRT2633516	hsa-miR-1252	CLIP-seq
MIRT2633518	hsa-miR-146b-3p	CLIP-seq
MIRT2633519	hsa-miR-1827	CLIP-seq
MIRT2117530	hsa-miR-22	CLIP-seq
MIRT2633520	hsa-miR-2861	CLIP-seq
MIRT2633521	hsa-miR-296-5p	CLIP-seq
MIRT2633522	hsa-miR-3064-5p	CLIP-seq
MIRT2117531	hsa-miR-3126-5p	CLIP-seq
MIRT2633523	hsa-miR-3150b-3p	CLIP-seq
MIRT2633524	hsa-miR-3157-3p	CLIP-seq
MIRT2339688	hsa-miR-3160-3p	CLIP-seq
MIRT2633525	hsa-miR-3173-5p	CLIP-seq
MIRT2633526	hsa-miR-3184	CLIP-seq
MIRT2117532	hsa-miR-3185	CLIP-seq
MIRT2117533	hsa-miR-3194-3p	CLIP-seq
MIRT2633527	hsa-miR-339-5p	CLIP-seq
MIRT2633528	hsa-miR-3612	CLIP-seq
MIRT2117534	hsa-miR-3663-3p	CLIP-seq
MIRT2633530	hsa-miR-3909	CLIP-seq
MIRT2117535	hsa-miR-3921	CLIP-seq
MIRT2633531	hsa-miR-3940-5p	CLIP-seq
MIRT2633532	hsa-miR-423-5p	CLIP-seq
MIRT2633533	hsa-miR-4283	CLIP-seq
MIRT2633534	hsa-miR-4292	CLIP-seq
MIRT2117536	hsa-miR-4303	CLIP-seq
MIRT2117537	hsa-miR-4419a	CLIP-seq
MIRT2633535	hsa-miR-4421	CLIP-seq
MIRT2633536	hsa-miR-4428	CLIP-seq
MIRT2633537	hsa-miR-4464	CLIP-seq
MIRT2633538	hsa-miR-4487	CLIP-seq
MIRT2633539	hsa-miR-4489	CLIP-seq
MIRT2633540	hsa-miR-4507	CLIP-seq
MIRT2117538	hsa-miR-4510	CLIP-seq
MIRT2117539	hsa-miR-4653-5p	CLIP-seq
MIRT2633541	hsa-miR-4656	CLIP-seq
MIRT2633542	hsa-miR-4663	CLIP-seq
MIRT2633543	hsa-miR-4688	CLIP-seq
MIRT2633544	hsa-miR-4689	CLIP-seq
MIRT2633545	hsa-miR-4710	CLIP-seq
MIRT2633546	hsa-miR-4731-5p	CLIP-seq
MIRT2117540	hsa-miR-4747-5p	CLIP-seq
MIRT2633547	hsa-miR-4748	CLIP-seq
MIRT2633548	hsa-miR-4757-5p	CLIP-seq
MIRT2633549	hsa-miR-4761-5p	CLIP-seq
MIRT2633550	hsa-miR-4779	CLIP-seq
MIRT2633551	hsa-miR-4780	CLIP-seq
MIRT2633552	hsa-miR-4784	CLIP-seq
MIRT2117541	hsa-miR-4786-5p	CLIP-seq
MIRT2633553	hsa-miR-544b	CLIP-seq
MIRT2633554	hsa-miR-558	CLIP-seq
MIRT2633555	hsa-miR-589	CLIP-seq
MIRT2117542	hsa-miR-603	CLIP-seq
MIRT2633556	hsa-miR-623	CLIP-seq
MIRT2633557	hsa-miR-624	CLIP-seq
MIRT2633558	hsa-miR-650	CLIP-seq
MIRT2117543	hsa-miR-769-5p	CLIP-seq
MIRT2633559	hsa-miR-874	CLIP-seq
MIRT2633560	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	TAS
GO:0005515	Function	Protein binding	IPI	25416956, 27173435, 28514442, 29892012, 31515488, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005813	Component	Centrosome	IBA	21873635
GO:0005813	Component	Centrosome	IDA	21399614
GO:0005829	Component	Cytosol	TAS
GO:0010389	Process	Regulation of G2/M transition of mitotic cell cycle	TAS
GO:0036064	Component	Ciliary basal body	IBA	21873635
GO:0042073	Process	Intraciliary transport	IEA
GO:0042802	Function	Identical protein binding	IPI	21516116, 25416956, 27107012, 32296183
GO:0060830	Process	Ciliary receptor clustering involved in smoothened signaling pathway	IEA
GO:0097711	Process	Ciliary basal body-plasma membrane docking	TAS

Other IDs

• MIM: 610882
• HGNC: 11321
• e!Ensembl: ENSG00000176101

Protein

• UniProt ID: O43805
• Protein name: Microtubule nucleation factor SSNA1 (Nuclear autoantigen of 14 kDa) (Sjoegren syndrome nuclear autoantigen 1)
• Protein function: Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST (PubMe
• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:9430706}.
• Sequence:

  MTQQGAALQNYNNELVKCIEELCQKREELCRQIQEEEDEKQRLQNEVRQLTEKLARVNEN
  LARKIASRNEFDRTIAETEAAYLKILESSQTLLSVLKREAGNLTKATAPDQKSSGGRDS

• Sequence length: 119

Pathways

Reactome:

Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Associations from Text Mining
Disease Name	Relationship Type	References
Sjogren's Syndrome	Associate	19273306