Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8633
Gene name	Unc-5 netrin receptor C
Gene symbol	UNC5C
Synonyms (NCBI Gene)	UNC5H3
Chromosome	4
Chromosome location	4q22.3
Summary	This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as rep

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Show/Hide all (192)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017932	hsa-miR-335-5p	Microarray	18185580
MIRT495575	hsa-miR-936	PAR-CLIP	22291592
MIRT495574	hsa-miR-199a-3p	PAR-CLIP	22291592
MIRT495573	hsa-miR-199b-3p	PAR-CLIP	22291592
MIRT495572	hsa-miR-3129-5p	PAR-CLIP	22291592
MIRT495571	hsa-miR-5088-3p	PAR-CLIP	22291592
MIRT495570	hsa-miR-6806-5p	PAR-CLIP	22291592
MIRT495569	hsa-miR-222-5p	PAR-CLIP	22291592
MIRT495568	hsa-miR-500a-5p	PAR-CLIP	22291592
MIRT495567	hsa-miR-3929	PAR-CLIP	22291592
MIRT495566	hsa-miR-4419b	PAR-CLIP	22291592
MIRT495565	hsa-miR-4478	PAR-CLIP	22291592
MIRT495564	hsa-miR-93-3p	PAR-CLIP	22291592
MIRT495563	hsa-miR-6762-3p	PAR-CLIP	22291592
MIRT444572	hsa-miR-651-3p	PAR-CLIP	22100165
MIRT444571	hsa-miR-323a-3p	PAR-CLIP	22100165
MIRT444570	hsa-miR-4496	PAR-CLIP	22100165
MIRT444569	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT444568	hsa-miR-4477b	PAR-CLIP	22100165
MIRT495575	hsa-miR-936	PAR-CLIP	22291592
MIRT495574	hsa-miR-199a-3p	PAR-CLIP	22291592
MIRT495573	hsa-miR-199b-3p	PAR-CLIP	22291592
MIRT495572	hsa-miR-3129-5p	PAR-CLIP	22291592
MIRT495571	hsa-miR-5088-3p	PAR-CLIP	22291592
MIRT495570	hsa-miR-6806-5p	PAR-CLIP	22291592
MIRT495569	hsa-miR-222-5p	PAR-CLIP	22291592
MIRT495568	hsa-miR-500a-5p	PAR-CLIP	22291592
MIRT495567	hsa-miR-3929	PAR-CLIP	22291592
MIRT495566	hsa-miR-4419b	PAR-CLIP	22291592
MIRT495565	hsa-miR-4478	PAR-CLIP	22291592
MIRT495564	hsa-miR-93-3p	PAR-CLIP	22291592
MIRT495563	hsa-miR-6762-3p	PAR-CLIP	22291592
MIRT444572	hsa-miR-651-3p	PAR-CLIP	22100165
MIRT444571	hsa-miR-323a-3p	PAR-CLIP	22100165
MIRT444570	hsa-miR-4496	PAR-CLIP	22100165
MIRT444569	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT444568	hsa-miR-4477b	PAR-CLIP	22100165
MIRT1475488	hsa-miR-103a	CLIP-seq
MIRT1475489	hsa-miR-103b	CLIP-seq
MIRT1475490	hsa-miR-107	CLIP-seq
MIRT1475491	hsa-miR-1184	CLIP-seq
MIRT1475492	hsa-miR-1197	CLIP-seq
MIRT1475493	hsa-miR-1205	CLIP-seq
MIRT1475494	hsa-miR-1206	CLIP-seq
MIRT1475495	hsa-miR-1224-5p	CLIP-seq
MIRT1475496	hsa-miR-1231	CLIP-seq
MIRT1475497	hsa-miR-1252	CLIP-seq
MIRT1475498	hsa-miR-1273g	CLIP-seq
MIRT739281	hsa-miR-132	CLIP-seq
MIRT1475499	hsa-miR-184	CLIP-seq
MIRT1475500	hsa-miR-190	CLIP-seq
MIRT1475501	hsa-miR-190b	CLIP-seq
MIRT739282	hsa-miR-194	CLIP-seq
MIRT1475502	hsa-miR-204	CLIP-seq
MIRT1475503	hsa-miR-205	CLIP-seq
MIRT1475504	hsa-miR-211	CLIP-seq
MIRT739280	hsa-miR-212	CLIP-seq
MIRT1475505	hsa-miR-221	CLIP-seq
MIRT1475506	hsa-miR-222	CLIP-seq
MIRT1475507	hsa-miR-2355-3p	CLIP-seq
MIRT1475508	hsa-miR-2467-3p	CLIP-seq
MIRT1475509	hsa-miR-28-3p	CLIP-seq
MIRT1475510	hsa-miR-3127-3p	CLIP-seq
MIRT1475511	hsa-miR-3145-3p	CLIP-seq
MIRT1475512	hsa-miR-3151	CLIP-seq
MIRT1475513	hsa-miR-3158-5p	CLIP-seq
MIRT1475514	hsa-miR-3160-5p	CLIP-seq
MIRT1475515	hsa-miR-3170	CLIP-seq
MIRT740231	hsa-miR-340	CLIP-seq
MIRT1475516	hsa-miR-34b	CLIP-seq
MIRT1475517	hsa-miR-3613-5p	CLIP-seq
MIRT1475518	hsa-miR-3622a-3p	CLIP-seq
MIRT1475519	hsa-miR-3622b-3p	CLIP-seq
MIRT1475520	hsa-miR-3646	CLIP-seq
MIRT1475521	hsa-miR-3662	CLIP-seq
MIRT1475522	hsa-miR-3678-3p	CLIP-seq
MIRT1475523	hsa-miR-3679-3p	CLIP-seq
MIRT1475524	hsa-miR-3685	CLIP-seq
MIRT739279	hsa-miR-3688-3p	CLIP-seq
MIRT1475525	hsa-miR-3690	CLIP-seq
MIRT1475526	hsa-miR-376a	CLIP-seq
MIRT1475527	hsa-miR-376b	CLIP-seq
MIRT1475528	hsa-miR-376c	CLIP-seq
MIRT1475529	hsa-miR-3975	CLIP-seq
MIRT1475530	hsa-miR-4265	CLIP-seq
MIRT1475531	hsa-miR-4296	CLIP-seq
MIRT1475532	hsa-miR-4322	CLIP-seq
MIRT740229	hsa-miR-4427	CLIP-seq
MIRT1475533	hsa-miR-4446-5p	CLIP-seq
MIRT1475534	hsa-miR-4447	CLIP-seq
MIRT1475535	hsa-miR-4472	CLIP-seq
MIRT1475536	hsa-miR-4477a	CLIP-seq
MIRT1475537	hsa-miR-4494	CLIP-seq
MIRT1475538	hsa-miR-4499	CLIP-seq
MIRT1475539	hsa-miR-4513	CLIP-seq
MIRT1475540	hsa-miR-4646-3p	CLIP-seq
MIRT1475541	hsa-miR-4649-5p	CLIP-seq
MIRT1475542	hsa-miR-4659a-3p	CLIP-seq
MIRT1475543	hsa-miR-4659b-3p	CLIP-seq
MIRT1475544	hsa-miR-4699-5p	CLIP-seq
MIRT1475545	hsa-miR-4705	CLIP-seq
MIRT740230	hsa-miR-4724-5p	CLIP-seq
MIRT1475546	hsa-miR-4751	CLIP-seq
MIRT1475547	hsa-miR-4755-5p	CLIP-seq
MIRT1475548	hsa-miR-4756-3p	CLIP-seq
MIRT1475549	hsa-miR-4761-5p	CLIP-seq
MIRT1475550	hsa-miR-4764-3p	CLIP-seq
MIRT1475551	hsa-miR-4781-3p	CLIP-seq
MIRT1475552	hsa-miR-4804-5p	CLIP-seq
MIRT1475553	hsa-miR-490-3p	CLIP-seq
MIRT1475554	hsa-miR-491-3p	CLIP-seq
MIRT1475555	hsa-miR-491-5p	CLIP-seq
MIRT1475556	hsa-miR-501-3p	CLIP-seq
MIRT1475557	hsa-miR-502-3p	CLIP-seq
MIRT1475558	hsa-miR-502-5p	CLIP-seq
MIRT1475559	hsa-miR-513c	CLIP-seq
MIRT1475560	hsa-miR-514b-5p	CLIP-seq
MIRT1475561	hsa-miR-516b	CLIP-seq
MIRT1475562	hsa-miR-544	CLIP-seq
MIRT1475563	hsa-miR-579	CLIP-seq
MIRT1475564	hsa-miR-586	CLIP-seq
MIRT1475565	hsa-miR-619	CLIP-seq
MIRT1475566	hsa-miR-623	CLIP-seq
MIRT1475567	hsa-miR-654-3p	CLIP-seq
MIRT740228	hsa-miR-656	CLIP-seq
MIRT1475568	hsa-miR-676	CLIP-seq
MIRT1475569	hsa-miR-767-5p	CLIP-seq
MIRT739283	hsa-miR-802	CLIP-seq
MIRT1475570	hsa-miR-885-3p	CLIP-seq
MIRT739281	hsa-miR-132	CLIP-seq
MIRT739282	hsa-miR-194	CLIP-seq
MIRT739280	hsa-miR-212	CLIP-seq
MIRT739279	hsa-miR-3688-3p	CLIP-seq
MIRT739283	hsa-miR-802	CLIP-seq
MIRT1475494	hsa-miR-1206	CLIP-seq
MIRT2143294	hsa-miR-1207-5p	CLIP-seq
MIRT2143295	hsa-miR-1256	CLIP-seq
MIRT2143296	hsa-miR-134	CLIP-seq
MIRT2143297	hsa-miR-153	CLIP-seq
MIRT2143298	hsa-miR-183	CLIP-seq
MIRT2143299	hsa-miR-1909	CLIP-seq
MIRT1475508	hsa-miR-2467-3p	CLIP-seq
MIRT2143300	hsa-miR-3118	CLIP-seq
MIRT2143301	hsa-miR-3121-3p	CLIP-seq
MIRT2143302	hsa-miR-3171	CLIP-seq
MIRT2143303	hsa-miR-324-5p	CLIP-seq
MIRT2143304	hsa-miR-329	CLIP-seq
MIRT740231	hsa-miR-340	CLIP-seq
MIRT2143305	hsa-miR-362-3p	CLIP-seq
MIRT2143306	hsa-miR-3647-3p	CLIP-seq
MIRT2143307	hsa-miR-3660	CLIP-seq
MIRT2143308	hsa-miR-3908	CLIP-seq
MIRT2143309	hsa-miR-4257	CLIP-seq
MIRT2143310	hsa-miR-4314	CLIP-seq
MIRT2143311	hsa-miR-4488	CLIP-seq
MIRT2143312	hsa-miR-4502	CLIP-seq
MIRT2143313	hsa-miR-4505	CLIP-seq
MIRT2143314	hsa-miR-4526	CLIP-seq
MIRT2143315	hsa-miR-4667-5p	CLIP-seq
MIRT2143316	hsa-miR-4679	CLIP-seq
MIRT2143317	hsa-miR-4688	CLIP-seq
MIRT2143318	hsa-miR-4697-5p	CLIP-seq
MIRT2143319	hsa-miR-4700-5p	CLIP-seq
MIRT2143320	hsa-miR-4731-5p	CLIP-seq
MIRT2143321	hsa-miR-4733-5p	CLIP-seq
MIRT2143322	hsa-miR-4763-3p	CLIP-seq
MIRT2143323	hsa-miR-486-3p	CLIP-seq
MIRT2143324	hsa-miR-526b	CLIP-seq
MIRT2143325	hsa-miR-541	CLIP-seq
MIRT2143326	hsa-miR-548p	CLIP-seq
MIRT2143327	hsa-miR-556-3p	CLIP-seq
MIRT1475563	hsa-miR-579	CLIP-seq
MIRT2143328	hsa-miR-637	CLIP-seq
MIRT2143329	hsa-miR-654-5p	CLIP-seq
MIRT2143330	hsa-miR-943	CLIP-seq
MIRT1475493	hsa-miR-1205	CLIP-seq
MIRT2363570	hsa-miR-1276	CLIP-seq
MIRT2363571	hsa-miR-128	CLIP-seq
MIRT2143302	hsa-miR-3171	CLIP-seq
MIRT2363572	hsa-miR-3612	CLIP-seq
MIRT2363573	hsa-miR-3672	CLIP-seq
MIRT2363574	hsa-miR-3974	CLIP-seq
MIRT2363575	hsa-miR-4443	CLIP-seq
MIRT2363576	hsa-miR-4463	CLIP-seq
MIRT2363577	hsa-miR-583	CLIP-seq
MIRT2363578	hsa-miR-650	CLIP-seq
MIRT1475494	hsa-miR-1206	CLIP-seq
MIRT1475507	hsa-miR-2355-3p	CLIP-seq
MIRT2462930	hsa-miR-370	CLIP-seq
MIRT2462931	hsa-miR-4313	CLIP-seq
MIRT1475540	hsa-miR-4646-3p	CLIP-seq
MIRT1475568	hsa-miR-676	CLIP-seq

Show/Hide all (45)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005042	Function	Netrin receptor activity	IBA
GO:0005042	Function	Netrin receptor activity	IEA
GO:0005042	Function	Netrin receptor activity	TAS	9782087
GO:0005043	Function	Netrin receptor activity involved in chemorepulsion	IEA
GO:0005043	Function	Netrin receptor activity involved in chemorepulsion	ISS
GO:0005515	Function	Protein binding	IPI	22685302, 28483977
GO:0005886	Component	Plasma membrane	IDA	25419706
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007411	Process	Axon guidance	IBA
GO:0007411	Process	Axon guidance	IEA
GO:0007411	Process	Axon guidance	TAS
GO:0007420	Process	Brain development	IEA
GO:0007420	Process	Brain development	TAS	9782087
GO:0009986	Component	Cell surface	IEA
GO:0015631	Function	Tubulin binding	IEA
GO:0015631	Function	Tubulin binding	IPI	28483977
GO:0016020	Component	Membrane	IEA
GO:0019901	Function	Protein kinase binding	IPI	27068745
GO:0030027	Component	Lamellipodium	IEA
GO:0030027	Component	Lamellipodium	ISS
GO:0030175	Component	Filopodium	IEA
GO:0030175	Component	Filopodium	ISS
GO:0030334	Process	Regulation of cell migration	IEA
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030426	Component	Growth cone	IEA
GO:0030426	Component	Growth cone	ISS
GO:0033564	Process	Anterior/posterior axon guidance	IEA
GO:0035234	Process	Ectopic germ cell programmed cell death	IEA
GO:0038007	Process	Netrin-activated signaling pathway	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0045202	Component	Synapse	IEA
GO:0051094	Process	Positive regulation of developmental process	IEA
GO:0061643	Process	Chemorepulsion of axon	IEA
GO:0061643	Process	Chemorepulsion of axon	ISS
GO:1990791	Process	Dorsal root ganglion development	IDA	28483977
GO:2000243	Process	Positive regulation of reproductive process	IEA
GO:2001222	Process	Regulation of neuron migration	IEA

MIM	HGNC	e!Ensembl
603610	12569	ENSG00000182168

O95185

Protein name

Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C)

Protein function

Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from p

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07679	I-set	167 → 257	Immunoglobulin I-set domain	Domain
PF00090	TSP_1	264 → 313	Thrombospondin type 1 domain	Domain
PF00090	TSP_1	317 → 367	Thrombospondin type 1 domain	Domain
PF00791	ZU5	531 → 628	ZU5 domain	Family
PF17217	UPA	678 → 817	UPA domain	Domain
PF00531	Death	849 → 928	Death domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Mainly expressed in brain (PubMed:9782087). Expressed in temporal lobe cortical neurons and in neurons of the hippocampal pyramidal layer (PubMed:25419706). Also expressed in kidney (PubMed:9782087). Not expressed in developing or adul

Sequence

MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEP
LPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVR
EVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSL
EQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCV
AKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCE
GQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSK
NCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALN
GGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIK
VYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLG
GHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGAL
LTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHIL
TENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQ
MGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCT
FTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPS
AFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQN
FPDGNLSMLAAVLEEMGRHETVVSLAAEGQY

Sequence length

931

Interactions

View interactions

	KEGG
	Axon guidance

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Colon adenocarcinoma	Uncertain significance	rs139372477	RCV005930709
UNC5C-related disorder	Benign; Uncertain significance; Likely benign	rs61741188, rs929930790, rs34585936, rs146932015, rs147827953, rs773385589, rs201589427, rs187902349, rs146123204, rs4699423, rs2276322, rs1339815696, rs141315686, rs3733212, rs145013421 View all (8 more)	RCV003975856 RCV003402449 RCV003980923 RCV003938999 RCV003966407 RCV003919192 RCV003907101 RCV003923939 RCV003917311 RCV003974326 RCV003974548 RCV003974185 RCV003974272 RCV003984687 RCV003916845 RCV003964414 RCV003973856 RCV003909374 RCV003927364 RCV003939597 RCV003932325 RCV003956682 RCV003982213

Show/Hide Text Mining Associations (27)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenomatous Polyps	Associate	18054557
Adenomatous Polyps	Inhibit	28378635
Alzheimer Disease	Associate	27036079, 33522999, 35001095
Arthritis Rheumatoid	Stimulate	19822088
Atrophy	Associate	30883345
Brain Diseases	Associate	33522999
Carcinogenesis	Associate	18054557, 20032384, 24376576
Cognition Disorders	Associate	30883345
Colonic Neoplasms	Associate	19331160, 20032384
Colorectal Neoplasms	Inhibit	18054557, 21893118, 33706130
Colorectal Neoplasms	Associate	19331160, 21893118, 24415873, 26852919, 28378635, 29801399, 38172877
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	24415873
Hippocampal Sclerosis	Associate	30883345
Intestinal Neoplasms	Associate	21893118
Kidney Neoplasms	Stimulate	33706130
Neoplasm Metastasis	Associate	28378635
Neoplasms	Inhibit	16595896, 18077458, 19331160, 19940358, 28378635, 33706130
Neoplasms	Associate	24415873
Nervous System Diseases	Associate	30883345
Neurodegenerative Diseases	Associate	30883345
Non Muscle Invasive Bladder Neoplasms	Associate	25316812
Osteoarthritis	Stimulate	19822088
Polycystic Ovary Syndrome	Associate	32574161
Sick Sinus Syndrome	Associate	28378635
Stomach Neoplasms	Associate	20032384, 24376576, 24415873
Urinary Bladder Neoplasms	Associate	25316812
Vitamin E Deficiency	Associate	26446483

UNC5C (unc-5 netrin receptor C)