CBFA2T3 (CBFA2/RUNX1 partner transcriptional co-repressor 3)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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863 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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CBFA2/RUNX1 partner transcriptional co-repressor 3 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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CBFA2T3 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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ETO2, MTG16, MTGR2, RUNX1T3, ZMYND4 |
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Chromosome
Chromosome number
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16 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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16q24.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less co |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | O75081 | ||||||||||||||||||||
| Protein name | Protein CBFA2T3 (MTG8-related protein 2) (Myeloid translocation gene on chromosome 16 protein) (hMTG16) (Zinc finger MYND domain-containing protein 4) | ||||||||||||||||||||
| Protein function | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repre | ||||||||||||||||||||
| PDB | 9DE2 | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level). {ECO:0000269|PubMed:15231665, ECO:0000269|PubMed:9596646, | ||||||||||||||||||||
| Sequence |
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| Sequence length | 653 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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