Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
863
Gene name Gene Name - the full gene name approved by the HGNC.
CBFA2/RUNX1 partner transcriptional co-repressor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CBFA2T3
Synonyms (NCBI Gene) Gene synonyms aliases
ETO2, MTG16, MTGR2, RUNX1T3, ZMYND4
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q24.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less co
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT688804 hsa-miR-4768-3p HITS-CLIP 23313552
MIRT688803 hsa-miR-4459 HITS-CLIP 23313552
MIRT688802 hsa-miR-4433a-3p HITS-CLIP 23313552
MIRT688801 hsa-miR-4635 HITS-CLIP 23313552
MIRT688800 hsa-miR-15b-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0001666 Process Response to hypoxia IDA 23840896
GO:0003714 Function Transcription corepressor activity IBA 21873635
GO:0003714 Function Transcription corepressor activity TAS 23251453, 25974097
GO:0005515 Function Protein binding IPI 16966434, 20138877, 23251453, 25974097
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603870 1537 ENSG00000129993
Protein
UniProt ID O75081
Protein name Protein CBFA2T3 (MTG8-related protein 2) (Myeloid translocation gene on chromosome 16 protein) (hMTG16) (Zinc finger MYND domain-containing protein 4)
Protein function Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repre
PDB 9DE2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07531 TAFH 173 262 NHR1 homology to TAF Family
PF08788 NHR2 379 445 NHR2 domain like Domain
PF01753 zf-MYND 556 592 MYND finger Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level). {ECO:0000269|PubMed:15231665, ECO:0000269|PubMed:9596646,
Sequence
MPASRLRDRAASSASGSTCGSMSQTHPVLESGLLASAGCSAPRGPRKGGPAPVDRKAKAS
AMPDSPAEVKTQPRSTPPSMPPPPPAASQGATRPPSFTPHTHREDGPATLPHGRFHGCLK
WSMVCLLMNGSSHSPTAINGAPCTPNGFSNGPATSSTASLSTQHLPPACGARQLSKLKRF
LTTLQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANL
PLLQRELLHCARLAKQTPAQYL
AQHEQLLLDASASSPIDSSELLLEVNENGKRRTPDRTK
ENGSDRDPLHPEHLSKRPCTLNPAQRYSPSNGPPQPTPPPHYRLEDIAMAHHFRDAYRHP
DPRELRERHRPLVVPGSRQEEVIDHKLTEREWAEEWKHLNNLLNCIMDMVEKTRRSLTVL
RRCQEADREELNHWARRYSDAEDTK
KGPAPAAARPRSSSAGPEGPQLDVPREFLPRTLTG
YVPEDIWRKAEEAVNEVKRQAMSELQKAVSDAERKAHELITTERAKMERALAEAKRQASE
DALTVINQQEDSSESCWNCGRKASETCSGCNAARYCGSFCQHRDWEKHHHVCGQSLQGPT
AVVADPVPGPPEAAHSLGPSLPVGAASPSEAGSAGPSRPGSPSPPGPLDTVPR
Sequence length 653
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Megakaryoblastic leukemia without down syndrome Acute megakaryoblastic leukemia without Down syndrome rs121917830
Unknown
Disease term Disease name Evidence References Source
Vitiligo Vitiligo GWAS
Neuroticism Neuroticism GWAS
Melanoma Melanoma SMAD3 and SLC9A5 gain?of?function increases invasion capability of melanoma cells. GWAS, CBGDA
Multiple Sclerosis Multiple Sclerosis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 31370031
Atrophy Associate 31370031
Breast Neoplasms Associate 15301688
Carcinogenesis Associate 23840896
Carcinoma Non Small Cell Lung Associate 33580150
Cognition Disorders Associate 31370031
Colitis Ulcerative Associate 32908909
Hereditary Breast and Ovarian Cancer Syndrome Inhibit 19961547
Hypoxia Associate 23840896
Ketosis Associate 34139469