Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	8618
Gene name	Calcium dependent secretion activator
Gene symbol	CADPS
Synonyms (NCBI Gene)	CADPS1CAPSCAPS1UNC-31
Chromosome	3
Chromosome location	3p14.2
Summary	This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves th

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Show/Hide all (128)

miRTarBase ID	miRNA	Experiments	Reference
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608228	hsa-miR-5096	HITS-CLIP	23824327
MIRT672808	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608228	hsa-miR-5096	HITS-CLIP	23824327
MIRT672808	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608228	hsa-miR-5096	HITS-CLIP	23824327
MIRT672808	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	24906430
MIRT608230	hsa-miR-4643	HITS-CLIP	24906430
MIRT608229	hsa-miR-377-3p	HITS-CLIP	24906430
MIRT608228	hsa-miR-5096	HITS-CLIP	24906430
MIRT672808	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT672808	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT672808	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT672808	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT672808	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT608229	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608229	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608229	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608229	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608229	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608229	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608230	hsa-miR-4643	HITS-CLIP	27418678
MIRT608230	hsa-miR-4643	HITS-CLIP	27418678
MIRT608230	hsa-miR-4643	HITS-CLIP	27418678
MIRT608228	hsa-miR-5096	HITS-CLIP	27418678
MIRT608228	hsa-miR-5096	HITS-CLIP	27418678
MIRT608228	hsa-miR-5096	HITS-CLIP	27418678
MIRT608228	hsa-miR-5096	HITS-CLIP	27418678
MIRT608228	hsa-miR-5096	HITS-CLIP	27418678
MIRT608231	hsa-miR-8485	HITS-CLIP	27418678
MIRT608231	hsa-miR-8485	HITS-CLIP	27418678
MIRT608231	hsa-miR-8485	HITS-CLIP	27418678
MIRT608231	hsa-miR-8485	HITS-CLIP	27418678
MIRT608231	hsa-miR-8485	HITS-CLIP	27418678
MIRT608231	hsa-miR-8485	HITS-CLIP	27418678
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608228	hsa-miR-5096	HITS-CLIP	23824327
MIRT672808	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608228	hsa-miR-5096	HITS-CLIP	23824327
MIRT672808	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608228	hsa-miR-5096	HITS-CLIP	23824327
MIRT672808	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT858697	hsa-miR-103a	CLIP-seq
MIRT858698	hsa-miR-107	CLIP-seq
MIRT858699	hsa-miR-1183	CLIP-seq
MIRT858700	hsa-miR-1184	CLIP-seq
MIRT858701	hsa-miR-1205	CLIP-seq
MIRT858702	hsa-miR-124	CLIP-seq
MIRT858703	hsa-miR-1915	CLIP-seq
MIRT858704	hsa-miR-296-3p	CLIP-seq
MIRT858705	hsa-miR-3158-5p	CLIP-seq
MIRT858706	hsa-miR-3688-3p	CLIP-seq
MIRT858707	hsa-miR-3714	CLIP-seq
MIRT858708	hsa-miR-3910	CLIP-seq
MIRT858709	hsa-miR-3944-5p	CLIP-seq
MIRT858710	hsa-miR-3978	CLIP-seq
MIRT858711	hsa-miR-410	CLIP-seq
MIRT858712	hsa-miR-4666-5p	CLIP-seq
MIRT858713	hsa-miR-4802-3p	CLIP-seq
MIRT858714	hsa-miR-506	CLIP-seq
MIRT858715	hsa-miR-545	CLIP-seq
MIRT2495787	hsa-miR-136	CLIP-seq
MIRT2495788	hsa-miR-144	CLIP-seq
MIRT2495789	hsa-miR-186	CLIP-seq
MIRT2495790	hsa-miR-3133	CLIP-seq
MIRT2495791	hsa-miR-4790-3p	CLIP-seq
MIRT2495792	hsa-miR-515-5p	CLIP-seq
MIRT2495787	hsa-miR-136	CLIP-seq
MIRT2495788	hsa-miR-144	CLIP-seq
MIRT2495789	hsa-miR-186	CLIP-seq
MIRT2495790	hsa-miR-3133	CLIP-seq
MIRT2495791	hsa-miR-4790-3p	CLIP-seq
MIRT2495792	hsa-miR-515-5p	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17984325, 25416956
GO:0005829	Component	Cytosol	TAS	1516133
GO:0006887	Process	Exocytosis	IBA
GO:0006887	Process	Exocytosis	IEA
GO:0006887	Process	Exocytosis	TAS	1516133
GO:0008289	Function	Lipid binding	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016079	Process	Synaptic vesicle exocytosis	IEA
GO:0019901	Function	Protein kinase binding	ISS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0045202	Component	Synapse	IEA
GO:0045921	Process	Positive regulation of exocytosis	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0098793	Component	Presynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IBA
GO:0099012	Component	Neuronal dense core vesicle membrane	IEA
GO:1990504	Process	Dense core granule exocytosis	IEA

MIM	HGNC	e!Ensembl
604667	1426	ENSG00000163618

Q9ULU8

Protein name

Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1)

Protein function

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs.

PDB

1WI1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	522 → 624	PH domain	Domain
PF06292	DUF1041	836 → 940	Domain of Unknown Function (DUF1041)	Domain

Tissue specificity

TISSUE SPECIFICITY: Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobe

Sequence

MLDPSSSEEESDEIVEEESGKEVLGSAPSGARLSPSRTSEGSAGSAGLGGGGAGAGAGVG
AGGGGGSGASSGGGAGGLQPSSRAGGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQ
LYVFVMRCIAYPFNAKQPTDMARRQQKISKQQLQTVKDRFQAFLNGETQIMADEAFMNAV
QSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPEIDGLSKETVLSSWMAK
FDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNP
DEQAAQIRRELDGRLQMADQIARERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVS
KGGEFKLQKLKRSHNASIIDMGEESENQLSKSDVVLSFSLEVVIMEVQGLKSLAPNRIVY
CTMEVEGGEKLQTDQAEASKPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRV
ILHPTPNSPKQSEWHKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWAIGKNVWKRWK
KRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTDPQPGLEGGRAFFNAVKEGD
TVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFYADRA
QKHGMDEFISSNPCNFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNG
VRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNRPDGIGTVTVEEKERFE
EIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRK
CLEQAALVNYSRLSEYAKIEENQKDAENVGRLITPAKKLEDTIRLAELVIEVLQQNEEHH
AEPHVDKGEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQPPDTWDSFPLFQLLNDFLRT
DYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVKSLTSNLPNVNL
PNVNLPKVPNLPVNIPLGIPQMPTFSAPSWMAAIYDADNGSGTSEDLFWKLDALQTFIRD
LHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSRSTDFRVPQSICTMFNV
MVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYD
EGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQ
WYNSSMNVICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQGVLDSTLNSKTYETIRN
RLTVEEATASVSEGGGLQGISMKDSDEEDEEDD

Sequence length

1353

Interactions

View interactions

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
CADPS-related disorder	Uncertain significance; Likely benign; Benign	rs771045473, rs1707040888, rs1158576022, rs898296147, rs2529893116, rs745876740, rs779869722, rs372017906, rs765741289, rs140977565, rs185882358, rs199626657, rs139420058, rs150724919, rs79260062 View all (16 more)	RCV003966289 RCV003394491 RCV003408477 RCV003402706 RCV003402942 RCV003898943 RCV003897069 RCV003906986 RCV003909418 RCV003909455 RCV003904538 RCV003984763 RCV003909811 RCV003939827 RCV003942108 RCV003964084 RCV003927204 RCV003924555 RCV003951627 RCV003951633 RCV003936994 RCV003924260 RCV003926839 RCV003949226 RCV003944625 RCV003957288 RCV003947273 RCV003959392 RCV003972166 RCV003978048 RCV003978047
Prostate cancer	Uncertain significance	rs193921128	RCV000149385
Thymoma	Benign	rs74991517	RCV005933481
Uterine corpus endometrial carcinoma	Benign	rs145339043	RCV005903109

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Autoimmune Hypophysitis	Associate	22193973
Carcinoma Hepatocellular	Associate	21659380
Cardiomyopathy Hypertrophic Familial	Associate	31638236
Cerebral Infarction	Associate	36916413
Colorectal Neoplasms	Associate	31638236
Diabetes Mellitus Type 2	Associate	31932636
Infarction Middle Cerebral Artery	Stimulate	36916413
Memory Disorders	Inhibit	36916413
Neoplasm Metastasis	Stimulate	31638236
Neoplasms	Associate	34135559, 37284741
Pancreatic Neoplasms	Associate	34389782
Parkinson Disease	Associate	34659588
Stomach Neoplasms	Associate	34135559

CADPS (calcium dependent secretion activator)