Gene Gene information from NCBI Gene database.
Entrez ID 8614
Gene name Stanniocalcin 2
Gene symbol STC2
Synonyms (NCBI Gene)
STC-2STCRP
Chromosome 5
Chromosome location 5q35.2
Summary This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is
miRNA miRNA information provided by mirtarbase database.
914
miRTarBase ID miRNA Experiments Reference
MIRT022465 hsa-miR-124-3p Microarray 18668037
MIRT027537 hsa-miR-98-5p Microarray 19088304
MIRT028041 hsa-miR-93-5p Sequencing 20371350
MIRT046093 hsa-miR-125b-5p CLASH 23622248
MIRT438359 hsa-miR-206 qRT-PCR 24855559
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0005179 Function Hormone activity IEA
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space HDA 16502470
GO:0005615 Component Extracellular space IBA
GO:0005783 Component Endoplasmic reticulum IDA 22503972
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603665 11374 ENSG00000113739
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O76061
Protein name Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP)
Protein function Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
PDB 7Y5Q , 8A7D , 8A7E , 8HGH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03298 Stanniocalcin 12 215 Stanniocalcin family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes.
Sequence
Sequence length 302
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cervical cancer Benign rs114346665 RCV005907790
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acquired ichthyosis Associate 36303457
Adenocarcinoma Associate 35109912
Arthritis Rheumatoid Associate 27141097
Atherosclerosis Associate 31173256
Biliary Tract Diseases Associate 33234031
Breast Neoplasms Associate 15546506, 24505115, 27556857, 29593009
Breast Neoplasms Stimulate 29956502
Breast Neoplasms Male Stimulate 29956502
Carcinogenesis Stimulate 22094876
Carcinogenesis Associate 31173256