PLA2G4C (phospholipase A2 group IVC)

Gene

• Entrez ID: 8605
• Gene name: Phospholipase A2 group IVC
• Gene symbol: PLA2G4C
• Synonyms (NCBI Gene): CPLA2-gamma
• Chromosome: 19
• Chromosome location: 19q13.33
• Summary: This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The en

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021740	hsa-miR-132-3p	Microarray	17612493
MIRT022128	hsa-miR-124-3p	Microarray	18668037
MIRT025081	hsa-miR-181a-5p	Microarray	17612493
MIRT1238709	hsa-miR-1197	CLIP-seq
MIRT1238710	hsa-miR-1258	CLIP-seq
MIRT1238711	hsa-miR-128	CLIP-seq
MIRT1238712	hsa-miR-27a	CLIP-seq
MIRT1238713	hsa-miR-27b	CLIP-seq
MIRT1238714	hsa-miR-3117-3p	CLIP-seq
MIRT1238715	hsa-miR-4680-5p	CLIP-seq
MIRT1238716	hsa-miR-4698	CLIP-seq
MIRT1238717	hsa-miR-4761-5p	CLIP-seq
MIRT1238709	hsa-miR-1197	CLIP-seq
MIRT1238710	hsa-miR-1258	CLIP-seq
MIRT1238711	hsa-miR-128	CLIP-seq
MIRT2594891	hsa-miR-1291	CLIP-seq
MIRT2594892	hsa-miR-146b-3p	CLIP-seq
MIRT1238712	hsa-miR-27a	CLIP-seq
MIRT1238713	hsa-miR-27b	CLIP-seq
MIRT1238714	hsa-miR-3117-3p	CLIP-seq
MIRT2594893	hsa-miR-3179	CLIP-seq
MIRT2594894	hsa-miR-3185	CLIP-seq
MIRT2594895	hsa-miR-328	CLIP-seq
MIRT2594896	hsa-miR-3922-5p	CLIP-seq
MIRT2594897	hsa-miR-4299	CLIP-seq
MIRT2594898	hsa-miR-4474-3p	CLIP-seq
MIRT2594899	hsa-miR-4476	CLIP-seq
MIRT2594900	hsa-miR-4493	CLIP-seq
MIRT1238715	hsa-miR-4680-5p	CLIP-seq
MIRT1238716	hsa-miR-4698	CLIP-seq
MIRT2594901	hsa-miR-4753-5p	CLIP-seq
MIRT1238717	hsa-miR-4761-5p	CLIP-seq
MIRT2594902	hsa-miR-4773	CLIP-seq
MIRT2594903	hsa-miR-509-3p	CLIP-seq
MIRT2594904	hsa-miR-644	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004620	Function	Phospholipase activity	IEA
GO:0004622	Function	Phosphatidylcholine lysophospholipase activity	IDA	15944408, 19501189
GO:0004622	Function	Phosphatidylcholine lysophospholipase activity	IEA
GO:0004622	Function	Phosphatidylcholine lysophospholipase activity	TAS
GO:0004623	Function	Phospholipase A2 activity	IEA
GO:0005509	Function	Calcium ion binding	IBA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005543	Function	Phospholipid binding	NAS	10085124
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005635	Component	Nuclear envelope	IBA
GO:0005635	Component	Nuclear envelope	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	15944408, 19501189
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005811	Component	Lipid droplet	IDA	28336330
GO:0005811	Component	Lipid droplet	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS	10085124
GO:0005886	Component	Plasma membrane	IEA
GO:0005938	Component	Cell cortex	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006644	Process	Phospholipid metabolic process	TAS	10085124
GO:0006650	Process	Glycerophospholipid metabolic process	IEA
GO:0006663	Process	Platelet activating factor biosynthetic process	IDA	19501189
GO:0006954	Process	Inflammatory response	NAS	10085124
GO:0007567	Process	Parturition	NAS	10085124
GO:0008374	Function	O-acyltransferase activity	IDA	15944408, 19501189
GO:0008970	Function	Phospholipase A1 activity	TAS
GO:0009395	Process	Phospholipid catabolic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	10085124
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019369	Process	Arachidonate metabolic process	NAS	10085124
GO:0031966	Component	Mitochondrial membrane	IDA	15944408, 19501189
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0035556	Process	Intracellular signal transduction	NAS	10085124
GO:0036151	Process	Phosphatidylcholine acyl-chain remodeling	IDA	19501189
GO:0036151	Process	Phosphatidylcholine acyl-chain remodeling	TAS
GO:0036152	Process	Phosphatidylethanolamine acyl-chain remodeling	IDA	19501189
GO:0036152	Process	Phosphatidylethanolamine acyl-chain remodeling	TAS
GO:0046475	Process	Glycerophospholipid catabolic process	IBA
GO:0046475	Process	Glycerophospholipid catabolic process	IDA	10085124
GO:0047498	Function	Calcium-dependent phospholipase A2 activity	IBA
GO:0047499	Function	Calcium-independent phospholipase A2 activity	IDA	10085124
GO:0140042	Process	Lipid droplet formation	IMP	28336330

Other IDs

• MIM: 603602
• HGNC: 9037
• e!Ensembl: ENSG00000105499

Protein

• UniProt ID: Q9UP65
• Protein name: Cytosolic phospholipase A2 gamma (cPLA2-gamma) (EC 3.1.1.4) (Cytosolic lysophospholipase) (EC 3.1.1.5) (Cytosolic lysophospholipid O-acyltransferase) (EC 2.3.1.-) (Phospholipase A2 group IVC)
• Protein function: Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis (PubMed:10085124, PubMed:10358058, PubMed
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01735	PLA2_B	44 → 246	Lysophospholipase catalytic domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in heart and skeletal muscle. {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:9705332}.
• Sequence:

  MGSSEVSIIPGLQKEEKAAVERRRLHVLKALKKLRIEADEAPVVAVLGSGGGLRAHIACL
  GVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDGDMEALEADLKHRFTRQEWDLAKSL
  QKTIQAARSENYSLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAIDNDLQ
  PSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFLRGLWG
  SALGNTEVIREYIFDQLRNLTLKGLWRRAVANAKSIGHLIFARLLRLQESSQGEHPPPED
  EGGEPEHTWLTEMLENWTRTSLEKQEQPHEDPERKGSLSNLMDFVKKTGICASKWEWGTT
  HNFLYKHGGIRDKIMSSRKHLHLVDAGLAINTPFPLVLPPTREVHLILSFDFSAGDPFET
  IRATTDYCRRHKIPFPQVEEAELDLWSKAPASCYILKGETGPVVMHFPLFNIDACGGDIE
  AWSDTYDTFKLADTYTLDVVVLLLALAKKNVRENKKKILRELMNVAGLYYPKDSARSCCL
  A

• Sequence length: 541

Pathways

KEGG:

Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
MAPK signaling pathway
Ras signaling pathway
Phospholipase D signaling pathway
Necroptosis
Vascular smooth muscle contraction
VEGF signaling pathway
Platelet activation
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Glutamatergic synapse
Serotonergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Ovarian steroidogenesis
Oxytocin signaling pathway
Choline metabolism in cancer

Reactome:

Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Hydrolysis of LPC
Hydrolysis of LPE

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Cervical cancer	Likely benign	rs753212492	RCV005932585
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs1372212107	RCV004557893

Associations from Text Mining
Disease Name	Relationship Type	References
Cardiovascular Diseases	Associate	37958793
Chromosome 19 trisomy 19q	Associate	11958371
Glioma	Associate	11958371
Homozygous Familial Hypercholesterolemia	Associate	34052320
Obesity	Associate	37770949
Status Asthmaticus	Stimulate	33626953