Gene Gene information from NCBI Gene database.
Entrez ID 8570
Gene name KH-type splicing regulatory protein
Gene symbol KHSRP
Synonyms (NCBI Gene)
FBP2FUBP2KSRPp75
Chromosome 19
Chromosome location 19p13.3
Summary The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175
miRNA miRNA information provided by mirtarbase database.
849
miRTarBase ID miRNA Experiments Reference
MIRT005397 hsa-miR-24-3p qRT-PCR 19296935
MIRT006988 hsa-miR-27b-3p "H69 cells (SV40-transformed normal human biliary epithelial cells originally derived from livers harvested for transplant) 22615562
MIRT016217 hsa-miR-590-3p Sequencing 20371350
MIRT005397 hsa-miR-24-3p Microarray 19748357
MIRT052159 hsa-let-7b-5p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
BRCA1 Repression 21099359
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
35
GO ID Ontology Definition Evidence Reference
GO:0000178 Component Exosome (RNase complex) NAS 16126846
GO:0000375 Process RNA splicing, via transesterification reactions TAS 10911989
GO:0003676 Function Nucleic acid binding IEA
GO:0003677 Function DNA binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603445 6316 ENSG00000088247
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92945
Protein name Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75)
Protein function Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subj
PDB 2HH2 , 2HH3 , 2JVZ , 2OPU , 2OPV , 4B8T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00013 KH_1 146 210 KH domain Domain
PF00013 KH_1 235 301 KH domain Domain
PF00013 KH_1 324 388 KH domain Domain
PF00013 KH_1 426 493 KH domain Domain
PF09005 DUF1897 609 635 Domain of unknown function (DUF1897) Domain
PF09005 DUF1897 665 688 Domain of unknown function (DUF1897) Domain
Tissue specificity TISSUE SPECIFICITY: Detected in neural and non-neural cell lines.
Sequence
MSDYSTGGPPPGPPPPAGGGGGAGGAGGGPPPGPPGAGDRGGGGPGGGGPGGGSAGGPSQ
PPGGGGPGIRKDAFADAVQRARQIAAKIGGDAATTVNNSTPDFGFGGQKRQLEDGDQPES
KKLASQGDSISSQLGPIHPPPRTSMTEEYRVPDGMVGLIIGRGGEQINKIQQDSGCKVQI
SPDSGGLPERSVSLTGAPESVQKAKMMLDD
IVSRGRGGPPGQFHDNANGGQNGTVQEIMI
PAGKAGLVIGKGGETIKQLQERAGVKMILIQDGSQNTNVDKPLRIIGDPYKVQQACEMVM
D
ILRERDQGGFGDRNEYGSRIGGGIDVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKQ
DDGTGPEKIAHIMGPPDRCEHAARIIND
LLQSLRSGPPGPPGGPGMPPGGRGRGRGQGNW
GPPGGEMTFSIPTHKCGLVIGRGGENVKAINQQTGAFVEISRQLPPNGDPNFKLFIIRGS
PQQIDHAKQLIEE
KIEGPLCPVGPGPGGPGPAGPMGPFNPGPFNQGPPGAPPHAGGPPPH
QYPPQGWGNTYPQWQPPAPHDPSKAAAAAADPNAAWAAYYSHYYQQPPGPVPGPAPAPAA
PPAQGEPPQPPPTGQSDYTKAWEEYYKKIGQQPQQPGAPPQQDYTKAWEEYYKKQAQVAT
GGGPGAPPGSQPDYSAAWAEYYRQQAAYYGQTPGPGGPQPPPTQQGQQQAQ
Sequence length 711
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    ATF4 activates genes in response to endoplasmic reticulum stress
KSRP (KHSRP) binds and destabilizes mRNA