Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	8563
Gene name	THO complex subunit 5
Gene symbol	THOC5
Synonyms (NCBI Gene)	C22orf19FmipPK1.3fSAP79
Chromosome	22
Chromosome location	22q12.2

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miRTarBase ID	miRNA	Experiments	Reference
MIRT027661	hsa-miR-98-5p	Microarray	19088304
MIRT052279	hsa-let-7b-5p	CLASH	23622248
MIRT051410	hsa-let-7f-5p	CLASH	23622248
MIRT049915	hsa-miR-30a-3p	CLASH	23622248
MIRT044988	hsa-miR-186-5p	CLASH	23622248
MIRT039858	hsa-miR-615-3p	CLASH	23622248
MIRT716137	hsa-miR-510-5p	HITS-CLIP	19536157
MIRT716136	hsa-miR-6863	HITS-CLIP	19536157
MIRT716135	hsa-miR-1972	HITS-CLIP	19536157
MIRT716134	hsa-miR-4650-5p	HITS-CLIP	19536157
MIRT716133	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT716132	hsa-miR-4793-3p	HITS-CLIP	19536157
MIRT716131	hsa-miR-4252	HITS-CLIP	19536157
MIRT716130	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT716129	hsa-miR-7703	HITS-CLIP	19536157
MIRT514879	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT514878	hsa-miR-4740-3p	PAR-CLIP	23446348
MIRT514877	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT514876	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT514875	hsa-miR-6778-3p	PAR-CLIP	23446348
MIRT514874	hsa-miR-3652	PAR-CLIP	23446348
MIRT514873	hsa-miR-4430	PAR-CLIP	23446348
MIRT514872	hsa-miR-4505	PAR-CLIP	23446348
MIRT514871	hsa-miR-5787	PAR-CLIP	23446348
MIRT514870	hsa-miR-5095	PAR-CLIP	23446348
MIRT514869	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT514868	hsa-miR-6842-3p	PAR-CLIP	23446348
MIRT514867	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT716133	hsa-miR-1273g-3p	PAR-CLIP	27292025
MIRT716131	hsa-miR-4252	PAR-CLIP	27292025
MIRT716132	hsa-miR-4793-3p	PAR-CLIP	27292025
MIRT716129	hsa-miR-7703	PAR-CLIP	27292025
MIRT716137	hsa-miR-510-5p	HITS-CLIP	19536157
MIRT716136	hsa-miR-6863	HITS-CLIP	19536157
MIRT716135	hsa-miR-1972	HITS-CLIP	19536157
MIRT716134	hsa-miR-4650-5p	HITS-CLIP	19536157
MIRT716133	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT716132	hsa-miR-4793-3p	HITS-CLIP	19536157
MIRT716131	hsa-miR-4252	HITS-CLIP	19536157
MIRT716130	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT716129	hsa-miR-7703	HITS-CLIP	19536157
MIRT514879	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT514878	hsa-miR-4740-3p	PAR-CLIP	23446348
MIRT514877	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT514876	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT514875	hsa-miR-6778-3p	PAR-CLIP	23446348
MIRT514874	hsa-miR-3652	PAR-CLIP	23446348
MIRT514873	hsa-miR-4430	PAR-CLIP	23446348
MIRT514872	hsa-miR-4505	PAR-CLIP	23446348
MIRT514871	hsa-miR-5787	PAR-CLIP	23446348
MIRT514870	hsa-miR-5095	PAR-CLIP	23446348
MIRT514869	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT514868	hsa-miR-6842-3p	PAR-CLIP	23446348
MIRT514867	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT1423483	hsa-miR-1245b-5p	CLIP-seq
MIRT1423484	hsa-miR-1266	CLIP-seq
MIRT1423485	hsa-miR-1275	CLIP-seq
MIRT1423486	hsa-miR-1825	CLIP-seq
MIRT1423487	hsa-miR-2278	CLIP-seq
MIRT1423488	hsa-miR-298	CLIP-seq
MIRT1423489	hsa-miR-299-3p	CLIP-seq
MIRT1423490	hsa-miR-3142	CLIP-seq
MIRT1423491	hsa-miR-3189-3p	CLIP-seq
MIRT1423492	hsa-miR-4265	CLIP-seq
MIRT1423493	hsa-miR-4296	CLIP-seq
MIRT1423494	hsa-miR-4316	CLIP-seq
MIRT1423495	hsa-miR-4322	CLIP-seq
MIRT1423496	hsa-miR-4417	CLIP-seq
MIRT1423497	hsa-miR-4468	CLIP-seq
MIRT1423498	hsa-miR-4518	CLIP-seq
MIRT1423499	hsa-miR-4525	CLIP-seq
MIRT1423500	hsa-miR-4640-5p	CLIP-seq
MIRT1423501	hsa-miR-4665-5p	CLIP-seq
MIRT1423502	hsa-miR-4710	CLIP-seq
MIRT1423503	hsa-miR-4717-3p	CLIP-seq
MIRT1423504	hsa-miR-4723-5p	CLIP-seq
MIRT1423505	hsa-miR-4726-5p	CLIP-seq
MIRT1423506	hsa-miR-625	CLIP-seq
MIRT2348705	hsa-miR-592	CLIP-seq
MIRT2348706	hsa-miR-597	CLIP-seq
MIRT2348707	hsa-miR-892a	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000346	Component	Transcription export complex	IDA	15833825, 15998806
GO:0000347	Component	THO complex	IDA	15998806
GO:0000445	Component	THO complex part of transcription export complex	IBA
GO:0000445	Component	THO complex part of transcription export complex	IDA	15998806
GO:0000781	Component	Chromosome, telomeric region	IDA	24270157
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	19059247, 19165146, 22365833, 23299939, 26382858, 26496610, 28514442, 33961781, 37020021
GO:0005634	Component	Nucleus	IDA	19059247
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0006406	Process	MRNA export from nucleus	IBA
GO:0006406	Process	MRNA export from nucleus	IDA	17190602
GO:0006406	Process	MRNA export from nucleus	IMP	22144908
GO:0008380	Process	RNA splicing	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030224	Process	Monocyte differentiation	IDA	19015024
GO:0051028	Process	MRNA transport	IEA
GO:0060215	Process	Primitive hemopoiesis	ISS

MIM	HGNC	e!Ensembl
612733	19074	ENSG00000100296

Q13769

Protein name

THO complex subunit 5 (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90)

Protein function

Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:159988

PDB

7APK , 7ZNK , 7ZNL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09766	FmiP_Thoc5	97 → 452	Fms-interacting protein/Thoc5	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed.

Sequence

MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQ
ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAK
QKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM
GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQAS
LPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKAL
FKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVL
HLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQY
QFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASHMETTMKLLK
TRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIV
DAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRA
MEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLR
LFRGPSRMKPFKYNHPQGFFSHR

Sequence length

683

Interactions

View interactions

	KEGG		Reactome
	Nucleocytoplasmic transport		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination

THOC5 (THO complex subunit 5)