Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8559
Gene name	Pre-mRNA processing factor 18
Gene symbol	PRPF18
Synonyms (NCBI Gene)	PRP18hPrp18
Chromosome	10
Chromosome location	10p13
Summary	Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which func

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miRTarBase ID	miRNA	Experiments
MIRT1265321	hsa-miR-369-3p	CLIP-seq
MIRT1265322	hsa-miR-374a	CLIP-seq
MIRT1265323	hsa-miR-374b	CLIP-seq
MIRT1265324	hsa-miR-4724-5p	CLIP-seq
MIRT2078013	hsa-miR-2115	CLIP-seq
MIRT2078014	hsa-miR-3646	CLIP-seq
MIRT2078015	hsa-miR-4327	CLIP-seq
MIRT2078016	hsa-miR-451b	CLIP-seq
MIRT2078017	hsa-miR-516a-3p	CLIP-seq
MIRT2078018	hsa-miR-548c-3p	CLIP-seq
MIRT2078019	hsa-miR-596	CLIP-seq
MIRT2304506	hsa-miR-203	CLIP-seq
MIRT2078014	hsa-miR-3646	CLIP-seq
MIRT2304507	hsa-miR-4291	CLIP-seq
MIRT2078015	hsa-miR-4327	CLIP-seq
MIRT2304508	hsa-miR-4493	CLIP-seq
MIRT2304509	hsa-miR-4753-5p	CLIP-seq
MIRT2304510	hsa-miR-545	CLIP-seq
MIRT2304511	hsa-miR-548p	CLIP-seq
MIRT2601432	hsa-miR-1237	CLIP-seq
MIRT2601433	hsa-miR-1246	CLIP-seq
MIRT2601434	hsa-miR-1267	CLIP-seq
MIRT2601435	hsa-miR-1290	CLIP-seq
MIRT2601436	hsa-miR-1294	CLIP-seq
MIRT2601437	hsa-miR-3127-3p	CLIP-seq
MIRT2601438	hsa-miR-3148	CLIP-seq
MIRT2601439	hsa-miR-3167	CLIP-seq
MIRT2601440	hsa-miR-3182	CLIP-seq
MIRT2601441	hsa-miR-3915	CLIP-seq
MIRT2601442	hsa-miR-3928	CLIP-seq
MIRT2601443	hsa-miR-3974	CLIP-seq
MIRT2601444	hsa-miR-4316	CLIP-seq
MIRT2601445	hsa-miR-4640-3p	CLIP-seq
MIRT2601446	hsa-miR-4652-3p	CLIP-seq
MIRT2601447	hsa-miR-4796-5p	CLIP-seq
MIRT2601448	hsa-miR-548a-3p	CLIP-seq
MIRT2078018	hsa-miR-548c-3p	CLIP-seq
MIRT2601449	hsa-miR-548e	CLIP-seq
MIRT2601450	hsa-miR-548f	CLIP-seq
MIRT2601451	hsa-miR-876-5p	CLIP-seq
MIRT2601432	hsa-miR-1237	CLIP-seq
MIRT2601433	hsa-miR-1246	CLIP-seq
MIRT2601434	hsa-miR-1267	CLIP-seq
MIRT2688676	hsa-miR-1269	CLIP-seq
MIRT2688677	hsa-miR-1269b	CLIP-seq
MIRT2601435	hsa-miR-1290	CLIP-seq
MIRT2601436	hsa-miR-1294	CLIP-seq
MIRT2601437	hsa-miR-3127-3p	CLIP-seq
MIRT2601438	hsa-miR-3148	CLIP-seq
MIRT2601439	hsa-miR-3167	CLIP-seq
MIRT2601440	hsa-miR-3182	CLIP-seq
MIRT2601441	hsa-miR-3915	CLIP-seq
MIRT2601442	hsa-miR-3928	CLIP-seq
MIRT2601443	hsa-miR-3974	CLIP-seq
MIRT2601444	hsa-miR-4316	CLIP-seq
MIRT2688678	hsa-miR-4520b-3p	CLIP-seq
MIRT2688679	hsa-miR-4529-3p	CLIP-seq
MIRT2601445	hsa-miR-4640-3p	CLIP-seq
MIRT2601446	hsa-miR-4652-3p	CLIP-seq
MIRT2688680	hsa-miR-4775	CLIP-seq
MIRT2601447	hsa-miR-4796-5p	CLIP-seq
MIRT2601448	hsa-miR-548a-3p	CLIP-seq
MIRT2078018	hsa-miR-548c-3p	CLIP-seq
MIRT2601449	hsa-miR-548e	CLIP-seq
MIRT2601450	hsa-miR-548f	CLIP-seq
MIRT2688681	hsa-miR-590-3p	CLIP-seq
MIRT2601451	hsa-miR-876-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000350	Process	Generation of catalytic spliceosome for second transesterification step	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9000057
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005681	Component	Spliceosomal complex	TAS	9000057
GO:0005682	Component	U5 snRNP	IBA
GO:0006397	Process	MRNA processing	IEA
GO:0006397	Process	MRNA processing	TAS	9000057
GO:0008380	Process	RNA splicing	IEA
GO:0008380	Process	RNA splicing	TAS	9000057
GO:0016607	Component	Nuclear speck	IEA
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IBA
GO:0071021	Component	U2-type post-spliceosomal complex	IBA

MIM	HGNC	e!Ensembl
604993	17351	ENSG00000165630

Q99633

Protein name

Pre-mRNA-splicing factor 18 (PRP18 homolog) (hPRP18)

Protein function

Participates in the second step of pre-mRNA splicing.

PDB

2DK4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08799	PRP4	84 → 112	pre-mRNA processing factor 4 (PRP4) like	Domain
PF02840	Prp18	189 → 331	Prp18 domain	Family

Sequence

MDILKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKIQPKEEDQKPLT
SSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETDYDAFQRLRKIEILTPEVN
KGLRNDLKAALDKIDQQYLNEIVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGD
DHKDMDIITKFLKFLLGVWAKELNAREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKR
NLPADIKESITDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSK
HVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL

Sequence length

342

Interactions

View interactions

	KEGG
	Spliceosome

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
HEMORRHOID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUPUS NEPHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE INTELLECTUAL DISABILITY, AGENESIS OF CORPUS CALLOSUM, FACIAL DYSMORPHISM, CEREBELLAR ATAXIA SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Influenza Human	Associate	27852861	★★★★★ ★☆☆☆☆ Found in Text Mining only

PRPF18 (pre-mRNA processing factor 18)