TSLP (thymic stromal lymphopoietin)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
85480
Gene name Gene Name - the full gene name approved by the HGNC.
Thymic stromal lymphopoietin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TSLP
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attract
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT017769 hsa-miR-335-5p Microarray 18185580
MIRT527990 hsa-miR-652-5p PAR-CLIP 22012620
MIRT527989 hsa-miR-6732-3p PAR-CLIP 22012620
MIRT527988 hsa-miR-4323 PAR-CLIP 22012620
MIRT527987 hsa-miR-3943 PAR-CLIP 22012620
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
NFKB1 Unknown 22270071
RELA Unknown 22270071
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001961 Process Positive regulation of cytokine-mediated signaling pathway IBA
GO:0001961 Process Positive regulation of cytokine-mediated signaling pathway IDA 11418668
GO:0005125 Function Cytokine activity IBA
GO:0005125 Function Cytokine activity IDA 11418668, 20974963
GO:0005125 Function Cytokine activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
607003 30743 ENSG00000145777
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q969D9
Protein name Thymic stromal lymphopoietin
Protein function [Isoform 1]: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. {ECO:00002
PDB 5J11 , 5J12 , 5J13 , 8QFZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15216 TSLP 29 → 153 Thymic stromal lymphopoietin Domain
Tissue specificity TISSUE SPECIFICITY: Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva. {ECO:0000269|PubMed:11480573
Sequence
Sequence length 159
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
JAK-STAT signaling pathway 		  Interleukin-7 signaling
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (6)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Pediatric asthma, Asthma (childhood onset), Nonatopic asthma, Age of onset of adult onset asthma, Atopic asthma, Age of onset of childhood onset asthma, Asthma in any disease, Asthma (adult onset), Asthma (moderate or severe), Asthma onset (childhood vs adult), Asthma (age of onset), Asthma N/A N/A GWAS
Dermatitis Atopic dermatitis N/A N/A GWAS
Eczema Eczema N/A N/A GWAS
Eosinophilia Eosinophilic esophagitis N/A N/A GWAS
Show/Hide Text Mining Associations (138)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Spontaneous Associate 20538796, 24453244, 36096448
Acute Coronary Syndrome Associate 24356513
Acute Lung Injury Associate 27385084
Adenocarcinoma of Lung Inhibit 37640192
Airway Obstruction Associate 15944327, 30185520, 33486314
Allergic Fungal Sinusitis Stimulate 23688414
Allergic Fungal Sinusitis Associate 27744031
Alzheimer Disease Associate 37742913
Angioedema Associate 27240835
Arthritis Rheumatoid Associate 23190696, 25433812, 25817699, 36726974