FCN3 (ficolin 3)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8547
Gene name Gene Name - the full gene name approved by the HGNC.
Ficolin 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FCN3
Synonyms (NCBI Gene) Gene synonyms aliases
FCNH, HAKA1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p36.11
Summary Summary of gene provided in NCBI Entrez Gene.
Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglyc
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(7)
miRTarBase ID miRNA Experiments Reference
MIRT994064 hsa-miR-185 CLIP-seq
MIRT994065 hsa-miR-4306 CLIP-seq
MIRT994066 hsa-miR-4644 CLIP-seq
MIRT994067 hsa-miR-4700-3p CLIP-seq
MIRT994068 hsa-miR-4718 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(18)
GO ID Ontology Definition Evidence Reference
GO:0001867 Process Complement activation, lectin pathway IDA 11907111
GO:0001867 Process Complement activation, lectin pathway TAS
GO:0003823 Function Antigen binding IDA 22851708
GO:0005515 Function Protein binding IPI 11907111
GO:0005576 Component Extracellular region NAS 14718574
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604973 3625 ENSG00000142748
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O75636
Protein name Ficolin-3 (Collagen/fibrinogen domain-containing lectin 3 p35) (Collagen/fibrinogen domain-containing protein 3) (Hakata antigen)
Protein function May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and
PDB 2J5Z , 2J60 , 2J64
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00147 Fibrinogen_C 89 → 299 Fibrinogen beta and gamma chains, C-terminal globular domain Domain
Tissue specificity TISSUE SPECIFICITY: Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells. {ECO:0000269|PubMed:10330454}.
Sequence
Sequence length 299
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Lectin pathway of complement activation
Initial triggering of complement
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Complement component deficiency Complement deficiency disease rs387906509, rs1467298230, rs1022194067, rs774370086, rs121964922, rs372345940, rs121913052, rs121913053, rs460897, rs121913054, rs121913056, rs121913058, rs796052138, rs41286844, rs121909592
View all (29 more)		 25662573
Immunodeficiency Immunodeficiency due to ficolin3 deficiency rs1565678077, rs121908002, rs1421444086, rs1565688667, rs944235493, rs121918314, rs587776713, rs137852678, rs587776714, rs128620188, rs2147483647, rs1569556522, rs137853331, rs137853332, rs179363866
View all (256 more)
Show/Hide Text Mining Associations (41)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Inhibit 39390580
Aortic Aneurysm Abdominal Stimulate 28039962
Arthritis Rheumatoid Associate 32820945
Autoimmune Diseases Associate 36263058
Brain Neoplasms Inhibit 33878734
Carcinoma Hepatocellular Associate 17006932, 33878734, 37484802
Carcinoma Hepatocellular Inhibit 35402624, 36632465
Carcinoma Squamous Cell Associate 33717076
Carcinoma Squamous Cell Inhibit 39390580
Cardiomyopathies Associate 36863704