DIXDC1 (DIX domain containing 1)

Gene

• Entrez ID: 85458
• Gene name: DIX domain containing 1
• Gene symbol: DIXDC1
• Synonyms (NCBI Gene): CCD1
• Chromosome: 11
• Chromosome location: 11q23.1
• Summary: The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms.

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1419374563	C>G,T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant, stop gained, 5 prime UTR variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016151	hsa-miR-615-3p	Sequencing	20371350
MIRT051092	hsa-miR-16-5p	CLASH	23622248
MIRT438828	hsa-miR-582-5p	qRT-PCR	23295946
MIRT438826	hsa-miR-582-3p	qRT-PCR	23295946
MIRT438828	hsa-miR-582-5p	qRT-PCR	23295946
MIRT438826	hsa-miR-582-3p	qRT-PCR	23295946
MIRT755713	hsa-miR-1246	Western blotting, RNA-seq	38287447
MIRT937348	hsa-miR-1254	CLIP-seq
MIRT937349	hsa-miR-1255a	CLIP-seq
MIRT937350	hsa-miR-1255b	CLIP-seq
MIRT937351	hsa-miR-1270	CLIP-seq
MIRT937352	hsa-miR-1271	CLIP-seq
MIRT937353	hsa-miR-1273e	CLIP-seq
MIRT937354	hsa-miR-1286	CLIP-seq
MIRT937355	hsa-miR-1290	CLIP-seq
MIRT937356	hsa-miR-1305	CLIP-seq
MIRT937357	hsa-miR-1343	CLIP-seq
MIRT937358	hsa-miR-143	CLIP-seq
MIRT937359	hsa-miR-182	CLIP-seq
MIRT937360	hsa-miR-219-2-3p	CLIP-seq
MIRT937361	hsa-miR-28-5p	CLIP-seq
MIRT937362	hsa-miR-2964a-3p	CLIP-seq
MIRT937363	hsa-miR-299-5p	CLIP-seq
MIRT937364	hsa-miR-3116	CLIP-seq
MIRT937365	hsa-miR-3134	CLIP-seq
MIRT937366	hsa-miR-3139	CLIP-seq
MIRT937367	hsa-miR-3167	CLIP-seq
MIRT937368	hsa-miR-3175	CLIP-seq
MIRT937369	hsa-miR-3177-5p	CLIP-seq
MIRT937370	hsa-miR-34a	CLIP-seq
MIRT937371	hsa-miR-34c-5p	CLIP-seq
MIRT937372	hsa-miR-3658	CLIP-seq
MIRT937373	hsa-miR-3689d	CLIP-seq
MIRT937374	hsa-miR-371-5p	CLIP-seq
MIRT937375	hsa-miR-378g	CLIP-seq
MIRT937376	hsa-miR-383	CLIP-seq
MIRT937377	hsa-miR-3907	CLIP-seq
MIRT937378	hsa-miR-4274	CLIP-seq
MIRT937379	hsa-miR-4436a	CLIP-seq
MIRT937380	hsa-miR-4437	CLIP-seq
MIRT937381	hsa-miR-4443	CLIP-seq
MIRT937382	hsa-miR-449a	CLIP-seq
MIRT937383	hsa-miR-449b	CLIP-seq
MIRT937384	hsa-miR-451b	CLIP-seq
MIRT937385	hsa-miR-4531	CLIP-seq
MIRT937386	hsa-miR-4534	CLIP-seq
MIRT937387	hsa-miR-4674	CLIP-seq
MIRT937388	hsa-miR-4690-5p	CLIP-seq
MIRT937389	hsa-miR-4766-3p	CLIP-seq
MIRT937390	hsa-miR-4770	CLIP-seq
MIRT937391	hsa-miR-4772-3p	CLIP-seq
MIRT937392	hsa-miR-4772-5p	CLIP-seq
MIRT937393	hsa-miR-498	CLIP-seq
MIRT937394	hsa-miR-539	CLIP-seq
MIRT937395	hsa-miR-548a-3p	CLIP-seq
MIRT937396	hsa-miR-548ac	CLIP-seq
MIRT937397	hsa-miR-548ae	CLIP-seq
MIRT937398	hsa-miR-548aj	CLIP-seq
MIRT937399	hsa-miR-548am	CLIP-seq
MIRT937400	hsa-miR-548d-3p	CLIP-seq
MIRT937401	hsa-miR-548e	CLIP-seq
MIRT937402	hsa-miR-548f	CLIP-seq
MIRT937403	hsa-miR-548x	CLIP-seq
MIRT937404	hsa-miR-548z	CLIP-seq
MIRT937405	hsa-miR-562	CLIP-seq
MIRT937406	hsa-miR-581	CLIP-seq
MIRT937407	hsa-miR-620	CLIP-seq
MIRT937408	hsa-miR-636	CLIP-seq
MIRT937409	hsa-miR-708	CLIP-seq
MIRT937410	hsa-miR-876-5p	CLIP-seq
MIRT937411	hsa-miR-96	CLIP-seq
MIRT937352	hsa-miR-1271	CLIP-seq
MIRT937412	hsa-miR-1273	CLIP-seq
MIRT937413	hsa-miR-1273c	CLIP-seq
MIRT937414	hsa-miR-151-3p	CLIP-seq
MIRT937359	hsa-miR-182	CLIP-seq
MIRT937415	hsa-miR-2909	CLIP-seq
MIRT937416	hsa-miR-3140-3p	CLIP-seq
MIRT937417	hsa-miR-3162-5p	CLIP-seq
MIRT937369	hsa-miR-3177-5p	CLIP-seq
MIRT937418	hsa-miR-3185	CLIP-seq
MIRT937370	hsa-miR-34a	CLIP-seq
MIRT937371	hsa-miR-34c-5p	CLIP-seq
MIRT937419	hsa-miR-3591-5p	CLIP-seq
MIRT937373	hsa-miR-3689d	CLIP-seq
MIRT937420	hsa-miR-4280	CLIP-seq
MIRT937421	hsa-miR-4328	CLIP-seq
MIRT937381	hsa-miR-4443	CLIP-seq
MIRT937422	hsa-miR-4463	CLIP-seq
MIRT937423	hsa-miR-4471	CLIP-seq
MIRT937424	hsa-miR-4499	CLIP-seq
MIRT937382	hsa-miR-449a	CLIP-seq
MIRT937383	hsa-miR-449b	CLIP-seq
MIRT937425	hsa-miR-4514	CLIP-seq
MIRT937426	hsa-miR-4692	CLIP-seq
MIRT937427	hsa-miR-4709-3p	CLIP-seq
MIRT937428	hsa-miR-4733-3p	CLIP-seq
MIRT937429	hsa-miR-4735-5p	CLIP-seq
MIRT937430	hsa-miR-4778-5p	CLIP-seq
MIRT937431	hsa-miR-513a-5p	CLIP-seq
MIRT937406	hsa-miR-581	CLIP-seq
MIRT937432	hsa-miR-630	CLIP-seq
MIRT937411	hsa-miR-96	CLIP-seq
MIRT1977471	hsa-miR-150	CLIP-seq
MIRT937375	hsa-miR-378g	CLIP-seq
MIRT1977472	hsa-miR-409-3p	CLIP-seq
MIRT1977473	hsa-miR-4680-5p	CLIP-seq
MIRT1977474	hsa-miR-4722-3p	CLIP-seq
MIRT1977475	hsa-miR-4724-5p	CLIP-seq
MIRT1977476	hsa-miR-587	CLIP-seq
MIRT1977477	hsa-miR-590-3p	CLIP-seq
MIRT2212783	hsa-miR-15a	CLIP-seq
MIRT2212784	hsa-miR-15b	CLIP-seq
MIRT2212785	hsa-miR-16	CLIP-seq
MIRT2212786	hsa-miR-195	CLIP-seq
MIRT2212787	hsa-miR-3180-5p	CLIP-seq
MIRT2212788	hsa-miR-324-5p	CLIP-seq
MIRT2212789	hsa-miR-3622b-5p	CLIP-seq
MIRT937376	hsa-miR-383	CLIP-seq
MIRT2212790	hsa-miR-424	CLIP-seq
MIRT2212791	hsa-miR-4524	CLIP-seq
MIRT2212792	hsa-miR-4693-3p	CLIP-seq
MIRT2212793	hsa-miR-4712-3p	CLIP-seq
MIRT937429	hsa-miR-4735-5p	CLIP-seq
MIRT2212794	hsa-miR-4749-3p	CLIP-seq
MIRT937392	hsa-miR-4772-5p	CLIP-seq
MIRT2212795	hsa-miR-497	CLIP-seq
MIRT2212796	hsa-miR-503	CLIP-seq
MIRT2212797	hsa-miR-520a-5p	CLIP-seq
MIRT2212798	hsa-miR-525-5p	CLIP-seq
MIRT2212799	hsa-miR-646	CLIP-seq
MIRT2212800	hsa-miR-1324	CLIP-seq
MIRT2212801	hsa-miR-203	CLIP-seq
MIRT1977476	hsa-miR-587	CLIP-seq
MIRT937352	hsa-miR-1271	CLIP-seq
MIRT937414	hsa-miR-151-3p	CLIP-seq
MIRT937359	hsa-miR-182	CLIP-seq
MIRT937416	hsa-miR-3140-3p	CLIP-seq
MIRT937369	hsa-miR-3177-5p	CLIP-seq
MIRT937370	hsa-miR-34a	CLIP-seq
MIRT937371	hsa-miR-34c-5p	CLIP-seq
MIRT937373	hsa-miR-3689d	CLIP-seq
MIRT937381	hsa-miR-4443	CLIP-seq
MIRT937422	hsa-miR-4463	CLIP-seq
MIRT937424	hsa-miR-4499	CLIP-seq
MIRT937382	hsa-miR-449a	CLIP-seq
MIRT937383	hsa-miR-449b	CLIP-seq
MIRT937425	hsa-miR-4514	CLIP-seq
MIRT937426	hsa-miR-4692	CLIP-seq
MIRT937431	hsa-miR-513a-5p	CLIP-seq
MIRT937406	hsa-miR-581	CLIP-seq
MIRT937411	hsa-miR-96	CLIP-seq
MIRT2448285	hsa-miR-3925-5p	CLIP-seq
MIRT937423	hsa-miR-4471	CLIP-seq
MIRT937384	hsa-miR-451b	CLIP-seq
MIRT2448286	hsa-miR-543	CLIP-seq
MIRT2516579	hsa-miR-1224-3p	CLIP-seq
MIRT2516580	hsa-miR-1224-5p	CLIP-seq
MIRT937348	hsa-miR-1254	CLIP-seq
MIRT2516581	hsa-miR-1260	CLIP-seq
MIRT2516582	hsa-miR-1260b	CLIP-seq
MIRT937351	hsa-miR-1270	CLIP-seq
MIRT937412	hsa-miR-1273	CLIP-seq
MIRT937413	hsa-miR-1273c	CLIP-seq
MIRT2516583	hsa-miR-1280	CLIP-seq
MIRT937355	hsa-miR-1290	CLIP-seq
MIRT2516584	hsa-miR-1293	CLIP-seq
MIRT2516585	hsa-miR-129-3p	CLIP-seq
MIRT937356	hsa-miR-1305	CLIP-seq
MIRT2212800	hsa-miR-1324	CLIP-seq
MIRT937357	hsa-miR-1343	CLIP-seq
MIRT2516586	hsa-miR-145	CLIP-seq
MIRT2212783	hsa-miR-15a	CLIP-seq
MIRT2212784	hsa-miR-15b	CLIP-seq
MIRT2212785	hsa-miR-16	CLIP-seq
MIRT2516587	hsa-miR-181a	CLIP-seq
MIRT2516588	hsa-miR-181b	CLIP-seq
MIRT2516589	hsa-miR-181c	CLIP-seq
MIRT2516590	hsa-miR-181d	CLIP-seq
MIRT2516591	hsa-miR-188-3p	CLIP-seq
MIRT2516592	hsa-miR-1911	CLIP-seq
MIRT2212786	hsa-miR-195	CLIP-seq
MIRT2516593	hsa-miR-2052	CLIP-seq
MIRT2516594	hsa-miR-2110	CLIP-seq
MIRT2516595	hsa-miR-224	CLIP-seq
MIRT937361	hsa-miR-28-5p	CLIP-seq
MIRT2516596	hsa-miR-3065-3p	CLIP-seq
MIRT2516597	hsa-miR-3115	CLIP-seq
MIRT937364	hsa-miR-3116	CLIP-seq
MIRT2516598	hsa-miR-3121-3p	CLIP-seq
MIRT2516599	hsa-miR-3132	CLIP-seq
MIRT2516600	hsa-miR-3135	CLIP-seq
MIRT937366	hsa-miR-3139	CLIP-seq
MIRT2516601	hsa-miR-3156-3p	CLIP-seq
MIRT2516602	hsa-miR-3163	CLIP-seq
MIRT937367	hsa-miR-3167	CLIP-seq
MIRT2516603	hsa-miR-3182	CLIP-seq
MIRT2516604	hsa-miR-3187-3p	CLIP-seq
MIRT2516605	hsa-miR-338-5p	CLIP-seq
MIRT2516606	hsa-miR-340	CLIP-seq
MIRT2516607	hsa-miR-3613-3p	CLIP-seq
MIRT2212789	hsa-miR-3622b-5p	CLIP-seq
MIRT2516608	hsa-miR-3651	CLIP-seq
MIRT2516609	hsa-miR-3653	CLIP-seq
MIRT2516610	hsa-miR-3661	CLIP-seq
MIRT937374	hsa-miR-371-5p	CLIP-seq
MIRT937375	hsa-miR-378g	CLIP-seq
MIRT2516611	hsa-miR-3925-3p	CLIP-seq
MIRT2516612	hsa-miR-3936	CLIP-seq
MIRT2516613	hsa-miR-3978	CLIP-seq
MIRT1977472	hsa-miR-409-3p	CLIP-seq
MIRT2212790	hsa-miR-424	CLIP-seq
MIRT2516614	hsa-miR-4262	CLIP-seq
MIRT2516615	hsa-miR-4271	CLIP-seq
MIRT2516616	hsa-miR-432	CLIP-seq
MIRT2516617	hsa-miR-4330	CLIP-seq
MIRT2516618	hsa-miR-4433	CLIP-seq
MIRT2516619	hsa-miR-4434	CLIP-seq
MIRT937380	hsa-miR-4437	CLIP-seq
MIRT2516620	hsa-miR-4457	CLIP-seq
MIRT2516621	hsa-miR-4459	CLIP-seq
MIRT2516622	hsa-miR-4464	CLIP-seq
MIRT2516623	hsa-miR-4483	CLIP-seq
MIRT2516624	hsa-miR-4496	CLIP-seq
MIRT2516625	hsa-miR-4516	CLIP-seq
MIRT2212791	hsa-miR-4524	CLIP-seq
MIRT2516626	hsa-miR-4529-5p	CLIP-seq
MIRT937385	hsa-miR-4531	CLIP-seq
MIRT2516627	hsa-miR-4633-5p	CLIP-seq
MIRT2516628	hsa-miR-4651	CLIP-seq
MIRT2516629	hsa-miR-4652-3p	CLIP-seq
MIRT2516630	hsa-miR-4659a-3p	CLIP-seq
MIRT2516631	hsa-miR-4659b-3p	CLIP-seq
MIRT2516632	hsa-miR-4666-3p	CLIP-seq
MIRT2516633	hsa-miR-4667-5p	CLIP-seq
MIRT937387	hsa-miR-4674	CLIP-seq
MIRT2516634	hsa-miR-4684-3p	CLIP-seq
MIRT2516635	hsa-miR-4687-5p	CLIP-seq
MIRT2516636	hsa-miR-4695-5p	CLIP-seq
MIRT2516637	hsa-miR-4700-5p	CLIP-seq
MIRT2516638	hsa-miR-4715-3p	CLIP-seq
MIRT2516639	hsa-miR-4725-3p	CLIP-seq
MIRT937428	hsa-miR-4733-3p	CLIP-seq
MIRT2516640	hsa-miR-4738-3p	CLIP-seq
MIRT2516641	hsa-miR-4742-3p	CLIP-seq
MIRT2516642	hsa-miR-4748	CLIP-seq
MIRT2516643	hsa-miR-4751	CLIP-seq
MIRT2516644	hsa-miR-4768-3p	CLIP-seq
MIRT2516645	hsa-miR-483-3p	CLIP-seq
MIRT2516646	hsa-miR-494	CLIP-seq
MIRT2212795	hsa-miR-497	CLIP-seq
MIRT937393	hsa-miR-498	CLIP-seq
MIRT2516647	hsa-miR-499a-5p	CLIP-seq
MIRT2212796	hsa-miR-503	CLIP-seq
MIRT2516648	hsa-miR-508-5p	CLIP-seq
MIRT2516649	hsa-miR-5096	CLIP-seq
MIRT2516650	hsa-miR-515-5p	CLIP-seq
MIRT2516651	hsa-miR-532-5p	CLIP-seq
MIRT2516652	hsa-miR-548c-3p	CLIP-seq
MIRT2516653	hsa-miR-548g	CLIP-seq
MIRT2516654	hsa-miR-548p	CLIP-seq
MIRT1977476	hsa-miR-587	CLIP-seq
MIRT2516655	hsa-miR-608	CLIP-seq
MIRT2516656	hsa-miR-617	CLIP-seq
MIRT937407	hsa-miR-620	CLIP-seq
MIRT2516657	hsa-miR-626	CLIP-seq
MIRT2516658	hsa-miR-631	CLIP-seq
MIRT2516659	hsa-miR-645	CLIP-seq
MIRT2212799	hsa-miR-646	CLIP-seq
MIRT2516660	hsa-miR-663b	CLIP-seq
MIRT937409	hsa-miR-708	CLIP-seq
MIRT2516661	hsa-miR-766	CLIP-seq
MIRT937410	hsa-miR-876-5p	CLIP-seq
MIRT2516585	hsa-miR-129-3p	CLIP-seq
MIRT2516587	hsa-miR-181a	CLIP-seq
MIRT2516588	hsa-miR-181b	CLIP-seq
MIRT2516589	hsa-miR-181c	CLIP-seq
MIRT2516590	hsa-miR-181d	CLIP-seq
MIRT2516605	hsa-miR-338-5p	CLIP-seq
MIRT2516608	hsa-miR-3651	CLIP-seq
MIRT2516613	hsa-miR-3978	CLIP-seq
MIRT2516614	hsa-miR-4262	CLIP-seq
MIRT2516632	hsa-miR-4666-3p	CLIP-seq
MIRT2516635	hsa-miR-4687-5p	CLIP-seq
MIRT2516641	hsa-miR-4742-3p	CLIP-seq
MIRT2516653	hsa-miR-548g	CLIP-seq
MIRT2516657	hsa-miR-626	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001725	Component	Stress fiber	IEA
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	17043677, 20823832, 21189423, 31413325, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	19375513
GO:0005829	Component	Cytosol	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005925	Component	Focal adhesion	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0019904	Function	Protein domain specific binding	IEA
GO:0021795	Process	Cerebral cortex cell migration	IEA
GO:0021799	Process	Cerebral cortex radially oriented cell migration	IEA
GO:0021846	Process	Cell proliferation in forebrain	IEA
GO:0021869	Process	Forebrain ventricular zone progenitor cell division	IEA
GO:0030177	Process	Positive regulation of Wnt signaling pathway	IEA
GO:0032956	Process	Regulation of actin cytoskeleton organization	IEA
GO:0043015	Function	Gamma-tubulin binding	IDA	19375513
GO:0045665	Process	Negative regulation of neuron differentiation	IEA
GO:0060070	Process	Canonical Wnt signaling pathway	IBA
GO:0060070	Process	Canonical Wnt signaling pathway	IDA	21189423
GO:0060070	Process	Canonical Wnt signaling pathway	IEA
GO:0070161	Component	Anchoring junction	IEA
GO:0070507	Process	Regulation of microtubule cytoskeleton organization	IEA
GO:0098794	Component	Postsynapse	IEA
GO:0098885	Process	Modification of postsynaptic actin cytoskeleton	IEA
GO:0098978	Component	Glutamatergic synapse	IEA

Other IDs

• MIM: 610493
• HGNC: 23695
• e!Ensembl: ENSG00000150764

Protein

• UniProt ID: Q155Q3
• Protein name: Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1)
• Protein function: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.
• PDB: 3PZ7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00307	CH	20 → 128	Calponin homology (CH) domain	Domain
  PF00778	DIX	599 → 678	DIX domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed with higher expression in cardiac and skeletal muscles. {ECO:0000269|PubMed:16814745}.
• Sequence:

  MLACLTRGNLLDVLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLI
  EIVAGEKLSGVQLSPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVL
  ALAAHFKPGSSRTVNQGRDSRAPLQSHRPHCATAVAQGAAAALADVCHDMSRSGRDVFRY
  RQRNSSMDEEIENPYWSVRALVQQYEGQQRSPSESSCSSLTSPSPIHSAKSESIITQSEE
  KADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKK
  MISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKC
  KQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLL
  GEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEA
  TNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSL
  EQGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRESWPPNSKLPHSQSSPTVSSTC
  TKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEIFH
  DDDAIPGWEGKIVAWVEEDHGEN

• Sequence length: 683

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Obesity	Likely pathogenic	rs1419374563	RCV000787972

Associations from Text Mining
Disease Name	Relationship Type	References
Brain Neoplasms	Associate	22688887
Carcinoma Hepatocellular	Inhibit	27468723
Colorectal Neoplasms	Associate	27817168
Glioma	Associate	22688887, 27817168
Neoplasms	Inhibit	27468723
Squamous Cell Carcinoma of Head and Neck	Associate	32495922
Stomach Neoplasms	Associate	27817168, 28800791, 34898351