ZFHX2 (zinc finger homeobox 2)

Gene

• Entrez ID: 85446
• Gene name: Zinc finger homeobox 2
• Gene symbol: ZFHX2
• Synonyms (NCBI Gene): MARSIS, ZFH-5, ZFH5, ZNF409
• Disease Acronyms (UniProt): MARSIS
• Chromosome: 14
• Chromosome location: 14q11.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019857	hsa-miR-375	Microarray	20215506
MIRT572540	hsa-miR-586	PAR-CLIP	20371350
MIRT572539	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT572538	hsa-miR-567	PAR-CLIP	20371350
MIRT572537	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT572536	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT572535	hsa-miR-4666b	PAR-CLIP	20371350
MIRT572534	hsa-miR-675-3p	PAR-CLIP	20371350
MIRT572533	hsa-miR-297	PAR-CLIP	20371350
MIRT572532	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT572540	hsa-miR-586	PAR-CLIP	20371350
MIRT572539	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT572538	hsa-miR-567	PAR-CLIP	20371350
MIRT572537	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT572536	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT572535	hsa-miR-4666b	PAR-CLIP	20371350
MIRT572534	hsa-miR-675-3p	PAR-CLIP	20371350
MIRT572533	hsa-miR-297	PAR-CLIP	20371350
MIRT572532	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT1509850	hsa-miR-3155	CLIP-seq
MIRT1509851	hsa-miR-3155b	CLIP-seq
MIRT1509852	hsa-miR-4265	CLIP-seq
MIRT1509853	hsa-miR-4296	CLIP-seq
MIRT1509854	hsa-miR-4322	CLIP-seq
MIRT1509855	hsa-miR-4417	CLIP-seq
MIRT1509856	hsa-miR-4437	CLIP-seq
MIRT1509857	hsa-miR-4641	CLIP-seq
MIRT1509858	hsa-miR-4674	CLIP-seq
MIRT1509859	hsa-miR-4711-3p	CLIP-seq
MIRT1509860	hsa-miR-4755-3p	CLIP-seq
MIRT1509861	hsa-miR-484	CLIP-seq
MIRT1509862	hsa-miR-765	CLIP-seq
MIRT2153554	hsa-miR-2467-3p	CLIP-seq
MIRT2373858	hsa-miR-147	CLIP-seq
MIRT2373859	hsa-miR-3612	CLIP-seq
MIRT2373860	hsa-miR-3911	CLIP-seq
MIRT2373861	hsa-miR-644	CLIP-seq
MIRT2373862	hsa-miR-650	CLIP-seq
MIRT2373863	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	29253101
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0007420	Process	Brain development	IBA	21873635
GO:0008270	Function	Zinc ion binding	IEA
GO:0030534	Process	Adult behavior	IEA
GO:0045664	Process	Regulation of neuron differentiation	IBA	21873635
GO:0051930	Process	Regulation of sensory perception of pain	IMP	29253101

Other IDs

• MIM: 617828
• HGNC: 20152
• e!Ensembl: ENSG00000136367

Protein

• UniProt ID: Q9C0A1
• Protein name: Zinc finger homeobox protein 2 (Zinc finger homeodomain protein 2) (ZFH-2)
• Protein function: Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00046	Homeodomain	1596 → 1652	Homeodomain	Domain
  PF00046	Homeodomain	1858 → 1914	Homeodomain	Domain
  PF00046	Homeodomain	2066 → 2122	Homeodomain	Domain

• Sequence:

  MATLNSASTTGTTPSPGHNAPSLPSDTFSSSTPSDPVTKDPPAASSTSENMRSSEPGGQL
  LESGCGLVPPKEIGEPQEGPDCGHFPPNDPGVEKDKEQEEEEEGLPPMDLSNHLFFTAGG
  EAYLVAKLSLPGGSELLLPKGFPWGEAGIKEEPSLPFLAYPPPSHLTALHIQHGFDPIQG
  FSSSDQILSHDTSAPSPAACEERHGAFWSYQLAPNPPGDPKDGPMGNSGGNHVAVFWLCL
  LCRLGFSKPQAFMDHTQSHGVKLTPAQYQGLSGSPAVLQEGDEGCKALISFLEPKLPARP
  SSDIPLDNSSTVNMEANVAQTEDGPPEAEVQALILLDEEVMALSPPSPPTATWDPSPTQA
  KESPVAAGEAGPDWFPEGQEEDGGLCPPLNQSSPTSKEGGTLPAPVGSPEDPSDPPQPYR
  LADDYTPAPAAFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESN
  SHCSYCSAGGAHPRLARGESYNCGYKPYRCDVCNYSTTTKGNLSIHMQSDKHLANLQGFQ
  AGPGGQGSPPEASLPPSAGDKEPKTKSSWQCKVCSYETNISRNLRIHMTSEKHMQNVLML
  HQGLPLGLPPGLMGPGPPPPPGATPTSPPELFQYFGPQALGQPQTPLAGPGLRPDKPLEA
  QLLLNGFHHVGAPARKFPTSAPGSLSPDAHLPPSQLLGSSSDSLPTSPPPDDSLSLKVFR
  CLVCQAFSTDSLELLLYHCSIGRSLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTD
  KHAQKYQLAAHLREGGGAMGTPSPASLGDGAPYGSVSPLHLRCNICDFESNSKEKMQLHA
  RGAAHEENSQIYKFLLDMEGAEAGAELGLYHCLLCAWETPSRLAVLQHLRTPAHRDAQAQ
  RRLQLLQNGPTTEEGLAALQSILSFSHGQLRTPGKAPVTPLAEPPTPEKDAQNKTEQLAS
  EETENKTGPSRDSANQTTVYCCPYCSFLSPESSQVRAHTLSQHAVQPKYRCPLCQEQLVG
  RPALHFHLSHLHNVVPECVEKLLLVATTVEMTFTTKVLSAPTLSPLDNGQEPPTHGPEPT
  PSRDQAAEGPNLTPEASPDPLPEPPLASVEVPDKPSGSPGQPPSPAPSPVPEPDAQAEDV
  APPPTMAEEEEGTTGELRSAEPAPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESF
  TQKNILLVHYNSVSHLHKMKKAAIDPSAPARGEAGAPPTTTAATDKPFKCTVCRVSYNQS
  STLEIHMRSVLHQTRSRGTKTDSKIEGPERSQEEPKEGETEGEVGTEKKGPDTSGFISGL
  PFLSPPPPPLDLHRFPAPLFTPPVLPPFPLVPESLLKLQQQQLLLPFYLHDLKVGPKLTL
  AGPAPVLSLPAATPPPPPQPPKAELAEREWERPPMAKEGNEAGPSSPPDPLPNEAARTAA
  KALLENFGFELVIQYNEGKQAVPPPPTPPPPEALGGGDKLACGACGKLFSNMLILKTHEE
  HVHRRFLPFEALSRYAAQFRKSYDSLYPPLAEPPKPPDGSLDSPVPHLGPPFLVPEPEAG
  GTRAPEERSRAGGHWPIEEEESSRGNLPPLVPAGRRFSRTKFTEFQTQALQSFFETSAYP
  KDGEVERLASLLGLASRVVVVWFQNARQKARKNACEGGSMPTGGGTGGASGCRRCHATFS
  CVFELVRHLKKCYDDQTLEEEEEEAERGEEEEEVEEEEVEEEQGLEPPAGPEGPLPEPPD
  GEELSQAEATKAGGKEPEEKATPSPSPAHTCDQCAISFSSQDLLTSHRRLHFLPSLQPSA
  PPQLLDLPLLVFGERNPLVAATSPMPGPPLKRKHEDGSLSPTGSEAGGGGEGEPPRDKRL
  RTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRST
  PGGVPSPAVKPPATATPASLPKFNLLLGKVDDGTGREAPKREAPAFPYPTATLASGPQPF
  LPPGKEATTPTPEPPLPLLPPPPPSEEEGPEEPPKASPESEACSLSAGDLSDSSASSLAE
  PESPGAGGTSGGPGGGTGVPDGMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGE
  EIGLPKRVIQVWFQNARAKEKKAKLQGTAAGSTGGSSEGLLAAQRTDCPYCDVKYDFYVS
  CRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPEAPPALKAPPATTPASMPLGAAPTL
  PRLAPVLLSGPALAQPPLGNLAPFNSGPAASSGLLGLATSVLPTTTVVQTAGPGRPLPQR
  PMPDQTNTSTAGTTDPVPGPPTEPLGDKVSSERKPVAGPTSSSNDALKNLKALKTTVPAL
  LGGQFLPFPLPPAGGTAPPAVFGPQLQGAYFQQLYGMKKGLFPMNPMIPQTLIGLLPNAL
  LQPPPQPPEPTATAPPKPPELPAPGEGEAGEVDELLTGSTGISTVDVTHRYLCRQCKMAF
  DGEAPATAHQRSFCFFGRGSGGSMPPPLRVPICTYHCLACEVLLSGREALASHLRSSAHR
  RKAAPPQGGPPISITNAATAASAAVAFAKEEARLPHTDSNPKTTTTSTLLAL

• Sequence length: 2572