Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
85444
Gene name Gene Name - the full gene name approved by the HGNC.
Leucine rich repeat and coiled-coil centrosomal protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LRRCC1
Synonyms (NCBI Gene) Gene synonyms aliases
CLERC, CLERK, SAP2, VFL1
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q21.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a centrosomal protein that maintains the structural integrity of the centrosome and plays a key role in mitotic spindle formation. The encoded protein contains an N-terminal leucine-rich repeat domain and a C-terminal coiled-coil domain.
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT024691 hsa-miR-215-5p Microarray 19074876
MIRT026773 hsa-miR-192-5p Microarray 19074876
MIRT1120792 hsa-miR-338-5p CLIP-seq
MIRT2264582 hsa-miR-3168 CLIP-seq
MIRT2264583 hsa-miR-4662a-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005813 Component Centrosome IBA 21873635
GO:0005813 Component Centrosome IDA 21399614
GO:0005814 Component Centriole IEA
GO:0007049 Process Cell cycle IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
617791 29373 ENSG00000133739
Protein
UniProt ID Q9C099
Protein name Leucine-rich repeat and coiled-coil domain-containing protein 1 (Centrosomal leucine-rich repeat and coiled-coil domain-containing protein)
Protein function Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis.
Family and domains
Sequence
MEAAAAVVAAEAEVENEDGDSSCGDVCFMDKGLQSISELSLDSTLHAVNLHCNNISKIEA
IDHIWNLQHLDLSSNQISRIEGLNTLTKLCTLNLSCNLITKVEGLEELINLTRLNVSYNH
IDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLHFLTNLILEKDGDDNPVCRL
PGYRAVILQTLPQLRILDCKNIFGEPVNLTEINSSQLQCLEGLLDNLVSSDSPLNISEDE
IIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQNEIKLQKL
DDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRSKIPYDAKTI
QTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQSHSED
NTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIF
RERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQA
AQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTD
ADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDG
FENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQ
INTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSL
AQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHI
KRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAY
STLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAF
KRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQ
LAFALNEIQQDM
Sequence length 1032
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Cerebellar vermis agenesis Familial aplasia of the vermis rs201108965, rs13297509, rs121918129, rs121918130, rs121918197, rs121918198, rs121918199, rs121918203, rs121918204, rs145665129, rs121434348, rs121434349, rs267606641, rs201391050, rs387907003
View all (121 more)
Diastrophic dysplasia Diastrophic dysplasia rs386833498, rs786200881, rs104893915, rs104893919, rs104893920, rs104893916, rs104893921, rs386833492, rs104893924, rs121908078, rs386833493, rs386833494, rs386833495, rs386833496, rs386833497
View all (32 more)
Keratosis follicularis Keratosis Follicularis rs28929478, rs121912731, rs1592839705, rs121912732, rs121912734, rs2137673961, rs1566240208, rs121912738, rs1592864859
Retinal dystrophy Retinal Dystrophies rs267606794, rs200691042, rs397704718, rs202193201, rs794728002, rs121965036, rs121965057, rs121918129, rs137853190, rs386834252, rs121918165, rs137853113, rs137853114, rs121918328, rs587777803
View all (2328 more)
Associations from Text Mining
Disease Name Relationship Type References
Ciliopathies Associate 27894351
Sphingolipidoses Associate 1371116