Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	85439
Gene name	Stonin 2
Gene symbol	STON2
Synonyms (NCBI Gene)	STN2STNBSTNB2
Chromosome	14
Chromosome location	14q31.1
Summary	This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. T

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019363	hsa-miR-148b-3p	Microarray	17612493
MIRT021263	hsa-miR-146a-5p	Microarray	18057241
MIRT715415	hsa-miR-5684	HITS-CLIP	19536157
MIRT715414	hsa-miR-4499	HITS-CLIP	19536157
MIRT715413	hsa-miR-4293	HITS-CLIP	19536157
MIRT715412	hsa-miR-596	HITS-CLIP	19536157
MIRT715411	hsa-miR-4494	HITS-CLIP	19536157
MIRT715410	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT715409	hsa-miR-1251-5p	HITS-CLIP	19536157
MIRT715408	hsa-miR-4329	HITS-CLIP	19536157
MIRT715407	hsa-miR-6776-5p	HITS-CLIP	19536157
MIRT715406	hsa-miR-6857-3p	HITS-CLIP	19536157
MIRT715405	hsa-miR-4252	HITS-CLIP	19536157
MIRT715404	hsa-miR-661	HITS-CLIP	19536157
MIRT715403	hsa-miR-542-3p	HITS-CLIP	19536157
MIRT715402	hsa-miR-1287-3p	HITS-CLIP	19536157
MIRT715401	hsa-miR-1262	HITS-CLIP	19536157
MIRT715400	hsa-miR-4701-3p	HITS-CLIP	19536157
MIRT715399	hsa-miR-6736-5p	HITS-CLIP	19536157
MIRT666048	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT666047	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT666046	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT666045	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT666044	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT666043	hsa-miR-103b	HITS-CLIP	23824327
MIRT653060	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT653059	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT666042	hsa-miR-4672	HITS-CLIP	23824327
MIRT653058	hsa-miR-376a-3p	HITS-CLIP	23824327
MIRT653057	hsa-miR-376b-3p	HITS-CLIP	23824327
MIRT653054	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT653061	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT653060	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT653059	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT653058	hsa-miR-376a-3p	HITS-CLIP	23824327
MIRT653057	hsa-miR-376b-3p	HITS-CLIP	23824327
MIRT653056	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT653055	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT653054	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT653053	hsa-miR-576-3p	HITS-CLIP	23824327
MIRT653052	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT653051	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT653050	hsa-miR-5695	HITS-CLIP	23824327
MIRT653049	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT653048	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT653047	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT653046	hsa-miR-192-3p	HITS-CLIP	23824327
MIRT653045	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT653044	hsa-miR-8061	HITS-CLIP	23824327
MIRT715415	hsa-miR-5684	HITS-CLIP	19536157
MIRT715414	hsa-miR-4499	HITS-CLIP	19536157
MIRT715413	hsa-miR-4293	HITS-CLIP	19536157
MIRT715412	hsa-miR-596	HITS-CLIP	19536157
MIRT715411	hsa-miR-4494	HITS-CLIP	19536157
MIRT715410	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT715409	hsa-miR-1251-5p	HITS-CLIP	19536157
MIRT715408	hsa-miR-4329	HITS-CLIP	19536157
MIRT715407	hsa-miR-6776-5p	HITS-CLIP	19536157
MIRT715406	hsa-miR-6857-3p	HITS-CLIP	19536157
MIRT715405	hsa-miR-4252	HITS-CLIP	19536157
MIRT715404	hsa-miR-661	HITS-CLIP	19536157
MIRT715403	hsa-miR-542-3p	HITS-CLIP	19536157
MIRT715402	hsa-miR-1287-3p	HITS-CLIP	19536157
MIRT715401	hsa-miR-1262	HITS-CLIP	19536157
MIRT715400	hsa-miR-4701-3p	HITS-CLIP	19536157
MIRT715399	hsa-miR-6736-5p	HITS-CLIP	19536157
MIRT666048	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT666047	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT666046	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT666045	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT666044	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT666043	hsa-miR-103b	HITS-CLIP	23824327
MIRT653060	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT653059	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT666042	hsa-miR-4672	HITS-CLIP	23824327
MIRT653058	hsa-miR-376a-3p	HITS-CLIP	23824327
MIRT653057	hsa-miR-376b-3p	HITS-CLIP	23824327
MIRT653054	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT653061	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT653060	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT653059	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT653058	hsa-miR-376a-3p	HITS-CLIP	23824327
MIRT653057	hsa-miR-376b-3p	HITS-CLIP	23824327
MIRT653056	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT653055	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT653054	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT653053	hsa-miR-576-3p	HITS-CLIP	23824327
MIRT653052	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT653051	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT653050	hsa-miR-5695	HITS-CLIP	23824327
MIRT653049	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT653048	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT653047	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT653046	hsa-miR-192-3p	HITS-CLIP	23824327
MIRT653045	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT653044	hsa-miR-8061	HITS-CLIP	23824327

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	11454741, 18200045, 19380743, 21102408, 33961781, 35044719, 37219487
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006897	Process	Endocytosis	IEA
GO:0008021	Component	Synaptic vesicle	IBA
GO:0016020	Component	Membrane	IEA
GO:0030100	Process	Regulation of endocytosis	IBA
GO:0030100	Process	Regulation of endocytosis	IEA
GO:0030100	Process	Regulation of endocytosis	ISS	14726597
GO:0030122	Component	AP-2 adaptor complex	IBA
GO:0035615	Function	Clathrin adaptor activity	IBA
GO:0043005	Component	Neuron projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0048488	Process	Synaptic vesicle endocytosis	IBA
GO:0048488	Process	Synaptic vesicle endocytosis	IGI	21102408
GO:0072583	Process	Clathrin-dependent endocytosis	IBA

MIM	HGNC	e!Ensembl
608467	30652	ENSG00000140022

Q8WXE9

Protein name

Stonin-2 (Stoned B)

Protein function

Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.

PDB

2JXC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12016	Stonin2_N	1 → 340	Stonin 2	Family
PF00928	Adap_comp_sub	557 → 874	Adaptor complexes medium subunit family	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11381094}.

Sequence

MTTLDHVIATHQSEWVSFNEEPPFPAHSQGGTEEHLPGLSSSPDQSESSSGENHVVDGGS
QDHSHSEQDDSSEKMGLISEAASPPGSPEQPPPDLASAISNWVQFEDDTPWASTSPPHQE
TAETALPLTMPCWTCPSFDSLGRCPLTSESSWTTHSEDTSSPSFGCSYTDLQLINAEEQT
SGQASGADSTDNSSSLQEDEEVEMEAISWQASSPAMNGHPAPPVTSARFPSWVTFDDNEV
SCPLPPVTSPLKPNTPPSASVIPDVPYNSMGSFKKRDRPKSTLMNFSKVQKLDISSLNRT
PSVTEASPWRATNPFLNETLQDVQPSPINPFSAFFEEQERRSQNSSISSTTGKSQRDSLI
VIYQDAISFDDSSKTQSHSDAVEKLKQLQIDDPDHFGSATLPDDDPVAWIELDAHPPGSA
RSQPRDGWPMMLRIPEKKNIMSSRHWGPIFVKLTDTGYLQLYYEQGLEKPFREFKLEICH
EISEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHTAEREQVIKLGTTNYDDFLS
FIHAVQDRLMDLPVLSMDLSTVGLNYLEEEITVDVRDEFSGIVSKGDNQILQHHVLTRIH
ILSFLSGLAECRLGLNDILVKGNEIVLRQDIMPTTTTKWIKLHECRFHGCVDEDVFHNSR
VILFNPLDACRFELMRFRTVFAEKTLPFTLRTATSVNGAEVEVQSWLRMSTGFSANRDPL
TQVPCENVMIRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSTSVSGSEPVMRVTLG
TAKYEHAFNSIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTT
SASKASVRSISVEDKTDVRKWVNYSAHYSYQVALGSIWLMLPTPFVHPTTLPLLFLLAML
TMFAW

Sequence length

905

Interactions

View interactions

	Reactome
			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

STON2 (stonin 2)