Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	85439
Gene name Gene Name - the full gene name approved by the HGNC.	Stonin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	STON2
Synonyms (NCBI Gene) Gene synonyms aliases	STN2, STNB, STNB2
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q31.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. T

Show/Hide all(96)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019363	hsa-miR-148b-3p	Microarray	17612493
MIRT021263	hsa-miR-146a-5p	Microarray	18057241
MIRT715415	hsa-miR-5684	HITS-CLIP	19536157
MIRT715414	hsa-miR-4499	HITS-CLIP	19536157
MIRT715413	hsa-miR-4293	HITS-CLIP	19536157
MIRT715412	hsa-miR-596	HITS-CLIP	19536157
MIRT715411	hsa-miR-4494	HITS-CLIP	19536157
MIRT715410	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT715409	hsa-miR-1251-5p	HITS-CLIP	19536157
MIRT715408	hsa-miR-4329	HITS-CLIP	19536157
MIRT715407	hsa-miR-6776-5p	HITS-CLIP	19536157
MIRT715406	hsa-miR-6857-3p	HITS-CLIP	19536157
MIRT715405	hsa-miR-4252	HITS-CLIP	19536157
MIRT715404	hsa-miR-661	HITS-CLIP	19536157
MIRT715403	hsa-miR-542-3p	HITS-CLIP	19536157
MIRT715402	hsa-miR-1287-3p	HITS-CLIP	19536157
MIRT715401	hsa-miR-1262	HITS-CLIP	19536157
MIRT715400	hsa-miR-4701-3p	HITS-CLIP	19536157
MIRT715399	hsa-miR-6736-5p	HITS-CLIP	19536157
MIRT666048	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT666047	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT666046	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT666045	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT666044	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT666043	hsa-miR-103b	HITS-CLIP	23824327
MIRT653060	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT653059	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT666042	hsa-miR-4672	HITS-CLIP	23824327
MIRT653058	hsa-miR-376a-3p	HITS-CLIP	23824327
MIRT653057	hsa-miR-376b-3p	HITS-CLIP	23824327
MIRT653054	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT653061	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT653060	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT653059	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT653058	hsa-miR-376a-3p	HITS-CLIP	23824327
MIRT653057	hsa-miR-376b-3p	HITS-CLIP	23824327
MIRT653056	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT653055	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT653054	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT653053	hsa-miR-576-3p	HITS-CLIP	23824327
MIRT653052	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT653051	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT653050	hsa-miR-5695	HITS-CLIP	23824327
MIRT653049	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT653048	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT653047	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT653046	hsa-miR-192-3p	HITS-CLIP	23824327
MIRT653045	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT653044	hsa-miR-8061	HITS-CLIP	23824327
MIRT715415	hsa-miR-5684	HITS-CLIP	19536157
MIRT715414	hsa-miR-4499	HITS-CLIP	19536157
MIRT715413	hsa-miR-4293	HITS-CLIP	19536157
MIRT715412	hsa-miR-596	HITS-CLIP	19536157
MIRT715411	hsa-miR-4494	HITS-CLIP	19536157
MIRT715410	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT715409	hsa-miR-1251-5p	HITS-CLIP	19536157
MIRT715408	hsa-miR-4329	HITS-CLIP	19536157
MIRT715407	hsa-miR-6776-5p	HITS-CLIP	19536157
MIRT715406	hsa-miR-6857-3p	HITS-CLIP	19536157
MIRT715405	hsa-miR-4252	HITS-CLIP	19536157
MIRT715404	hsa-miR-661	HITS-CLIP	19536157
MIRT715403	hsa-miR-542-3p	HITS-CLIP	19536157
MIRT715402	hsa-miR-1287-3p	HITS-CLIP	19536157
MIRT715401	hsa-miR-1262	HITS-CLIP	19536157
MIRT715400	hsa-miR-4701-3p	HITS-CLIP	19536157
MIRT715399	hsa-miR-6736-5p	HITS-CLIP	19536157
MIRT666048	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT666047	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT666046	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT666045	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT666044	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT666043	hsa-miR-103b	HITS-CLIP	23824327
MIRT653060	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT653059	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT666042	hsa-miR-4672	HITS-CLIP	23824327
MIRT653058	hsa-miR-376a-3p	HITS-CLIP	23824327
MIRT653057	hsa-miR-376b-3p	HITS-CLIP	23824327
MIRT653054	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT653061	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT653060	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT653059	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT653058	hsa-miR-376a-3p	HITS-CLIP	23824327
MIRT653057	hsa-miR-376b-3p	HITS-CLIP	23824327
MIRT653056	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT653055	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT653054	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT653053	hsa-miR-576-3p	HITS-CLIP	23824327
MIRT653052	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT653051	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT653050	hsa-miR-5695	HITS-CLIP	23824327
MIRT653049	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT653048	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT653047	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT653046	hsa-miR-192-3p	HITS-CLIP	23824327
MIRT653045	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT653044	hsa-miR-8061	HITS-CLIP	23824327

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	11454741, 18200045, 19380743, 21102408
GO:0005730	Component	Nucleolus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0008021	Component	Synaptic vesicle	IBA	21873635
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IBA	21873635
GO:0030100	Process	Regulation of endocytosis	IBA	21873635
GO:0030100	Process	Regulation of endocytosis	ISS	14726597
GO:0030136	Component	Clathrin-coated vesicle	IBA	21873635
GO:0031410	Component	Cytoplasmic vesicle	IBA	21873635
GO:0035615	Function	Clathrin adaptor activity	IBA	21873635
GO:0043005	Component	Neuron projection	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA	21873635
GO:0048488	Process	Synaptic vesicle endocytosis	IBA	21873635
GO:0048488	Process	Synaptic vesicle endocytosis	IGI	21102408
GO:0061024	Process	Membrane organization	TAS

MIM	HGNC	e!Ensembl
608467	30652	ENSG00000140022

Protein

UniProt ID

Q8WXE9

Protein name

Stonin-2 (Stoned B)

Protein function

Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.

PDB

2JXC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12016	Stonin2_N	1 → 340	Stonin 2	Family
PF00928	Adap_comp_sub	557 → 874	Adaptor complexes medium subunit family	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11381094}.

Sequence

MTTLDHVIATHQSEWVSFNEEPPFPAHSQGGTEEHLPGLSSSPDQSESSSGENHVVDGGS
QDHSHSEQDDSSEKMGLISEAASPPGSPEQPPPDLASAISNWVQFEDDTPWASTSPPHQE
TAETALPLTMPCWTCPSFDSLGRCPLTSESSWTTHSEDTSSPSFGCSYTDLQLINAEEQT
SGQASGADSTDNSSSLQEDEEVEMEAISWQASSPAMNGHPAPPVTSARFPSWVTFDDNEV
SCPLPPVTSPLKPNTPPSASVIPDVPYNSMGSFKKRDRPKSTLMNFSKVQKLDISSLNRT
PSVTEASPWRATNPFLNETLQDVQPSPINPFSAFFEEQERRSQNSSISSTTGKSQRDSLI
VIYQDAISFDDSSKTQSHSDAVEKLKQLQIDDPDHFGSATLPDDDPVAWIELDAHPPGSA
RSQPRDGWPMMLRIPEKKNIMSSRHWGPIFVKLTDTGYLQLYYEQGLEKPFREFKLEICH
EISEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHTAEREQVIKLGTTNYDDFLS
FIHAVQDRLMDLPVLSMDLSTVGLNYLEEEITVDVRDEFSGIVSKGDNQILQHHVLTRIH
ILSFLSGLAECRLGLNDILVKGNEIVLRQDIMPTTTTKWIKLHECRFHGCVDEDVFHNSR
VILFNPLDACRFELMRFRTVFAEKTLPFTLRTATSVNGAEVEVQSWLRMSTGFSANRDPL
TQVPCENVMIRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSTSVSGSEPVMRVTLG
TAKYEHAFNSIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTT
SASKASVRSISVEDKTDVRKWVNYSAHYSYQVALGSIWLMLPTPFVHPTTLPLLFLLAML
TMFAW

Sequence length

905

Interactions

View interactions

	Reactome
			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Schizophrenia	Schizophrenia, SCHIZOPHRENIA 11	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	21407139, 23785397

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining
Ascites	Associate	28758939
Carcinoma Ovarian Epithelial	Associate	28758939
Neoplasm Invasiveness	Associate	28758939
Neoplasm Metastasis	Associate	28758939
Neoplasms	Associate	28758939
Ovarian Neoplasms	Associate	28758939
Schizophrenia	Associate	23785397

STON2 (stonin 2)