Gene Gene information from NCBI Gene database.
Entrez ID 8543
Gene name LIM domain only 4
Gene symbol LMO4
Synonyms (NCBI Gene)
-
Chromosome 1
Chromosome location 1p22.3
Summary This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The encoded protein may play a role as a transcriptional regulator or as an oncogene. [provided by RefSeq, Aug 2008]
miRNA miRNA information provided by mirtarbase database.
329
miRTarBase ID miRNA Experiments Reference
MIRT734687 hsa-miR-409-3p Luciferase reporter assay 33139574
MIRT1111915 hsa-miR-1197 CLIP-seq
MIRT1111916 hsa-miR-1273e CLIP-seq
MIRT1111917 hsa-miR-1298 CLIP-seq
MIRT1111918 hsa-miR-214 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
SP1 Unknown 23291272
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0001843 Process Neural tube closure IEA
GO:0001843 Process Neural tube closure ISS
GO:0003281 Process Ventricular septum development IEA
GO:0003712 Function Transcription coregulator activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603129 6644 ENSG00000143013
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61968
Protein name LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4)
Protein function Transcription cofactor. Plays a role in establishing motor neuron identity, in concert with MNX1, acting, at least in part, to disrupt LDB1-LHX3 complexes thereby negatively modulating interneuron genes in motor neurons. {ECO:0000250|UniProtKB:P
PDB 9F5B
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00412 LIM 23 81 LIM domain Domain
PF00412 LIM 87 143 LIM domain Domain
Sequence
Sequence length 165
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANKYLOSING SPONDYLITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Breast Neoplasms Stimulate 11751867
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 19099607, 20814902, 21909792, 27354352, 31215771
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 19099607
★☆☆☆☆
Found in Text Mining only
Carcinoma Associate 20814902
★☆☆☆☆
Found in Text Mining only
Carcinoma Pancreatic Ductal Associate 18231110
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Associate 12771919, 33906487
★☆☆☆☆
Found in Text Mining only
Diabetic Retinopathy Stimulate 34725544
★☆☆☆☆
Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome Associate 19099607
★☆☆☆☆
Found in Text Mining only
Inflammation Associate 34725544
★☆☆☆☆
Found in Text Mining only
Macular dystrophy retinal 1 North Carolina type Associate 34725544
★☆☆☆☆
Found in Text Mining only