Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	85415
Gene name Gene Name - the full gene name approved by the HGNC.	Rhophilin Rho GTPase binding protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RHPN2
Synonyms (NCBI Gene) Gene synonyms aliases	P76RBE, RHOBP
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.11
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by R

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miRTarBase ID	miRNA	Experiments	Reference
MIRT028291	hsa-miR-32-5p	Sequencing	20371350
MIRT048413	hsa-miR-100-5p	CLASH	23622248
MIRT736300	hsa-miR-146b-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	33877886
MIRT736301	hsa-miR-146a-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	33877886
MIRT1306283	hsa-let-7a	CLIP-seq
MIRT1306284	hsa-let-7b	CLIP-seq
MIRT1306285	hsa-let-7c	CLIP-seq
MIRT1306286	hsa-let-7d	CLIP-seq
MIRT1306287	hsa-let-7e	CLIP-seq
MIRT1306288	hsa-let-7f	CLIP-seq
MIRT1306289	hsa-let-7g	CLIP-seq
MIRT1306290	hsa-let-7i	CLIP-seq
MIRT1306291	hsa-miR-1228	CLIP-seq
MIRT1306292	hsa-miR-1273g	CLIP-seq
MIRT1306293	hsa-miR-1291	CLIP-seq
MIRT1306294	hsa-miR-1293	CLIP-seq
MIRT1306295	hsa-miR-1304	CLIP-seq
MIRT1306296	hsa-miR-15a	CLIP-seq
MIRT1306297	hsa-miR-15b	CLIP-seq
MIRT1306298	hsa-miR-16	CLIP-seq
MIRT1306299	hsa-miR-183	CLIP-seq
MIRT1306300	hsa-miR-195	CLIP-seq
MIRT1306301	hsa-miR-202	CLIP-seq
MIRT1306302	hsa-miR-2114	CLIP-seq
MIRT1306303	hsa-miR-2115	CLIP-seq
MIRT1306304	hsa-miR-24	CLIP-seq
MIRT1306305	hsa-miR-25	CLIP-seq
MIRT1306306	hsa-miR-28-5p	CLIP-seq
MIRT1306307	hsa-miR-2861	CLIP-seq
MIRT1306308	hsa-miR-3065-3p	CLIP-seq
MIRT1306309	hsa-miR-3117-5p	CLIP-seq
MIRT1306310	hsa-miR-3121-3p	CLIP-seq
MIRT1306311	hsa-miR-3122	CLIP-seq
MIRT1306312	hsa-miR-3127-5p	CLIP-seq
MIRT1306313	hsa-miR-3139	CLIP-seq
MIRT1306314	hsa-miR-3140-5p	CLIP-seq
MIRT1306315	hsa-miR-3145-3p	CLIP-seq
MIRT1306316	hsa-miR-3157-5p	CLIP-seq
MIRT1306317	hsa-miR-3160-3p	CLIP-seq
MIRT1306318	hsa-miR-3165	CLIP-seq
MIRT1306319	hsa-miR-3167	CLIP-seq
MIRT1306320	hsa-miR-32	CLIP-seq
MIRT1306321	hsa-miR-328	CLIP-seq
MIRT1306322	hsa-miR-3591-5p	CLIP-seq
MIRT1306323	hsa-miR-3606	CLIP-seq
MIRT1306324	hsa-miR-363	CLIP-seq
MIRT1306325	hsa-miR-3658	CLIP-seq
MIRT1306326	hsa-miR-367	CLIP-seq
MIRT1306327	hsa-miR-3671	CLIP-seq
MIRT1306328	hsa-miR-3689a-3p	CLIP-seq
MIRT1306329	hsa-miR-3689c	CLIP-seq
MIRT1306330	hsa-miR-380	CLIP-seq
MIRT1306331	hsa-miR-3913-5p	CLIP-seq
MIRT1306332	hsa-miR-3918	CLIP-seq
MIRT1306333	hsa-miR-3924	CLIP-seq
MIRT1306334	hsa-miR-3929	CLIP-seq
MIRT1306335	hsa-miR-3977	CLIP-seq
MIRT1306336	hsa-miR-421	CLIP-seq
MIRT1306337	hsa-miR-424	CLIP-seq
MIRT1306338	hsa-miR-4284	CLIP-seq
MIRT1306339	hsa-miR-4318	CLIP-seq
MIRT1306340	hsa-miR-4328	CLIP-seq
MIRT1306341	hsa-miR-4419b	CLIP-seq
MIRT1306342	hsa-miR-4458	CLIP-seq
MIRT1306343	hsa-miR-4477b	CLIP-seq
MIRT1306344	hsa-miR-4478	CLIP-seq
MIRT1306345	hsa-miR-4483	CLIP-seq
MIRT1306346	hsa-miR-4487	CLIP-seq
MIRT1306347	hsa-miR-4495	CLIP-seq
MIRT1306348	hsa-miR-4500	CLIP-seq
MIRT1306349	hsa-miR-4512	CLIP-seq
MIRT1306350	hsa-miR-4645-5p	CLIP-seq
MIRT1306351	hsa-miR-4662a-3p	CLIP-seq
MIRT1306352	hsa-miR-4673	CLIP-seq
MIRT1306353	hsa-miR-4691-3p	CLIP-seq
MIRT1306354	hsa-miR-4693-5p	CLIP-seq
MIRT1306355	hsa-miR-4709-5p	CLIP-seq
MIRT1306356	hsa-miR-4728-5p	CLIP-seq
MIRT1306357	hsa-miR-4729	CLIP-seq
MIRT1306358	hsa-miR-4735-5p	CLIP-seq
MIRT1306359	hsa-miR-4753-5p	CLIP-seq
MIRT1306360	hsa-miR-4755-3p	CLIP-seq
MIRT1306361	hsa-miR-485-5p	CLIP-seq
MIRT1306362	hsa-miR-497	CLIP-seq
MIRT1306363	hsa-miR-505	CLIP-seq
MIRT1306364	hsa-miR-516a-3p	CLIP-seq
MIRT1306365	hsa-miR-548c-3p	CLIP-seq
MIRT1306366	hsa-miR-558	CLIP-seq
MIRT1306367	hsa-miR-579	CLIP-seq
MIRT1306368	hsa-miR-587	CLIP-seq
MIRT1306369	hsa-miR-592	CLIP-seq
MIRT1306370	hsa-miR-597	CLIP-seq
MIRT1306371	hsa-miR-708	CLIP-seq
MIRT1306372	hsa-miR-766	CLIP-seq
MIRT1306373	hsa-miR-876-3p	CLIP-seq
MIRT1306374	hsa-miR-876-5p	CLIP-seq
MIRT1306375	hsa-miR-885-5p	CLIP-seq
MIRT1306376	hsa-miR-892a	CLIP-seq
MIRT1306377	hsa-miR-921	CLIP-seq
MIRT1306378	hsa-miR-922	CLIP-seq
MIRT1306379	hsa-miR-92a	CLIP-seq
MIRT1306380	hsa-miR-92b	CLIP-seq
MIRT1306381	hsa-miR-98	CLIP-seq
MIRT1306291	hsa-miR-1228	CLIP-seq
MIRT2090740	hsa-miR-1285	CLIP-seq
MIRT1306293	hsa-miR-1291	CLIP-seq
MIRT1306295	hsa-miR-1304	CLIP-seq
MIRT2090741	hsa-miR-154	CLIP-seq
MIRT1306296	hsa-miR-15a	CLIP-seq
MIRT1306297	hsa-miR-15b	CLIP-seq
MIRT1306298	hsa-miR-16	CLIP-seq
MIRT2090742	hsa-miR-1915	CLIP-seq
MIRT1306300	hsa-miR-195	CLIP-seq
MIRT1306306	hsa-miR-28-5p	CLIP-seq
MIRT1306309	hsa-miR-3117-5p	CLIP-seq
MIRT1306311	hsa-miR-3122	CLIP-seq
MIRT1306313	hsa-miR-3139	CLIP-seq
MIRT1306317	hsa-miR-3160-3p	CLIP-seq
MIRT1306319	hsa-miR-3167	CLIP-seq
MIRT2090743	hsa-miR-3180	CLIP-seq
MIRT2090744	hsa-miR-3180-3p	CLIP-seq
MIRT2090745	hsa-miR-3196	CLIP-seq
MIRT1306321	hsa-miR-328	CLIP-seq
MIRT2090746	hsa-miR-3616-3p	CLIP-seq
MIRT1306328	hsa-miR-3689a-3p	CLIP-seq
MIRT1306329	hsa-miR-3689c	CLIP-seq
MIRT2090747	hsa-miR-369-3p	CLIP-seq
MIRT2090748	hsa-miR-374a	CLIP-seq
MIRT2090749	hsa-miR-374b	CLIP-seq
MIRT2090750	hsa-miR-376a	CLIP-seq
MIRT2090751	hsa-miR-376b	CLIP-seq
MIRT1306331	hsa-miR-3913-5p	CLIP-seq
MIRT1306334	hsa-miR-3929	CLIP-seq
MIRT1306337	hsa-miR-424	CLIP-seq
MIRT2090752	hsa-miR-4307	CLIP-seq
MIRT1306341	hsa-miR-4419b	CLIP-seq
MIRT2090753	hsa-miR-4427	CLIP-seq
MIRT2090754	hsa-miR-4452	CLIP-seq
MIRT1306343	hsa-miR-4477b	CLIP-seq
MIRT1306344	hsa-miR-4478	CLIP-seq
MIRT2090755	hsa-miR-4488	CLIP-seq
MIRT2090756	hsa-miR-4680-3p	CLIP-seq
MIRT2090757	hsa-miR-4697-5p	CLIP-seq
MIRT2090758	hsa-miR-4726-3p	CLIP-seq
MIRT1306356	hsa-miR-4728-5p	CLIP-seq
MIRT1306358	hsa-miR-4735-5p	CLIP-seq
MIRT1306361	hsa-miR-485-5p	CLIP-seq
MIRT1306362	hsa-miR-497	CLIP-seq
MIRT1306365	hsa-miR-548c-3p	CLIP-seq
MIRT1306367	hsa-miR-579	CLIP-seq
MIRT2090759	hsa-miR-582-5p	CLIP-seq
MIRT2090760	hsa-miR-633	CLIP-seq
MIRT2090761	hsa-miR-640	CLIP-seq
MIRT2090762	hsa-miR-658	CLIP-seq
MIRT2090763	hsa-miR-665	CLIP-seq
MIRT1306371	hsa-miR-708	CLIP-seq
MIRT1306372	hsa-miR-766	CLIP-seq
MIRT1306374	hsa-miR-876-5p	CLIP-seq
MIRT1306378	hsa-miR-922	CLIP-seq
MIRT1306283	hsa-let-7a	CLIP-seq
MIRT1306284	hsa-let-7b	CLIP-seq
MIRT1306285	hsa-let-7c	CLIP-seq
MIRT1306286	hsa-let-7d	CLIP-seq
MIRT1306287	hsa-let-7e	CLIP-seq
MIRT1306288	hsa-let-7f	CLIP-seq
MIRT1306289	hsa-let-7g	CLIP-seq
MIRT1306290	hsa-let-7i	CLIP-seq
MIRT1306291	hsa-miR-1228	CLIP-seq
MIRT1306292	hsa-miR-1273g	CLIP-seq
MIRT2090740	hsa-miR-1285	CLIP-seq
MIRT2315409	hsa-miR-1287	CLIP-seq
MIRT1306294	hsa-miR-1293	CLIP-seq
MIRT2315410	hsa-miR-1302	CLIP-seq
MIRT1306295	hsa-miR-1304	CLIP-seq
MIRT2315411	hsa-miR-141	CLIP-seq
MIRT2090741	hsa-miR-154	CLIP-seq
MIRT1306296	hsa-miR-15a	CLIP-seq
MIRT1306297	hsa-miR-15b	CLIP-seq
MIRT1306298	hsa-miR-16	CLIP-seq
MIRT1306299	hsa-miR-183	CLIP-seq
MIRT2315412	hsa-miR-1910	CLIP-seq
MIRT2090742	hsa-miR-1915	CLIP-seq
MIRT1306300	hsa-miR-195	CLIP-seq
MIRT2315413	hsa-miR-200a	CLIP-seq
MIRT1306301	hsa-miR-202	CLIP-seq
MIRT1306302	hsa-miR-2114	CLIP-seq
MIRT1306303	hsa-miR-2115	CLIP-seq
MIRT1306304	hsa-miR-24	CLIP-seq
MIRT1306305	hsa-miR-25	CLIP-seq
MIRT1306308	hsa-miR-3065-3p	CLIP-seq
MIRT1306309	hsa-miR-3117-5p	CLIP-seq
MIRT1306310	hsa-miR-3121-3p	CLIP-seq
MIRT1306311	hsa-miR-3122	CLIP-seq
MIRT2315414	hsa-miR-3135b	CLIP-seq
MIRT1306314	hsa-miR-3140-5p	CLIP-seq
MIRT1306315	hsa-miR-3145-3p	CLIP-seq
MIRT1306316	hsa-miR-3157-5p	CLIP-seq
MIRT1306317	hsa-miR-3160-3p	CLIP-seq
MIRT1306318	hsa-miR-3165	CLIP-seq
MIRT1306319	hsa-miR-3167	CLIP-seq
MIRT2090743	hsa-miR-3180	CLIP-seq
MIRT2090744	hsa-miR-3180-3p	CLIP-seq
MIRT2090745	hsa-miR-3196	CLIP-seq
MIRT1306320	hsa-miR-32	CLIP-seq
MIRT2315415	hsa-miR-337-3p	CLIP-seq
MIRT1306322	hsa-miR-3591-5p	CLIP-seq
MIRT1306323	hsa-miR-3606	CLIP-seq
MIRT2315416	hsa-miR-3613-3p	CLIP-seq
MIRT2090746	hsa-miR-3616-3p	CLIP-seq
MIRT1306324	hsa-miR-363	CLIP-seq
MIRT1306325	hsa-miR-3658	CLIP-seq
MIRT2315417	hsa-miR-3661	CLIP-seq
MIRT1306326	hsa-miR-367	CLIP-seq
MIRT1306327	hsa-miR-3671	CLIP-seq
MIRT1306328	hsa-miR-3689a-3p	CLIP-seq
MIRT1306329	hsa-miR-3689c	CLIP-seq
MIRT2090747	hsa-miR-369-3p	CLIP-seq
MIRT2315418	hsa-miR-371-5p	CLIP-seq
MIRT2315419	hsa-miR-371b-5p	CLIP-seq
MIRT2090748	hsa-miR-374a	CLIP-seq
MIRT2090749	hsa-miR-374b	CLIP-seq
MIRT2090750	hsa-miR-376a	CLIP-seq
MIRT2090751	hsa-miR-376b	CLIP-seq
MIRT2315420	hsa-miR-3909	CLIP-seq
MIRT1306331	hsa-miR-3913-5p	CLIP-seq
MIRT2315421	hsa-miR-3926	CLIP-seq
MIRT1306334	hsa-miR-3929	CLIP-seq
MIRT1306335	hsa-miR-3977	CLIP-seq
MIRT1306336	hsa-miR-421	CLIP-seq
MIRT1306337	hsa-miR-424	CLIP-seq
MIRT2315422	hsa-miR-4252	CLIP-seq
MIRT2315423	hsa-miR-4256	CLIP-seq
MIRT1306338	hsa-miR-4284	CLIP-seq
MIRT2315424	hsa-miR-4298	CLIP-seq
MIRT2315425	hsa-miR-4325	CLIP-seq
MIRT1306340	hsa-miR-4328	CLIP-seq
MIRT1306341	hsa-miR-4419b	CLIP-seq
MIRT2090754	hsa-miR-4452	CLIP-seq
MIRT1306342	hsa-miR-4458	CLIP-seq
MIRT2315426	hsa-miR-4476	CLIP-seq
MIRT1306343	hsa-miR-4477b	CLIP-seq
MIRT1306344	hsa-miR-4478	CLIP-seq
MIRT1306345	hsa-miR-4483	CLIP-seq
MIRT1306346	hsa-miR-4487	CLIP-seq
MIRT2090755	hsa-miR-4488	CLIP-seq
MIRT1306348	hsa-miR-4500	CLIP-seq
MIRT1306350	hsa-miR-4645-5p	CLIP-seq
MIRT1306351	hsa-miR-4662a-3p	CLIP-seq
MIRT1306352	hsa-miR-4673	CLIP-seq
MIRT1306353	hsa-miR-4691-3p	CLIP-seq
MIRT2090757	hsa-miR-4697-5p	CLIP-seq
MIRT1306355	hsa-miR-4709-5p	CLIP-seq
MIRT2090758	hsa-miR-4726-3p	CLIP-seq
MIRT1306356	hsa-miR-4728-5p	CLIP-seq
MIRT1306357	hsa-miR-4729	CLIP-seq
MIRT1306358	hsa-miR-4735-5p	CLIP-seq
MIRT1306359	hsa-miR-4753-5p	CLIP-seq
MIRT1306360	hsa-miR-4755-3p	CLIP-seq
MIRT2315427	hsa-miR-4760-5p	CLIP-seq
MIRT1306361	hsa-miR-485-5p	CLIP-seq
MIRT1306362	hsa-miR-497	CLIP-seq
MIRT1306363	hsa-miR-505	CLIP-seq
MIRT1306364	hsa-miR-516a-3p	CLIP-seq
MIRT1306365	hsa-miR-548c-3p	CLIP-seq
MIRT2315428	hsa-miR-548s	CLIP-seq
MIRT1306366	hsa-miR-558	CLIP-seq
MIRT2315429	hsa-miR-569	CLIP-seq
MIRT1306367	hsa-miR-579	CLIP-seq
MIRT2090759	hsa-miR-582-5p	CLIP-seq
MIRT1306368	hsa-miR-587	CLIP-seq
MIRT2315430	hsa-miR-631	CLIP-seq
MIRT2090760	hsa-miR-633	CLIP-seq
MIRT2090761	hsa-miR-640	CLIP-seq
MIRT2090762	hsa-miR-658	CLIP-seq
MIRT2090763	hsa-miR-665	CLIP-seq
MIRT1306372	hsa-miR-766	CLIP-seq
MIRT2315431	hsa-miR-802	CLIP-seq
MIRT1306373	hsa-miR-876-3p	CLIP-seq
MIRT1306374	hsa-miR-876-5p	CLIP-seq
MIRT1306375	hsa-miR-885-5p	CLIP-seq
MIRT1306376	hsa-miR-892a	CLIP-seq
MIRT1306377	hsa-miR-921	CLIP-seq
MIRT1306379	hsa-miR-92a	CLIP-seq
MIRT1306380	hsa-miR-92b	CLIP-seq
MIRT1306381	hsa-miR-98	CLIP-seq
MIRT1306291	hsa-miR-1228	CLIP-seq
MIRT1306294	hsa-miR-1293	CLIP-seq
MIRT1306304	hsa-miR-24	CLIP-seq
MIRT1306309	hsa-miR-3117-5p	CLIP-seq
MIRT1306311	hsa-miR-3122	CLIP-seq
MIRT1306322	hsa-miR-3591-5p	CLIP-seq
MIRT1306323	hsa-miR-3606	CLIP-seq
MIRT1306328	hsa-miR-3689a-3p	CLIP-seq
MIRT1306329	hsa-miR-3689c	CLIP-seq
MIRT1306331	hsa-miR-3913-5p	CLIP-seq
MIRT1306334	hsa-miR-3929	CLIP-seq
MIRT1306338	hsa-miR-4284	CLIP-seq
MIRT1306340	hsa-miR-4328	CLIP-seq
MIRT1306341	hsa-miR-4419b	CLIP-seq
MIRT1306344	hsa-miR-4478	CLIP-seq
MIRT1306345	hsa-miR-4483	CLIP-seq
MIRT1306356	hsa-miR-4728-5p	CLIP-seq
MIRT1306358	hsa-miR-4735-5p	CLIP-seq
MIRT1306361	hsa-miR-485-5p	CLIP-seq
MIRT1306377	hsa-miR-921	CLIP-seq
MIRT1306294	hsa-miR-1293	CLIP-seq
MIRT1306295	hsa-miR-1304	CLIP-seq
MIRT1306311	hsa-miR-3122	CLIP-seq
MIRT1306318	hsa-miR-3165	CLIP-seq
MIRT1306328	hsa-miR-3689a-3p	CLIP-seq
MIRT1306329	hsa-miR-3689c	CLIP-seq
MIRT1306331	hsa-miR-3913-5p	CLIP-seq
MIRT1306334	hsa-miR-3929	CLIP-seq
MIRT1306341	hsa-miR-4419b	CLIP-seq
MIRT1306344	hsa-miR-4478	CLIP-seq
MIRT1306345	hsa-miR-4483	CLIP-seq
MIRT1306356	hsa-miR-4728-5p	CLIP-seq
MIRT1306361	hsa-miR-485-5p	CLIP-seq
MIRT1306367	hsa-miR-579	CLIP-seq
MIRT1306294	hsa-miR-1293	CLIP-seq
MIRT1306295	hsa-miR-1304	CLIP-seq
MIRT1306311	hsa-miR-3122	CLIP-seq
MIRT1306318	hsa-miR-3165	CLIP-seq
MIRT2611692	hsa-miR-3617	CLIP-seq
MIRT1306328	hsa-miR-3689a-3p	CLIP-seq
MIRT1306329	hsa-miR-3689c	CLIP-seq
MIRT1306331	hsa-miR-3913-5p	CLIP-seq
MIRT1306334	hsa-miR-3929	CLIP-seq
MIRT1306341	hsa-miR-4419b	CLIP-seq
MIRT1306344	hsa-miR-4478	CLIP-seq
MIRT1306345	hsa-miR-4483	CLIP-seq
MIRT1306356	hsa-miR-4728-5p	CLIP-seq
MIRT1306361	hsa-miR-485-5p	CLIP-seq
MIRT1306367	hsa-miR-579	CLIP-seq
MIRT2611693	hsa-miR-641	CLIP-seq
MIRT1306294	hsa-miR-1293	CLIP-seq
MIRT1306295	hsa-miR-1304	CLIP-seq
MIRT1306311	hsa-miR-3122	CLIP-seq
MIRT1306318	hsa-miR-3165	CLIP-seq
MIRT1306328	hsa-miR-3689a-3p	CLIP-seq
MIRT1306329	hsa-miR-3689c	CLIP-seq
MIRT1306331	hsa-miR-3913-5p	CLIP-seq
MIRT1306334	hsa-miR-3929	CLIP-seq
MIRT1306341	hsa-miR-4419b	CLIP-seq
MIRT1306344	hsa-miR-4478	CLIP-seq
MIRT1306345	hsa-miR-4483	CLIP-seq
MIRT1306356	hsa-miR-4728-5p	CLIP-seq
MIRT1306361	hsa-miR-485-5p	CLIP-seq
MIRT1306367	hsa-miR-579	CLIP-seq

Show/Hide all(8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003094	Process	Glomerular filtration	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	25071083
GO:0007165	Process	Signal transduction	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051497	Process	Negative regulation of stress fiber assembly	IBA
GO:0051497	Process	Negative regulation of stress fiber assembly	IDA	25071083

MIM	HGNC	e!Ensembl
617932	19974	ENSG00000131941

Protein

UniProt ID

Q8IUC4

Protein name

Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE)

Protein function

Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.

PDB

2VSV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02185	HR1	39 → 102	Hr1 repeat	Family
PF03097	BRO1	112 → 516	BRO1-like domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas. Expressed at lower level in brain, spinal cord, kidney, placenta and liver. {ECO:0000269|PubMed:12221077, ECO:0000269|PubMed:12473120}.

Sequence

MTDALLPAAPQPLEKENDGYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENL
LKVATNSKVREQVRLELSFVNSDLQMLKEELEGLNISVGVYQNTEEAFTIPLIPLGLKET
KDVDFAVVLKDFILEHYSEDGYLYEDEIADLMDLRQACRTPSRDEAGVELLMTYFIQLGF
VESRFFPPTRQMGLLFTWYDSLTGVPVSQQNLLLEKASVLFNTGALYTQIGTRCDRQTQA
GLESAIDAFQRAAGVLNYLKDTFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKISLPGI
RNEFFMLVKVAQEAAKVGEVYQQLHAAMSQAPVKENIPYSWASLACVKAHHYAALAHYFT
AILLIDHQVKPGTDLDHQEKCLSQLYDHMPEGLTPLATLKNDQQRRQLGKSHLRRAMAHH
EESVREASLCKKLRSIEVLQKVLCAAQERSRLTYAQHQEEDDLLNLIDAPSVVAKTEQEV
DIILPQFSKLTVTDFFQKLGPLSVFSANKRWTPPRSIRFTAEEGDLGFTLRGNAPVQVHF
LDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFGEDEIEMKVVSLLDSTSSM
HNKSATYSVGMQKTYSMICLAIDDDDKTDKTKKISKKLSFLSWGTNKNRQKSASTLCLPS
VGAARPQVKKKLPSPFSLLNSDSSWY

Sequence length

686

Interactions

View interactions

	Reactome
			RHO GTPases Activate Rhotekin and Rhophilins

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Colorectal Cancer	Colorectal cancer	N/A	N/A	GWAS
Dementia	Dementia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Carcinoid Tumor	Associate	29422640
Cleft Palate	Associate	31262291
Colorectal Neoplasms	Associate	20501757, 20648012, 21071539, 21119214, 21314996, 21531788, 22367214, 22999960, 24753543, 24854447, 25799222
Hereditary Breast and Ovarian Cancer Syndrome	Associate	35893033
Stomach Neoplasms	Associate	24854447

RHPN2 (rhophilin Rho GTPase binding protein 2)