SLC22A16 (solute carrier family 22 member 16)

Gene

• Entrez ID: 85413
• Gene name: Solute carrier family 22 member 16
• Gene symbol: SLC22A16
• Synonyms (NCBI Gene): CT2, FLIPT2, HEL-S-18, OAT6, OCT6, OKB1, dJ261K5.1
• Chromosome: 6
• Chromosome location: 6q21|6q21-q22.1
• Summary: This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019055	hsa-miR-335-5p	Microarray	18185580

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005275	Function	Amine transmembrane transporter activity	IDA	15963465
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IC	15963465
GO:0005886	Component	Plasma membrane	IDA	12089149, 20037140
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007338	Process	Single fertilization	IMP	12089149
GO:0015101	Function	Organic cation transmembrane transporter activity	IBA
GO:0015101	Function	Organic cation transmembrane transporter activity	IDA	12089149, 15963465, 20037140
GO:0015226	Function	Carnitine transmembrane transporter activity	IDA	12089149, 20037140
GO:0015226	Function	Carnitine transmembrane transporter activity	TAS
GO:0015606	Function	Spermidine transmembrane transporter activity	IDA	20037140
GO:0015695	Process	Organic cation transport	IBA
GO:0015695	Process	Organic cation transport	IDA	15963465
GO:0015695	Process	Organic cation transport	IDA	12089149, 20037140
GO:0015837	Process	Amine transport	IEA
GO:0015879	Process	Carnitine transport	IDA	12089149
GO:0015879	Process	Carnitine transport	IDA	12089149
GO:0016020	Component	Membrane	IDA	12089149
GO:0016020	Component	Membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030317	Process	Flagellated sperm motility	IMP	12089149
GO:0046717	Process	Acid secretion	IDA	12089149
GO:0055085	Process	Transmembrane transport	IEA
GO:1902603	Process	Carnitine transmembrane transport	IDA	12089149, 20037140
GO:1903711	Process	Spermidine transmembrane transport	IDA	20037140

Other IDs

• MIM: 608276
• HGNC: 20302
• e!Ensembl: ENSG00000004809

Protein

• UniProt ID: Q86VW1
• Protein name: Solute carrier family 22 member 16 (Carnitine transporter 2) (CT2) (Fly-like putative transporter 2) (FLIPT2) (Flipt 2) (Organic cation transporter OKB1) (Organic cation/carnitine transporter 6)
• Protein function: Facilitative organic cation transporter that mediates the transport of carnitine as well as the polyamine spermidine (PubMed:12089149, PubMed:20037140). Mediates the partially Na(+)-dependent bidirectional transport of carnitine (PubMed:12089149
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00083	Sugar_tr	103 → 538	Sugar (and other) transporter	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in testis and epididymis (at protein level) (PubMed:12089149, PubMed:12384147, PubMed:15963465). Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly
• Sequence:

  MGSRHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQ
  VVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSK
  KEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLG
  RRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRT
  WASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGR
  YEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTL
  TVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAY
  SLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGS
  GSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAA
  KLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE

• Sequence length: 577

Pathways

Reactome:

Organic cation transport