Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	85360
Gene name	Synapse defective Rho GTPase activating protein 1
Gene symbol	SYDE1
Synonyms (NCBI Gene)	7h3SYD1
Chromosome	19
Chromosome location	19p13.12
Summary	The protein encoded by this gene is a Rho GTPase-activating protein highly expressed in placenta. The encoded protein is involved in cytoskeletal remodeling and trophoblast cell migration. Decreased expression of this gene has been associated with intraut

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miRTarBase ID	miRNA	Experiments
MIRT1405129	hsa-miR-1178	CLIP-seq
MIRT1405130	hsa-miR-128	CLIP-seq
MIRT1405131	hsa-miR-1321	CLIP-seq
MIRT1405132	hsa-miR-148a	CLIP-seq
MIRT1405133	hsa-miR-148b	CLIP-seq
MIRT1405134	hsa-miR-152	CLIP-seq
MIRT1405135	hsa-miR-15a	CLIP-seq
MIRT1405136	hsa-miR-15b	CLIP-seq
MIRT1405137	hsa-miR-16	CLIP-seq
MIRT1405138	hsa-miR-195	CLIP-seq
MIRT1405139	hsa-miR-197	CLIP-seq
MIRT1405140	hsa-miR-200b	CLIP-seq
MIRT1405141	hsa-miR-200c	CLIP-seq
MIRT1405142	hsa-miR-2110	CLIP-seq
MIRT1405143	hsa-miR-27a	CLIP-seq
MIRT1405144	hsa-miR-27b	CLIP-seq
MIRT1405145	hsa-miR-3127-5p	CLIP-seq
MIRT1405146	hsa-miR-3150a-3p	CLIP-seq
MIRT1405147	hsa-miR-3167	CLIP-seq
MIRT1405148	hsa-miR-330-3p	CLIP-seq
MIRT1405149	hsa-miR-424	CLIP-seq
MIRT1405150	hsa-miR-429	CLIP-seq
MIRT1405151	hsa-miR-4419a	CLIP-seq
MIRT1405152	hsa-miR-4450	CLIP-seq
MIRT1405153	hsa-miR-4510	CLIP-seq
MIRT1405154	hsa-miR-451b	CLIP-seq
MIRT1405155	hsa-miR-4728-5p	CLIP-seq
MIRT1405156	hsa-miR-4733-3p	CLIP-seq
MIRT1405157	hsa-miR-4739	CLIP-seq
MIRT1405158	hsa-miR-4756-5p	CLIP-seq
MIRT1405159	hsa-miR-4787-5p	CLIP-seq
MIRT1405160	hsa-miR-497	CLIP-seq
MIRT1405161	hsa-miR-582-3p	CLIP-seq
MIRT1405162	hsa-miR-592	CLIP-seq
MIRT1405163	hsa-miR-599	CLIP-seq
MIRT1405164	hsa-miR-659	CLIP-seq
MIRT1405165	hsa-miR-767-5p	CLIP-seq
MIRT1405166	hsa-miR-876-5p	CLIP-seq
MIRT2121540	hsa-miR-136	CLIP-seq
MIRT2121541	hsa-miR-31	CLIP-seq
MIRT1405145	hsa-miR-3127-5p	CLIP-seq
MIRT1405147	hsa-miR-3167	CLIP-seq
MIRT2121542	hsa-miR-3612	CLIP-seq
MIRT2121543	hsa-miR-3664-5p	CLIP-seq
MIRT2121544	hsa-miR-3978	CLIP-seq
MIRT1405151	hsa-miR-4419a	CLIP-seq
MIRT2121545	hsa-miR-4426	CLIP-seq
MIRT1405152	hsa-miR-4450	CLIP-seq
MIRT2121546	hsa-miR-4459	CLIP-seq
MIRT1405153	hsa-miR-4510	CLIP-seq
MIRT2121547	hsa-miR-4522	CLIP-seq
MIRT2121548	hsa-miR-4647	CLIP-seq
MIRT2121549	hsa-miR-4662b	CLIP-seq
MIRT2121550	hsa-miR-4667-3p	CLIP-seq
MIRT2121551	hsa-miR-4707-5p	CLIP-seq
MIRT2121552	hsa-miR-4753-5p	CLIP-seq
MIRT2121553	hsa-miR-4779	CLIP-seq
MIRT2121554	hsa-miR-628-5p	CLIP-seq
MIRT2121555	hsa-miR-650	CLIP-seq
MIRT1405166	hsa-miR-876-5p	CLIP-seq
MIRT2121540	hsa-miR-136	CLIP-seq
MIRT1405135	hsa-miR-15a	CLIP-seq
MIRT1405136	hsa-miR-15b	CLIP-seq
MIRT1405137	hsa-miR-16	CLIP-seq
MIRT1405138	hsa-miR-195	CLIP-seq
MIRT1405140	hsa-miR-200b	CLIP-seq
MIRT1405141	hsa-miR-200c	CLIP-seq
MIRT1405145	hsa-miR-3127-5p	CLIP-seq
MIRT1405148	hsa-miR-330-3p	CLIP-seq
MIRT2343595	hsa-miR-3664-3p	CLIP-seq
MIRT2121543	hsa-miR-3664-5p	CLIP-seq
MIRT2121544	hsa-miR-3978	CLIP-seq
MIRT1405149	hsa-miR-424	CLIP-seq
MIRT1405150	hsa-miR-429	CLIP-seq
MIRT2343596	hsa-miR-4293	CLIP-seq
MIRT2343597	hsa-miR-4313	CLIP-seq
MIRT2121545	hsa-miR-4426	CLIP-seq
MIRT1405154	hsa-miR-451b	CLIP-seq
MIRT2121547	hsa-miR-4522	CLIP-seq
MIRT2121548	hsa-miR-4647	CLIP-seq
MIRT2121549	hsa-miR-4662b	CLIP-seq
MIRT2121552	hsa-miR-4753-5p	CLIP-seq
MIRT1405160	hsa-miR-497	CLIP-seq
MIRT1405164	hsa-miR-659	CLIP-seq
MIRT2343598	hsa-miR-873	CLIP-seq
MIRT2343599	hsa-miR-885-3p	CLIP-seq
MIRT1405135	hsa-miR-15a	CLIP-seq
MIRT1405136	hsa-miR-15b	CLIP-seq
MIRT1405137	hsa-miR-16	CLIP-seq
MIRT1405138	hsa-miR-195	CLIP-seq
MIRT1405149	hsa-miR-424	CLIP-seq
MIRT1405154	hsa-miR-451b	CLIP-seq
MIRT1405160	hsa-miR-497	CLIP-seq
MIRT2343599	hsa-miR-885-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IDA	27917469
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	IMP	27917469
GO:0005096	Function	GTPase activator activity	ISS
GO:0007165	Process	Signal transduction	IEA
GO:0016477	Process	Cell migration	IBA
GO:0016477	Process	Cell migration	IDA	27917469
GO:0016477	Process	Cell migration	IMP	27917469
GO:0030036	Process	Actin cytoskeleton organization	IDA	27917469
GO:0030695	Function	GTPase regulator activity	IDA	27917469
GO:0030695	Function	GTPase regulator activity	IMP	27917469
GO:0046578	Process	Regulation of Ras protein signal transduction	IBA
GO:0051493	Process	Regulation of cytoskeleton organization	IMP	27917469
GO:0090630	Process	Activation of GTPase activity	ISS
GO:0097060	Component	Synaptic membrane	IBA
GO:1901165	Process	Positive regulation of trophoblast cell migration	IMP	27917469

MIM	HGNC	e!Ensembl
617377	25824	ENSG00000105137

Q6ZW31

Protein name

Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1)

Protein function

GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPas

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00620	RhoGAP	414 → 570	RhoGAP domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in trophoblast cells of placental villi. {ECO:0000269|PubMed:27917469}.

Sequence

MAEPLLRKTFSRLRGREKLPRKKSDAKERGHPAQRPEPSPPEPEPQAPEGSQAGAEGPSS
PEASRSPARGAYLQSLEPSSRRWVLGGAKPAEDTSLGPGVPGTGEPAGEIWYNPIPEEDP
RPPAPEPPGPQPGSAESEGLAPQGAAPASPPTKASRTKSPGPARRLSIKMKKLPELRRRL
SLRGPRAGRERERAAPAGSVISRYHLDSSVGGPGPAAGPGGTRSPRAGYLSDGDSPERPA
GPPSPTSFRPYEVGPAARAPPAALWGRLSLHLYGLGGLRPAPGATPRDLCCLLQVDGEAR
ARTGPLRGGPDFLRLDHTFHLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTVFRGC
QAQQLAVRLEPQGLLYAKLTLSEQQEAPATAEPRVFGLPLPLLVERERPPGQVPLIIQKC
VGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGILKDYLR
ELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVS
SFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLASAVDFKHHIEVLHYLLQSW
PDPRLPRQSPDVAPYLRPKRQPPLHLPLADPEVVTRPRGRGGPESPPSNRYAGDWSVCGR
DFLPCGRDFLSGPDYDHVTGSDSEDEDEEVGEPRVTGDFEDDFDAPFNPHLNLKDFDALI
LDLERELSKQINVCL

Sequence length

735

Interactions

View interactions

	Reactome
			Rho GTPase cycle

SYDE1 (synapse defective Rho GTPase activating protein 1)