CPZ (carboxypeptidase Z)

Gene
Gene SNPs miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8532
Gene name Gene Name - the full gene name approved by the HGNC.
Carboxypeptidase Z
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CPZ
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4p16.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of meta
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Gene ontology Other IDs Protein
Show/Hide all(2)
SNP ID Visualize variation Clinical significance Consequence
rs375633720 C>T Likely-pathogenic Coding sequence variant, missense variant
rs775707132 G>A,T Likely-pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Gene ontology Other IDs Protein
Show/Hide all(6)
miRTarBase ID miRNA Experiments Reference
MIRT035807 hsa-miR-1909-5p CLASH 23622248
MIRT907820 hsa-miR-1908 CLIP-seq
MIRT907821 hsa-miR-3656 CLIP-seq
MIRT907822 hsa-miR-4731-5p CLIP-seq
MIRT907823 hsa-miR-4793-5p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Gene ontology Other IDs Protein
Show/Hide all(16)
GO ID Ontology Definition Evidence Reference
GO:0004180 Function Carboxypeptidase activity IEA
GO:0004181 Function Metallocarboxypeptidase activity IBA
GO:0004181 Function Metallocarboxypeptidase activity IEA
GO:0004181 Function Metallocarboxypeptidase activity TAS 9099699
GO:0005576 Component Extracellular region IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Gene ontology Other IDs Protein
MIM HGNC e!Ensembl
603105 2333 ENSG00000109625
Protein
Gene SNPs miRNA Gene ontology Other IDs Protein
UniProt ID Q66K79
Protein name Carboxypeptidase Z (CPZ) (EC 3.4.17.-)
Protein function Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing. {ECO:0000269|PubMed:11766880, ECO:0000269|PubMed:12
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01392 Fz 43 → 154 Fz domain Domain
PF00246 Peptidase_M14 193 → 494 Zinc carboxypeptidase Domain
PF13620 CarboxypepD_reg 505 → 582 Domain
Tissue specificity TISSUE SPECIFICITY: In placenta, it is present within invasive trophoblasts and in the surrounding extracellular space. Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type. Present in normal pituitary gl
Sequence
Sequence length 652
Interactions View interactions
<