Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8527
Gene name Gene Name - the full gene name approved by the HGNC.
Diacylglycerol kinase delta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DGKD
Synonyms (NCBI Gene) Gene synonyms aliases
DGK-delta, DGKdelta, dgkd-2
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q37.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs147134923 G>A Conflicting-interpretations-of-pathogenicity Coding sequence variant, genic downstream transcript variant, downstream transcript variant, synonymous variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019754 hsa-miR-375 Microarray 20215506
MIRT044251 hsa-miR-106b-5p CLASH 23622248
MIRT037279 hsa-miR-877-5p CLASH 23622248
MIRT621054 hsa-miR-6515-3p HITS-CLIP 23824327
MIRT621053 hsa-miR-412-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003951 Function NAD+ kinase activity IEA
GO:0004143 Function Diacylglycerol kinase activity IBA 21873635
GO:0004143 Function Diacylglycerol kinase activity IDA 12200442, 17880279, 23949095
GO:0004143 Function Diacylglycerol kinase activity TAS 8626538, 12200442
GO:0005515 Function Protein binding IPI 17880279, 23414517
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601826 2851 ENSG00000077044
Protein
UniProt ID Q16760
Protein name Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta)
Protein function Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the si
PDB 1R79 , 3BQ7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00169 PH 54 146 PH domain Domain
PF00130 C1_1 164 216 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00130 C1_1 236 289 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00781 DAGK_cat 321 443 Diacylglycerol kinase catalytic domain Family
PF00609 DAGK_acc 763 920 Diacylglycerol kinase accessory domain Family
PF07647 SAM_2 1142 1206 SAM domain (Sterile alpha motif) Domain
Tissue specificity TISSUE SPECIFICITY: [Isoform 2]: Widely expressed. {ECO:0000269|PubMed:12200442}.; TISSUE SPECIFICITY: [Isoform 1]: Only detected in ovary, and to a lesser extent in spleen. {ECO:0000269|PubMed:12200442}.
Sequence
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGML
TKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVITP
CRKLILCADNRKEMEDWIAALKTVQN
REHFEPTQYSMDHFSGMHNWYACSHARPTYCNVC
REALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWT
TLASIGKDIIEDADGIAMPHQWLE
GNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLG
LCKVSVIPPTA
LNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPH
LGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGS
ACDDDTQLPQILEKLERASTKML
DRWSVMAYEAKLPRQASSSTVTEDFSEDSEVQQILFY
EDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCS
VLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLVASACPARP
QIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSESEEKMDHRVC
PPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPALNTKIL
YPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIGLDAKISLDF
NNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPLPSLQGIAV
LNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCR
TVKISILGDEGVPVQVDGEA
WVQPPGYIRIVHKNRAQTLTRDRAFESTLKSWEDKQKCEL
PRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAHAVNASSKSM
DRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQLGSALAEMD
RQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKNKEAHSSLGA
PVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTKVGHMKRILC
GIKELS
RSAPAVEA
Sequence length 1214
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycerolipid metabolism
Glycerophospholipid metabolism
Metabolic pathways
Phosphatidylinositol signaling system
Phospholipase D signaling pathway
Choline metabolism in cancer
  Effects of PIP2 hydrolysis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
30718926
Glaucoma Glaucoma, Open-Angle rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328
View all (29 more)
29891935
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Urolithiasis Urolithiasis GWAS
Obesity Obesity GWAS
Associations from Text Mining
Disease Name Relationship Type References
Diabetic Retinopathy Associate 23209562
Kidney Calculi Associate 40372791, 40759569
Neoplasms Associate 23184957
Obesity Associate 37107557
Parkinson Disease Associate 22406787
Prostatic Neoplasms Associate 22761715