Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
85236
Gene name Gene Name - the full gene name approved by the HGNC.
H2B clustered histone 12
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
H2BC12
Synonyms (NCBI Gene) Gene synonyms aliases
H2B/S, H2BFAiii, H2BFT, H2BK, HIST1H2BK
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p22.1
Summary Summary of gene provided in NCBI Entrez Gene.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000786 Component Nucleosome IEA
GO:0002227 Process Innate immune response in mucosa IDA 12860195
GO:0003674 Function Molecular_function ND
GO:0003677 Function DNA binding IBA 21873635
GO:0005515 Function Protein binding IPI 31759698
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
615045 13954 ENSG00000197903
Protein
UniProt ID O60814
Protein name Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1)
Protein function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair,
PDB 2CV5 , 6KE9 , 6L9H , 6LE9 , 6T79 , 6T7A , 6T7B , 6T7C , 6T7D , 6V92 , 6Y5D , 7BWD , 7DBP , 7JZV , 7PET , 7PEU , 7PEV , 7PEW , 7PEX , 7PEY , 7PEZ , 7PF0 , 7PF2 , 7PF3 , 7PF4 , 7PF5 , 7PF6 , 7PFA , 7PFC , 7PFD , 7PFE , 7PFF , 7PFT , 7PFU , 7PFV , 7PFW , 7PFX , 7V90 , 7V96 , 7V99 , 7V9C , 7V9J , 7V9K , 7V9S , 7VA4 , 7XCR , 7XCT , 7XD1 , 8GRQ , 8HQY , 8HR1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00125 Histone 2 102 Core histone H2A/H2B/H3/H4 Domain
Sequence
Sequence length 126
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Neutrophil extracellular trap formation
Alcoholism
Viral carcinogenesis
Systemic lupus erythematosus
  Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression
HCMV Early Events
HCMV Late Events
Amyloid fiber formation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
17659439
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
17659439
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
17659439