Gene Gene information from NCBI Gene database.
Entrez ID 8522
Gene name Growth arrest specific 7
Gene symbol GAS7
Synonyms (NCBI Gene)
-
Chromosome 17
Chromosome location 17p13.1
Summary Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary
miRNA miRNA information provided by mirtarbase database.
865
miRTarBase ID miRNA Experiments Reference
MIRT021949 hsa-miR-128-3p Microarray 17612493
MIRT526756 hsa-miR-6837-3p PAR-CLIP 22012620
MIRT526755 hsa-miR-3124-3p PAR-CLIP 22012620
MIRT526754 hsa-miR-337-3p PAR-CLIP 22012620
MIRT526753 hsa-miR-202-5p PAR-CLIP 22012620
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 27107012, 31515488, 32296183
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
GO:0005886 Component Plasma membrane IBA
GO:0005905 Component Clathrin-coated pit IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603127 4169 ENSG00000007237
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O60861
Protein name Growth arrest-specific protein 7 (GAS-7)
Protein function May play a role in promoting maturation and morphological differentiation of cerebellar neurons.
PDB 2LX7 , 2YSH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14604 SH3_9 8 58 Variant SH3 domain Domain
PF00397 WW 79 108 WW domain Domain
PF16623 WW_FCH_linker 109 201 Disordered
PF00611 FCH 219 291 Fes/CIP4, and EFC/F-BAR homology domain Family
Sequence
MSGARCRTLYPFSGERHGQGLRFAAGELITLLQVPDGGWWEGEKEDGLRGWFPASYVQLL
EKPGMVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPASPGS
HRSSLPPTVNGYHASGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVT
FPHPDTMPEQQLLKPTEWSYC
DYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEF
IRERIKIEEDYAKNLAKLSQNSLASQEEGSLGEAWAQVKKSLADEAEVHLK
FSAKLHSEV
EKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIK
LSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIR
QHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI
Sequence length 476
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
14
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs2240740, rs16958993 RCV005919624
RCV005925152
Gastric cancer Benign rs75455559, rs2240740 RCV005916747
RCV005919626
Lung cancer Benign rs75455559 RCV005916749
Malignant tumor of esophagus Benign rs75455559, rs16958993 RCV005916746
RCV005925153
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 25287138
Colorectal Neoplasms Associate 21298349, 24441198
Glaucoma Open Angle Associate 25414181, 25637523, 29261660, 35400990, 38240248
Leukemia Associate 10706619
Leukemia Myeloid Acute Associate 10706619, 31925702
Lung Neoplasms Associate 28475688
Melanoma Associate 26489459
Neoplasms Associate 15614045, 24441198, 25287138, 31925702
Neoplasms Inhibit 28475688, 28771526
Neoplasms Stimulate 36177918