Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	8520
Gene name	Histone acetyltransferase 1
Gene symbol	HAT1
Synonyms (NCBI Gene)	KAT1
Chromosome	2
Chromosome location	2q31.1
Summary	The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. H

194

Show/Hide all (194)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028253	hsa-miR-32-5p	Sequencing	20371350
MIRT498997	hsa-miR-3133	PAR-CLIP	20371350
MIRT498995	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT498994	hsa-miR-1243	PAR-CLIP	20371350
MIRT498993	hsa-miR-4463	PAR-CLIP	20371350
MIRT498992	hsa-miR-4494	PAR-CLIP	20371350
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	20371350
MIRT498990	hsa-miR-1261	PAR-CLIP	20371350
MIRT498997	hsa-miR-3133	PAR-CLIP	21572407
MIRT498995	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT498994	hsa-miR-1243	PAR-CLIP	21572407
MIRT498993	hsa-miR-4463	PAR-CLIP	21572407
MIRT498992	hsa-miR-4494	PAR-CLIP	21572407
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	21572407
MIRT498990	hsa-miR-1261	PAR-CLIP	21572407
MIRT498997	hsa-miR-3133	PAR-CLIP	22012620
MIRT498995	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT527666	hsa-miR-8485	PAR-CLIP	22012620
MIRT527665	hsa-miR-329-3p	PAR-CLIP	22012620
MIRT527664	hsa-miR-362-3p	PAR-CLIP	22012620
MIRT527663	hsa-miR-603	PAR-CLIP	22012620
MIRT498994	hsa-miR-1243	PAR-CLIP	22012620
MIRT498993	hsa-miR-4463	PAR-CLIP	22012620
MIRT498992	hsa-miR-4494	PAR-CLIP	22012620
MIRT527662	hsa-miR-5190	PAR-CLIP	22012620
MIRT523319	hsa-miR-542-3p	PAR-CLIP	22012620
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	22012620
MIRT527661	hsa-miR-3941	PAR-CLIP	22012620
MIRT449463	hsa-miR-4789-5p	PAR-CLIP	22012620
MIRT498990	hsa-miR-1261	PAR-CLIP	22012620
MIRT498997	hsa-miR-3133	PAR-CLIP	23446348
MIRT498995	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT498994	hsa-miR-1243	PAR-CLIP	23446348
MIRT498993	hsa-miR-4463	PAR-CLIP	23446348
MIRT498992	hsa-miR-4494	PAR-CLIP	23446348
MIRT523319	hsa-miR-542-3p	PAR-CLIP	23446348
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	23446348
MIRT449463	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT498990	hsa-miR-1261	PAR-CLIP	23446348
MIRT498997	hsa-miR-3133	PAR-CLIP	23446348
MIRT498995	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT498994	hsa-miR-1243	PAR-CLIP	23446348
MIRT498993	hsa-miR-4463	PAR-CLIP	23446348
MIRT498992	hsa-miR-4494	PAR-CLIP	23446348
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	23446348
MIRT498990	hsa-miR-1261	PAR-CLIP	23446348
MIRT498997	hsa-miR-3133	PAR-CLIP	24398324
MIRT498995	hsa-miR-186-5p	PAR-CLIP	24398324
MIRT498994	hsa-miR-1243	PAR-CLIP	24398324
MIRT498993	hsa-miR-4463	PAR-CLIP	24398324
MIRT498992	hsa-miR-4494	PAR-CLIP	24398324
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	24398324
MIRT498990	hsa-miR-1261	PAR-CLIP	24398324
MIRT475853	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT475852	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT299418	hsa-miR-10b-3p	PAR-CLIP	23592263
MIRT475851	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT475850	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT475849	hsa-let-7a-2-3p	PAR-CLIP	23592263
MIRT475848	hsa-let-7g-3p	PAR-CLIP	23592263
MIRT475847	hsa-miR-493-5p	PAR-CLIP	23592263
MIRT475846	hsa-miR-5096	PAR-CLIP	23592263
MIRT475845	hsa-miR-335-3p	PAR-CLIP	23592263
MIRT449473	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT449472	hsa-miR-300	PAR-CLIP	22100165
MIRT449471	hsa-miR-381-3p	PAR-CLIP	22100165
MIRT449470	hsa-miR-4666a-3p	PAR-CLIP	22100165
MIRT449469	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT449467	hsa-miR-4635	PAR-CLIP	22100165
MIRT449468	hsa-let-7a-3p	PAR-CLIP	22100165
MIRT449466	hsa-let-7b-3p	PAR-CLIP	22100165
MIRT449465	hsa-let-7f-1-3p	PAR-CLIP	22100165
MIRT449464	hsa-miR-98-3p	PAR-CLIP	22100165
MIRT449463	hsa-miR-4789-5p	PAR-CLIP	22100165
MIRT449462	hsa-let-7f-2-3p	PAR-CLIP	22100165
MIRT449461	hsa-miR-1185-1-3p	PAR-CLIP	22100165
MIRT449460	hsa-miR-1185-2-3p	PAR-CLIP	22100165
MIRT449459	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT733470	hsa-miR-486-5p	qRT-PCR	26654953
MIRT733470	hsa-miR-486-5p	RNA-seq	34199766
MIRT733470	hsa-miR-486-5p	ELISAIn situ hybridizationLuciferase reporter assayMicroarrayqRT-PCRWestern blotting	33244226
MIRT498997	hsa-miR-3133	PAR-CLIP	20371350
MIRT498995	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT498994	hsa-miR-1243	PAR-CLIP	20371350
MIRT498993	hsa-miR-4463	PAR-CLIP	20371350
MIRT498992	hsa-miR-4494	PAR-CLIP	20371350
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	20371350
MIRT498990	hsa-miR-1261	PAR-CLIP	20371350
MIRT498997	hsa-miR-3133	PAR-CLIP	21572407
MIRT498995	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT498994	hsa-miR-1243	PAR-CLIP	21572407
MIRT498993	hsa-miR-4463	PAR-CLIP	21572407
MIRT498992	hsa-miR-4494	PAR-CLIP	21572407
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	21572407
MIRT498990	hsa-miR-1261	PAR-CLIP	21572407
MIRT498997	hsa-miR-3133	PAR-CLIP	22012620
MIRT498995	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT527666	hsa-miR-8485	PAR-CLIP	22012620
MIRT527665	hsa-miR-329-3p	PAR-CLIP	22012620
MIRT527664	hsa-miR-362-3p	PAR-CLIP	22012620
MIRT527663	hsa-miR-603	PAR-CLIP	22012620
MIRT498994	hsa-miR-1243	PAR-CLIP	22012620
MIRT498993	hsa-miR-4463	PAR-CLIP	22012620
MIRT498992	hsa-miR-4494	PAR-CLIP	22012620
MIRT527662	hsa-miR-5190	PAR-CLIP	22012620
MIRT523319	hsa-miR-542-3p	PAR-CLIP	22012620
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	22012620
MIRT527661	hsa-miR-3941	PAR-CLIP	22012620
MIRT449463	hsa-miR-4789-5p	PAR-CLIP	22012620
MIRT498990	hsa-miR-1261	PAR-CLIP	22012620
MIRT498997	hsa-miR-3133	PAR-CLIP	23446348
MIRT498995	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT498994	hsa-miR-1243	PAR-CLIP	23446348
MIRT498993	hsa-miR-4463	PAR-CLIP	23446348
MIRT498992	hsa-miR-4494	PAR-CLIP	23446348
MIRT523319	hsa-miR-542-3p	PAR-CLIP	23446348
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	23446348
MIRT449463	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT498990	hsa-miR-1261	PAR-CLIP	23446348
MIRT498997	hsa-miR-3133	PAR-CLIP	23446348
MIRT498995	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT498994	hsa-miR-1243	PAR-CLIP	23446348
MIRT498993	hsa-miR-4463	PAR-CLIP	23446348
MIRT498992	hsa-miR-4494	PAR-CLIP	23446348
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	23446348
MIRT498990	hsa-miR-1261	PAR-CLIP	23446348
MIRT498997	hsa-miR-3133	PAR-CLIP	24398324
MIRT498995	hsa-miR-186-5p	PAR-CLIP	24398324
MIRT498994	hsa-miR-1243	PAR-CLIP	24398324
MIRT498993	hsa-miR-4463	PAR-CLIP	24398324
MIRT498992	hsa-miR-4494	PAR-CLIP	24398324
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	24398324
MIRT498990	hsa-miR-1261	PAR-CLIP	24398324
MIRT475853	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT475852	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT299418	hsa-miR-10b-3p	PAR-CLIP	23592263
MIRT475851	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT475850	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT475849	hsa-let-7a-2-3p	PAR-CLIP	23592263
MIRT475848	hsa-let-7g-3p	PAR-CLIP	23592263
MIRT475847	hsa-miR-493-5p	PAR-CLIP	23592263
MIRT475846	hsa-miR-5096	PAR-CLIP	23592263
MIRT475845	hsa-miR-335-3p	PAR-CLIP	23592263
MIRT449473	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT449472	hsa-miR-300	PAR-CLIP	22100165
MIRT449471	hsa-miR-381-3p	PAR-CLIP	22100165
MIRT449470	hsa-miR-4666a-3p	PAR-CLIP	22100165
MIRT449469	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT449467	hsa-miR-4635	PAR-CLIP	22100165
MIRT449468	hsa-let-7a-3p	PAR-CLIP	22100165
MIRT449466	hsa-let-7b-3p	PAR-CLIP	22100165
MIRT449465	hsa-let-7f-1-3p	PAR-CLIP	22100165
MIRT449464	hsa-miR-98-3p	PAR-CLIP	22100165
MIRT449463	hsa-miR-4789-5p	PAR-CLIP	22100165
MIRT449462	hsa-let-7f-2-3p	PAR-CLIP	22100165
MIRT449461	hsa-miR-1185-1-3p	PAR-CLIP	22100165
MIRT449460	hsa-miR-1185-2-3p	PAR-CLIP	22100165
MIRT449459	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT1040988	hsa-miR-144	CLIP-seq
MIRT1040989	hsa-miR-216b	CLIP-seq
MIRT1040990	hsa-miR-381	CLIP-seq
MIRT1040991	hsa-miR-4666-3p	CLIP-seq
MIRT1040992	hsa-miR-618	CLIP-seq
MIRT2008572	hsa-miR-4282	CLIP-seq
MIRT2008573	hsa-miR-4457	CLIP-seq
MIRT2008574	hsa-miR-4698	CLIP-seq
MIRT2008575	hsa-miR-513b	CLIP-seq
MIRT2008576	hsa-miR-548p	CLIP-seq
MIRT2241011	hsa-miR-199a-3p	CLIP-seq
MIRT2241012	hsa-miR-199b-3p	CLIP-seq
MIRT2241013	hsa-miR-27a	CLIP-seq
MIRT2241014	hsa-miR-27b	CLIP-seq
MIRT2241015	hsa-miR-3129-5p	CLIP-seq
MIRT2241016	hsa-miR-3942-3p	CLIP-seq
MIRT2544574	hsa-miR-2278	CLIP-seq
MIRT2241013	hsa-miR-27a	CLIP-seq
MIRT2241014	hsa-miR-27b	CLIP-seq
MIRT2544575	hsa-miR-3647-3p	CLIP-seq
MIRT2008572	hsa-miR-4282	CLIP-seq
MIRT2008573	hsa-miR-4457	CLIP-seq
MIRT2544576	hsa-miR-450b-5p	CLIP-seq
MIRT2544577	hsa-miR-4797-5p	CLIP-seq
MIRT2008575	hsa-miR-513b	CLIP-seq
MIRT2544578	hsa-miR-516a-3p	CLIP-seq
MIRT2544574	hsa-miR-2278	CLIP-seq
MIRT2241013	hsa-miR-27a	CLIP-seq
MIRT2241014	hsa-miR-27b	CLIP-seq
MIRT2544575	hsa-miR-3647-3p	CLIP-seq
MIRT2008572	hsa-miR-4282	CLIP-seq
MIRT2008573	hsa-miR-4457	CLIP-seq
MIRT2544576	hsa-miR-450b-5p	CLIP-seq
MIRT2544577	hsa-miR-4797-5p	CLIP-seq
MIRT2008575	hsa-miR-513b	CLIP-seq
MIRT2544578	hsa-miR-516a-3p	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000781	Component	Chromosome, telomeric region	HDA	19135898
GO:0000785	Component	Chromatin	IDA	14718166
GO:0004402	Function	Histone acetyltransferase activity	IEA
GO:0004402	Function	Histone acetyltransferase activity	TAS	9427644
GO:0005515	Function	Protein binding	IPI	19862764, 22190034, 22615379, 24981860, 25416956, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9427644
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006334	Process	Nucleosome assembly	IDA	14718166
GO:0006475	Process	Internal protein amino acid acetylation	TAS	9427644
GO:0010485	Function	Histone H4 acetyltransferase activity	IBA
GO:0016363	Component	Nuclear matrix	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0031509	Process	Subtelomeric heterochromatin formation	IEA
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0042393	Function	Histone binding	IEA
GO:0043997	Function	Histone H4K12 acetyltransferase activity	IDA	22615379
GO:0051276	Process	Chromosome organization	TAS	9427644
GO:0061733	Function	Protein-lysine-acetyltransferase activity	IEA

MIM	HGNC	e!Ensembl
603053	4821	ENSG00000128708

O14929

Protein name

Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1)

Protein function

Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:20953179, PubMed:23653357, PubMed:31278053, PubMed:32081014). Coo

PDB

2P0W , 6VO5 , 9MJG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10394	Hat1_N	25 → 187	Histone acetyl transferase HAT1 N-terminus	Domain

Sequence

MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLF
GDDETAFGYKGLKILLYYIAGSLSTMFRVEYASKVDENFDCVEADDVEGKIRQIIPPGFC
TNTNDFLSLLEKEVDFKPFGTLLHTYSVLSPTGGENFTFQIYKADMTCRGFREYHERLQT
FLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQ
MLILTPFQGQGHGAQLLETVHRYYTEFPTVLDITAEDPSKSYVKLRDFVLVKLCQDLPCF
SREKLMQGFNEDMAIEAQQKFKINKQHARRVYEILRLLVTDMSDAEQYRSYRLDIKRRLI
SPYKKKQRDLAKMRKCLRPEELTNQMNQIEISMQHEQLEESFQELVEDYRRVIERLAQE

Sequence length

419

Interactions

View interactions

	KEGG		Reactome
	Neutrophil extracellular trap formation Alcoholism		HATs acetylate histones

HAT1 (histone acetyltransferase 1)