Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8520
Gene name Gene Name - the full gene name approved by the HGNC.	Histone acetyltransferase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HAT1
Synonyms (NCBI Gene) Gene synonyms aliases	KAT1
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q31.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. H

Show/Hide all(194)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028253	hsa-miR-32-5p	Sequencing	20371350
MIRT498997	hsa-miR-3133	PAR-CLIP	20371350
MIRT498995	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT498994	hsa-miR-1243	PAR-CLIP	20371350
MIRT498993	hsa-miR-4463	PAR-CLIP	20371350
MIRT498992	hsa-miR-4494	PAR-CLIP	20371350
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	20371350
MIRT498990	hsa-miR-1261	PAR-CLIP	20371350
MIRT498997	hsa-miR-3133	PAR-CLIP	21572407
MIRT498995	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT498994	hsa-miR-1243	PAR-CLIP	21572407
MIRT498993	hsa-miR-4463	PAR-CLIP	21572407
MIRT498992	hsa-miR-4494	PAR-CLIP	21572407
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	21572407
MIRT498990	hsa-miR-1261	PAR-CLIP	21572407
MIRT498997	hsa-miR-3133	PAR-CLIP	22012620
MIRT498995	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT527666	hsa-miR-8485	PAR-CLIP	22012620
MIRT527665	hsa-miR-329-3p	PAR-CLIP	22012620
MIRT527664	hsa-miR-362-3p	PAR-CLIP	22012620
MIRT527663	hsa-miR-603	PAR-CLIP	22012620
MIRT498994	hsa-miR-1243	PAR-CLIP	22012620
MIRT498993	hsa-miR-4463	PAR-CLIP	22012620
MIRT498992	hsa-miR-4494	PAR-CLIP	22012620
MIRT527662	hsa-miR-5190	PAR-CLIP	22012620
MIRT523319	hsa-miR-542-3p	PAR-CLIP	22012620
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	22012620
MIRT527661	hsa-miR-3941	PAR-CLIP	22012620
MIRT449463	hsa-miR-4789-5p	PAR-CLIP	22012620
MIRT498990	hsa-miR-1261	PAR-CLIP	22012620
MIRT498997	hsa-miR-3133	PAR-CLIP	23446348
MIRT498995	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT498994	hsa-miR-1243	PAR-CLIP	23446348
MIRT498993	hsa-miR-4463	PAR-CLIP	23446348
MIRT498992	hsa-miR-4494	PAR-CLIP	23446348
MIRT523319	hsa-miR-542-3p	PAR-CLIP	23446348
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	23446348
MIRT449463	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT498990	hsa-miR-1261	PAR-CLIP	23446348
MIRT498997	hsa-miR-3133	PAR-CLIP	23446348
MIRT498995	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT498994	hsa-miR-1243	PAR-CLIP	23446348
MIRT498993	hsa-miR-4463	PAR-CLIP	23446348
MIRT498992	hsa-miR-4494	PAR-CLIP	23446348
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	23446348
MIRT498990	hsa-miR-1261	PAR-CLIP	23446348
MIRT498997	hsa-miR-3133	PAR-CLIP	24398324
MIRT498995	hsa-miR-186-5p	PAR-CLIP	24398324
MIRT498994	hsa-miR-1243	PAR-CLIP	24398324
MIRT498993	hsa-miR-4463	PAR-CLIP	24398324
MIRT498992	hsa-miR-4494	PAR-CLIP	24398324
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	24398324
MIRT498990	hsa-miR-1261	PAR-CLIP	24398324
MIRT475853	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT475852	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT299418	hsa-miR-10b-3p	PAR-CLIP	23592263
MIRT475851	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT475850	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT475849	hsa-let-7a-2-3p	PAR-CLIP	23592263
MIRT475848	hsa-let-7g-3p	PAR-CLIP	23592263
MIRT475847	hsa-miR-493-5p	PAR-CLIP	23592263
MIRT475846	hsa-miR-5096	PAR-CLIP	23592263
MIRT475845	hsa-miR-335-3p	PAR-CLIP	23592263
MIRT449473	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT449472	hsa-miR-300	PAR-CLIP	22100165
MIRT449471	hsa-miR-381-3p	PAR-CLIP	22100165
MIRT449470	hsa-miR-4666a-3p	PAR-CLIP	22100165
MIRT449469	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT449467	hsa-miR-4635	PAR-CLIP	22100165
MIRT449468	hsa-let-7a-3p	PAR-CLIP	22100165
MIRT449466	hsa-let-7b-3p	PAR-CLIP	22100165
MIRT449465	hsa-let-7f-1-3p	PAR-CLIP	22100165
MIRT449464	hsa-miR-98-3p	PAR-CLIP	22100165
MIRT449463	hsa-miR-4789-5p	PAR-CLIP	22100165
MIRT449462	hsa-let-7f-2-3p	PAR-CLIP	22100165
MIRT449461	hsa-miR-1185-1-3p	PAR-CLIP	22100165
MIRT449460	hsa-miR-1185-2-3p	PAR-CLIP	22100165
MIRT449459	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT733470	hsa-miR-486-5p	qRT-PCR	26654953
MIRT733470	hsa-miR-486-5p	RNA-seq	34199766
MIRT733470	hsa-miR-486-5p	ELISA, In situ hybridization, Luciferase reporter assay, Microarray, qRT-PCR, Western blotting	33244226
MIRT498997	hsa-miR-3133	PAR-CLIP	20371350
MIRT498995	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT498994	hsa-miR-1243	PAR-CLIP	20371350
MIRT498993	hsa-miR-4463	PAR-CLIP	20371350
MIRT498992	hsa-miR-4494	PAR-CLIP	20371350
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	20371350
MIRT498990	hsa-miR-1261	PAR-CLIP	20371350
MIRT498997	hsa-miR-3133	PAR-CLIP	21572407
MIRT498995	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT498994	hsa-miR-1243	PAR-CLIP	21572407
MIRT498993	hsa-miR-4463	PAR-CLIP	21572407
MIRT498992	hsa-miR-4494	PAR-CLIP	21572407
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	21572407
MIRT498990	hsa-miR-1261	PAR-CLIP	21572407
MIRT498997	hsa-miR-3133	PAR-CLIP	22012620
MIRT498995	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT527666	hsa-miR-8485	PAR-CLIP	22012620
MIRT527665	hsa-miR-329-3p	PAR-CLIP	22012620
MIRT527664	hsa-miR-362-3p	PAR-CLIP	22012620
MIRT527663	hsa-miR-603	PAR-CLIP	22012620
MIRT498994	hsa-miR-1243	PAR-CLIP	22012620
MIRT498993	hsa-miR-4463	PAR-CLIP	22012620
MIRT498992	hsa-miR-4494	PAR-CLIP	22012620
MIRT527662	hsa-miR-5190	PAR-CLIP	22012620
MIRT523319	hsa-miR-542-3p	PAR-CLIP	22012620
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	22012620
MIRT527661	hsa-miR-3941	PAR-CLIP	22012620
MIRT449463	hsa-miR-4789-5p	PAR-CLIP	22012620
MIRT498990	hsa-miR-1261	PAR-CLIP	22012620
MIRT498997	hsa-miR-3133	PAR-CLIP	23446348
MIRT498995	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT498994	hsa-miR-1243	PAR-CLIP	23446348
MIRT498993	hsa-miR-4463	PAR-CLIP	23446348
MIRT498992	hsa-miR-4494	PAR-CLIP	23446348
MIRT523319	hsa-miR-542-3p	PAR-CLIP	23446348
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	23446348
MIRT449463	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT498990	hsa-miR-1261	PAR-CLIP	23446348
MIRT498997	hsa-miR-3133	PAR-CLIP	23446348
MIRT498995	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT498994	hsa-miR-1243	PAR-CLIP	23446348
MIRT498993	hsa-miR-4463	PAR-CLIP	23446348
MIRT498992	hsa-miR-4494	PAR-CLIP	23446348
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	23446348
MIRT498990	hsa-miR-1261	PAR-CLIP	23446348
MIRT498997	hsa-miR-3133	PAR-CLIP	24398324
MIRT498995	hsa-miR-186-5p	PAR-CLIP	24398324
MIRT498994	hsa-miR-1243	PAR-CLIP	24398324
MIRT498993	hsa-miR-4463	PAR-CLIP	24398324
MIRT498992	hsa-miR-4494	PAR-CLIP	24398324
MIRT498991	hsa-miR-4536-5p	PAR-CLIP	24398324
MIRT498990	hsa-miR-1261	PAR-CLIP	24398324
MIRT475853	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT475852	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT299418	hsa-miR-10b-3p	PAR-CLIP	23592263
MIRT475851	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT475850	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT475849	hsa-let-7a-2-3p	PAR-CLIP	23592263
MIRT475848	hsa-let-7g-3p	PAR-CLIP	23592263
MIRT475847	hsa-miR-493-5p	PAR-CLIP	23592263
MIRT475846	hsa-miR-5096	PAR-CLIP	23592263
MIRT475845	hsa-miR-335-3p	PAR-CLIP	23592263
MIRT449473	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT449472	hsa-miR-300	PAR-CLIP	22100165
MIRT449471	hsa-miR-381-3p	PAR-CLIP	22100165
MIRT449470	hsa-miR-4666a-3p	PAR-CLIP	22100165
MIRT449469	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT449467	hsa-miR-4635	PAR-CLIP	22100165
MIRT449468	hsa-let-7a-3p	PAR-CLIP	22100165
MIRT449466	hsa-let-7b-3p	PAR-CLIP	22100165
MIRT449465	hsa-let-7f-1-3p	PAR-CLIP	22100165
MIRT449464	hsa-miR-98-3p	PAR-CLIP	22100165
MIRT449463	hsa-miR-4789-5p	PAR-CLIP	22100165
MIRT449462	hsa-let-7f-2-3p	PAR-CLIP	22100165
MIRT449461	hsa-miR-1185-1-3p	PAR-CLIP	22100165
MIRT449460	hsa-miR-1185-2-3p	PAR-CLIP	22100165
MIRT449459	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT1040988	hsa-miR-144	CLIP-seq
MIRT1040989	hsa-miR-216b	CLIP-seq
MIRT1040990	hsa-miR-381	CLIP-seq
MIRT1040991	hsa-miR-4666-3p	CLIP-seq
MIRT1040992	hsa-miR-618	CLIP-seq
MIRT2008572	hsa-miR-4282	CLIP-seq
MIRT2008573	hsa-miR-4457	CLIP-seq
MIRT2008574	hsa-miR-4698	CLIP-seq
MIRT2008575	hsa-miR-513b	CLIP-seq
MIRT2008576	hsa-miR-548p	CLIP-seq
MIRT2241011	hsa-miR-199a-3p	CLIP-seq
MIRT2241012	hsa-miR-199b-3p	CLIP-seq
MIRT2241013	hsa-miR-27a	CLIP-seq
MIRT2241014	hsa-miR-27b	CLIP-seq
MIRT2241015	hsa-miR-3129-5p	CLIP-seq
MIRT2241016	hsa-miR-3942-3p	CLIP-seq
MIRT2544574	hsa-miR-2278	CLIP-seq
MIRT2241013	hsa-miR-27a	CLIP-seq
MIRT2241014	hsa-miR-27b	CLIP-seq
MIRT2544575	hsa-miR-3647-3p	CLIP-seq
MIRT2008572	hsa-miR-4282	CLIP-seq
MIRT2008573	hsa-miR-4457	CLIP-seq
MIRT2544576	hsa-miR-450b-5p	CLIP-seq
MIRT2544577	hsa-miR-4797-5p	CLIP-seq
MIRT2008575	hsa-miR-513b	CLIP-seq
MIRT2544578	hsa-miR-516a-3p	CLIP-seq
MIRT2544574	hsa-miR-2278	CLIP-seq
MIRT2241013	hsa-miR-27a	CLIP-seq
MIRT2241014	hsa-miR-27b	CLIP-seq
MIRT2544575	hsa-miR-3647-3p	CLIP-seq
MIRT2008572	hsa-miR-4282	CLIP-seq
MIRT2008573	hsa-miR-4457	CLIP-seq
MIRT2544576	hsa-miR-450b-5p	CLIP-seq
MIRT2544577	hsa-miR-4797-5p	CLIP-seq
MIRT2008575	hsa-miR-513b	CLIP-seq
MIRT2544578	hsa-miR-516a-3p	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000781	Component	Chromosome, telomeric region	HDA	19135898
GO:0000785	Component	Chromatin	IDA	14718166
GO:0004402	Function	Histone acetyltransferase activity	TAS	9427644
GO:0005515	Function	Protein binding	IPI	19862764, 22190034, 22615379, 24981860, 25416956, 32296183
GO:0005634	Component	Nucleus	TAS	9427644
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0006323	Process	DNA packaging	TAS	9427644
GO:0006335	Process	DNA replication-dependent nucleosome assembly	IDA	14718166
GO:0006336	Process	DNA replication-independent nucleosome assembly	IDA	14718166
GO:0006348	Process	Chromatin silencing at telomere	IEA
GO:0006475	Process	Internal protein amino acid acetylation	TAS	9427644
GO:0007584	Process	Response to nutrient	IEA
GO:0010485	Function	H4 histone acetyltransferase activity	IBA	21873635
GO:0010485	Function	H4 histone acetyltransferase activity	IDA	22615379
GO:0016363	Component	Nuclear matrix	IEA
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0042393	Function	Histone binding	IEA
GO:0043967	Process	Histone H4 acetylation	IBA	21873635
GO:0043967	Process	Histone H4 acetylation	IDA	22615379

MIM	HGNC	e!Ensembl
603053	4821	ENSG00000128708

Protein

UniProt ID

O14929

Protein name

Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1)

Protein function

Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:20953179, PubMed:23653357, PubMed:31278053, PubMed:32081014). Coo

PDB

2P0W , 6VO5 , 9MJG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10394	Hat1_N	25 → 187	Histone acetyl transferase HAT1 N-terminus	Domain

Sequence

MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLF
GDDETAFGYKGLKILLYYIAGSLSTMFRVEYASKVDENFDCVEADDVEGKIRQIIPPGFC
TNTNDFLSLLEKEVDFKPFGTLLHTYSVLSPTGGENFTFQIYKADMTCRGFREYHERLQT
FLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQ
MLILTPFQGQGHGAQLLETVHRYYTEFPTVLDITAEDPSKSYVKLRDFVLVKLCQDLPCF
SREKLMQGFNEDMAIEAQQKFKINKQHARRVYEILRLLVTDMSDAEQYRSYRLDIKRRLI
SPYKKKQRDLAKMRKCLRPEELTNQMNQIEISMQHEQLEESFQELVEDYRRVIERLAQE

Sequence length

419

Interactions

View interactions

	KEGG		Reactome
	Neutrophil extracellular trap formation Alcoholism		HATs acetylate histones

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800 View all (467 more)
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	31374203

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Diabetes	Diabetes			GWAS

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text Mining
Altitude Sickness	Associate	32299499
Atherosclerosis	Associate	31565149
Breast Neoplasms	Associate	12841681
Carcinogenesis	Associate	33372411
Carcinoma Hepatocellular	Stimulate	33372411
Carcinoma Hepatocellular	Associate	37763801
Cholangiocarcinoma	Stimulate	33372411
Esophageal Neoplasms	Associate	25120766
Esophageal Squamous Cell Carcinoma	Associate	25120766
HIV Infections	Associate	29615725
Hypoxia	Associate	30385847
Inflammation	Associate	33244226
Neoplasms	Stimulate	25120766
Neoplasms	Associate	33372411
Osteoarthritis	Inhibit	30385847
Osteoporosis	Inhibit	30385847
Osteosarcoma	Associate	30942624
Pancreatic Neoplasms	Stimulate	33372411
Pulmonary Disease Chronic Obstructive	Associate	33244226

HAT1 (histone acetyltransferase 1)