Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8514
Gene name Gene Name - the full gene name approved by the HGNC.	Potassium voltage-gated channel subfamily A regulatory beta subunit 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	KCNAB2
Synonyms (NCBI Gene) Gene synonyms aliases	AKR6A5, HKvbeta2, HKvbeta2.1, HKvbeta2.2, KCNA2B, KV-BETA-2
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p36.31
Summary Summary of gene provided in NCBI Entrez Gene.	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuro

Show/Hide all(110)

miRTarBase ID	miRNA	Experiments
MIRT1080364	hsa-miR-125a-5p	CLIP-seq
MIRT1080365	hsa-miR-125b	CLIP-seq
MIRT1080366	hsa-miR-3124-3p	CLIP-seq
MIRT1080367	hsa-miR-3180-5p	CLIP-seq
MIRT1080368	hsa-miR-324-5p	CLIP-seq
MIRT1080369	hsa-miR-362-5p	CLIP-seq
MIRT1080370	hsa-miR-4270	CLIP-seq
MIRT1080371	hsa-miR-4319	CLIP-seq
MIRT1080372	hsa-miR-4441	CLIP-seq
MIRT1080373	hsa-miR-4685-5p	CLIP-seq
MIRT1080374	hsa-miR-4732-3p	CLIP-seq
MIRT1080375	hsa-miR-500b	CLIP-seq
MIRT1080376	hsa-miR-544b	CLIP-seq
MIRT1080377	hsa-miR-670	CLIP-seq
MIRT1080378	hsa-miR-339-5p	CLIP-seq
MIRT1080379	hsa-miR-3649	CLIP-seq
MIRT1080380	hsa-miR-3667-3p	CLIP-seq
MIRT1080381	hsa-miR-3689a-3p	CLIP-seq
MIRT1080382	hsa-miR-3689c	CLIP-seq
MIRT1080383	hsa-miR-4648	CLIP-seq
MIRT1080384	hsa-miR-4728-5p	CLIP-seq
MIRT1080385	hsa-miR-483-3p	CLIP-seq
MIRT1080386	hsa-miR-668	CLIP-seq
MIRT1080387	hsa-miR-671-5p	CLIP-seq
MIRT1080388	hsa-miR-1286	CLIP-seq
MIRT1080389	hsa-miR-214	CLIP-seq
MIRT1080390	hsa-miR-3155	CLIP-seq
MIRT1080391	hsa-miR-3155b	CLIP-seq
MIRT1080392	hsa-miR-3169	CLIP-seq
MIRT1080393	hsa-miR-3619-5p	CLIP-seq
MIRT1080394	hsa-miR-3654	CLIP-seq
MIRT1080395	hsa-miR-4515	CLIP-seq
MIRT1080396	hsa-miR-4520a-3p	CLIP-seq
MIRT1080397	hsa-miR-4638-3p	CLIP-seq
MIRT1080398	hsa-miR-4690-5p	CLIP-seq
MIRT1080399	hsa-miR-484	CLIP-seq
MIRT1080400	hsa-miR-761	CLIP-seq
MIRT1080401	hsa-miR-2355-5p	CLIP-seq
MIRT1080402	hsa-miR-3202	CLIP-seq
MIRT1080403	hsa-miR-4286	CLIP-seq
MIRT1080404	hsa-miR-4425	CLIP-seq
MIRT1080405	hsa-miR-4475	CLIP-seq
MIRT1080406	hsa-miR-4747-5p	CLIP-seq
MIRT1080407	hsa-miR-617	CLIP-seq
MIRT2019979	hsa-miR-4447	CLIP-seq
MIRT2019980	hsa-miR-4472	CLIP-seq
MIRT2019979	hsa-miR-4447	CLIP-seq
MIRT2019980	hsa-miR-4472	CLIP-seq
MIRT2019981	hsa-miR-4514	CLIP-seq
MIRT2019982	hsa-miR-4651	CLIP-seq
MIRT2019983	hsa-miR-4692	CLIP-seq
MIRT2019984	hsa-miR-608	CLIP-seq
MIRT2452158	hsa-miR-1302	CLIP-seq
MIRT1080389	hsa-miR-214	CLIP-seq
MIRT2452159	hsa-miR-2861	CLIP-seq
MIRT2452160	hsa-miR-3122	CLIP-seq
MIRT1080390	hsa-miR-3155	CLIP-seq
MIRT1080391	hsa-miR-3155b	CLIP-seq
MIRT1080392	hsa-miR-3169	CLIP-seq
MIRT1080393	hsa-miR-3619-5p	CLIP-seq
MIRT1080394	hsa-miR-3654	CLIP-seq
MIRT1080381	hsa-miR-3689a-3p	CLIP-seq
MIRT1080382	hsa-miR-3689c	CLIP-seq
MIRT2452161	hsa-miR-3689d	CLIP-seq
MIRT2452162	hsa-miR-3913-5p	CLIP-seq
MIRT2452163	hsa-miR-3978	CLIP-seq
MIRT2452164	hsa-miR-4298	CLIP-seq
MIRT1080395	hsa-miR-4515	CLIP-seq
MIRT1080396	hsa-miR-4520a-3p	CLIP-seq
MIRT1080397	hsa-miR-4638-3p	CLIP-seq
MIRT2452165	hsa-miR-4650-5p	CLIP-seq
MIRT1080398	hsa-miR-4690-5p	CLIP-seq
MIRT1080384	hsa-miR-4728-5p	CLIP-seq
MIRT2452166	hsa-miR-4796-3p	CLIP-seq
MIRT1080399	hsa-miR-484	CLIP-seq
MIRT2452167	hsa-miR-661	CLIP-seq
MIRT2452168	hsa-miR-7	CLIP-seq
MIRT1080400	hsa-miR-761	CLIP-seq
MIRT2452169	hsa-miR-765	CLIP-seq
MIRT2452158	hsa-miR-1302	CLIP-seq
MIRT2452159	hsa-miR-2861	CLIP-seq
MIRT2452160	hsa-miR-3122	CLIP-seq
MIRT2452162	hsa-miR-3913-5p	CLIP-seq
MIRT2452164	hsa-miR-4298	CLIP-seq
MIRT2452165	hsa-miR-4650-5p	CLIP-seq
MIRT2452167	hsa-miR-661	CLIP-seq
MIRT1080389	hsa-miR-214	CLIP-seq
MIRT1080390	hsa-miR-3155	CLIP-seq
MIRT1080391	hsa-miR-3155b	CLIP-seq
MIRT1080392	hsa-miR-3169	CLIP-seq
MIRT1080393	hsa-miR-3619-5p	CLIP-seq
MIRT1080394	hsa-miR-3654	CLIP-seq
MIRT1080395	hsa-miR-4515	CLIP-seq
MIRT1080396	hsa-miR-4520a-3p	CLIP-seq
MIRT1080397	hsa-miR-4638-3p	CLIP-seq
MIRT1080398	hsa-miR-4690-5p	CLIP-seq
MIRT1080399	hsa-miR-484	CLIP-seq
MIRT1080400	hsa-miR-761	CLIP-seq
MIRT1080389	hsa-miR-214	CLIP-seq
MIRT1080390	hsa-miR-3155	CLIP-seq
MIRT1080391	hsa-miR-3155b	CLIP-seq
MIRT1080392	hsa-miR-3169	CLIP-seq
MIRT1080393	hsa-miR-3619-5p	CLIP-seq
MIRT1080394	hsa-miR-3654	CLIP-seq
MIRT1080395	hsa-miR-4515	CLIP-seq
MIRT1080396	hsa-miR-4520a-3p	CLIP-seq
MIRT1080397	hsa-miR-4638-3p	CLIP-seq
MIRT1080398	hsa-miR-4690-5p	CLIP-seq
MIRT1080399	hsa-miR-484	CLIP-seq
MIRT1080400	hsa-miR-761	CLIP-seq

Show/Hide all(36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005249	Function	Voltage-gated potassium channel activity	IEA
GO:0005515	Function	Protein binding	IPI	21357749, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	ISS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	ISS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	IEA
GO:0008076	Component	Voltage-gated potassium channel complex	IBA
GO:0008076	Component	Voltage-gated potassium channel complex	IDA	11086297
GO:0008106	Function	Alcohol dehydrogenase (NADP+) activity	IBA
GO:0008106	Function	Alcohol dehydrogenase (NADP+) activity	ISS
GO:0009898	Component	Cytoplasmic side of plasma membrane	ISS
GO:0015459	Function	Potassium channel regulator activity	IBA
GO:0015459	Function	Potassium channel regulator activity	IDA	7649300
GO:0016020	Component	Membrane	IDA	11086297
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0030424	Component	Axon	IEA
GO:0035579	Component	Specific granule membrane	TAS
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0044224	Component	Juxtaparanode region of axon	IBA
GO:0044224	Component	Juxtaparanode region of axon	IDA	11086297
GO:0044224	Component	Juxtaparanode region of axon	ISS
GO:0044325	Function	Transmembrane transporter binding	IBA
GO:0045202	Component	Synapse	IEA
GO:0070821	Component	Tertiary granule membrane	TAS
GO:0071805	Process	Potassium ion transmembrane transport	IEA
GO:1901379	Process	Regulation of potassium ion transmembrane transport	IBA
GO:1901379	Process	Regulation of potassium ion transmembrane transport	IDA	7649300
GO:1990002	Function	Methylglyoxal reductase (NADPH) (acetol producing) activity	IEA
GO:1990031	Component	Pinceau fiber	ISS
GO:2000008	Process	Regulation of protein localization to cell surface	ISS

MIM	HGNC	e!Ensembl
601142	6229	ENSG00000069424

Protein

UniProt ID

Q13303

Protein name

Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2)

Protein function

Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:11825900, PubMed:7649300). The beta-2/KCNAB2 cytoplasmic subunit prom

PDB

1ZSX , 7EJ1 , 7EJ2 , 7WF3 , 7WF4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00248	Aldo_ket_red	51 → 356	Aldo/keto reductase family	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in myelinated nerve fibers in the spinal cord, in the juxtaparanodal region of the nodes of Ranvier, but also in the paranodal region (PubMed:11086297). Detected in hippocampus (at protein level) (PubMed:21357749). Detected in

Sequence

MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTF
GGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF
WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG
MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA
MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG
CTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPY
SKKDYRS

Sequence length

367

Interactions

View interactions

	Reactome
			Voltage gated Potassium channels Neutrophil degranulation

KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2)