Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8502
Gene name Gene Name - the full gene name approved by the HGNC.	Plakophilin 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PKP4
Synonyms (NCBI Gene) Gene synonyms aliases	p0071
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q24.1
Summary Summary of gene provided in NCBI Entrez Gene.	Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila `armadillo` gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number o

Show/Hide all(228)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024827	hsa-miR-215-5p	Microarray	19074876
MIRT026600	hsa-miR-192-5p	Microarray	19074876
MIRT439956	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439956	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1238163	hsa-miR-1226	CLIP-seq
MIRT1238164	hsa-miR-1228	CLIP-seq
MIRT1238165	hsa-miR-1254	CLIP-seq
MIRT1238166	hsa-miR-147	CLIP-seq
MIRT1238167	hsa-miR-197	CLIP-seq
MIRT1238168	hsa-miR-2115	CLIP-seq
MIRT1238169	hsa-miR-218	CLIP-seq
MIRT1238170	hsa-miR-23a	CLIP-seq
MIRT1238171	hsa-miR-23b	CLIP-seq
MIRT1238172	hsa-miR-23c	CLIP-seq
MIRT1238173	hsa-miR-3116	CLIP-seq
MIRT1238174	hsa-miR-3140-3p	CLIP-seq
MIRT1238175	hsa-miR-3165	CLIP-seq
MIRT1238176	hsa-miR-3197	CLIP-seq
MIRT1238177	hsa-miR-34a	CLIP-seq
MIRT1238178	hsa-miR-34c-5p	CLIP-seq
MIRT1238179	hsa-miR-361-5p	CLIP-seq
MIRT1238180	hsa-miR-3616-5p	CLIP-seq
MIRT1238181	hsa-miR-3622b-5p	CLIP-seq
MIRT1238182	hsa-miR-3647-5p	CLIP-seq
MIRT1238183	hsa-miR-3690	CLIP-seq
MIRT1238184	hsa-miR-3911	CLIP-seq
MIRT1238185	hsa-miR-3945	CLIP-seq
MIRT1238186	hsa-miR-3973	CLIP-seq
MIRT1238187	hsa-miR-412	CLIP-seq
MIRT1238188	hsa-miR-4253	CLIP-seq
MIRT1238189	hsa-miR-4436b-5p	CLIP-seq
MIRT1238190	hsa-miR-449b	CLIP-seq
MIRT1238191	hsa-miR-4733-3p	CLIP-seq
MIRT1238192	hsa-miR-4795-5p	CLIP-seq
MIRT1238193	hsa-miR-4803	CLIP-seq
MIRT1238194	hsa-miR-516a-3p	CLIP-seq
MIRT1238195	hsa-miR-548k	CLIP-seq
MIRT1238196	hsa-miR-573	CLIP-seq
MIRT1238197	hsa-miR-634	CLIP-seq
MIRT1238198	hsa-miR-636	CLIP-seq
MIRT1238199	hsa-miR-644	CLIP-seq
MIRT1238200	hsa-miR-652	CLIP-seq
MIRT1238201	hsa-miR-676	CLIP-seq
MIRT1238202	hsa-miR-1297	CLIP-seq
MIRT1238203	hsa-miR-1305	CLIP-seq
MIRT1238204	hsa-miR-216b	CLIP-seq
MIRT1238205	hsa-miR-26a	CLIP-seq
MIRT1238206	hsa-miR-26b	CLIP-seq
MIRT1238179	hsa-miR-361-5p	CLIP-seq
MIRT1238207	hsa-miR-3671	CLIP-seq
MIRT1238208	hsa-miR-3686	CLIP-seq
MIRT1238209	hsa-miR-3908	CLIP-seq
MIRT1238210	hsa-miR-3942-5p	CLIP-seq
MIRT1238185	hsa-miR-3945	CLIP-seq
MIRT1238188	hsa-miR-4253	CLIP-seq
MIRT1238211	hsa-miR-4465	CLIP-seq
MIRT1238212	hsa-miR-4652-3p	CLIP-seq
MIRT1238213	hsa-miR-4703-5p	CLIP-seq
MIRT1238214	hsa-miR-4753-3p	CLIP-seq
MIRT1238215	hsa-miR-4762-5p	CLIP-seq
MIRT1238216	hsa-miR-4766-3p	CLIP-seq
MIRT1238217	hsa-miR-498	CLIP-seq
MIRT1238218	hsa-miR-607	CLIP-seq
MIRT1238219	hsa-miR-642b	CLIP-seq
MIRT1238170	hsa-miR-23a	CLIP-seq
MIRT1238171	hsa-miR-23b	CLIP-seq
MIRT1238172	hsa-miR-23c	CLIP-seq
MIRT1238179	hsa-miR-361-5p	CLIP-seq
MIRT1238208	hsa-miR-3686	CLIP-seq
MIRT1238185	hsa-miR-3945	CLIP-seq
MIRT1238188	hsa-miR-4253	CLIP-seq
MIRT1238189	hsa-miR-4436b-5p	CLIP-seq
MIRT1238212	hsa-miR-4652-3p	CLIP-seq
MIRT1238170	hsa-miR-23a	CLIP-seq
MIRT1238171	hsa-miR-23b	CLIP-seq
MIRT1238172	hsa-miR-23c	CLIP-seq
MIRT1238189	hsa-miR-4436b-5p	CLIP-seq
MIRT1238215	hsa-miR-4762-5p	CLIP-seq
MIRT1238163	hsa-miR-1226	CLIP-seq
MIRT1238164	hsa-miR-1228	CLIP-seq
MIRT1238165	hsa-miR-1254	CLIP-seq
MIRT2297322	hsa-miR-1256	CLIP-seq
MIRT2297323	hsa-miR-1267	CLIP-seq
MIRT1238166	hsa-miR-147	CLIP-seq
MIRT2297324	hsa-miR-183	CLIP-seq
MIRT1238167	hsa-miR-197	CLIP-seq
MIRT1238168	hsa-miR-2115	CLIP-seq
MIRT1238169	hsa-miR-218	CLIP-seq
MIRT1238170	hsa-miR-23a	CLIP-seq
MIRT1238171	hsa-miR-23b	CLIP-seq
MIRT1238172	hsa-miR-23c	CLIP-seq
MIRT2297325	hsa-miR-302f	CLIP-seq
MIRT2297326	hsa-miR-3065-5p	CLIP-seq
MIRT1238173	hsa-miR-3116	CLIP-seq
MIRT1238174	hsa-miR-3140-3p	CLIP-seq
MIRT2297327	hsa-miR-3147	CLIP-seq
MIRT1238175	hsa-miR-3165	CLIP-seq
MIRT2297328	hsa-miR-3688-5p	CLIP-seq
MIRT1238183	hsa-miR-3690	CLIP-seq
MIRT1238184	hsa-miR-3911	CLIP-seq
MIRT1238185	hsa-miR-3945	CLIP-seq
MIRT1238186	hsa-miR-3973	CLIP-seq
MIRT1238187	hsa-miR-412	CLIP-seq
MIRT1238188	hsa-miR-4253	CLIP-seq
MIRT2297329	hsa-miR-4326	CLIP-seq
MIRT2297330	hsa-miR-4425	CLIP-seq
MIRT2297331	hsa-miR-4426	CLIP-seq
MIRT2297332	hsa-miR-451b	CLIP-seq
MIRT2297333	hsa-miR-4647	CLIP-seq
MIRT2297334	hsa-miR-4662b	CLIP-seq
MIRT2297335	hsa-miR-4699-3p	CLIP-seq
MIRT2297336	hsa-miR-4704-5p	CLIP-seq
MIRT2297337	hsa-miR-4705	CLIP-seq
MIRT1238191	hsa-miR-4733-3p	CLIP-seq
MIRT1238215	hsa-miR-4762-5p	CLIP-seq
MIRT1238194	hsa-miR-516a-3p	CLIP-seq
MIRT2297338	hsa-miR-545	CLIP-seq
MIRT1238195	hsa-miR-548k	CLIP-seq
MIRT2297339	hsa-miR-587	CLIP-seq
MIRT2297340	hsa-miR-624	CLIP-seq
MIRT1238197	hsa-miR-634	CLIP-seq
MIRT1238198	hsa-miR-636	CLIP-seq
MIRT1238199	hsa-miR-644	CLIP-seq
MIRT1238209	hsa-miR-3908	CLIP-seq
MIRT1238210	hsa-miR-3942-5p	CLIP-seq
MIRT1238213	hsa-miR-4703-5p	CLIP-seq
MIRT1238216	hsa-miR-4766-3p	CLIP-seq
MIRT2594635	hsa-miR-1238	CLIP-seq
MIRT2297322	hsa-miR-1256	CLIP-seq
MIRT2594636	hsa-miR-125a-5p	CLIP-seq
MIRT2594637	hsa-miR-125b	CLIP-seq
MIRT2594638	hsa-miR-150	CLIP-seq
MIRT2297324	hsa-miR-183	CLIP-seq
MIRT1238170	hsa-miR-23a	CLIP-seq
MIRT1238171	hsa-miR-23b	CLIP-seq
MIRT1238172	hsa-miR-23c	CLIP-seq
MIRT2297326	hsa-miR-3065-5p	CLIP-seq
MIRT2594639	hsa-miR-3121-3p	CLIP-seq
MIRT2594640	hsa-miR-3183	CLIP-seq
MIRT2594641	hsa-miR-33a	CLIP-seq
MIRT2594642	hsa-miR-33b	CLIP-seq
MIRT2594643	hsa-miR-3591-3p	CLIP-seq
MIRT2594644	hsa-miR-3613-3p	CLIP-seq
MIRT1238179	hsa-miR-361-5p	CLIP-seq
MIRT2594645	hsa-miR-3617	CLIP-seq
MIRT1238208	hsa-miR-3686	CLIP-seq
MIRT2297328	hsa-miR-3688-5p	CLIP-seq
MIRT2594646	hsa-miR-371b-5p	CLIP-seq
MIRT1238209	hsa-miR-3908	CLIP-seq
MIRT2594647	hsa-miR-3909	CLIP-seq
MIRT1238210	hsa-miR-3942-5p	CLIP-seq
MIRT1238185	hsa-miR-3945	CLIP-seq
MIRT1238188	hsa-miR-4253	CLIP-seq
MIRT2594648	hsa-miR-4319	CLIP-seq
MIRT2297331	hsa-miR-4426	CLIP-seq
MIRT2297332	hsa-miR-451b	CLIP-seq
MIRT2594649	hsa-miR-4539	CLIP-seq
MIRT2297333	hsa-miR-4647	CLIP-seq
MIRT1238212	hsa-miR-4652-3p	CLIP-seq
MIRT2297334	hsa-miR-4662b	CLIP-seq
MIRT2594650	hsa-miR-4666-3p	CLIP-seq
MIRT2297335	hsa-miR-4699-3p	CLIP-seq
MIRT1238213	hsa-miR-4703-5p	CLIP-seq
MIRT2297337	hsa-miR-4705	CLIP-seq
MIRT2594651	hsa-miR-4713-5p	CLIP-seq
MIRT2594652	hsa-miR-4723-3p	CLIP-seq
MIRT2594653	hsa-miR-4732-3p	CLIP-seq
MIRT1238215	hsa-miR-4762-5p	CLIP-seq
MIRT1238216	hsa-miR-4766-3p	CLIP-seq
MIRT1238193	hsa-miR-4803	CLIP-seq
MIRT2594654	hsa-miR-5096	CLIP-seq
MIRT2594655	hsa-miR-520d-5p	CLIP-seq
MIRT2594656	hsa-miR-524-5p	CLIP-seq
MIRT2594657	hsa-miR-532-3p	CLIP-seq
MIRT2297338	hsa-miR-545	CLIP-seq
MIRT2297339	hsa-miR-587	CLIP-seq
MIRT2297340	hsa-miR-624	CLIP-seq
MIRT2594658	hsa-miR-641	CLIP-seq
MIRT1238219	hsa-miR-642b	CLIP-seq
MIRT2594659	hsa-miR-670	CLIP-seq
MIRT2594635	hsa-miR-1238	CLIP-seq
MIRT2297322	hsa-miR-1256	CLIP-seq
MIRT2594636	hsa-miR-125a-5p	CLIP-seq
MIRT2594637	hsa-miR-125b	CLIP-seq
MIRT2594638	hsa-miR-150	CLIP-seq
MIRT2297324	hsa-miR-183	CLIP-seq
MIRT1238170	hsa-miR-23a	CLIP-seq
MIRT1238171	hsa-miR-23b	CLIP-seq
MIRT1238172	hsa-miR-23c	CLIP-seq
MIRT2297326	hsa-miR-3065-5p	CLIP-seq
MIRT2594639	hsa-miR-3121-3p	CLIP-seq
MIRT2594640	hsa-miR-3183	CLIP-seq
MIRT2594641	hsa-miR-33a	CLIP-seq
MIRT2594642	hsa-miR-33b	CLIP-seq
MIRT2594643	hsa-miR-3591-3p	CLIP-seq
MIRT2594644	hsa-miR-3613-3p	CLIP-seq
MIRT2594645	hsa-miR-3617	CLIP-seq
MIRT2297328	hsa-miR-3688-5p	CLIP-seq
MIRT2594646	hsa-miR-371b-5p	CLIP-seq
MIRT1238209	hsa-miR-3908	CLIP-seq
MIRT2594647	hsa-miR-3909	CLIP-seq
MIRT1238210	hsa-miR-3942-5p	CLIP-seq
MIRT1238185	hsa-miR-3945	CLIP-seq
MIRT1238188	hsa-miR-4253	CLIP-seq
MIRT2594648	hsa-miR-4319	CLIP-seq
MIRT2297331	hsa-miR-4426	CLIP-seq
MIRT2297332	hsa-miR-451b	CLIP-seq
MIRT2594649	hsa-miR-4539	CLIP-seq
MIRT2297333	hsa-miR-4647	CLIP-seq
MIRT2297334	hsa-miR-4662b	CLIP-seq
MIRT2297335	hsa-miR-4699-3p	CLIP-seq
MIRT1238213	hsa-miR-4703-5p	CLIP-seq
MIRT2297337	hsa-miR-4705	CLIP-seq
MIRT2594651	hsa-miR-4713-5p	CLIP-seq
MIRT2594652	hsa-miR-4723-3p	CLIP-seq
MIRT2594653	hsa-miR-4732-3p	CLIP-seq
MIRT1238215	hsa-miR-4762-5p	CLIP-seq
MIRT1238216	hsa-miR-4766-3p	CLIP-seq
MIRT2594654	hsa-miR-5096	CLIP-seq
MIRT2594655	hsa-miR-520d-5p	CLIP-seq
MIRT2594656	hsa-miR-524-5p	CLIP-seq
MIRT2594657	hsa-miR-532-3p	CLIP-seq
MIRT2297338	hsa-miR-545	CLIP-seq
MIRT2297339	hsa-miR-587	CLIP-seq
MIRT2297340	hsa-miR-624	CLIP-seq
MIRT2594658	hsa-miR-641	CLIP-seq
MIRT1238219	hsa-miR-642b	CLIP-seq
MIRT2594659	hsa-miR-670	CLIP-seq

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IDA	17115030
GO:0001533	Component	Cornified envelope	TAS
GO:0005515	Function	Protein binding	IPI	12047349, 16203728, 17115030, 19706687, 22965878, 24550280, 25009281, 25416956, 30126976, 31515488
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	22965878
GO:0005856	Component	Cytoskeleton	IDA	8937994
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	8937994
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	IDA	8937994
GO:0005912	Component	Adherens junction	IBA	21873635
GO:0007043	Process	Cell-cell junction assembly	IBA	21873635
GO:0007043	Process	Cell-cell junction assembly	ISS
GO:0007267	Process	Cell-cell signaling	NAS	8937994
GO:0009898	Component	Cytoplasmic side of plasma membrane	IDA	17115030
GO:0030054	Component	Cell junction	IDA
GO:0030057	Component	Desmosome	IDA	8937994
GO:0030155	Process	Regulation of cell adhesion	NAS	8937994
GO:0030496	Component	Midbody	IDA	17115030
GO:0030496	Component	Midbody	IDA	22965878
GO:0031424	Process	Keratinization	TAS
GO:0032467	Process	Positive regulation of cytokinesis	IMP	17115030
GO:0043547	Process	Positive regulation of GTPase activity	IDA	17115030
GO:0044291	Component	Cell-cell contact zone	IDA	22965878
GO:0045296	Function	Cadherin binding	IBA	21873635
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	8937994
GO:0051233	Component	Spindle midzone	IDA	17115030
GO:0070268	Process	Cornification	TAS
GO:0072686	Component	Mitotic spindle	IDA	17115030
GO:0098609	Process	Cell-cell adhesion	IBA	21873635

MIM	HGNC	e!Ensembl
604276	9026	ENSG00000144283

Protein

UniProt ID

Q99569

Protein name

Plakophilin-4 (p0071)

Protein function

Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00514	Arm	559 → 599	Armadillo/beta-catenin-like repeat	Repeat
PF00514	Arm	603 → 644	Armadillo/beta-catenin-like repeat	Repeat
PF00514	Arm	863 → 901	Armadillo/beta-catenin-like repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Expressed in salivary glands (at protein level) (PubMed:30479852). Expressed in arrector pili muscle (at protein level) (PubMed:29034528). {ECO:0000269|PubMed:29034528, ECO:0000269|PubMed:30479852}.

Sequence

MPAPEQASLVEEGQPQTRQEAASTGPGMEPETTATTILASVKEQELQFQRLTRELEVERQ
IVASQLERCRLGAESPSIASTSSTEKSFPWRSTDVPNTGVSKPRVSDAVQPNNYLIRTEP
EQGTLYSPEQTSLHESEGSLGNSRSSTQMNSYSDSGYQEAGSFHNSQNVSKADNRQQHSF
IGSTNNHVVRNSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVISTGVSPSRGSLRTS
LGSGFGSPSVTDPRPLNPSAYSSTTLPAARAASPYSQRPASPTAIRRIGSVTSRQTSNPN
GPTPQYQTTARVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGPSLQRTVHD
MEQFGQQQYDIYERMVPPRPDSLTGLRSSYASQHSQLGQDLRSAVSPDLHITPIYEGRTY
YSPVYRSPNHGTVELQGSQTALYRTGSVGIGNLQRTSSQRSTLTYQRNNYALNTTATYAE
PYRPIQYRVQECNYNRLQHAVPADDGTTRSPSIDSIQKDPREFAWRDPELPEVIHMLQHQ
FPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFG
KSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMTIIRDALSTL
TNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDS
LLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKD
SEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNP
ATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA
LDVRNKELIGKYAMRDLVNRLPGGNGPSVLSDETMAAICCALHEVTSKNMENAKALADSG
GIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQNHFITPVSTLER
DRFKSHPSLSTTNQQMSPIIQSVGSTSSSPALLGIRDPRSEYDRTQPPMQYYNSQGDATH
KGLYPGSSKPSPIYISSYSSPAREQNRRLQHQQLYYSQDDSNRKNFDAYRLYLQSPHSYE
DPYFDDRVHFPASTDYSTQYGLKSTTNYVDFYSTKRPSYRAEQYPGSPDSWV

Sequence length

1192

Interactions

View interactions

	Reactome
			Keratinization Formation of the cornified envelope

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Source
Unknown
Hypertension	Hypertension	GWAS
Metabolic Syndrome	Metabolic Syndrome	GWAS
Insomnia	Insomnia	GWAS

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining
Arrhythmogenic Right Ventricular Dysplasia	Associate	20152563
Bipolar Disorder	Associate	28632202
Borderline Personality Disorder	Associate	28632202
Immunologic Deficiency Syndromes	Associate	22965878
Neoplasms	Associate	22965878
Schizophrenia	Associate	28632202
Sick Sinus Syndrome	Associate	27182706

PKP4 (plakophilin 4)