Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84991
Gene name Gene Name - the full gene name approved by the HGNC.	RNA binding motif protein 17
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RBM17
Synonyms (NCBI Gene) Gene synonyms aliases	SPF45
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10p15.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chrom

Show/Hide all(85)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021290	hsa-miR-125a-5p	Sequencing	20371350
MIRT025594	hsa-miR-10a-5p	Sequencing	20371350
MIRT047772	hsa-miR-7-5p	CLASH	23622248
MIRT047489	hsa-miR-10b-5p	CLASH	23622248
MIRT1295086	hsa-miR-1290	CLIP-seq
MIRT1295087	hsa-miR-130a	CLIP-seq
MIRT1295088	hsa-miR-130b	CLIP-seq
MIRT1295089	hsa-miR-2053	CLIP-seq
MIRT1295090	hsa-miR-301a	CLIP-seq
MIRT1295091	hsa-miR-301b	CLIP-seq
MIRT1295092	hsa-miR-3120-5p	CLIP-seq
MIRT1295093	hsa-miR-3591-5p	CLIP-seq
MIRT1295094	hsa-miR-3647-3p	CLIP-seq
MIRT1295095	hsa-miR-3666	CLIP-seq
MIRT1295096	hsa-miR-3667-3p	CLIP-seq
MIRT1295097	hsa-miR-3671	CLIP-seq
MIRT1295098	hsa-miR-3692	CLIP-seq
MIRT1295099	hsa-miR-4275	CLIP-seq
MIRT1295100	hsa-miR-4295	CLIP-seq
MIRT1295101	hsa-miR-4473	CLIP-seq
MIRT1295102	hsa-miR-454	CLIP-seq
MIRT1295103	hsa-miR-4671-3p	CLIP-seq
MIRT1295104	hsa-miR-4696	CLIP-seq
MIRT1295105	hsa-miR-4705	CLIP-seq
MIRT1295106	hsa-miR-4775	CLIP-seq
MIRT1295107	hsa-miR-4778-5p	CLIP-seq
MIRT1295108	hsa-miR-569	CLIP-seq
MIRT1295109	hsa-miR-607	CLIP-seq
MIRT1295110	hsa-miR-889	CLIP-seq
MIRT1295111	hsa-miR-924	CLIP-seq
MIRT1295112	hsa-miR-340	CLIP-seq
MIRT1295113	hsa-miR-3664-3p	CLIP-seq
MIRT1295114	hsa-miR-4282	CLIP-seq
MIRT1295115	hsa-miR-4311	CLIP-seq
MIRT1295116	hsa-miR-4433	CLIP-seq
MIRT1295117	hsa-miR-4445	CLIP-seq
MIRT1295118	hsa-miR-4459	CLIP-seq
MIRT1295119	hsa-miR-4768-3p	CLIP-seq
MIRT1295120	hsa-miR-510	CLIP-seq
MIRT1295121	hsa-miR-513a-3p	CLIP-seq
MIRT1295122	hsa-miR-590-3p	CLIP-seq
MIRT1295087	hsa-miR-130a	CLIP-seq
MIRT1295088	hsa-miR-130b	CLIP-seq
MIRT1295090	hsa-miR-301a	CLIP-seq
MIRT1295091	hsa-miR-301b	CLIP-seq
MIRT1295093	hsa-miR-3591-5p	CLIP-seq
MIRT1295095	hsa-miR-3666	CLIP-seq
MIRT1295100	hsa-miR-4295	CLIP-seq
MIRT1295101	hsa-miR-4473	CLIP-seq
MIRT1295102	hsa-miR-454	CLIP-seq
MIRT1295103	hsa-miR-4671-3p	CLIP-seq
MIRT1295104	hsa-miR-4696	CLIP-seq
MIRT1295087	hsa-miR-130a	CLIP-seq
MIRT1295088	hsa-miR-130b	CLIP-seq
MIRT1295090	hsa-miR-301a	CLIP-seq
MIRT1295091	hsa-miR-301b	CLIP-seq
MIRT1295093	hsa-miR-3591-5p	CLIP-seq
MIRT1295095	hsa-miR-3666	CLIP-seq
MIRT1295100	hsa-miR-4295	CLIP-seq
MIRT1295101	hsa-miR-4473	CLIP-seq
MIRT1295102	hsa-miR-454	CLIP-seq
MIRT1295103	hsa-miR-4671-3p	CLIP-seq
MIRT1295104	hsa-miR-4696	CLIP-seq
MIRT2087710	hsa-miR-3612	CLIP-seq
MIRT2087711	hsa-miR-4443	CLIP-seq
MIRT2087712	hsa-miR-4802-5p	CLIP-seq
MIRT2087713	hsa-miR-485-5p	CLIP-seq
MIRT2087714	hsa-miR-650	CLIP-seq
MIRT2312512	hsa-miR-34a	CLIP-seq
MIRT2312513	hsa-miR-34c-5p	CLIP-seq
MIRT1295096	hsa-miR-3667-3p	CLIP-seq
MIRT2312514	hsa-miR-3691-3p	CLIP-seq
MIRT2312515	hsa-miR-4496	CLIP-seq
MIRT2312516	hsa-miR-449a	CLIP-seq
MIRT2312517	hsa-miR-449b	CLIP-seq
MIRT2312518	hsa-miR-4663	CLIP-seq
MIRT2312519	hsa-miR-4682	CLIP-seq
MIRT2312520	hsa-miR-4728-3p	CLIP-seq
MIRT2087712	hsa-miR-4802-5p	CLIP-seq
MIRT2312521	hsa-miR-490-5p	CLIP-seq
MIRT2312522	hsa-miR-518a-5p	CLIP-seq
MIRT2312523	hsa-miR-526b	CLIP-seq
MIRT2312524	hsa-miR-527	CLIP-seq
MIRT2312525	hsa-miR-582-5p	CLIP-seq
MIRT1295111	hsa-miR-924	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000375	Process	RNA splicing, via transesterification reactions	IEA
GO:0000380	Process	Alternative mRNA splicing, via spliceosome	IBA
GO:0000380	Process	Alternative mRNA splicing, via spliceosome	IMP	17589525
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 17332742, 17577209, 17589525, 18337722, 21516116, 22365833, 25416956, 26420826, 28514442, 29021621, 31515488, 32296183, 32814053, 33961781, 35271311, 37219487
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0045292	Process	MRNA cis splicing, via spliceosome	IEA

MIM	HGNC	e!Ensembl
606935	16944	ENSG00000134453

Protein

UniProt ID

Q96I25

Protein name

Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17)

Protein function

Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes th

PDB

2PE8 , 2PEH , 5LSO , 6HIP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01585	G-patch	235 → 279	G-patch domain	Family
PF00076	RRM_1	323 → 383	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Sequence

MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRG
GSSDDRQIVDTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQ
RQRELERQKEIEEREKRRKDRHEASGFARRPDPDSDEDEDYERERRKRSMGGAAIAPPTS
LVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEQDRPRSPTGPSNSFLANMGGTVAH
KIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGDATEKDASKKSDSNPLTEIL
KCPTKVVLLRNMVGAGEVDEDLEVETKEECEKYGKVGKCVIFEIPGAPDDEAVRIFLEFE
RVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQV

Sequence length

401

Interactions

View interactions

	KEGG		Reactome
	Spliceosome		mRNA Splicing - Major Pathway

Show/Hide Unknown Diseases (10)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma	N/A	N/A	GWAS
Dermatitis	Atopic dermatitis	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Diabetes	Type 1 diabetes	N/A	N/A	GWAS
Eczema	Eczema	N/A	N/A	GWAS
Hypothyroidism	Hypothyroidism	N/A	N/A	GWAS
Multiple Sclerosis	Multiple sclerosis	N/A	N/A	GWAS
Rheumatoid arthritis	Rheumatoid arthritis	N/A	N/A	GWAS
Stress Disorder	Post-traumatic stress disorder	N/A	N/A	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Carcinoma Hepatocellular	Associate	15526362
Carcinoma Hepatocellular	Stimulate	32497093
Leukemia	Associate	35781533
Leukemia Myeloid Acute	Associate	35781533
Mouth Neoplasms	Associate	40243905
Neoplasms	Associate	14578179, 32497093
Neoplasms Squamous Cell	Associate	40243905
Ovarian Neoplasms	Associate	14578179
Squamous Cell Carcinoma of Head and Neck	Associate	40243905

RBM17 (RNA binding motif protein 17)