PPFIA2 (PPFI scaffold protein A2)

Gene

• Entrez ID: 8499
• Gene name: PPFI scaffold protein A2
• Gene symbol: PPFIA2
• Synonyms (NCBI Gene): -
• Chromosome: 12
• Chromosome location: 12q21.31
• Summary: The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018789	hsa-miR-335-5p	Microarray	18185580
MIRT1252445	hsa-miR-3121-3p	CLIP-seq
MIRT1252446	hsa-miR-3688-3p	CLIP-seq
MIRT1252447	hsa-miR-3978	CLIP-seq
MIRT1252448	hsa-miR-4477a	CLIP-seq
MIRT1252449	hsa-miR-4795-3p	CLIP-seq
MIRT1252450	hsa-miR-133a	CLIP-seq
MIRT1252451	hsa-miR-133b	CLIP-seq
MIRT1252452	hsa-miR-578	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12923177, 30021165
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	9624153
GO:0005829	Component	Cytosol	TAS
GO:0007160	Process	Cell-matrix adhesion	TAS	9624153
GO:0008021	Component	Synaptic vesicle	IEA
GO:0009986	Component	Cell surface	IEA
GO:0014069	Component	Postsynaptic density	IEA
GO:0030424	Component	Axon	IEA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043197	Component	Dendritic spine	IDA	30021165
GO:0043197	Component	Dendritic spine	IEA
GO:0045202	Component	Synapse	IEA
GO:0048786	Component	Presynaptic active zone	IBA
GO:0048786	Component	Presynaptic active zone	TAS	15217342
GO:0050808	Process	Synapse organization	IBA
GO:0060998	Process	Regulation of dendritic spine development	IMP	30021165
GO:0061001	Process	Regulation of dendritic spine morphogenesis	IMP	30021165
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0098919	Function	Structural constituent of postsynaptic density	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099172	Process	Presynapse organization	IEA
GO:0099181	Function	Structural constituent of presynapse	IEA
GO:0099519	Process	Dense core granule cytoskeletal transport	IMP	30021165
GO:0099562	Process	Maintenance of postsynaptic density structure	IEA
GO:0099572	Component	Postsynaptic specialization	IEA
GO:2000300	Process	Regulation of synaptic vesicle exocytosis	IEA

Other IDs

• MIM: 603143
• HGNC: 9246
• e!Ensembl: ENSG00000139220

Protein

• UniProt ID: O75334
• Protein name: Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2)
• Protein function: Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their intera
• PDB: 3TAC, 3TAD, 6IUH, 7D2E, 7D2G, 7D2H
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00536	SAM_1	896 → 961	SAM domain (Sterile alpha motif)	Domain
  PF00536	SAM_1	1018 → 1082	SAM domain (Sterile alpha motif)	Domain
  PF07647	SAM_2	1105 → 1175	SAM domain (Sterile alpha motif)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed only in brain. {ECO:0000269|PubMed:9624153}.
• Sequence:

  MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQ
  QRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEK
  EEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSL
  FEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESE
  HLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGE
  VEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDM
  NDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAAL
  TKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERL
  QLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLI
  EPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEW
  NRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAI
  NKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLASSSPPS
  GHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIKCETSPPPTPR
  ALRMTHTLPSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHKAPKKKGIKSSIGRLFGK
  KEKARLGQLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHELLEEARRKGLPFAQWDG
  PTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQE
  MVSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKTKESEEGSWAQCPVFLQTLAYGDMN
  HEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMC
  LKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRWIQAIGLREYANNILESGVHGSLIA
  LDENFDYSSLALLLQIPTQNTQARQILEREYNNLLALGTERRLDESDDKNFRRGSTWRRQ
  FPPREVHGISMMPGSSETLPAGFRLTTTSGQSRKMTTDVASSRLQRLDNSTVRTYSC

• Sequence length: 1257

Pathways

Reactome:

Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Receptor-type tyrosine-protein phosphatases