PPP1R16A (protein phosphatase 1 regulatory subunit 16A)

Gene

• Entrez ID: 84988
• Gene name: Protein phosphatase 1 regulatory subunit 16A
• Gene symbol: PPP1R16A
• Synonyms (NCBI Gene): MYPT3
• Chromosome: 8
• Chromosome location: 8q24.3
• Summary: Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subun

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024002	hsa-miR-1-3p	Microarray	18668037
MIRT2302127	hsa-miR-101	CLIP-seq
MIRT2302128	hsa-miR-1286	CLIP-seq
MIRT2302129	hsa-miR-1301	CLIP-seq
MIRT2302130	hsa-miR-144	CLIP-seq
MIRT2302131	hsa-miR-1470	CLIP-seq
MIRT2302132	hsa-miR-199a-5p	CLIP-seq
MIRT2302133	hsa-miR-199b-5p	CLIP-seq
MIRT2302134	hsa-miR-3182	CLIP-seq
MIRT2302135	hsa-miR-3184	CLIP-seq
MIRT2302136	hsa-miR-335	CLIP-seq
MIRT2302137	hsa-miR-3661	CLIP-seq
MIRT2302138	hsa-miR-423-5p	CLIP-seq
MIRT2302139	hsa-miR-4256	CLIP-seq
MIRT2302140	hsa-miR-4324	CLIP-seq
MIRT2302141	hsa-miR-4640-5p	CLIP-seq
MIRT2302142	hsa-miR-4645-5p	CLIP-seq
MIRT2302143	hsa-miR-4667-3p	CLIP-seq
MIRT2302144	hsa-miR-4673	CLIP-seq
MIRT2302145	hsa-miR-4722-5p	CLIP-seq
MIRT2302146	hsa-miR-4726-5p	CLIP-seq
MIRT2302147	hsa-miR-486-5p	CLIP-seq
MIRT2302148	hsa-miR-5047	CLIP-seq
MIRT2302149	hsa-miR-548c-3p	CLIP-seq
MIRT2302150	hsa-miR-631	CLIP-seq
MIRT2302151	hsa-miR-936	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004857	Function	Enzyme inhibitor activity	IBA
GO:0005515	Function	Protein binding	IPI	16169070, 16189514, 19060904, 21516116, 25416956, 28330616, 31515488, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0017020	Function	Myosin phosphatase regulator activity	IBA
GO:0019888	Function	Protein phosphatase regulator activity	IEA

Other IDs

• MIM: 609172
• HGNC: 14941
• e!Ensembl: ENSG00000160972

Protein

• UniProt ID: Q96I34
• Protein name: Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3)
• Protein function: Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12796	Ank_2	75 → 167	Ankyrin repeats (3 copies)	Repeat
  PF13637	Ank_4	117 → 157		Repeat
  PF12796	Ank_2	208 → 295	Ankyrin repeats (3 copies)	Repeat

• Sequence:

  MAEHLELLAEMPMVGRMSTQERLKHAQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAAS
  QGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMV
  QQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDE
  QTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAA
  ANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDET
  PLDVCGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDL
  YRKQHAQEAIVWQQPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPV
  RHLYSKRLDRSVSYQLSPLDSTTPHTLVHDKAHHTLADLKRQRAAAKLQRPPPEGPESPE
  TAEPGLPGDTVTPQPDCGFRAGGDPPLLKLTAPAVEAPVERRPCCLLM

• Sequence length: 528

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations