Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84959
Gene name Gene Name - the full gene name approved by the HGNC.	Ubiquitin associated and SH3 domain containing B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	UBASH3B
Synonyms (NCBI Gene) Gene synonyms aliases	STS-1, STS1, TULA-2, TULA2, p70
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q24.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024758	hsa-miR-215-5p	Microarray	19074876
MIRT026942	hsa-miR-192-5p	Microarray	19074876
MIRT053353	hsa-miR-200a-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23784775
MIRT492023	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT492022	hsa-miR-486-5p	PAR-CLIP	23592263
MIRT492021	hsa-let-7a-2-3p	PAR-CLIP	23592263
MIRT492020	hsa-let-7g-3p	PAR-CLIP	23592263
MIRT443795	hsa-miR-455-5p	PAR-CLIP	22100165
MIRT443794	hsa-miR-3662	PAR-CLIP	22100165
MIRT443793	hsa-miR-586	PAR-CLIP	22100165
MIRT443792	hsa-miR-4275	PAR-CLIP	22100165
MIRT443791	hsa-miR-1227-3p	PAR-CLIP	22100165
MIRT443790	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT443789	hsa-miR-491-3p	PAR-CLIP	22100165
MIRT492023	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT492022	hsa-miR-486-5p	PAR-CLIP	23592263
MIRT492021	hsa-let-7a-2-3p	PAR-CLIP	23592263
MIRT492020	hsa-let-7g-3p	PAR-CLIP	23592263
MIRT443795	hsa-miR-455-5p	PAR-CLIP	22100165
MIRT443794	hsa-miR-3662	PAR-CLIP	22100165
MIRT443793	hsa-miR-586	PAR-CLIP	22100165
MIRT443792	hsa-miR-4275	PAR-CLIP	22100165
MIRT443791	hsa-miR-1227-3p	PAR-CLIP	22100165
MIRT443790	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT443789	hsa-miR-491-3p	PAR-CLIP	22100165
MIRT1466855	hsa-miR-1225-3p	CLIP-seq
MIRT1466856	hsa-miR-1227	CLIP-seq
MIRT1466857	hsa-miR-1228	CLIP-seq
MIRT1466858	hsa-miR-1233	CLIP-seq
MIRT1466859	hsa-miR-1237	CLIP-seq
MIRT1466860	hsa-miR-1245b-5p	CLIP-seq
MIRT1466861	hsa-miR-1248	CLIP-seq
MIRT1466862	hsa-miR-219-5p	CLIP-seq
MIRT1466863	hsa-miR-24	CLIP-seq
MIRT1466864	hsa-miR-27a	CLIP-seq
MIRT1466865	hsa-miR-27b	CLIP-seq
MIRT1466866	hsa-miR-3124-3p	CLIP-seq
MIRT1466867	hsa-miR-3142	CLIP-seq
MIRT1466868	hsa-miR-3145-5p	CLIP-seq
MIRT1466869	hsa-miR-3157-5p	CLIP-seq
MIRT1466870	hsa-miR-3187-3p	CLIP-seq
MIRT1466871	hsa-miR-342-3p	CLIP-seq
MIRT1466872	hsa-miR-3682-3p	CLIP-seq
MIRT1466873	hsa-miR-3934	CLIP-seq
MIRT1466874	hsa-miR-3942-3p	CLIP-seq
MIRT1466875	hsa-miR-4284	CLIP-seq
MIRT1466876	hsa-miR-4433	CLIP-seq
MIRT1466877	hsa-miR-4445	CLIP-seq
MIRT1466878	hsa-miR-4459	CLIP-seq
MIRT1466879	hsa-miR-4502	CLIP-seq
MIRT1466880	hsa-miR-4529-5p	CLIP-seq
MIRT1466881	hsa-miR-4640-5p	CLIP-seq
MIRT1466882	hsa-miR-4688	CLIP-seq
MIRT1466883	hsa-miR-4691-3p	CLIP-seq
MIRT1466884	hsa-miR-4722-5p	CLIP-seq
MIRT1466885	hsa-miR-4726-5p	CLIP-seq
MIRT1466886	hsa-miR-4782-3p	CLIP-seq
MIRT1466887	hsa-miR-486-3p	CLIP-seq
MIRT1466888	hsa-miR-500a	CLIP-seq
MIRT1466889	hsa-miR-508-3p	CLIP-seq
MIRT1466890	hsa-miR-513a-5p	CLIP-seq
MIRT1466891	hsa-miR-595	CLIP-seq
MIRT1466892	hsa-miR-603	CLIP-seq
MIRT1466893	hsa-miR-659	CLIP-seq
MIRT1466894	hsa-miR-665	CLIP-seq
MIRT1466895	hsa-miR-885-3p	CLIP-seq
MIRT1466855	hsa-miR-1225-3p	CLIP-seq
MIRT1466858	hsa-miR-1233	CLIP-seq
MIRT2140320	hsa-miR-1257	CLIP-seq
MIRT2140321	hsa-miR-141	CLIP-seq
MIRT2140322	hsa-miR-200a	CLIP-seq
MIRT1466869	hsa-miR-3157-5p	CLIP-seq
MIRT1466870	hsa-miR-3187-3p	CLIP-seq
MIRT1466871	hsa-miR-342-3p	CLIP-seq
MIRT2140323	hsa-miR-3667-3p	CLIP-seq
MIRT2140324	hsa-miR-3681	CLIP-seq
MIRT1466874	hsa-miR-3942-3p	CLIP-seq
MIRT1466876	hsa-miR-4433	CLIP-seq
MIRT1466878	hsa-miR-4459	CLIP-seq
MIRT2140325	hsa-miR-4495	CLIP-seq
MIRT1466880	hsa-miR-4529-5p	CLIP-seq
MIRT1466882	hsa-miR-4688	CLIP-seq
MIRT1466883	hsa-miR-4691-3p	CLIP-seq
MIRT1466884	hsa-miR-4722-5p	CLIP-seq
MIRT1466887	hsa-miR-486-3p	CLIP-seq
MIRT1466894	hsa-miR-665	CLIP-seq
MIRT1466857	hsa-miR-1228	CLIP-seq
MIRT2361053	hsa-miR-1256	CLIP-seq
MIRT2140320	hsa-miR-1257	CLIP-seq
MIRT1466864	hsa-miR-27a	CLIP-seq
MIRT1466865	hsa-miR-27b	CLIP-seq
MIRT2361054	hsa-miR-3122	CLIP-seq
MIRT2361055	hsa-miR-3155	CLIP-seq
MIRT2361056	hsa-miR-3155b	CLIP-seq
MIRT2361057	hsa-miR-3160-5p	CLIP-seq
MIRT2361058	hsa-miR-3689a-3p	CLIP-seq
MIRT2361059	hsa-miR-3689c	CLIP-seq
MIRT2361060	hsa-miR-3913-5p	CLIP-seq
MIRT1466874	hsa-miR-3942-3p	CLIP-seq
MIRT2361061	hsa-miR-4452	CLIP-seq
MIRT2361062	hsa-miR-4471	CLIP-seq
MIRT2361063	hsa-miR-450b-5p	CLIP-seq
MIRT1466882	hsa-miR-4688	CLIP-seq
MIRT2361064	hsa-miR-4720-5p	CLIP-seq
MIRT2361065	hsa-miR-4753-3p	CLIP-seq
MIRT2361066	hsa-miR-4799-3p	CLIP-seq
MIRT2361067	hsa-miR-484	CLIP-seq
MIRT1466887	hsa-miR-486-3p	CLIP-seq
MIRT1466888	hsa-miR-500a	CLIP-seq
MIRT1466890	hsa-miR-513a-5p	CLIP-seq
MIRT2361068	hsa-miR-518a-5p	CLIP-seq
MIRT2361069	hsa-miR-527	CLIP-seq
MIRT2361070	hsa-miR-584	CLIP-seq
MIRT2361071	hsa-miR-593	CLIP-seq
MIRT2396576	hsa-miR-4774-5p	CLIP-seq
MIRT2441575	hsa-miR-3140-5p	CLIP-seq
MIRT2441576	hsa-miR-3622a-3p	CLIP-seq
MIRT2441577	hsa-miR-3622b-3p	CLIP-seq
MIRT2441578	hsa-miR-3692	CLIP-seq
MIRT2441579	hsa-miR-4680-3p	CLIP-seq
MIRT2441580	hsa-miR-578	CLIP-seq
MIRT2441581	hsa-miR-944	CLIP-seq
MIRT2462737	hsa-miR-106a	CLIP-seq
MIRT2462738	hsa-miR-106b	CLIP-seq
MIRT2462739	hsa-miR-10a	CLIP-seq
MIRT2462740	hsa-miR-10b	CLIP-seq
MIRT2462741	hsa-miR-1270	CLIP-seq
MIRT2462742	hsa-miR-17	CLIP-seq
MIRT2462743	hsa-miR-185	CLIP-seq
MIRT2462744	hsa-miR-20a	CLIP-seq
MIRT2462745	hsa-miR-20b	CLIP-seq
MIRT2462746	hsa-miR-302a	CLIP-seq
MIRT2462747	hsa-miR-302b	CLIP-seq
MIRT2462748	hsa-miR-302c	CLIP-seq
MIRT2462749	hsa-miR-302d	CLIP-seq
MIRT2462750	hsa-miR-302e	CLIP-seq
MIRT2462751	hsa-miR-339-5p	CLIP-seq
MIRT2462752	hsa-miR-372	CLIP-seq
MIRT2462753	hsa-miR-373	CLIP-seq
MIRT2462754	hsa-miR-4306	CLIP-seq
MIRT2462755	hsa-miR-4421	CLIP-seq
MIRT2462756	hsa-miR-4531	CLIP-seq
MIRT2462757	hsa-miR-4644	CLIP-seq
MIRT2462758	hsa-miR-4725-5p	CLIP-seq
MIRT2462759	hsa-miR-4786-5p	CLIP-seq
MIRT2462760	hsa-miR-504	CLIP-seq
MIRT2462761	hsa-miR-519d	CLIP-seq
MIRT2462762	hsa-miR-520a-3p	CLIP-seq
MIRT2462763	hsa-miR-520b	CLIP-seq
MIRT2462764	hsa-miR-520c-3p	CLIP-seq
MIRT2462765	hsa-miR-520d-3p	CLIP-seq
MIRT2462766	hsa-miR-520e	CLIP-seq
MIRT2462767	hsa-miR-520f	CLIP-seq
MIRT2462768	hsa-miR-548ac	CLIP-seq
MIRT2462769	hsa-miR-548ae	CLIP-seq
MIRT2462770	hsa-miR-548aj	CLIP-seq
MIRT2462771	hsa-miR-548am	CLIP-seq
MIRT2462772	hsa-miR-548d-3p	CLIP-seq
MIRT2462773	hsa-miR-548p	CLIP-seq
MIRT2462774	hsa-miR-548t	CLIP-seq
MIRT2462775	hsa-miR-548x	CLIP-seq
MIRT2462776	hsa-miR-548z	CLIP-seq
MIRT2361071	hsa-miR-593	CLIP-seq
MIRT2462777	hsa-miR-620	CLIP-seq
MIRT2462778	hsa-miR-769-5p	CLIP-seq
MIRT2462779	hsa-miR-93	CLIP-seq
MIRT2462739	hsa-miR-10a	CLIP-seq
MIRT2462740	hsa-miR-10b	CLIP-seq
MIRT1466855	hsa-miR-1225-3p	CLIP-seq
MIRT1466858	hsa-miR-1233	CLIP-seq
MIRT2462751	hsa-miR-339-5p	CLIP-seq
MIRT2462755	hsa-miR-4421	CLIP-seq
MIRT1466876	hsa-miR-4433	CLIP-seq
MIRT1466878	hsa-miR-4459	CLIP-seq
MIRT1466882	hsa-miR-4688	CLIP-seq
MIRT1466884	hsa-miR-4722-5p	CLIP-seq
MIRT2462758	hsa-miR-4725-5p	CLIP-seq
MIRT2462759	hsa-miR-4786-5p	CLIP-seq
MIRT1466887	hsa-miR-486-3p	CLIP-seq
MIRT2462760	hsa-miR-504	CLIP-seq
MIRT2462768	hsa-miR-548ac	CLIP-seq
MIRT2462769	hsa-miR-548ae	CLIP-seq
MIRT2462770	hsa-miR-548aj	CLIP-seq
MIRT2462771	hsa-miR-548am	CLIP-seq
MIRT2462772	hsa-miR-548d-3p	CLIP-seq
MIRT2462775	hsa-miR-548x	CLIP-seq
MIRT2462776	hsa-miR-548z	CLIP-seq
MIRT2361071	hsa-miR-593	CLIP-seq
MIRT1466894	hsa-miR-665	CLIP-seq
MIRT2462778	hsa-miR-769-5p	CLIP-seq
MIRT2462739	hsa-miR-10a	CLIP-seq
MIRT2462740	hsa-miR-10b	CLIP-seq
MIRT2694585	hsa-miR-1183	CLIP-seq
MIRT1466855	hsa-miR-1225-3p	CLIP-seq
MIRT1466858	hsa-miR-1233	CLIP-seq
MIRT2694586	hsa-miR-1271	CLIP-seq
MIRT2694587	hsa-miR-1279	CLIP-seq
MIRT2694588	hsa-miR-182	CLIP-seq
MIRT2694589	hsa-miR-186	CLIP-seq
MIRT2694590	hsa-miR-25	CLIP-seq
MIRT2694591	hsa-miR-3177-5p	CLIP-seq
MIRT2694592	hsa-miR-32	CLIP-seq
MIRT2462751	hsa-miR-339-5p	CLIP-seq
MIRT2694593	hsa-miR-363	CLIP-seq
MIRT2694594	hsa-miR-367	CLIP-seq
MIRT2462755	hsa-miR-4421	CLIP-seq
MIRT1466876	hsa-miR-4433	CLIP-seq
MIRT1466878	hsa-miR-4459	CLIP-seq
MIRT2694595	hsa-miR-4462	CLIP-seq
MIRT2361063	hsa-miR-450b-5p	CLIP-seq
MIRT1466882	hsa-miR-4688	CLIP-seq
MIRT1466884	hsa-miR-4722-5p	CLIP-seq
MIRT2462758	hsa-miR-4725-5p	CLIP-seq
MIRT2462759	hsa-miR-4786-5p	CLIP-seq
MIRT2694596	hsa-miR-4803	CLIP-seq
MIRT1466887	hsa-miR-486-3p	CLIP-seq
MIRT2462760	hsa-miR-504	CLIP-seq
MIRT2361068	hsa-miR-518a-5p	CLIP-seq
MIRT2694597	hsa-miR-520d-5p	CLIP-seq
MIRT2694598	hsa-miR-524-5p	CLIP-seq
MIRT2361069	hsa-miR-527	CLIP-seq
MIRT2462768	hsa-miR-548ac	CLIP-seq
MIRT2462769	hsa-miR-548ae	CLIP-seq
MIRT2462770	hsa-miR-548aj	CLIP-seq
MIRT2462771	hsa-miR-548am	CLIP-seq
MIRT2462772	hsa-miR-548d-3p	CLIP-seq
MIRT2462775	hsa-miR-548x	CLIP-seq
MIRT2462776	hsa-miR-548z	CLIP-seq
MIRT2694599	hsa-miR-552	CLIP-seq
MIRT2361070	hsa-miR-584	CLIP-seq
MIRT2361071	hsa-miR-593	CLIP-seq
MIRT1466891	hsa-miR-595	CLIP-seq
MIRT1466894	hsa-miR-665	CLIP-seq
MIRT2462778	hsa-miR-769-5p	CLIP-seq
MIRT2694600	hsa-miR-92a	CLIP-seq
MIRT2694601	hsa-miR-92b	CLIP-seq
MIRT2694602	hsa-miR-96	CLIP-seq

Show/Hide all(28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	17599067, 20585042, 24722188, 25416956, 28514442, 31515488, 32296183, 33961781, 36179048
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0009968	Process	Negative regulation of signal transduction	IBA
GO:0009968	Process	Negative regulation of signal transduction	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030168	Process	Platelet activation	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IEA
GO:0038063	Process	Collagen-activated tyrosine kinase receptor signaling pathway	IBA
GO:0038063	Process	Collagen-activated tyrosine kinase receptor signaling pathway	IEA
GO:0038065	Process	Collagen-activated signaling pathway	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0045670	Process	Regulation of osteoclast differentiation	IBA
GO:0045670	Process	Regulation of osteoclast differentiation	IEA
GO:0045671	Process	Negative regulation of osteoclast differentiation	IEA
GO:0045779	Process	Negative regulation of bone resorption	IBA
GO:0045779	Process	Negative regulation of bone resorption	IEA
GO:0051219	Function	Phosphoprotein binding	IEA
GO:0051279	Process	Regulation of release of sequestered calcium ion into cytosol	IBA
GO:0051279	Process	Regulation of release of sequestered calcium ion into cytosol	IEA
GO:0070527	Process	Platelet aggregation	IBA
GO:0070527	Process	Platelet aggregation	IEA
GO:0090331	Process	Negative regulation of platelet aggregation	IEA

MIM	HGNC	e!Ensembl
609201	29884	ENSG00000154127

Protein

UniProt ID

Q8TF42

Protein name

Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)

Protein function

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity t

PDB

2CPW , 2E5K , 5VR6 , 5W5G , 8U5M , 8U7E

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00627	UBA	39 → 73	UBA/TS-N domain	Domain
PF14604	SH3_9	261 → 315	Variant SH3 domain	Domain
PF00300	His_Phos_1	426 → 610	Histidine phosphatase superfamily (branch 1)	Domain

Sequence

MAQYGHPSPLGMAAREELYSKVTPRRNRQQRPGTIKHGSALDVLLSMGFPRARAQKALAS
TGGRSVQAACDWLFSHVGDPFLDDPLPREYVLYLRPTGPLAQKLSDFWQQSKQICGKNKA
HNIFPHITLCQFFMCEDSKVDALGEALQTTVSRWKCKFSAPLPLELYTSSNFIGLFVKED
SAEVLKKFAADFAAEAASKTEVHVEPHKKQLHVTLAYHFQASHLPTLEKLAQNIDVKLGC
DWVATIFSRDIRFANHETLQVIYPYTPQNDDELELVPGDFIFMSPMEQTSTSEGWIYGTS
LTTGCSGLLPENYITKADECSTWIFHGSYSILNTSSSNSLTFGDGVLERRPYEDQGLGET
TPLTIICQPMQPLRVNSQPGPQKRCLFVCRHGERMDVVFGKYWLSQCFDAKGRYIRTNLN
MPHSLPQRSGGFRDYEKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHN
ILKGLQQENHLKIRVEPGLFEWTKWVAGSTLPAWIPPSELAAANLSVDTTYRPHIPISKL
VVSESYDTYISRSFQVTKEIISECKSKGNNILIVAHASSLEACTCQLQGLSPQNSKDFVQ
MVRKIPYLGFCSCEELGETGIWQLTDPPILPLTHGPTGGFNWRETLLQE

Sequence length

649

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Hypertension	Hypertension (confirmatory factor analysis Factor 12)	N/A	N/A	GWAS
Multiple Sclerosis	Multiple sclerosis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Behcet Syndrome	Associate	19442274
Hemorrhage	Associate	36453946
Infectious Mononucleosis	Associate	2295000
Leukemia	Associate	33556471
Lymphoma	Associate	11337356
Nijmegen Breakage Syndrome	Associate	25119968, 25214013, 25485873
Pancreatic Neoplasms	Associate	40486509
Pneumococcal Infections	Associate	26956584
Progeroid syndrome neonatal	Associate	25214013
Pulmonary Disease Chronic Obstructive	Associate	37678858
Renal Insufficiency Chronic	Associate	34946851
Severe Acute Respiratory Syndrome	Associate	21819616
Telomeric 22q13 Monosomy Syndrome	Associate	25214013

UBASH3B (ubiquitin associated and SH3 domain containing B)