PPFIBP2 (PPFIB scaffold protein 2)

Gene

• Entrez ID: 8495
• Gene name: PPFIB scaffold protein 2
• Gene symbol: PPFIBP2
• Synonyms (NCBI Gene): Cclp1
• Chromosome: 11
• Chromosome location: 11p15.4
• Summary: This gene encodes a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. The encoded protein is a beta liprin and plays a role in axon guidance and neuronal synapse development by recruiting LAR protein-tyrosine phosphatases

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1252593	hsa-miR-124	CLIP-seq
MIRT1252594	hsa-miR-3714	CLIP-seq
MIRT1252595	hsa-miR-3910	CLIP-seq
MIRT1252596	hsa-miR-506	CLIP-seq
MIRT2074413	hsa-miR-1208	CLIP-seq
MIRT2074414	hsa-miR-668	CLIP-seq
MIRT2301318	hsa-miR-1206	CLIP-seq
MIRT2074413	hsa-miR-1208	CLIP-seq
MIRT1252593	hsa-miR-124	CLIP-seq
MIRT2301319	hsa-miR-1294	CLIP-seq
MIRT2301320	hsa-miR-3607-5p	CLIP-seq
MIRT2301321	hsa-miR-3692	CLIP-seq
MIRT1252594	hsa-miR-3714	CLIP-seq
MIRT2301322	hsa-miR-3907	CLIP-seq
MIRT1252595	hsa-miR-3910	CLIP-seq
MIRT2301323	hsa-miR-4318	CLIP-seq
MIRT2301324	hsa-miR-4436b-5p	CLIP-seq
MIRT2301325	hsa-miR-4699-5p	CLIP-seq
MIRT2301326	hsa-miR-4706	CLIP-seq
MIRT2301327	hsa-miR-4710	CLIP-seq
MIRT2301328	hsa-miR-4749-5p	CLIP-seq
MIRT2301329	hsa-miR-4787-5p	CLIP-seq
MIRT1252596	hsa-miR-506	CLIP-seq
MIRT2301330	hsa-miR-548q	CLIP-seq
MIRT2074414	hsa-miR-668	CLIP-seq
MIRT2301331	hsa-miR-744	CLIP-seq
MIRT2598107	hsa-miR-1287	CLIP-seq
MIRT2598108	hsa-miR-1915	CLIP-seq
MIRT2598109	hsa-miR-302f	CLIP-seq
MIRT2598110	hsa-miR-3135b	CLIP-seq
MIRT2598111	hsa-miR-3136-3p	CLIP-seq
MIRT2598112	hsa-miR-4731-3p	CLIP-seq
MIRT2598113	hsa-miR-4801	CLIP-seq
MIRT2598107	hsa-miR-1287	CLIP-seq
MIRT2598108	hsa-miR-1915	CLIP-seq
MIRT2598109	hsa-miR-302f	CLIP-seq
MIRT2598110	hsa-miR-3135b	CLIP-seq
MIRT2598111	hsa-miR-3136-3p	CLIP-seq
MIRT2598112	hsa-miR-4731-3p	CLIP-seq
MIRT2598113	hsa-miR-4801	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19447967, 26871637, 32296183, 33961781
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007528	Process	Neuromuscular junction development	IBA
GO:0042802	Function	Identical protein binding	IDA	21462929
GO:0048786	Component	Presynaptic active zone	IBA
GO:0098793	Component	Presynapse	IEA

Other IDs

• MIM: 603142
• HGNC: 9250
• e!Ensembl: ENSG00000166387

Protein

• UniProt ID: Q8ND30
• Protein name: Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2)
• Protein function: May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.
• PDB: 3QH9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00536	SAM_1	556 → 620	SAM domain (Sterile alpha motif)	Domain
  PF00536	SAM_1	631 → 691	SAM domain (Sterile alpha motif)	Domain
  PF07647	SAM_2	715 → 785	SAM domain (Sterile alpha motif)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:9624153}.
• Sequence:

  MASDASHALEAALEQMDGIIAGTKTGADLSDGTCEPGLASPASYMNPFPVLHLIEDLRLA
  LEMLELPQERAALLSQIPGPTAAYIKEWFEESLSQVNHHSAASNETYQERLARLEGDKES
  LILQVSVLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEMLQQELLSRTSLETQKLDLMTE
  VSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQYEWKLKATKAEV
  AQLQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRI
  EELTGLLNQYRKVKEIVMVTQGPSERTLSINEEEPEGGFSKWNATNKDPEELFKQEMPPR
  CSSPTVGPPPLPQKSLETRAQKKLSCSLEDLRSESVDKCMDGNQPFPVLEPKDSPFLAEH
  KYPTLPGKLSGATPNGEAAKSPPTICQPDATGSSLLRLRDTESGWDDTAVVNDLSSTSSG
  TESGPQSPLTPDGKRNPKGIKKFWGKIRRTQSGNFYTDTLGMAEFRRGGLRATAGPRLSR
  TRDSKGQKSDANAPFAQWSTERVCAWLEDFGLAQYVIFARQWVSSGHTLLTATPQDMEKE
  LGIKHPLHRKKLVLAVKAINTKQEEKSALLDHIWVTRWLDDIGLPQYKDQFHESRVDRRM
  LQYLTVNDLLFLKVTSQLHHLSIKCAIHVLHVNKFNPHCLHRRPADESNLSPSEVVQWSN
  HRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLRRHLTTK
  FNALIGPEAEQEKREKMASPAYTPLTTTAKVRPRKLGFSHFGNIRKKKFDESTDYICPME
  PSDGVSDSHRVYSGYRGLSPLDAPELDGLDQVGQIS

• Sequence length: 876

Pathways

Reactome:

Receptor-type tyrosine-protein phosphatases

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Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Dementia	Dementia	N/A	N/A	GWAS
Prostate cancer	Prostate cancer, Prostate cancer (advanced)	N/A	N/A	GWAS
Renal Carcinoma	Renal cell carcinoma	N/A	N/A	GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Biliary Tract Neoplasms	Associate	37330435
Carotid Body Tumor	Associate	30967136
Cholangiocarcinoma	Associate	15855163, 26774260
Neoplasms	Associate	26774260