Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8495
Gene name Gene Name - the full gene name approved by the HGNC.	PPFIB scaffold protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PPFIBP2
Synonyms (NCBI Gene) Gene synonyms aliases	Cclp1
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11p15.4
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. The encoded protein is a beta liprin and plays a role in axon guidance and neuronal synapse development by recruiting LAR protein-tyrosine phosphatases

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miRTarBase ID	miRNA	Experiments
MIRT1252593	hsa-miR-124	CLIP-seq
MIRT1252594	hsa-miR-3714	CLIP-seq
MIRT1252595	hsa-miR-3910	CLIP-seq
MIRT1252596	hsa-miR-506	CLIP-seq
MIRT2074413	hsa-miR-1208	CLIP-seq
MIRT2074414	hsa-miR-668	CLIP-seq
MIRT2301318	hsa-miR-1206	CLIP-seq
MIRT2074413	hsa-miR-1208	CLIP-seq
MIRT1252593	hsa-miR-124	CLIP-seq
MIRT2301319	hsa-miR-1294	CLIP-seq
MIRT2301320	hsa-miR-3607-5p	CLIP-seq
MIRT2301321	hsa-miR-3692	CLIP-seq
MIRT1252594	hsa-miR-3714	CLIP-seq
MIRT2301322	hsa-miR-3907	CLIP-seq
MIRT1252595	hsa-miR-3910	CLIP-seq
MIRT2301323	hsa-miR-4318	CLIP-seq
MIRT2301324	hsa-miR-4436b-5p	CLIP-seq
MIRT2301325	hsa-miR-4699-5p	CLIP-seq
MIRT2301326	hsa-miR-4706	CLIP-seq
MIRT2301327	hsa-miR-4710	CLIP-seq
MIRT2301328	hsa-miR-4749-5p	CLIP-seq
MIRT2301329	hsa-miR-4787-5p	CLIP-seq
MIRT1252596	hsa-miR-506	CLIP-seq
MIRT2301330	hsa-miR-548q	CLIP-seq
MIRT2074414	hsa-miR-668	CLIP-seq
MIRT2301331	hsa-miR-744	CLIP-seq
MIRT2598107	hsa-miR-1287	CLIP-seq
MIRT2598108	hsa-miR-1915	CLIP-seq
MIRT2598109	hsa-miR-302f	CLIP-seq
MIRT2598110	hsa-miR-3135b	CLIP-seq
MIRT2598111	hsa-miR-3136-3p	CLIP-seq
MIRT2598112	hsa-miR-4731-3p	CLIP-seq
MIRT2598113	hsa-miR-4801	CLIP-seq
MIRT2598107	hsa-miR-1287	CLIP-seq
MIRT2598108	hsa-miR-1915	CLIP-seq
MIRT2598109	hsa-miR-302f	CLIP-seq
MIRT2598110	hsa-miR-3135b	CLIP-seq
MIRT2598111	hsa-miR-3136-3p	CLIP-seq
MIRT2598112	hsa-miR-4731-3p	CLIP-seq
MIRT2598113	hsa-miR-4801	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	19447967, 26871637, 32296183
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005829	Component	Cytosol	TAS
GO:0007528	Process	Neuromuscular junction development	IBA	21873635
GO:0042802	Function	Identical protein binding	IDA	21462929
GO:0048786	Component	Presynaptic active zone	IBA	21873635
GO:0050808	Process	Synapse organization	IBA	21873635

MIM	HGNC	e!Ensembl
603142	9250	ENSG00000166387

Protein

UniProt ID

Q8ND30

Protein name

Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2)

Protein function

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.

PDB

3QH9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00536	SAM_1	556 → 620	SAM domain (Sterile alpha motif)	Domain
PF00536	SAM_1	631 → 691	SAM domain (Sterile alpha motif)	Domain
PF07647	SAM_2	715 → 785	SAM domain (Sterile alpha motif)	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:9624153}.

Sequence

MASDASHALEAALEQMDGIIAGTKTGADLSDGTCEPGLASPASYMNPFPVLHLIEDLRLA
LEMLELPQERAALLSQIPGPTAAYIKEWFEESLSQVNHHSAASNETYQERLARLEGDKES
LILQVSVLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEMLQQELLSRTSLETQKLDLMTE
VSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQYEWKLKATKAEV
AQLQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRI
EELTGLLNQYRKVKEIVMVTQGPSERTLSINEEEPEGGFSKWNATNKDPEELFKQEMPPR
CSSPTVGPPPLPQKSLETRAQKKLSCSLEDLRSESVDKCMDGNQPFPVLEPKDSPFLAEH
KYPTLPGKLSGATPNGEAAKSPPTICQPDATGSSLLRLRDTESGWDDTAVVNDLSSTSSG
TESGPQSPLTPDGKRNPKGIKKFWGKIRRTQSGNFYTDTLGMAEFRRGGLRATAGPRLSR
TRDSKGQKSDANAPFAQWSTERVCAWLEDFGLAQYVIFARQWVSSGHTLLTATPQDMEKE
LGIKHPLHRKKLVLAVKAINTKQEEKSALLDHIWVTRWLDDIGLPQYKDQFHESRVDRRM
LQYLTVNDLLFLKVTSQLHHLSIKCAIHVLHVNKFNPHCLHRRPADESNLSPSEVVQWSN
HRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLRRHLTTK
FNALIGPEAEQEKREKMASPAYTPLTTTAKVRPRKLGFSHFGNIRKKKFDESTDYICPME
PSDGVSDSHRVYSGYRGLSPLDAPELDGLDQVGQIS

Sequence length

876

Interactions

View interactions

	Reactome
			Receptor-type tyrosine-protein phosphatases

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Prostate cancer	Malignant neoplasm of prostate, Prostate carcinoma, Prostate cancer, familial	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	26443449, 29892016
Prostate cancer, hereditary	PROSTATE CANCER, HEREDITARY, 1	rs387906327, rs193929331, rs74315365, rs397516896, rs794729219, rs121913349, rs587782641, rs1114167673, rs1597371666, rs2073394466	29892016

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Dementia	Dementia	GWAS
Renal Carcinoma	Renal Carcinoma	GWAS

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Biliary Tract Neoplasms	Associate	37330435
Carotid Body Tumor	Associate	30967136
Cholangiocarcinoma	Associate	15855163, 26774260
Neoplasms	Associate	26774260

PPFIBP2 (PPFIB scaffold protein 2)