ATG4C (autophagy related 4C cysteine peptidase)

Gene

• Entrez ID: 84938
• Gene name: Autophagy related 4C cysteine peptidase
• Gene symbol: ATG4C
• Synonyms (NCBI Gene): APG4-C, APG4C, AUTL1, AUTL3, HsAPG4C
• Chromosome: 1
• Chromosome location: 1p31.3
• Summary: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT052446	hsa-let-7a-5p	CLASH	23622248
MIRT052951	hsa-miR-376b-3p	Immunoblot, Luciferase reporter assay, qRT-PCR	22248718
MIRT052951	hsa-miR-376b-3p	5.0	22248718
MIRT052951	hsa-miR-376b-3p	5.0	22248718
MIRT438047	hsa-miR-376a-3p	Luciferase reporter assay, Western blot	24358205
MIRT438047	hsa-miR-376a-3p	Luciferase reporter assay, Western blot	24358205
MIRT438047	hsa-miR-376a-3p	Luciferase reporter assay, Western blot	24358205
MIRT438047	hsa-miR-376a-3p	Luciferase reporter assay, Western blot	24358205
MIRT438047	hsa-miR-376a-3p	Luciferase reporter assay, Western blot	24358205
MIRT438047	hsa-miR-376a-3p	Luciferase reporter assay, Western blot	24358205
MIRT805532	hsa-miR-3591-3p	CLIP-seq
MIRT805533	hsa-miR-3927	CLIP-seq
MIRT805534	hsa-miR-410	CLIP-seq
MIRT805535	hsa-miR-4251	CLIP-seq
MIRT805536	hsa-miR-4650-3p	CLIP-seq
MIRT805537	hsa-miR-4738-3p	CLIP-seq
MIRT805538	hsa-miR-4799-5p	CLIP-seq
MIRT805539	hsa-miR-548ag	CLIP-seq
MIRT805540	hsa-miR-548ai	CLIP-seq
MIRT805541	hsa-miR-580	CLIP-seq
MIRT805542	hsa-miR-582-5p	CLIP-seq
MIRT805543	hsa-miR-600	CLIP-seq
MIRT1937878	hsa-miR-3163	CLIP-seq
MIRT1937879	hsa-miR-4719	CLIP-seq
MIRT2480811	hsa-miR-1275	CLIP-seq
MIRT2480812	hsa-miR-4260	CLIP-seq
MIRT2480813	hsa-miR-4525	CLIP-seq
MIRT2480814	hsa-miR-4665-5p	CLIP-seq
MIRT1937879	hsa-miR-4719	CLIP-seq
MIRT2480815	hsa-miR-4723-5p	CLIP-seq
MIRT2480816	hsa-miR-4728-5p	CLIP-seq
MIRT805537	hsa-miR-4738-3p	CLIP-seq
MIRT2480817	hsa-miR-625	CLIP-seq
MIRT2480818	hsa-miR-889	CLIP-seq
MIRT2480819	hsa-miR-9	CLIP-seq
MIRT2480811	hsa-miR-1275	CLIP-seq
MIRT2675584	hsa-miR-146a	CLIP-seq
MIRT2675585	hsa-miR-146b-5p	CLIP-seq
MIRT2480812	hsa-miR-4260	CLIP-seq
MIRT2480813	hsa-miR-4525	CLIP-seq
MIRT2480814	hsa-miR-4665-5p	CLIP-seq
MIRT1937879	hsa-miR-4719	CLIP-seq
MIRT2480815	hsa-miR-4723-5p	CLIP-seq
MIRT2480816	hsa-miR-4728-5p	CLIP-seq
MIRT805537	hsa-miR-4738-3p	CLIP-seq
MIRT2675586	hsa-miR-589	CLIP-seq
MIRT2480817	hsa-miR-625	CLIP-seq
MIRT2480818	hsa-miR-889	CLIP-seq
MIRT2480819	hsa-miR-9	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000045	Process	Autophagosome assembly	IBA
GO:0000045	Process	Autophagosome assembly	IDA	21177865
GO:0000045	Process	Autophagosome assembly	IMP	24290141
GO:0000423	Process	Mitophagy	IBA
GO:0004197	Function	Cysteine-type endopeptidase activity	IBA
GO:0004197	Function	Cysteine-type endopeptidase activity	IDA	21177865
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006508	Process	Proteolysis	IDA	21177865
GO:0006508	Process	Proteolysis	IEA
GO:0006914	Process	Autophagy	IDA	30661429
GO:0006914	Process	Autophagy	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IDA	21177865, 30661429
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016485	Process	Protein processing	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019786	Function	Protein-phosphatidylethanolamide deconjugating activity	IBA
GO:0019786	Function	Protein-phosphatidylethanolamide deconjugating activity	IEA
GO:0034727	Process	Piecemeal microautophagy of the nucleus	IBA
GO:0035973	Process	Aggrephagy	IBA
GO:0051697	Process	Protein delipidation	IDA	29458288

Other IDs

• MIM: 611339
• HGNC: 16040
• e!Ensembl: ENSG00000125703

Protein

• UniProt ID: Q96DT6
• Protein name: Cysteine protease ATG4C (EC 3.4.22.-) (AUT-like 3 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 3) (Autophagin-3) (Autophagy-related protein 4 homolog C) (HsAPG4C)
• Protein function: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:21177865, PubMed:29458288, PubMed:30661429). The protease activity is required for proteolytic activat
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03416	Peptidase_C54	76 → 400	Peptidase family C54	Family

• Sequence:

  MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP
  AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL
  AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE
  TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI
  LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE
  RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF
  PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN
  GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL

• Sequence length: 458

Pathways

KEGG:

Autophagy - other
Autophagy - animal

Reactome:

Macroautophagy