MASTL (microtubule associated serine/threonine kinase like)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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84930 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Microtubule associated serine/threonine kinase like |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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MASTL |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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GREATWALL, GW, GWL, MAST-L, THC2 |
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Chromosome
Chromosome number
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10 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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10p12.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | Q96GX5 | |||||||||||||||
| Protein name | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | |||||||||||||||
| Protein function | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit P | |||||||||||||||
| PDB | 5LOH , 8V5H | |||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 879 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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