Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84920
Gene name Gene Name - the full gene name approved by the HGNC.	ALG10 alpha-1,2-glucosyltransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ALG10
Synonyms (NCBI Gene) Gene synonyms aliases	ALG10A, DIE2, KCR1
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12p11.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the l

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SNP ID	Visualize variation	Clinical significance	Consequence
rs121908850	G>A,T	Risk-factor	Coding sequence variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024467	hsa-miR-215-5p	Microarray	19074876
MIRT026608	hsa-miR-192-5p	Microarray	19074876
MIRT777902	hsa-miR-1182	CLIP-seq
MIRT777903	hsa-miR-122	CLIP-seq
MIRT777904	hsa-miR-1269	CLIP-seq
MIRT777905	hsa-miR-1269b	CLIP-seq
MIRT777906	hsa-miR-1276	CLIP-seq
MIRT777907	hsa-miR-1288	CLIP-seq
MIRT777908	hsa-miR-1294	CLIP-seq
MIRT777909	hsa-miR-151-3p	CLIP-seq
MIRT777910	hsa-miR-1827	CLIP-seq
MIRT777911	hsa-miR-188-3p	CLIP-seq
MIRT777912	hsa-miR-193a-5p	CLIP-seq
MIRT777913	hsa-miR-25	CLIP-seq
MIRT777914	hsa-miR-2964a-3p	CLIP-seq
MIRT777915	hsa-miR-30a	CLIP-seq
MIRT777916	hsa-miR-30b	CLIP-seq
MIRT777917	hsa-miR-30c	CLIP-seq
MIRT777918	hsa-miR-30d	CLIP-seq
MIRT777919	hsa-miR-30e	CLIP-seq
MIRT777920	hsa-miR-3117-5p	CLIP-seq
MIRT777921	hsa-miR-3145-5p	CLIP-seq
MIRT777922	hsa-miR-3176	CLIP-seq
MIRT777923	hsa-miR-32	CLIP-seq
MIRT777924	hsa-miR-338-5p	CLIP-seq
MIRT777925	hsa-miR-3607-5p	CLIP-seq
MIRT777926	hsa-miR-3613-3p	CLIP-seq
MIRT777927	hsa-miR-3618	CLIP-seq
MIRT777928	hsa-miR-363	CLIP-seq
MIRT777929	hsa-miR-3647-3p	CLIP-seq
MIRT777930	hsa-miR-365	CLIP-seq
MIRT777931	hsa-miR-367	CLIP-seq
MIRT777932	hsa-miR-3688-3p	CLIP-seq
MIRT777933	hsa-miR-374c	CLIP-seq
MIRT777934	hsa-miR-3915	CLIP-seq
MIRT777935	hsa-miR-3922-3p	CLIP-seq
MIRT777936	hsa-miR-3928	CLIP-seq
MIRT777937	hsa-miR-4252	CLIP-seq
MIRT777938	hsa-miR-4272	CLIP-seq
MIRT777939	hsa-miR-4275	CLIP-seq
MIRT777940	hsa-miR-4292	CLIP-seq
MIRT777941	hsa-miR-4316	CLIP-seq
MIRT777942	hsa-miR-4325	CLIP-seq
MIRT777943	hsa-miR-4330	CLIP-seq
MIRT777944	hsa-miR-4463	CLIP-seq
MIRT777945	hsa-miR-4470	CLIP-seq
MIRT777946	hsa-miR-4494	CLIP-seq
MIRT777947	hsa-miR-450b-5p	CLIP-seq
MIRT777948	hsa-miR-4515	CLIP-seq
MIRT777949	hsa-miR-4528	CLIP-seq
MIRT777950	hsa-miR-4639-5p	CLIP-seq
MIRT777951	hsa-miR-4646-5p	CLIP-seq
MIRT777952	hsa-miR-4666-3p	CLIP-seq
MIRT777953	hsa-miR-4677-3p	CLIP-seq
MIRT777954	hsa-miR-4691-3p	CLIP-seq
MIRT777955	hsa-miR-4699-5p	CLIP-seq
MIRT777956	hsa-miR-4733-5p	CLIP-seq
MIRT777957	hsa-miR-4740-5p	CLIP-seq
MIRT777958	hsa-miR-4747-5p	CLIP-seq
MIRT777959	hsa-miR-4757-5p	CLIP-seq
MIRT777960	hsa-miR-4777-5p	CLIP-seq
MIRT777961	hsa-miR-4803	CLIP-seq
MIRT777962	hsa-miR-490-5p	CLIP-seq
MIRT777963	hsa-miR-507	CLIP-seq
MIRT777964	hsa-miR-508-3p	CLIP-seq
MIRT777965	hsa-miR-510	CLIP-seq
MIRT777966	hsa-miR-512-5p	CLIP-seq
MIRT777967	hsa-miR-518d-5p	CLIP-seq
MIRT777968	hsa-miR-519b-5p	CLIP-seq
MIRT777969	hsa-miR-519c-5p	CLIP-seq
MIRT777970	hsa-miR-520c-5p	CLIP-seq
MIRT777971	hsa-miR-526a	CLIP-seq
MIRT777972	hsa-miR-548aa	CLIP-seq
MIRT777973	hsa-miR-548ac	CLIP-seq
MIRT777974	hsa-miR-548c-3p	CLIP-seq
MIRT777975	hsa-miR-548d-3p	CLIP-seq
MIRT777976	hsa-miR-548l	CLIP-seq
MIRT777977	hsa-miR-548n	CLIP-seq
MIRT777978	hsa-miR-548z	CLIP-seq
MIRT777979	hsa-miR-557	CLIP-seq
MIRT777980	hsa-miR-579	CLIP-seq
MIRT777981	hsa-miR-655	CLIP-seq
MIRT777982	hsa-miR-662	CLIP-seq
MIRT777983	hsa-miR-671-5p	CLIP-seq
MIRT777984	hsa-miR-802	CLIP-seq
MIRT777985	hsa-miR-92a	CLIP-seq
MIRT777986	hsa-miR-92b	CLIP-seq
MIRT777987	hsa-miR-934	CLIP-seq
MIRT777903	hsa-miR-122	CLIP-seq
MIRT777908	hsa-miR-1294	CLIP-seq
MIRT1929637	hsa-miR-145	CLIP-seq
MIRT777909	hsa-miR-151-3p	CLIP-seq
MIRT777910	hsa-miR-1827	CLIP-seq
MIRT1929638	hsa-miR-1912	CLIP-seq
MIRT777912	hsa-miR-193a-5p	CLIP-seq
MIRT1929639	hsa-miR-3064-3p	CLIP-seq
MIRT777915	hsa-miR-30a	CLIP-seq
MIRT777916	hsa-miR-30b	CLIP-seq
MIRT777917	hsa-miR-30c	CLIP-seq
MIRT777918	hsa-miR-30d	CLIP-seq
MIRT777919	hsa-miR-30e	CLIP-seq
MIRT777920	hsa-miR-3117-5p	CLIP-seq
MIRT1929640	hsa-miR-3130-5p	CLIP-seq
MIRT777922	hsa-miR-3176	CLIP-seq
MIRT1929641	hsa-miR-3613-5p	CLIP-seq
MIRT777929	hsa-miR-3647-3p	CLIP-seq
MIRT777932	hsa-miR-3688-3p	CLIP-seq
MIRT777934	hsa-miR-3915	CLIP-seq
MIRT777935	hsa-miR-3922-3p	CLIP-seq
MIRT777936	hsa-miR-3928	CLIP-seq
MIRT777937	hsa-miR-4252	CLIP-seq
MIRT1929642	hsa-miR-4264	CLIP-seq
MIRT777939	hsa-miR-4275	CLIP-seq
MIRT1929643	hsa-miR-4277	CLIP-seq
MIRT777940	hsa-miR-4292	CLIP-seq
MIRT1929644	hsa-miR-4307	CLIP-seq
MIRT777941	hsa-miR-4316	CLIP-seq
MIRT777942	hsa-miR-4325	CLIP-seq
MIRT1929645	hsa-miR-4328	CLIP-seq
MIRT777944	hsa-miR-4463	CLIP-seq
MIRT777945	hsa-miR-4470	CLIP-seq
MIRT1929646	hsa-miR-4482	CLIP-seq
MIRT777946	hsa-miR-4494	CLIP-seq
MIRT777947	hsa-miR-450b-5p	CLIP-seq
MIRT1929647	hsa-miR-4517	CLIP-seq
MIRT777951	hsa-miR-4646-5p	CLIP-seq
MIRT777953	hsa-miR-4677-3p	CLIP-seq
MIRT777955	hsa-miR-4699-5p	CLIP-seq
MIRT1929648	hsa-miR-4712-5p	CLIP-seq
MIRT1929649	hsa-miR-4715-3p	CLIP-seq
MIRT777958	hsa-miR-4747-5p	CLIP-seq
MIRT777959	hsa-miR-4757-5p	CLIP-seq
MIRT1929650	hsa-miR-4775	CLIP-seq
MIRT1929651	hsa-miR-4776-3p	CLIP-seq
MIRT1929652	hsa-miR-4797-3p	CLIP-seq
MIRT777961	hsa-miR-4803	CLIP-seq
MIRT777963	hsa-miR-507	CLIP-seq
MIRT777972	hsa-miR-548aa	CLIP-seq
MIRT777973	hsa-miR-548ac	CLIP-seq
MIRT777975	hsa-miR-548d-3p	CLIP-seq
MIRT777978	hsa-miR-548z	CLIP-seq
MIRT777979	hsa-miR-557	CLIP-seq
MIRT777980	hsa-miR-579	CLIP-seq
MIRT1929653	hsa-miR-600	CLIP-seq
MIRT777983	hsa-miR-671-5p	CLIP-seq
MIRT1929654	hsa-miR-770-5p	CLIP-seq
MIRT1929655	hsa-miR-890	CLIP-seq
MIRT777902	hsa-miR-1182	CLIP-seq
MIRT777903	hsa-miR-122	CLIP-seq
MIRT2170474	hsa-miR-1257	CLIP-seq
MIRT777908	hsa-miR-1294	CLIP-seq
MIRT777909	hsa-miR-151-3p	CLIP-seq
MIRT777910	hsa-miR-1827	CLIP-seq
MIRT777912	hsa-miR-193a-5p	CLIP-seq
MIRT777913	hsa-miR-25	CLIP-seq
MIRT777914	hsa-miR-2964a-3p	CLIP-seq
MIRT777915	hsa-miR-30a	CLIP-seq
MIRT777916	hsa-miR-30b	CLIP-seq
MIRT777917	hsa-miR-30c	CLIP-seq
MIRT777918	hsa-miR-30d	CLIP-seq
MIRT777919	hsa-miR-30e	CLIP-seq
MIRT777920	hsa-miR-3117-5p	CLIP-seq
MIRT777921	hsa-miR-3145-5p	CLIP-seq
MIRT777922	hsa-miR-3176	CLIP-seq
MIRT777923	hsa-miR-32	CLIP-seq
MIRT777925	hsa-miR-3607-5p	CLIP-seq
MIRT1929641	hsa-miR-3613-5p	CLIP-seq
MIRT2170475	hsa-miR-3620	CLIP-seq
MIRT777928	hsa-miR-363	CLIP-seq
MIRT777929	hsa-miR-3647-3p	CLIP-seq
MIRT777931	hsa-miR-367	CLIP-seq
MIRT777932	hsa-miR-3688-3p	CLIP-seq
MIRT777934	hsa-miR-3915	CLIP-seq
MIRT777935	hsa-miR-3922-3p	CLIP-seq
MIRT2170476	hsa-miR-3925-3p	CLIP-seq
MIRT777936	hsa-miR-3928	CLIP-seq
MIRT2170477	hsa-miR-3936	CLIP-seq
MIRT777939	hsa-miR-4275	CLIP-seq
MIRT777940	hsa-miR-4292	CLIP-seq
MIRT777941	hsa-miR-4316	CLIP-seq
MIRT777942	hsa-miR-4325	CLIP-seq
MIRT777943	hsa-miR-4330	CLIP-seq
MIRT777944	hsa-miR-4463	CLIP-seq
MIRT777945	hsa-miR-4470	CLIP-seq
MIRT2170478	hsa-miR-4477b	CLIP-seq
MIRT777946	hsa-miR-4494	CLIP-seq
MIRT777947	hsa-miR-450b-5p	CLIP-seq
MIRT2170479	hsa-miR-4511	CLIP-seq
MIRT777951	hsa-miR-4646-5p	CLIP-seq
MIRT777953	hsa-miR-4677-3p	CLIP-seq
MIRT777954	hsa-miR-4691-3p	CLIP-seq
MIRT777955	hsa-miR-4699-5p	CLIP-seq
MIRT2170480	hsa-miR-4705	CLIP-seq
MIRT2170481	hsa-miR-4712-3p	CLIP-seq
MIRT777959	hsa-miR-4757-5p	CLIP-seq
MIRT2170482	hsa-miR-4772-5p	CLIP-seq
MIRT777960	hsa-miR-4777-5p	CLIP-seq
MIRT777961	hsa-miR-4803	CLIP-seq
MIRT777962	hsa-miR-490-5p	CLIP-seq
MIRT777963	hsa-miR-507	CLIP-seq
MIRT777964	hsa-miR-508-3p	CLIP-seq
MIRT777965	hsa-miR-510	CLIP-seq
MIRT777966	hsa-miR-512-5p	CLIP-seq
MIRT777967	hsa-miR-518d-5p	CLIP-seq
MIRT777968	hsa-miR-519b-5p	CLIP-seq
MIRT777969	hsa-miR-519c-5p	CLIP-seq
MIRT777970	hsa-miR-520c-5p	CLIP-seq
MIRT777971	hsa-miR-526a	CLIP-seq
MIRT777972	hsa-miR-548aa	CLIP-seq
MIRT777973	hsa-miR-548ac	CLIP-seq
MIRT777975	hsa-miR-548d-3p	CLIP-seq
MIRT777976	hsa-miR-548l	CLIP-seq
MIRT777977	hsa-miR-548n	CLIP-seq
MIRT777978	hsa-miR-548z	CLIP-seq
MIRT777979	hsa-miR-557	CLIP-seq
MIRT777980	hsa-miR-579	CLIP-seq
MIRT2170483	hsa-miR-628-5p	CLIP-seq
MIRT777983	hsa-miR-671-5p	CLIP-seq
MIRT2170484	hsa-miR-766	CLIP-seq
MIRT777984	hsa-miR-802	CLIP-seq
MIRT1929655	hsa-miR-890	CLIP-seq
MIRT777985	hsa-miR-92a	CLIP-seq
MIRT777986	hsa-miR-92b	CLIP-seq
MIRT777908	hsa-miR-1294	CLIP-seq
MIRT777909	hsa-miR-151-3p	CLIP-seq
MIRT777920	hsa-miR-3117-5p	CLIP-seq
MIRT777922	hsa-miR-3176	CLIP-seq
MIRT777934	hsa-miR-3915	CLIP-seq
MIRT777935	hsa-miR-3922-3p	CLIP-seq
MIRT777936	hsa-miR-3928	CLIP-seq
MIRT777941	hsa-miR-4316	CLIP-seq
MIRT777946	hsa-miR-4494	CLIP-seq
MIRT777953	hsa-miR-4677-3p	CLIP-seq
MIRT777959	hsa-miR-4757-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006487	Process	Protein N-linked glycosylation	IBA
GO:0006488	Process	Dolichol-linked oligosaccharide biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0106073	Function	Dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity	IBA
GO:0106073	Function	Dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity	IEA

MIM	HGNC	e!Ensembl
618355	23162	ENSG00000139133

Protein

UniProt ID

Q5BKT4

Protein name

Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (EC 2.4.1.256) (Alpha-1,2-glucosyltransferase ALG10-A) (Alpha-2-glucosyltransferase ALG10-A) (Asparagine-linked glycosylation protein 10 homolog A)

Protein function

Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04922	DIE2_ALG10	31 → 427	DIE2/ALG10 family	Family

Sequence

MAQLEGYYFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQAQRYCEGHFSLSQWDP
MITTLPGLYLVSIGVIKPAIWIFGWSEHVVCSIGMLRFVNLLFSVGNFYLLYLLFCKVQP
RNKAASSIQRVLSTLTLAVFPTLYFFNFLYYTEAGSMFFTLFAYLMCLYGNHKTSAFLGF
CGFMFRQTNIIWAVFCAGNVIAQKLTEAWKTELQKKEDRLPPIKGPFAEFRKILQFLLAY
SMSFKNLSMLLLLTWPYILLGFLFCAFVVVNGGIVIGDRSSHEACLHFPQLFYFFSFTLF
FSFPHLLSPSKIKTFLSLVWKRRILFFVVTLVSVFLVWKFTYAHKYLLADNRHYTFYVWK
RVFQRYETVKYLLVPAYIFAGWSIADSLKSKSIFWNLMFFICLFTVIVPQKLLEFRYFIL
PYVIYRLNIPLPPTSRLICELSCYAVVNFITFFIFLNKTFQWPNSQDIQRFMW

Sequence length

473

Interactions

View interactions

	KEGG
	N-Glycan biosynthesis Metabolic pathways

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Long QT Syndrome	long qt syndrome 2	N/A	N/A	ClinVar

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Colorectal Neoplasms	Associate	35680565
Epileptic Encephalopathy Early Infantile 3	Associate	33798445
Neoplasms	Associate	36879254
Rectal Neoplasms	Associate	36879254

ALG10 (ALG10 alpha-1,2-glucosyltransferase)