PPP1R15B (protein phosphatase 1 regulatory subunit 15B)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 84919
Gene name Protein phosphatase 1 regulatory subunit 15B
Gene symbol PPP1R15B
Synonyms (NCBI Gene)
CREPMSSGM2
Chromosome 1
Chromosome location 1q32.1
Summary This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstre
miRNA miRNA information provided by mirtarbase database.
2097
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (2097)
miRTarBase ID miRNA Experiments Reference
MIRT016665 hsa-miR-425-5p Sequencing 20371350
MIRT020212 hsa-miR-130b-3p Sequencing 20371350
MIRT024204 hsa-miR-221-3p Sequencing 20371350
MIRT028000 hsa-miR-93-5p Sequencing 20371350
MIRT031169 hsa-miR-19b-3p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0000164 Component Protein phosphatase type 1 complex IBA
GO:0000164 Component Protein phosphatase type 1 complex IDA 26307080
GO:0000164 Component Protein phosphatase type 1 complex IEA
GO:0000164 Component Protein phosphatase type 1 complex ISS
GO:0001933 Process Negative regulation of protein phosphorylation IMP 26307080
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
613257 14951 ENSG00000158615
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5SWA1
Protein name Protein phosphatase 1 regulatory subunit 15B
Protein function Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.
PDB 4V0U , 4V0V , 4V0W , 4V0X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10472 CReP_N 1 → 410 Domain
PF10488 PP1c_bdg 413 → 699 Phosphatase-1 catalytic subunit binding region Domain
Sequence
Sequence length 713
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
20
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (4)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cervical cancer Benign; Likely benign rs199950235 RCV005903050
Microcephaly, short stature, and impaired glucose metabolism 2 Uncertain significance; Conflicting classifications of pathogenicity rs1008693335, rs869025335, rs1307686249, rs199600980, rs759915160 RCV005628355
RCV000207486
RCV003135124
RCV003130330
RCV000714871
PPP1R15B-related disorder Uncertain significance; Conflicting classifications of pathogenicity; Benign; Likely benign rs141538150, rs139539525, rs11799830, rs34146119, rs759915160, rs149785262, rs4492688, rs149427705, rs12094135, rs137955986 RCV003976218
RCV003906561
RCV003916547
RCV003984323
RCV003918154
RCV003926000
RCV003928418
RCV003910465
RCV003958277
RCV003953408
Thyroid cancer, nonmedullary, 1 Benign; Likely benign rs199950235 RCV005903051
Show/Hide Text Mining Associations (9)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Diabetes Gestational Associate 34190178
Diabetes Mellitus Associate 26159176
Genetic Diseases Inborn Associate 26307080
Growth Disorders Associate 26159176, 26307080
Insulinoma Associate 26159176
Intellectual Disability Associate 26159176, 26307080
Microcephaly Associate 26159176, 26307080
Neurologic Disease Infantile Multisystem with Osseous Fragility Associate 26159176
Wolcott Rallison syndrome Associate 26159176