PPP1R15B (protein phosphatase 1 regulatory subunit 15B)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
84919
Gene name Gene Name - the full gene name approved by the HGNC.
Protein phosphatase 1 regulatory subunit 15B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PPP1R15B
Synonyms (NCBI Gene) Gene synonyms aliases
CREP, MSSGM2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q32.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstre
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(2097)
miRTarBase ID miRNA Experiments Reference
MIRT016665 hsa-miR-425-5p Sequencing 20371350
MIRT020212 hsa-miR-130b-3p Sequencing 20371350
MIRT024204 hsa-miR-221-3p Sequencing 20371350
MIRT028000 hsa-miR-93-5p Sequencing 20371350
MIRT031169 hsa-miR-19b-3p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(17)
GO ID Ontology Definition Evidence Reference
GO:0000164 Component Protein phosphatase type 1 complex IBA
GO:0000164 Component Protein phosphatase type 1 complex IDA 26307080
GO:0000164 Component Protein phosphatase type 1 complex IEA
GO:0000164 Component Protein phosphatase type 1 complex ISS
GO:0001933 Process Negative regulation of protein phosphorylation IMP 26307080
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
613257 14951 ENSG00000158615
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q5SWA1
Protein name Protein phosphatase 1 regulatory subunit 15B
Protein function Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.
PDB 4V0U , 4V0V , 4V0W , 4V0X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10472 CReP_N 1 → 410 Domain
PF10488 PP1c_bdg 413 → 699 Phosphatase-1 catalytic subunit binding region Domain
Sequence
Sequence length 713
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Microcephaly, Short Stature, And Impaired Glucose Metabolism microcephaly, short stature, and impaired glucose metabolism 2 N/A N/A ClinVar
Microcephaly-Mild Intellectual Disability Diabetes Syndrome primary microcephaly-mild intellectual disability-young-onset diabetes syndrome N/A N/A GenCC
Show/Hide Text Mining Associations (9)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Diabetes Gestational Associate 34190178
Diabetes Mellitus Associate 26159176
Genetic Diseases Inborn Associate 26307080
Growth Disorders Associate 26159176, 26307080
Insulinoma Associate 26159176
Intellectual Disability Associate 26159176, 26307080
Microcephaly Associate 26159176, 26307080
Neurologic Disease Infantile Multisystem with Osseous Fragility Associate 26159176
Wolcott Rallison syndrome Associate 26159176