Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	84918
Gene name	LDL receptor related protein 11
Gene symbol	LRP11
Synonyms (NCBI Gene)	MANSC3bA350J20.3
Chromosome	6
Chromosome location	6q25.1

137

Show/Hide all (137)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023392	hsa-miR-122-5p	Microarray	17612493
MIRT039310	hsa-miR-425-5p	CLASH	23622248
MIRT037854	hsa-miR-455-3p	CLASH	23622248
MIRT1117787	hsa-miR-1178	CLIP-seq
MIRT1117788	hsa-miR-1200	CLIP-seq
MIRT1117789	hsa-miR-1273f	CLIP-seq
MIRT1117790	hsa-miR-143	CLIP-seq
MIRT1117791	hsa-miR-181a	CLIP-seq
MIRT1117792	hsa-miR-181b	CLIP-seq
MIRT1117793	hsa-miR-181c	CLIP-seq
MIRT1117794	hsa-miR-181d	CLIP-seq
MIRT1117795	hsa-miR-3065-5p	CLIP-seq
MIRT1117796	hsa-miR-3607-3p	CLIP-seq
MIRT1117797	hsa-miR-3613-3p	CLIP-seq
MIRT1117798	hsa-miR-3662	CLIP-seq
MIRT1117799	hsa-miR-3686	CLIP-seq
MIRT1117800	hsa-miR-421	CLIP-seq
MIRT1117801	hsa-miR-4262	CLIP-seq
MIRT1117802	hsa-miR-4272	CLIP-seq
MIRT1117803	hsa-miR-4282	CLIP-seq
MIRT1117804	hsa-miR-4324	CLIP-seq
MIRT1117805	hsa-miR-4506	CLIP-seq
MIRT1117806	hsa-miR-4652-3p	CLIP-seq
MIRT1117807	hsa-miR-4680-3p	CLIP-seq
MIRT1117808	hsa-miR-4708-5p	CLIP-seq
MIRT1117809	hsa-miR-4728-3p	CLIP-seq
MIRT1117810	hsa-miR-4770	CLIP-seq
MIRT1117811	hsa-miR-4793-5p	CLIP-seq
MIRT1117812	hsa-miR-4799-5p	CLIP-seq
MIRT1117813	hsa-miR-543	CLIP-seq
MIRT1117814	hsa-miR-544b	CLIP-seq
MIRT1117815	hsa-miR-548ag	CLIP-seq
MIRT1117816	hsa-miR-548ai	CLIP-seq
MIRT1117817	hsa-miR-548m	CLIP-seq
MIRT1117818	hsa-miR-758	CLIP-seq
MIRT2033299	hsa-miR-1179	CLIP-seq
MIRT2033300	hsa-miR-1271	CLIP-seq
MIRT2033301	hsa-miR-182	CLIP-seq
MIRT2033302	hsa-miR-1827	CLIP-seq
MIRT2033303	hsa-miR-3143	CLIP-seq
MIRT2033304	hsa-miR-3173-3p	CLIP-seq
MIRT2033305	hsa-miR-338-5p	CLIP-seq
MIRT2033306	hsa-miR-3612	CLIP-seq
MIRT2033307	hsa-miR-3622b-5p	CLIP-seq
MIRT2033308	hsa-miR-425	CLIP-seq
MIRT2033309	hsa-miR-4257	CLIP-seq
MIRT2033310	hsa-miR-4263	CLIP-seq
MIRT2033311	hsa-miR-4428	CLIP-seq
MIRT2033312	hsa-miR-4431	CLIP-seq
MIRT2033313	hsa-miR-4476	CLIP-seq
MIRT2033314	hsa-miR-4496	CLIP-seq
MIRT2033315	hsa-miR-4519	CLIP-seq
MIRT2033316	hsa-miR-4521	CLIP-seq
MIRT2033317	hsa-miR-4533	CLIP-seq
MIRT2033318	hsa-miR-4642	CLIP-seq
MIRT1117806	hsa-miR-4652-3p	CLIP-seq
MIRT2033319	hsa-miR-4691-3p	CLIP-seq
MIRT2033320	hsa-miR-4695-5p	CLIP-seq
MIRT2033321	hsa-miR-4757-3p	CLIP-seq
MIRT1117813	hsa-miR-543	CLIP-seq
MIRT2033322	hsa-miR-622	CLIP-seq
MIRT2033323	hsa-miR-650	CLIP-seq
MIRT2033324	hsa-miR-711	CLIP-seq
MIRT2033325	hsa-miR-96	CLIP-seq
MIRT2033302	hsa-miR-1827	CLIP-seq
MIRT2033304	hsa-miR-3173-3p	CLIP-seq
MIRT2033306	hsa-miR-3612	CLIP-seq
MIRT2033308	hsa-miR-425	CLIP-seq
MIRT2263660	hsa-miR-4274	CLIP-seq
MIRT2263661	hsa-miR-4300	CLIP-seq
MIRT2033311	hsa-miR-4428	CLIP-seq
MIRT1117805	hsa-miR-4506	CLIP-seq
MIRT2033315	hsa-miR-4519	CLIP-seq
MIRT2033316	hsa-miR-4521	CLIP-seq
MIRT2033319	hsa-miR-4691-3p	CLIP-seq
MIRT2033320	hsa-miR-4695-5p	CLIP-seq
MIRT2263662	hsa-miR-4709-5p	CLIP-seq
MIRT2263663	hsa-miR-4715-5p	CLIP-seq
MIRT1117811	hsa-miR-4793-5p	CLIP-seq
MIRT1117812	hsa-miR-4799-5p	CLIP-seq
MIRT2263664	hsa-miR-548ae	CLIP-seq
MIRT1117815	hsa-miR-548ag	CLIP-seq
MIRT1117816	hsa-miR-548ai	CLIP-seq
MIRT2263665	hsa-miR-548aj	CLIP-seq
MIRT2263666	hsa-miR-548am	CLIP-seq
MIRT1117817	hsa-miR-548m	CLIP-seq
MIRT2263667	hsa-miR-548x	CLIP-seq
MIRT2033322	hsa-miR-622	CLIP-seq
MIRT2033323	hsa-miR-650	CLIP-seq
MIRT2263668	hsa-miR-920	CLIP-seq
MIRT2033300	hsa-miR-1271	CLIP-seq
MIRT2033301	hsa-miR-182	CLIP-seq
MIRT2033307	hsa-miR-3622b-5p	CLIP-seq
MIRT2033318	hsa-miR-4642	CLIP-seq
MIRT2033325	hsa-miR-96	CLIP-seq
MIRT2033299	hsa-miR-1179	CLIP-seq
MIRT2562931	hsa-miR-1298	CLIP-seq
MIRT2033303	hsa-miR-3143	CLIP-seq
MIRT1117797	hsa-miR-3613-3p	CLIP-seq
MIRT2033310	hsa-miR-4263	CLIP-seq
MIRT1117803	hsa-miR-4282	CLIP-seq
MIRT2033312	hsa-miR-4431	CLIP-seq
MIRT2562932	hsa-miR-4719	CLIP-seq
MIRT2562933	hsa-miR-4775	CLIP-seq
MIRT1117812	hsa-miR-4799-5p	CLIP-seq
MIRT2562934	hsa-miR-513b	CLIP-seq
MIRT1117813	hsa-miR-543	CLIP-seq
MIRT2562935	hsa-miR-548g	CLIP-seq
MIRT2562936	hsa-miR-576-5p	CLIP-seq
MIRT2562937	hsa-miR-590-3p	CLIP-seq
MIRT2562938	hsa-miR-938	CLIP-seq
MIRT1117787	hsa-miR-1178	CLIP-seq
MIRT2562931	hsa-miR-1298	CLIP-seq
MIRT2684140	hsa-miR-1912	CLIP-seq
MIRT2684141	hsa-miR-3130-5p	CLIP-seq
MIRT2684142	hsa-miR-320a	CLIP-seq
MIRT2684143	hsa-miR-320b	CLIP-seq
MIRT2684144	hsa-miR-320c	CLIP-seq
MIRT2684145	hsa-miR-320d	CLIP-seq
MIRT1117797	hsa-miR-3613-3p	CLIP-seq
MIRT2684146	hsa-miR-3909	CLIP-seq
MIRT2033310	hsa-miR-4263	CLIP-seq
MIRT1117803	hsa-miR-4282	CLIP-seq
MIRT2684147	hsa-miR-4429	CLIP-seq
MIRT2684148	hsa-miR-4482	CLIP-seq
MIRT2684149	hsa-miR-4718	CLIP-seq
MIRT2562932	hsa-miR-4719	CLIP-seq
MIRT2562933	hsa-miR-4775	CLIP-seq
MIRT1117812	hsa-miR-4799-5p	CLIP-seq
MIRT2562934	hsa-miR-513b	CLIP-seq
MIRT2684150	hsa-miR-520d-5p	CLIP-seq
MIRT2684151	hsa-miR-524-5p	CLIP-seq
MIRT1117813	hsa-miR-543	CLIP-seq
MIRT2562935	hsa-miR-548g	CLIP-seq
MIRT2562936	hsa-miR-576-5p	CLIP-seq
MIRT2562937	hsa-miR-590-3p	CLIP-seq
MIRT2562938	hsa-miR-938	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IC	17620599
GO:0009408	Process	Response to heat	IEA
GO:0009409	Process	Response to cold	IEA
GO:0009414	Process	Response to water deprivation	IEA
GO:0009612	Process	Response to mechanical stimulus	IEA
GO:0016020	Component	Membrane	IEA
GO:0033555	Process	Multicellular organismal response to stress	IEA
GO:0035902	Process	Response to immobilization stress	IEA
GO:0042594	Process	Response to starvation	IEA
GO:0051219	Function	Phosphoprotein binding	IMP	17620599

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q86VZ4

Protein name

Low-density lipoprotein receptor-related protein 11 (LRP-11)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07502	MANEC	87 → 183	MANEC domain	Domain
PF00057	Ldl_recept_a	308 → 344	Low-density lipoprotein receptor domain class A	Repeat

Sequence

MASVAQESAGSQRRLPPRHGALRGLLLLCLWLPSGRAALPPAAPLSELHAQLSGVEQLLE
EFRRQLQQERPQEELELELRAGGGPQEDCPGPGSGGYSAMPDAIIRTKDSLAAGASFLRA
PAAVRGWRQCVAACCSEPRCSVAVVELPRRPAPPAAVLGCYLFNCTARGRNVCKFALHSG
YSSYSLSRAPDGAALATARASPRQEKDAPPLSKAGQDVVLHLPTDGVVLDGRESTDDHAI
VQYEWALLQGDPSVDMKVPQSGTLKLSHLQEGTYTFQLTVTDTAGQRSSDNVSVTVLRAA
YSTGGCLHTCSRYHFFCDDGCCIDITLACDGVQQCPDGSDEDFCQNLGLDRKMVTHTAAS
PALPRTTGPSEDAGGDSLVEKSQKATAPNKPPALSNTEKRNHSAFWGPESQIIPVMPDSS
SSGKNRKEESYIFESKGDGGGGEHPAPETGAVLPLALGLAITALLLLMVACRLRLVKQKL
KKARPITSEESDYLINGMYL

Sequence length

500

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CONNECTIVE TISSUE DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIXED CONNECTIVE TISSUE DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	34868337	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	30008265, 36930084	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Associate	38203854	★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Insufficiency Chronic	Associate	37816758	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Associate	36930084	★★★★★ ★☆☆☆☆ Found in Text Mining only

LRP11 (LDL receptor related protein 11)