Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8491
Gene name Gene Name - the full gene name approved by the HGNC.	Mitogen-activated protein kinase kinase kinase kinase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MAP4K3
Synonyms (NCBI Gene) Gene synonyms aliases	GLK, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p22.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observ

Show/Hide all(324)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029966	hsa-miR-26b-5p	Microarray	19088304
MIRT054069	hsa-let-7c-5p	H157	23981581
MIRT054069	hsa-let-7c-5p	H157	23981581
MIRT054069	hsa-let-7c-5p	Luciferase reporter assay, qRT-PCR, Western blot	28099144
MIRT054069	hsa-let-7c-5p	Luciferase reporter assay, qRT-PCR, Western blot	28099144
MIRT1129428	hsa-let-7a	CLIP-seq
MIRT1129429	hsa-let-7b	CLIP-seq
MIRT1129430	hsa-let-7c	CLIP-seq
MIRT1129431	hsa-let-7d	CLIP-seq
MIRT1129432	hsa-let-7e	CLIP-seq
MIRT1129433	hsa-let-7f	CLIP-seq
MIRT1129434	hsa-let-7g	CLIP-seq
MIRT1129435	hsa-let-7i	CLIP-seq
MIRT1129436	hsa-miR-1	CLIP-seq
MIRT1129437	hsa-miR-1184	CLIP-seq
MIRT1129438	hsa-miR-1202	CLIP-seq
MIRT1129439	hsa-miR-1301	CLIP-seq
MIRT1129440	hsa-miR-1323	CLIP-seq
MIRT1129441	hsa-miR-142-3p	CLIP-seq
MIRT1129442	hsa-miR-1914	CLIP-seq
MIRT1129443	hsa-miR-196a	CLIP-seq
MIRT1129444	hsa-miR-196b	CLIP-seq
MIRT1129445	hsa-miR-199b-5p	CLIP-seq
MIRT1129446	hsa-miR-19a	CLIP-seq
MIRT1129447	hsa-miR-19b	CLIP-seq
MIRT1129448	hsa-miR-200b	CLIP-seq
MIRT1129449	hsa-miR-200c	CLIP-seq
MIRT1129450	hsa-miR-202	CLIP-seq
MIRT1129451	hsa-miR-203	CLIP-seq
MIRT1129452	hsa-miR-206	CLIP-seq
MIRT1129453	hsa-miR-2113	CLIP-seq
MIRT1129454	hsa-miR-2116	CLIP-seq
MIRT1129455	hsa-miR-217	CLIP-seq
MIRT1129456	hsa-miR-27a	CLIP-seq
MIRT1129457	hsa-miR-27b	CLIP-seq
MIRT1129458	hsa-miR-297	CLIP-seq
MIRT1129459	hsa-miR-3129-3p	CLIP-seq
MIRT1129460	hsa-miR-3140-3p	CLIP-seq
MIRT1129461	hsa-miR-3149	CLIP-seq
MIRT1129462	hsa-miR-3174	CLIP-seq
MIRT1129463	hsa-miR-3187-3p	CLIP-seq
MIRT1129464	hsa-miR-3194-5p	CLIP-seq
MIRT1129465	hsa-miR-324-5p	CLIP-seq
MIRT1129466	hsa-miR-330-3p	CLIP-seq
MIRT1129467	hsa-miR-338-3p	CLIP-seq
MIRT1129468	hsa-miR-338-5p	CLIP-seq
MIRT1129469	hsa-miR-33a	CLIP-seq
MIRT1129470	hsa-miR-33b	CLIP-seq
MIRT1129471	hsa-miR-3591-3p	CLIP-seq
MIRT1129472	hsa-miR-3591-5p	CLIP-seq
MIRT1129473	hsa-miR-3606	CLIP-seq
MIRT1129474	hsa-miR-3617	CLIP-seq
MIRT1129475	hsa-miR-3673	CLIP-seq
MIRT1129476	hsa-miR-3688-3p	CLIP-seq
MIRT1129477	hsa-miR-374c	CLIP-seq
MIRT1129478	hsa-miR-3972	CLIP-seq
MIRT1129479	hsa-miR-409-3p	CLIP-seq
MIRT1129480	hsa-miR-4255	CLIP-seq
MIRT1129481	hsa-miR-4276	CLIP-seq
MIRT1129482	hsa-miR-4277	CLIP-seq
MIRT1129483	hsa-miR-4282	CLIP-seq
MIRT1129484	hsa-miR-429	CLIP-seq
MIRT1129485	hsa-miR-4302	CLIP-seq
MIRT1129486	hsa-miR-4317	CLIP-seq
MIRT1129487	hsa-miR-4320	CLIP-seq
MIRT1129488	hsa-miR-4418	CLIP-seq
MIRT1129489	hsa-miR-4424	CLIP-seq
MIRT1129490	hsa-miR-4435	CLIP-seq
MIRT1129491	hsa-miR-4458	CLIP-seq
MIRT1129492	hsa-miR-4500	CLIP-seq
MIRT1129493	hsa-miR-4528	CLIP-seq
MIRT1129494	hsa-miR-4529-5p	CLIP-seq
MIRT1129495	hsa-miR-4536	CLIP-seq
MIRT1129496	hsa-miR-4639-3p	CLIP-seq
MIRT1129497	hsa-miR-4660	CLIP-seq
MIRT1129498	hsa-miR-4677-5p	CLIP-seq
MIRT1129499	hsa-miR-4679	CLIP-seq
MIRT1129500	hsa-miR-4684-3p	CLIP-seq
MIRT1129501	hsa-miR-4700-3p	CLIP-seq
MIRT1129502	hsa-miR-4701-5p	CLIP-seq
MIRT1129503	hsa-miR-4777-5p	CLIP-seq
MIRT1129504	hsa-miR-498	CLIP-seq
MIRT1129505	hsa-miR-499-3p	CLIP-seq
MIRT1129506	hsa-miR-499a-3p	CLIP-seq
MIRT1129507	hsa-miR-5047	CLIP-seq
MIRT1129508	hsa-miR-509-3-5p	CLIP-seq
MIRT1129509	hsa-miR-5095	CLIP-seq
MIRT1129510	hsa-miR-509-5p	CLIP-seq
MIRT1129511	hsa-miR-513a-5p	CLIP-seq
MIRT1129512	hsa-miR-518d-5p	CLIP-seq
MIRT1129513	hsa-miR-519b-5p	CLIP-seq
MIRT1129514	hsa-miR-519c-5p	CLIP-seq
MIRT1129515	hsa-miR-520c-5p	CLIP-seq
MIRT1129516	hsa-miR-520d-5p	CLIP-seq
MIRT1129517	hsa-miR-524-5p	CLIP-seq
MIRT1129518	hsa-miR-526a	CLIP-seq
MIRT1129519	hsa-miR-539	CLIP-seq
MIRT1129520	hsa-miR-548o	CLIP-seq
MIRT1129521	hsa-miR-548s	CLIP-seq
MIRT1129522	hsa-miR-582-5p	CLIP-seq
MIRT1129523	hsa-miR-588	CLIP-seq
MIRT1129524	hsa-miR-600	CLIP-seq
MIRT1129525	hsa-miR-613	CLIP-seq
MIRT1129526	hsa-miR-641	CLIP-seq
MIRT1129527	hsa-miR-655	CLIP-seq
MIRT1129528	hsa-miR-802	CLIP-seq
MIRT1129529	hsa-miR-873	CLIP-seq
MIRT1129530	hsa-miR-885-5p	CLIP-seq
MIRT1129531	hsa-miR-921	CLIP-seq
MIRT1129532	hsa-miR-944	CLIP-seq
MIRT1129533	hsa-miR-98	CLIP-seq
MIRT1129436	hsa-miR-1	CLIP-seq
MIRT1129438	hsa-miR-1202	CLIP-seq
MIRT2036913	hsa-miR-1273g	CLIP-seq
MIRT1129441	hsa-miR-142-3p	CLIP-seq
MIRT1129448	hsa-miR-200b	CLIP-seq
MIRT1129449	hsa-miR-200c	CLIP-seq
MIRT1129451	hsa-miR-203	CLIP-seq
MIRT1129452	hsa-miR-206	CLIP-seq
MIRT1129453	hsa-miR-2113	CLIP-seq
MIRT1129454	hsa-miR-2116	CLIP-seq
MIRT1129456	hsa-miR-27a	CLIP-seq
MIRT1129457	hsa-miR-27b	CLIP-seq
MIRT2036914	hsa-miR-3163	CLIP-seq
MIRT1129462	hsa-miR-3174	CLIP-seq
MIRT1129464	hsa-miR-3194-5p	CLIP-seq
MIRT1129465	hsa-miR-324-5p	CLIP-seq
MIRT1129467	hsa-miR-338-3p	CLIP-seq
MIRT1129469	hsa-miR-33a	CLIP-seq
MIRT1129470	hsa-miR-33b	CLIP-seq
MIRT1129472	hsa-miR-3591-5p	CLIP-seq
MIRT1129473	hsa-miR-3606	CLIP-seq
MIRT1129474	hsa-miR-3617	CLIP-seq
MIRT1129475	hsa-miR-3673	CLIP-seq
MIRT1129476	hsa-miR-3688-3p	CLIP-seq
MIRT1129478	hsa-miR-3972	CLIP-seq
MIRT1129479	hsa-miR-409-3p	CLIP-seq
MIRT1129480	hsa-miR-4255	CLIP-seq
MIRT1129481	hsa-miR-4276	CLIP-seq
MIRT1129482	hsa-miR-4277	CLIP-seq
MIRT1129484	hsa-miR-429	CLIP-seq
MIRT1129485	hsa-miR-4302	CLIP-seq
MIRT1129486	hsa-miR-4317	CLIP-seq
MIRT2036915	hsa-miR-4503	CLIP-seq
MIRT2036916	hsa-miR-4517	CLIP-seq
MIRT1129495	hsa-miR-4536	CLIP-seq
MIRT1129496	hsa-miR-4639-3p	CLIP-seq
MIRT2036917	hsa-miR-4670-3p	CLIP-seq
MIRT1129498	hsa-miR-4677-5p	CLIP-seq
MIRT1129500	hsa-miR-4684-3p	CLIP-seq
MIRT1129504	hsa-miR-498	CLIP-seq
MIRT1129505	hsa-miR-499-3p	CLIP-seq
MIRT1129506	hsa-miR-499a-3p	CLIP-seq
MIRT1129511	hsa-miR-513a-5p	CLIP-seq
MIRT1129516	hsa-miR-520d-5p	CLIP-seq
MIRT1129517	hsa-miR-524-5p	CLIP-seq
MIRT2036918	hsa-miR-548n	CLIP-seq
MIRT2036919	hsa-miR-548t	CLIP-seq
MIRT1129522	hsa-miR-582-5p	CLIP-seq
MIRT1129525	hsa-miR-613	CLIP-seq
MIRT1129526	hsa-miR-641	CLIP-seq
MIRT1129530	hsa-miR-885-5p	CLIP-seq
MIRT1129531	hsa-miR-921	CLIP-seq
MIRT1129532	hsa-miR-944	CLIP-seq
MIRT1129436	hsa-miR-1	CLIP-seq
MIRT1129437	hsa-miR-1184	CLIP-seq
MIRT1129438	hsa-miR-1202	CLIP-seq
MIRT2036913	hsa-miR-1273g	CLIP-seq
MIRT1129439	hsa-miR-1301	CLIP-seq
MIRT2266971	hsa-miR-134	CLIP-seq
MIRT1129441	hsa-miR-142-3p	CLIP-seq
MIRT1129445	hsa-miR-199b-5p	CLIP-seq
MIRT1129446	hsa-miR-19a	CLIP-seq
MIRT1129447	hsa-miR-19b	CLIP-seq
MIRT2266972	hsa-miR-2054	CLIP-seq
MIRT1129452	hsa-miR-206	CLIP-seq
MIRT1129453	hsa-miR-2113	CLIP-seq
MIRT1129455	hsa-miR-217	CLIP-seq
MIRT2266973	hsa-miR-23a	CLIP-seq
MIRT2266974	hsa-miR-23b	CLIP-seq
MIRT2266975	hsa-miR-23c	CLIP-seq
MIRT2266976	hsa-miR-3118	CLIP-seq
MIRT1129460	hsa-miR-3140-3p	CLIP-seq
MIRT2266977	hsa-miR-3164	CLIP-seq
MIRT1129464	hsa-miR-3194-5p	CLIP-seq
MIRT1129465	hsa-miR-324-5p	CLIP-seq
MIRT1129467	hsa-miR-338-3p	CLIP-seq
MIRT1129471	hsa-miR-3591-3p	CLIP-seq
MIRT1129474	hsa-miR-3617	CLIP-seq
MIRT2266978	hsa-miR-3651	CLIP-seq
MIRT2266979	hsa-miR-3662	CLIP-seq
MIRT1129475	hsa-miR-3673	CLIP-seq
MIRT1129476	hsa-miR-3688-3p	CLIP-seq
MIRT1129477	hsa-miR-374c	CLIP-seq
MIRT2266980	hsa-miR-376c	CLIP-seq
MIRT1129478	hsa-miR-3972	CLIP-seq
MIRT2266981	hsa-miR-3977	CLIP-seq
MIRT1129479	hsa-miR-409-3p	CLIP-seq
MIRT1129480	hsa-miR-4255	CLIP-seq
MIRT1129481	hsa-miR-4276	CLIP-seq
MIRT1129482	hsa-miR-4277	CLIP-seq
MIRT1129485	hsa-miR-4302	CLIP-seq
MIRT1129486	hsa-miR-4317	CLIP-seq
MIRT1129488	hsa-miR-4418	CLIP-seq
MIRT1129495	hsa-miR-4536	CLIP-seq
MIRT1129496	hsa-miR-4639-3p	CLIP-seq
MIRT1129497	hsa-miR-4660	CLIP-seq
MIRT1129500	hsa-miR-4684-3p	CLIP-seq
MIRT1129504	hsa-miR-498	CLIP-seq
MIRT1129505	hsa-miR-499-3p	CLIP-seq
MIRT1129506	hsa-miR-499a-3p	CLIP-seq
MIRT1129507	hsa-miR-5047	CLIP-seq
MIRT1129508	hsa-miR-509-3-5p	CLIP-seq
MIRT1129510	hsa-miR-509-5p	CLIP-seq
MIRT1129522	hsa-miR-582-5p	CLIP-seq
MIRT1129525	hsa-miR-613	CLIP-seq
MIRT1129526	hsa-miR-641	CLIP-seq
MIRT1129527	hsa-miR-655	CLIP-seq
MIRT2266982	hsa-miR-758	CLIP-seq
MIRT1129528	hsa-miR-802	CLIP-seq
MIRT1129530	hsa-miR-885-5p	CLIP-seq
MIRT2266983	hsa-miR-935	CLIP-seq
MIRT1129532	hsa-miR-944	CLIP-seq
MIRT2266972	hsa-miR-2054	CLIP-seq
MIRT2266978	hsa-miR-3651	CLIP-seq
MIRT1129480	hsa-miR-4255	CLIP-seq
MIRT1129437	hsa-miR-1184	CLIP-seq
MIRT1129439	hsa-miR-1301	CLIP-seq
MIRT1129455	hsa-miR-217	CLIP-seq
MIRT1129460	hsa-miR-3140-3p	CLIP-seq
MIRT2430991	hsa-miR-3973	CLIP-seq
MIRT1129479	hsa-miR-409-3p	CLIP-seq
MIRT1129488	hsa-miR-4418	CLIP-seq
MIRT1129497	hsa-miR-4660	CLIP-seq
MIRT1129504	hsa-miR-498	CLIP-seq
MIRT1129507	hsa-miR-5047	CLIP-seq
MIRT1129508	hsa-miR-509-3-5p	CLIP-seq
MIRT1129510	hsa-miR-509-5p	CLIP-seq
MIRT1129516	hsa-miR-520d-5p	CLIP-seq
MIRT1129517	hsa-miR-524-5p	CLIP-seq
MIRT2430992	hsa-miR-548a-5p	CLIP-seq
MIRT2430993	hsa-miR-548ab	CLIP-seq
MIRT2430994	hsa-miR-548ak	CLIP-seq
MIRT2430995	hsa-miR-548b-5p	CLIP-seq
MIRT2430996	hsa-miR-548c-5p	CLIP-seq
MIRT2430997	hsa-miR-548d-5p	CLIP-seq
MIRT2430998	hsa-miR-548h	CLIP-seq
MIRT2430999	hsa-miR-548i	CLIP-seq
MIRT2431000	hsa-miR-548j	CLIP-seq
MIRT2431001	hsa-miR-548w	CLIP-seq
MIRT2431002	hsa-miR-548y	CLIP-seq
MIRT2431003	hsa-miR-559	CLIP-seq
MIRT1129530	hsa-miR-885-5p	CLIP-seq
MIRT1129516	hsa-miR-520d-5p	CLIP-seq
MIRT1129517	hsa-miR-524-5p	CLIP-seq
MIRT1129428	hsa-let-7a	CLIP-seq
MIRT1129429	hsa-let-7b	CLIP-seq
MIRT1129430	hsa-let-7c	CLIP-seq
MIRT1129431	hsa-let-7d	CLIP-seq
MIRT1129432	hsa-let-7e	CLIP-seq
MIRT1129433	hsa-let-7f	CLIP-seq
MIRT1129434	hsa-let-7g	CLIP-seq
MIRT1129435	hsa-let-7i	CLIP-seq
MIRT1129440	hsa-miR-1323	CLIP-seq
MIRT2266971	hsa-miR-134	CLIP-seq
MIRT1129442	hsa-miR-1914	CLIP-seq
MIRT1129443	hsa-miR-196a	CLIP-seq
MIRT1129444	hsa-miR-196b	CLIP-seq
MIRT1129448	hsa-miR-200b	CLIP-seq
MIRT1129449	hsa-miR-200c	CLIP-seq
MIRT1129450	hsa-miR-202	CLIP-seq
MIRT1129453	hsa-miR-2113	CLIP-seq
MIRT2566597	hsa-miR-224	CLIP-seq
MIRT1129458	hsa-miR-297	CLIP-seq
MIRT2266976	hsa-miR-3118	CLIP-seq
MIRT1129459	hsa-miR-3129-3p	CLIP-seq
MIRT1129461	hsa-miR-3149	CLIP-seq
MIRT2266977	hsa-miR-3164	CLIP-seq
MIRT1129463	hsa-miR-3187-3p	CLIP-seq
MIRT1129477	hsa-miR-374c	CLIP-seq
MIRT1129484	hsa-miR-429	CLIP-seq
MIRT1129490	hsa-miR-4435	CLIP-seq
MIRT1129491	hsa-miR-4458	CLIP-seq
MIRT1129492	hsa-miR-4500	CLIP-seq
MIRT2036916	hsa-miR-4517	CLIP-seq
MIRT1129493	hsa-miR-4528	CLIP-seq
MIRT1129494	hsa-miR-4529-5p	CLIP-seq
MIRT1129499	hsa-miR-4679	CLIP-seq
MIRT1129502	hsa-miR-4701-5p	CLIP-seq
MIRT1129516	hsa-miR-520d-5p	CLIP-seq
MIRT1129517	hsa-miR-524-5p	CLIP-seq
MIRT1129520	hsa-miR-548o	CLIP-seq
MIRT1129521	hsa-miR-548s	CLIP-seq
MIRT1129523	hsa-miR-588	CLIP-seq
MIRT1129527	hsa-miR-655	CLIP-seq
MIRT2266982	hsa-miR-758	CLIP-seq
MIRT1129528	hsa-miR-802	CLIP-seq
MIRT1129532	hsa-miR-944	CLIP-seq
MIRT1129533	hsa-miR-98	CLIP-seq
MIRT1129428	hsa-let-7a	CLIP-seq
MIRT1129429	hsa-let-7b	CLIP-seq
MIRT1129430	hsa-let-7c	CLIP-seq
MIRT1129431	hsa-let-7d	CLIP-seq
MIRT1129432	hsa-let-7e	CLIP-seq
MIRT1129433	hsa-let-7f	CLIP-seq
MIRT1129434	hsa-let-7g	CLIP-seq
MIRT1129435	hsa-let-7i	CLIP-seq
MIRT1129440	hsa-miR-1323	CLIP-seq
MIRT1129442	hsa-miR-1914	CLIP-seq
MIRT1129443	hsa-miR-196a	CLIP-seq
MIRT1129444	hsa-miR-196b	CLIP-seq
MIRT1129450	hsa-miR-202	CLIP-seq
MIRT1129458	hsa-miR-297	CLIP-seq
MIRT1129459	hsa-miR-3129-3p	CLIP-seq
MIRT1129461	hsa-miR-3149	CLIP-seq
MIRT1129491	hsa-miR-4458	CLIP-seq
MIRT1129492	hsa-miR-4500	CLIP-seq
MIRT1129493	hsa-miR-4528	CLIP-seq
MIRT1129499	hsa-miR-4679	CLIP-seq
MIRT1129516	hsa-miR-520d-5p	CLIP-seq
MIRT1129517	hsa-miR-524-5p	CLIP-seq
MIRT1129520	hsa-miR-548o	CLIP-seq
MIRT1129528	hsa-miR-802	CLIP-seq
MIRT1129533	hsa-miR-98	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	TAS	9275185
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	9275185
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	17474147, 20936779, 21983831, 32707033, 33961781
GO:0005524	Function	ATP binding	IDA	9275185
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0006468	Process	Protein phosphorylation	IDA	9275185
GO:0007254	Process	JNK cascade	TAS	9275185
GO:0008349	Function	MAP kinase kinase kinase kinase activity	IBA
GO:0008349	Function	MAP kinase kinase kinase kinase activity	IEA
GO:0009411	Process	Response to UV	IDA	9275185
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0034612	Process	Response to tumor necrosis factor	IDA	9275185
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IDA	9275185
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
604921	6865	ENSG00000011566

Protein

UniProt ID

Q8IVH8

Protein name

Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)

Protein function

Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (PubMed:9275185). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control

PDB

5J5T

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	16 → 273	Protein kinase domain	Domain
PF00780	CNH	566 → 864	CNH domain	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver. {ECO:0000269|PubMed:9275185}.

Sequence

MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ
EIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRET
LQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAP
EVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKM
KWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDF
DDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLD
SSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDD
ESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPP
PRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTP
KVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLF
PRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKF
SVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPC
PLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVT
QLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQG
RSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY

Sequence length

894

Interactions

View interactions

	KEGG
	MAPK signaling pathway

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Ependymoma	ependymoma	N/A	N/A	ClinVar

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Breast Neoplasms	Associate	26336805
Carcinoma Hepatocellular	Associate	27343552, 28099144, 31433582, 33204699
Carcinoma Non Small Cell Lung	Associate	30221690
Diabetes Gestational	Associate	34190178
Huntington Disease	Associate	33049985
Inflammation	Associate	22867055
Leukemia Myeloid Acute	Associate	31522654
Lupus Erythematosus Systemic	Associate	22867055, 34610951
Lymphoma Non Hodgkin	Associate	24548782
Multiple System Atrophy	Associate	27470294
Neoplasm Metastasis	Associate	28099144, 30221690
Neoplasms	Inhibit	19587239
Neoplasms	Associate	26553456, 27626165, 28489605
Pancreatic Neoplasms	Inhibit	19587239
Pancreatitis	Associate	19587239
Sezary Syndrome	Associate	28489605
Still's Disease Adult Onset	Stimulate	22867055
Synucleinopathies	Associate	27470294

MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3)