Gene Gene information from NCBI Gene database.
Entrez ID 84898
Gene name Plexin domain containing 2
Gene symbol PLXDC2
Synonyms (NCBI Gene)
PLXDC2-OTTEM7R
Chromosome 10
Chromosome location 10p12.31
miRNA miRNA information provided by mirtarbase database.
373
miRTarBase ID miRNA Experiments Reference
MIRT019264 hsa-miR-148b-3p Microarray 17612493
MIRT023594 hsa-miR-1-3p Proteomics 18668040
MIRT025068 hsa-miR-181a-5p Microarray 17612493
MIRT032203 hsa-let-7b-5p Proteomics 18668040
MIRT515875 hsa-miR-223-5p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
2
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15574754, 21903422, 28514442, 33961781
GO:0016020 Component Membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606827 21013 ENSG00000120594
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6UX71
Protein name Plexin domain-containing protein 2 (Tumor endothelial marker 7-related protein)
Protein function May play a role in tumor angiogenesis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01437 PSI 327 372 Plexin repeat Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the endothelial cells of the stroma but not in the endothelial cells of normal colonic tissue. {ECO:0000269|PubMed:11559528}.
Sequence
MARFPKADLAAAGVMLLCHFFTDQFQFADGKPGDQILDWQYGVTQAFPHTEEEVEVDSHA
YSHRWKRNLDFLKAVDTNRASVGQDSPEPRSFTDLLLDDGQDNNTQIEEDTDHNYYISRI
YGPSDSASRDLWVNIDQMEKDKVKIHGILSNTHRQAARVNLSFDFPFYGHFLREITVATG
GFIYTGEVVHRMLTATQYIAPLMANFDPSVSRNSTVRYFDNGTALVVQWDHVHLQDNYNL
GSFTFQATLLMDGRIIFGYKEIPVLVTQISSTNHPVKVGLSDAFVVVHRIQQIPNVRRRT
IYEYHRVELQMSKITNISAVEMTPLPTCLQFNRCGPCVSSQIGFNCSWCSKLQRCSSGFD
RHRQDWVDSGCP
EESKEKMCENTEPVETSSRTTTTVGATTTQFRVLTTTRRAVTSQFPTS
LPTEDDTKIALHLKDNGASTDDSAAEKKGGTLHAGLIIGILILVLIVATAILVTVYMYHH
PTSAASIFFIERRPSRWPAMKFRRGSGHPAYAEVEPVGEKEGFIVSEQC
Sequence length 529
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Gastric cancer Uncertain significance rs540394643 RCV005931243
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Blood Coagulation Disorders Associate 31271701
Breast Neoplasms Associate 35996498
Carcinoma Hepatocellular Associate 31271701
Carcinoma Squamous Cell Associate 27170308
Colorectal Neoplasms Associate 15761964
Diabetes Mellitus Associate 33995275
Diabetes Mellitus Type 2 Associate 27863428
Glaucoma Open Angle Associate 30326957
Laryngeal Neoplasms Associate 25719218
Lymphatic Metastasis Inhibit 27170308