Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
84898
Gene name Gene Name - the full gene name approved by the HGNC.
Plexin domain containing 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PLXDC2
Synonyms (NCBI Gene) Gene synonyms aliases
PLXDC2-OT, TEM7R
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p12.31
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019264 hsa-miR-148b-3p Microarray 17612493
MIRT023594 hsa-miR-1-3p Proteomics 18668040
MIRT025068 hsa-miR-181a-5p Microarray 17612493
MIRT032203 hsa-let-7b-5p Proteomics 18668040
MIRT515875 hsa-miR-223-5p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15574754, 21903422
GO:0016021 Component Integral component of membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606827 21013 ENSG00000120594
Protein
UniProt ID Q6UX71
Protein name Plexin domain-containing protein 2 (Tumor endothelial marker 7-related protein)
Protein function May play a role in tumor angiogenesis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01437 PSI 327 372 Plexin repeat Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the endothelial cells of the stroma but not in the endothelial cells of normal colonic tissue. {ECO:0000269|PubMed:11559528}.
Sequence
MARFPKADLAAAGVMLLCHFFTDQFQFADGKPGDQILDWQYGVTQAFPHTEEEVEVDSHA
YSHRWKRNLDFLKAVDTNRASVGQDSPEPRSFTDLLLDDGQDNNTQIEEDTDHNYYISRI
YGPSDSASRDLWVNIDQMEKDKVKIHGILSNTHRQAARVNLSFDFPFYGHFLREITVATG
GFIYTGEVVHRMLTATQYIAPLMANFDPSVSRNSTVRYFDNGTALVVQWDHVHLQDNYNL
GSFTFQATLLMDGRIIFGYKEIPVLVTQISSTNHPVKVGLSDAFVVVHRIQQIPNVRRRT
IYEYHRVELQMSKITNISAVEMTPLPTCLQFNRCGPCVSSQIGFNCSWCSKLQRCSSGFD
RHRQDWVDSGCP
EESKEKMCENTEPVETSSRTTTTVGATTTQFRVLTTTRRAVTSQFPTS
LPTEDDTKIALHLKDNGASTDDSAAEKKGGTLHAGLIIGILILVLIVATAILVTVYMYHH
PTSAASIFFIERRPSRWPAMKFRRGSGHPAYAEVEPVGEKEGFIVSEQC
Sequence length 529
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Kidney disease Chronic Kidney Diseases rs74315342, rs749740335, rs757649673, rs112417755, rs35138315 26420894
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Unknown
Disease term Disease name Evidence References Source
Diabetic Retinopathy Diabetic Retinopathy GWAS
Bronchopulmonary Dysplasia Bronchopulmonary Dysplasia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Blood Coagulation Disorders Associate 31271701
Breast Neoplasms Associate 35996498
Carcinoma Hepatocellular Associate 31271701
Carcinoma Squamous Cell Associate 27170308
Colorectal Neoplasms Associate 15761964
Diabetes Mellitus Associate 33995275
Diabetes Mellitus Type 2 Associate 27863428
Glaucoma Open Angle Associate 30326957
Laryngeal Neoplasms Associate 25719218
Lymphatic Metastasis Inhibit 27170308