Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84894
Gene name	Leucine rich repeat and Ig domain containing 1
Gene symbol	LINGO1
Synonyms (NCBI Gene)	LERN1LRRN6AMRT64UNQ201
Chromosome	15
Chromosome location	15q24.3

Show/Hide all (73)

miRTarBase ID	miRNA	Experiments	Reference
MIRT573965	hsa-miR-6077	PAR-CLIP	20371350
MIRT573964	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT573963	hsa-miR-765	PAR-CLIP	20371350
MIRT573962	hsa-miR-196a-3p	PAR-CLIP	20371350
MIRT736920	hsa-miR-15b-3p	Luciferase reporter assayWestern blottingRNA-seqImmunofluorescenceqRT-PCR	34187584
MIRT573965	hsa-miR-6077	PAR-CLIP	20371350
MIRT573964	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT573963	hsa-miR-765	PAR-CLIP	20371350
MIRT573962	hsa-miR-196a-3p	PAR-CLIP	20371350
MIRT1110512	hsa-miR-15a	CLIP-seq
MIRT1110513	hsa-miR-15b	CLIP-seq
MIRT1110514	hsa-miR-16	CLIP-seq
MIRT1110515	hsa-miR-185	CLIP-seq
MIRT1110516	hsa-miR-195	CLIP-seq
MIRT1110517	hsa-miR-198	CLIP-seq
MIRT1110518	hsa-miR-3120-3p	CLIP-seq
MIRT1110519	hsa-miR-3157-5p	CLIP-seq
MIRT1110520	hsa-miR-3649	CLIP-seq
MIRT1110521	hsa-miR-3665	CLIP-seq
MIRT1110522	hsa-miR-424	CLIP-seq
MIRT1110523	hsa-miR-4306	CLIP-seq
MIRT1110524	hsa-miR-4467	CLIP-seq
MIRT1110525	hsa-miR-4468	CLIP-seq
MIRT1110526	hsa-miR-4487	CLIP-seq
MIRT1110527	hsa-miR-4644	CLIP-seq
MIRT1110528	hsa-miR-4691-3p	CLIP-seq
MIRT1110529	hsa-miR-4693-3p	CLIP-seq
MIRT1110530	hsa-miR-4755-3p	CLIP-seq
MIRT1110531	hsa-miR-497	CLIP-seq
MIRT1110532	hsa-miR-520a-5p	CLIP-seq
MIRT1110533	hsa-miR-525-5p	CLIP-seq
MIRT1110534	hsa-miR-922	CLIP-seq
MIRT2030888	hsa-miR-1909	CLIP-seq
MIRT2030889	hsa-miR-4532	CLIP-seq
MIRT2030890	hsa-miR-4632	CLIP-seq
MIRT2030891	hsa-miR-4787-5p	CLIP-seq
MIRT2030892	hsa-miR-615-5p	CLIP-seq
MIRT2261538	hsa-miR-1253	CLIP-seq
MIRT2261539	hsa-miR-3173-3p	CLIP-seq
MIRT2261540	hsa-miR-3661	CLIP-seq
MIRT2030891	hsa-miR-4787-5p	CLIP-seq
MIRT2261541	hsa-miR-631	CLIP-seq
MIRT2390165	hsa-miR-1285	CLIP-seq
MIRT2390166	hsa-miR-3187-5p	CLIP-seq
MIRT2390167	hsa-miR-3529	CLIP-seq
MIRT2390168	hsa-miR-378g	CLIP-seq
MIRT2390169	hsa-miR-379	CLIP-seq
MIRT2390170	hsa-miR-4303	CLIP-seq
MIRT2390171	hsa-miR-4451	CLIP-seq
MIRT2390172	hsa-miR-4486	CLIP-seq
MIRT2390173	hsa-miR-4649-3p	CLIP-seq
MIRT2390174	hsa-miR-4650-3p	CLIP-seq
MIRT2390175	hsa-miR-612	CLIP-seq
MIRT2561559	hsa-miR-1224-3p	CLIP-seq
MIRT2561560	hsa-miR-296-5p	CLIP-seq
MIRT2561561	hsa-miR-342-5p	CLIP-seq
MIRT2561562	hsa-miR-4651	CLIP-seq
MIRT2561563	hsa-miR-4664-5p	CLIP-seq
MIRT2561564	hsa-miR-4758-3p	CLIP-seq
MIRT2561565	hsa-miR-541	CLIP-seq
MIRT2561566	hsa-miR-608	CLIP-seq
MIRT2561567	hsa-miR-654-5p	CLIP-seq
MIRT2561568	hsa-miR-766	CLIP-seq
MIRT2561559	hsa-miR-1224-3p	CLIP-seq
MIRT2561560	hsa-miR-296-5p	CLIP-seq
MIRT2561561	hsa-miR-342-5p	CLIP-seq
MIRT2561562	hsa-miR-4651	CLIP-seq
MIRT2561563	hsa-miR-4664-5p	CLIP-seq
MIRT2561564	hsa-miR-4758-3p	CLIP-seq
MIRT2561565	hsa-miR-541	CLIP-seq
MIRT2561566	hsa-miR-608	CLIP-seq
MIRT2561567	hsa-miR-654-5p	CLIP-seq
MIRT2561568	hsa-miR-766	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005154	Function	Epidermal growth factor receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	14966521, 17726113, 20659559, 22133804, 25416956, 32296183, 32814053, 33961781
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0038023	Function	Signaling receptor activity	IBA
GO:0048666	Process	Neuron development	IBA

MIM	HGNC	e!Ensembl
609791	21205	ENSG00000169783

Q96FE5

Protein name

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobulin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A)

Protein function

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative reg

PDB

2ID5 , 4OQT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	71 → 131	Leucine rich repeat	Repeat
PF13855	LRR_8	95 → 155	Leucine rich repeat	Repeat
PF13855	LRR_8	119 → 179	Leucine rich repeat	Repeat
PF13855	LRR_8	143 → 203	Leucine rich repeat	Repeat
PF13855	LRR_8	311 → 371	Leucine rich repeat	Repeat
PF07679	I-set	426 → 514	Immunoglobulin I-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra

Sequence

MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK
RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN
LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV
YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR
LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS
TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN
LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT
CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG
TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE
ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR
KSDAGISSADAPRKFNMKMI

Sequence length

620

Interactions

View interactions

	Reactome
			Axonal growth inhibition (RHOA activation)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Intellectual disability, autosomal recessive 64	Pathogenic	rs757077698, rs750612085	RCV000678221 RCV000678222

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
LINGO1-related disorder	Likely benign; Benign	rs370042281, rs147726308, rs780397720, rs375759643, rs200917454, rs574047775, rs141129663, rs765942091, rs776220853, rs377521757, rs76669376, rs370164787, rs187712243, rs11853548, rs61737307	RCV003919122 RCV003901043 RCV003964597 RCV003964607 RCV003911771 RCV003912189 RCV003974026 RCV003944472 RCV003914347 RCV003937159 RCV003976624 RCV003959852 RCV003969057 RCV003935909 RCV003915936

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	34600516
Cardiovascular Diseases	Associate	22503546
Cerebellar Diseases	Associate	23543187
Demyelinating Diseases	Associate	31928294
Essential Tremor	Associate	19720553, 19908305, 20369371, 20372186, 23543187, 23574883, 23951268
Essential Tremor	Stimulate	31932443
Genetic Diseases Inborn	Associate	28805617
Glioma	Associate	24158112
Intellectual Disability	Associate	28837161
Language Development Disorders	Associate	28837161
Microcephaly	Associate	28837161
Movement Disorders	Associate	23574883
Multiple Sclerosis	Associate	23574883
Neurodegenerative Diseases	Associate	23574883
Parkinson Disease	Associate	19720553, 19908305, 20369371
Parkinson Disease	Stimulate	31932443
Tremor	Associate	31932443

LINGO1 (leucine rich repeat and Ig domain containing 1)