Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
84890
Gene name Gene Name - the full gene name approved by the HGNC.
2-aminoethanethiol dioxygenase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ADO
Synonyms (NCBI Gene) Gene synonyms aliases
C10orf22
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q21.3
Summary Summary of gene provided in NCBI Entrez Gene.
Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020373 hsa-miR-29c-3p Sequencing 20371350
MIRT022087 hsa-miR-128-3p Sequencing 20371350
MIRT023381 hsa-miR-122-5p Microarray 17612493
MIRT025531 hsa-miR-34a-5p Sequencing 20371350
MIRT025852 hsa-miR-7-5p Microarray 19073608
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000098 Process Sulfur amino acid catabolic process TAS
GO:0005515 Function Protein binding IPI 32296183
GO:0005829 Component Cytosol TAS
GO:0046872 Function Metal ion binding IEA
GO:0047800 Function Cysteamine dioxygenase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611392 23506 ENSG00000181915
Protein
UniProt ID Q96SZ5
Protein name 2-aminoethanethiol dioxygenase (EC 1.13.11.19) (Cysteamine dioxygenase)
Protein function Plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate (PubMed:1758181
PDB 7REI , 8U9J , 8UAN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07847 PCO_ADO 57 268 PCO_ADO Family
Sequence
Sequence length 270
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Taurine and hypotaurine metabolism
Metabolic pathways
  Degradation of cysteine and homocysteine
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Alopecia Areata Alopecia Areata GWAS
Dermatitis Dermatitis GWAS
Gout Gout GWAS
Systemic lupus erythematosus Systemic lupus erythematosus GWAS
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 33098857
Behcet Syndrome Associate 29907633, 33393726
Breast Neoplasms Associate 26073781
Dermatitis Atopic Associate 33069716, 33901562
Melanoma Associate 39278925
Psoriasis Associate 33069716
Uveomeningoencephalitic Syndrome Associate 32437414