Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84870
Gene name Gene Name - the full gene name approved by the HGNC.	R-spondin 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RSPO3
Synonyms (NCBI Gene) Gene synonyms aliases	CRISTIN1, PWTSR, THSD2
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q22.33
Summary Summary of gene provided in NCBI Entrez Gene.	This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell g

Show/Hide all(146)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017040	hsa-miR-335-5p	Microarray	18185580
MIRT1321411	hsa-miR-3163	CLIP-seq
MIRT1321412	hsa-miR-3619-3p	CLIP-seq
MIRT1321413	hsa-miR-4503	CLIP-seq
MIRT1321414	hsa-miR-4659a-3p	CLIP-seq
MIRT1321415	hsa-miR-4659b-3p	CLIP-seq
MIRT1321416	hsa-miR-4668-3p	CLIP-seq
MIRT1321417	hsa-miR-4776-5p	CLIP-seq
MIRT1321418	hsa-miR-4800-5p	CLIP-seq
MIRT1321419	hsa-miR-576-5p	CLIP-seq
MIRT2095428	hsa-miR-188-5p	CLIP-seq
MIRT2095429	hsa-miR-409-3p	CLIP-seq
MIRT2095430	hsa-miR-4269	CLIP-seq
MIRT2095431	hsa-miR-4438	CLIP-seq
MIRT2095432	hsa-miR-5095	CLIP-seq
MIRT2319814	hsa-miR-1252	CLIP-seq
MIRT2319815	hsa-miR-1265	CLIP-seq
MIRT2319816	hsa-miR-141	CLIP-seq
MIRT2319817	hsa-miR-200a	CLIP-seq
MIRT2319818	hsa-miR-3121-5p	CLIP-seq
MIRT2615614	hsa-miR-103a	CLIP-seq
MIRT2615615	hsa-miR-107	CLIP-seq
MIRT2615616	hsa-miR-125a-3p	CLIP-seq
MIRT2615617	hsa-miR-1270	CLIP-seq
MIRT2615618	hsa-miR-128	CLIP-seq
MIRT2615619	hsa-miR-1283	CLIP-seq
MIRT2615620	hsa-miR-1285	CLIP-seq
MIRT2615621	hsa-miR-1343	CLIP-seq
MIRT2615622	hsa-miR-15a	CLIP-seq
MIRT2615623	hsa-miR-15b	CLIP-seq
MIRT2615624	hsa-miR-16	CLIP-seq
MIRT2615625	hsa-miR-194	CLIP-seq
MIRT2615626	hsa-miR-195	CLIP-seq
MIRT2615627	hsa-miR-205	CLIP-seq
MIRT2615628	hsa-miR-216a	CLIP-seq
MIRT2615629	hsa-miR-216b	CLIP-seq
MIRT2615630	hsa-miR-2278	CLIP-seq
MIRT2615631	hsa-miR-27a	CLIP-seq
MIRT2615632	hsa-miR-27b	CLIP-seq
MIRT2615633	hsa-miR-3187-5p	CLIP-seq
MIRT2615634	hsa-miR-338-5p	CLIP-seq
MIRT2615635	hsa-miR-3618	CLIP-seq
MIRT2615636	hsa-miR-3663-3p	CLIP-seq
MIRT2615637	hsa-miR-376c	CLIP-seq
MIRT2615638	hsa-miR-3925-3p	CLIP-seq
MIRT2615639	hsa-miR-3929	CLIP-seq
MIRT2615640	hsa-miR-3936	CLIP-seq
MIRT2615641	hsa-miR-3945	CLIP-seq
MIRT2615642	hsa-miR-410	CLIP-seq
MIRT2615643	hsa-miR-424	CLIP-seq
MIRT2615644	hsa-miR-4253	CLIP-seq
MIRT2615645	hsa-miR-4267	CLIP-seq
MIRT2095430	hsa-miR-4269	CLIP-seq
MIRT2615646	hsa-miR-4328	CLIP-seq
MIRT2615647	hsa-miR-4419b	CLIP-seq
MIRT2615648	hsa-miR-4422	CLIP-seq
MIRT2095431	hsa-miR-4438	CLIP-seq
MIRT2615649	hsa-miR-4473	CLIP-seq
MIRT2615650	hsa-miR-4474-5p	CLIP-seq
MIRT2615651	hsa-miR-4478	CLIP-seq
MIRT2615652	hsa-miR-4524	CLIP-seq
MIRT2615653	hsa-miR-4531	CLIP-seq
MIRT2615654	hsa-miR-4663	CLIP-seq
MIRT2615655	hsa-miR-4803	CLIP-seq
MIRT2615656	hsa-miR-485-5p	CLIP-seq
MIRT2615657	hsa-miR-490-5p	CLIP-seq
MIRT2615658	hsa-miR-497	CLIP-seq
MIRT2615659	hsa-miR-500a	CLIP-seq
MIRT2615660	hsa-miR-503	CLIP-seq
MIRT2095432	hsa-miR-5095	CLIP-seq
MIRT2615661	hsa-miR-512-3p	CLIP-seq
MIRT2615662	hsa-miR-513a-5p	CLIP-seq
MIRT2615663	hsa-miR-520f	CLIP-seq
MIRT2615664	hsa-miR-548n	CLIP-seq
MIRT2615665	hsa-miR-552	CLIP-seq
MIRT2615666	hsa-miR-563	CLIP-seq
MIRT2615667	hsa-miR-612	CLIP-seq
MIRT2615668	hsa-miR-620	CLIP-seq
MIRT2615669	hsa-miR-627	CLIP-seq
MIRT2615670	hsa-miR-646	CLIP-seq
MIRT2615671	hsa-miR-766	CLIP-seq
MIRT2615672	hsa-miR-769-5p	CLIP-seq
MIRT2615673	hsa-miR-924	CLIP-seq
MIRT2615614	hsa-miR-103a	CLIP-seq
MIRT2615615	hsa-miR-107	CLIP-seq
MIRT2615616	hsa-miR-125a-3p	CLIP-seq
MIRT2615617	hsa-miR-1270	CLIP-seq
MIRT2615618	hsa-miR-128	CLIP-seq
MIRT2615619	hsa-miR-1283	CLIP-seq
MIRT2615620	hsa-miR-1285	CLIP-seq
MIRT2615621	hsa-miR-1343	CLIP-seq
MIRT2615622	hsa-miR-15a	CLIP-seq
MIRT2615623	hsa-miR-15b	CLIP-seq
MIRT2615624	hsa-miR-16	CLIP-seq
MIRT2615625	hsa-miR-194	CLIP-seq
MIRT2615626	hsa-miR-195	CLIP-seq
MIRT2615627	hsa-miR-205	CLIP-seq
MIRT2615628	hsa-miR-216a	CLIP-seq
MIRT2615629	hsa-miR-216b	CLIP-seq
MIRT2615630	hsa-miR-2278	CLIP-seq
MIRT2615631	hsa-miR-27a	CLIP-seq
MIRT2615632	hsa-miR-27b	CLIP-seq
MIRT2615633	hsa-miR-3187-5p	CLIP-seq
MIRT2615634	hsa-miR-338-5p	CLIP-seq
MIRT2615635	hsa-miR-3618	CLIP-seq
MIRT2615636	hsa-miR-3663-3p	CLIP-seq
MIRT2615637	hsa-miR-376c	CLIP-seq
MIRT2615638	hsa-miR-3925-3p	CLIP-seq
MIRT2615639	hsa-miR-3929	CLIP-seq
MIRT2615640	hsa-miR-3936	CLIP-seq
MIRT2615641	hsa-miR-3945	CLIP-seq
MIRT2615642	hsa-miR-410	CLIP-seq
MIRT2615643	hsa-miR-424	CLIP-seq
MIRT2615644	hsa-miR-4253	CLIP-seq
MIRT2615645	hsa-miR-4267	CLIP-seq
MIRT2095430	hsa-miR-4269	CLIP-seq
MIRT2615646	hsa-miR-4328	CLIP-seq
MIRT2615647	hsa-miR-4419b	CLIP-seq
MIRT2615648	hsa-miR-4422	CLIP-seq
MIRT2095431	hsa-miR-4438	CLIP-seq
MIRT2615649	hsa-miR-4473	CLIP-seq
MIRT2615650	hsa-miR-4474-5p	CLIP-seq
MIRT2615651	hsa-miR-4478	CLIP-seq
MIRT2615652	hsa-miR-4524	CLIP-seq
MIRT2615653	hsa-miR-4531	CLIP-seq
MIRT2615654	hsa-miR-4663	CLIP-seq
MIRT2615655	hsa-miR-4803	CLIP-seq
MIRT2615656	hsa-miR-485-5p	CLIP-seq
MIRT2615657	hsa-miR-490-5p	CLIP-seq
MIRT2615658	hsa-miR-497	CLIP-seq
MIRT2615659	hsa-miR-500a	CLIP-seq
MIRT2615660	hsa-miR-503	CLIP-seq
MIRT2095432	hsa-miR-5095	CLIP-seq
MIRT2615661	hsa-miR-512-3p	CLIP-seq
MIRT2615662	hsa-miR-513a-5p	CLIP-seq
MIRT2615663	hsa-miR-520f	CLIP-seq
MIRT2615664	hsa-miR-548n	CLIP-seq
MIRT2615665	hsa-miR-552	CLIP-seq
MIRT2615666	hsa-miR-563	CLIP-seq
MIRT2615667	hsa-miR-612	CLIP-seq
MIRT2615668	hsa-miR-620	CLIP-seq
MIRT2615669	hsa-miR-627	CLIP-seq
MIRT2615670	hsa-miR-646	CLIP-seq
MIRT2615671	hsa-miR-766	CLIP-seq
MIRT2615672	hsa-miR-769-5p	CLIP-seq
MIRT2615673	hsa-miR-924	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0001974	Process	Blood vessel remodeling	IEA
GO:0001974	Process	Blood vessel remodeling	ISS
GO:0002040	Process	Sprouting angiogenesis	IEA
GO:0002040	Process	Sprouting angiogenesis	ISS
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005102	Function	Signaling receptor binding	IPI	22615920
GO:0005109	Function	Frizzled binding	IBA
GO:0005109	Function	Frizzled binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	NAS	24431302
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0008201	Function	Heparin binding	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0030177	Process	Positive regulation of Wnt signaling pathway	IDA	29769720
GO:0030177	Process	Positive regulation of Wnt signaling pathway	NAS	24431302
GO:0060070	Process	Canonical Wnt signaling pathway	IEA
GO:0060670	Process	Branching involved in labyrinthine layer morphogenesis	IEA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IBA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IEA
GO:2000052	Process	Positive regulation of non-canonical Wnt signaling pathway	IEA
GO:2000052	Process	Positive regulation of non-canonical Wnt signaling pathway	ISS
GO:2000096	Process	Positive regulation of Wnt signaling pathway, planar cell polarity pathway	TAS	24431302

MIM	HGNC	e!Ensembl
610574	20866	ENSG00000146374

Protein

UniProt ID

Q9BXY4

Protein name

R-spondin-3 (Protein with TSP type-1 repeat) (hPWTSR) (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2)

Protein function

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled recep

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15913	Furin-like_2	41 → 142	Furin-like repeat, cysteine-rich	Domain
PF19028	TSP1_spondin	148 → 206	Spondin-like TSP1 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node (PubMed:12463421). Highly expressed in endothelial cells (PubMed:26766444). {ECO:0000269|PubMed:12463421, ECO:0000269|PubMed:26

Sequence

MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR
LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL
HLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREII
QHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLES
SKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH

Sequence length

272

Interactions

View interactions

	KEGG		Reactome
	Wnt signaling pathway		Regulation of FZD by ubiquitination RUNX1 regulates transcription of genes involved in WNT signaling

Show/Hide Unknown Diseases (7)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Crohn Disease	Crohn's disease	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Glioblastoma	Glioblastoma	N/A	N/A	GWAS
Hypertension	Essential hypertension (PheCode 401.1), Hypertension, Hypertension (confirmatory factor analysis Factor 12), High blood pressure / hypertension, Hypertension (PheCode 401)	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Osteoporosis	Osteoporosis	N/A	N/A	GWAS
Uterine Fibroids	Uterine fibroids	N/A	N/A	GWAS

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenomatous Polyposis Coli	Associate	33320737
Breast Neoplasms	Stimulate	33320737
Carcinogenesis	Associate	36129915
Cholangiocarcinoma	Inhibit	37932819
Cholangitis Sclerosing	Associate	28779025, 29055915
Chronic Disease	Associate	35218958
Colonic Neoplasms	Associate	22895193
Colonic Neoplasms	Stimulate	33320737
Colorectal Neoplasms	Associate	22895193, 28100566, 35254413, 36129915, 37998393
Colorectal Neoplasms	Stimulate	33320737
Fractures Bone	Associate	35689460
Hypertension Pulmonary	Associate	37731513
Insulin Resistance	Associate	31739742
Neoplasms	Associate	32631391, 33320737, 34021172, 36129915
Neoplasms	Inhibit	34193438
Obesity	Associate	26132169
Pulmonary Fibrosis	Associate	37731513
Thyroid Cancer Papillary	Associate	26416247
Varicose Veins	Associate	35218958

RSPO3 (R-spondin 3)