Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	84870
Gene name	R-spondin 3
Gene symbol	RSPO3
Synonyms (NCBI Gene)	CRISTIN1PWTSRTHSD2
Chromosome	6
Chromosome location	6q22.33
Summary	This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell g

146

Show/Hide all (146)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017040	hsa-miR-335-5p	Microarray	18185580
MIRT1321411	hsa-miR-3163	CLIP-seq
MIRT1321412	hsa-miR-3619-3p	CLIP-seq
MIRT1321413	hsa-miR-4503	CLIP-seq
MIRT1321414	hsa-miR-4659a-3p	CLIP-seq
MIRT1321415	hsa-miR-4659b-3p	CLIP-seq
MIRT1321416	hsa-miR-4668-3p	CLIP-seq
MIRT1321417	hsa-miR-4776-5p	CLIP-seq
MIRT1321418	hsa-miR-4800-5p	CLIP-seq
MIRT1321419	hsa-miR-576-5p	CLIP-seq
MIRT2095428	hsa-miR-188-5p	CLIP-seq
MIRT2095429	hsa-miR-409-3p	CLIP-seq
MIRT2095430	hsa-miR-4269	CLIP-seq
MIRT2095431	hsa-miR-4438	CLIP-seq
MIRT2095432	hsa-miR-5095	CLIP-seq
MIRT2319814	hsa-miR-1252	CLIP-seq
MIRT2319815	hsa-miR-1265	CLIP-seq
MIRT2319816	hsa-miR-141	CLIP-seq
MIRT2319817	hsa-miR-200a	CLIP-seq
MIRT2319818	hsa-miR-3121-5p	CLIP-seq
MIRT2615614	hsa-miR-103a	CLIP-seq
MIRT2615615	hsa-miR-107	CLIP-seq
MIRT2615616	hsa-miR-125a-3p	CLIP-seq
MIRT2615617	hsa-miR-1270	CLIP-seq
MIRT2615618	hsa-miR-128	CLIP-seq
MIRT2615619	hsa-miR-1283	CLIP-seq
MIRT2615620	hsa-miR-1285	CLIP-seq
MIRT2615621	hsa-miR-1343	CLIP-seq
MIRT2615622	hsa-miR-15a	CLIP-seq
MIRT2615623	hsa-miR-15b	CLIP-seq
MIRT2615624	hsa-miR-16	CLIP-seq
MIRT2615625	hsa-miR-194	CLIP-seq
MIRT2615626	hsa-miR-195	CLIP-seq
MIRT2615627	hsa-miR-205	CLIP-seq
MIRT2615628	hsa-miR-216a	CLIP-seq
MIRT2615629	hsa-miR-216b	CLIP-seq
MIRT2615630	hsa-miR-2278	CLIP-seq
MIRT2615631	hsa-miR-27a	CLIP-seq
MIRT2615632	hsa-miR-27b	CLIP-seq
MIRT2615633	hsa-miR-3187-5p	CLIP-seq
MIRT2615634	hsa-miR-338-5p	CLIP-seq
MIRT2615635	hsa-miR-3618	CLIP-seq
MIRT2615636	hsa-miR-3663-3p	CLIP-seq
MIRT2615637	hsa-miR-376c	CLIP-seq
MIRT2615638	hsa-miR-3925-3p	CLIP-seq
MIRT2615639	hsa-miR-3929	CLIP-seq
MIRT2615640	hsa-miR-3936	CLIP-seq
MIRT2615641	hsa-miR-3945	CLIP-seq
MIRT2615642	hsa-miR-410	CLIP-seq
MIRT2615643	hsa-miR-424	CLIP-seq
MIRT2615644	hsa-miR-4253	CLIP-seq
MIRT2615645	hsa-miR-4267	CLIP-seq
MIRT2095430	hsa-miR-4269	CLIP-seq
MIRT2615646	hsa-miR-4328	CLIP-seq
MIRT2615647	hsa-miR-4419b	CLIP-seq
MIRT2615648	hsa-miR-4422	CLIP-seq
MIRT2095431	hsa-miR-4438	CLIP-seq
MIRT2615649	hsa-miR-4473	CLIP-seq
MIRT2615650	hsa-miR-4474-5p	CLIP-seq
MIRT2615651	hsa-miR-4478	CLIP-seq
MIRT2615652	hsa-miR-4524	CLIP-seq
MIRT2615653	hsa-miR-4531	CLIP-seq
MIRT2615654	hsa-miR-4663	CLIP-seq
MIRT2615655	hsa-miR-4803	CLIP-seq
MIRT2615656	hsa-miR-485-5p	CLIP-seq
MIRT2615657	hsa-miR-490-5p	CLIP-seq
MIRT2615658	hsa-miR-497	CLIP-seq
MIRT2615659	hsa-miR-500a	CLIP-seq
MIRT2615660	hsa-miR-503	CLIP-seq
MIRT2095432	hsa-miR-5095	CLIP-seq
MIRT2615661	hsa-miR-512-3p	CLIP-seq
MIRT2615662	hsa-miR-513a-5p	CLIP-seq
MIRT2615663	hsa-miR-520f	CLIP-seq
MIRT2615664	hsa-miR-548n	CLIP-seq
MIRT2615665	hsa-miR-552	CLIP-seq
MIRT2615666	hsa-miR-563	CLIP-seq
MIRT2615667	hsa-miR-612	CLIP-seq
MIRT2615668	hsa-miR-620	CLIP-seq
MIRT2615669	hsa-miR-627	CLIP-seq
MIRT2615670	hsa-miR-646	CLIP-seq
MIRT2615671	hsa-miR-766	CLIP-seq
MIRT2615672	hsa-miR-769-5p	CLIP-seq
MIRT2615673	hsa-miR-924	CLIP-seq
MIRT2615614	hsa-miR-103a	CLIP-seq
MIRT2615615	hsa-miR-107	CLIP-seq
MIRT2615616	hsa-miR-125a-3p	CLIP-seq
MIRT2615617	hsa-miR-1270	CLIP-seq
MIRT2615618	hsa-miR-128	CLIP-seq
MIRT2615619	hsa-miR-1283	CLIP-seq
MIRT2615620	hsa-miR-1285	CLIP-seq
MIRT2615621	hsa-miR-1343	CLIP-seq
MIRT2615622	hsa-miR-15a	CLIP-seq
MIRT2615623	hsa-miR-15b	CLIP-seq
MIRT2615624	hsa-miR-16	CLIP-seq
MIRT2615625	hsa-miR-194	CLIP-seq
MIRT2615626	hsa-miR-195	CLIP-seq
MIRT2615627	hsa-miR-205	CLIP-seq
MIRT2615628	hsa-miR-216a	CLIP-seq
MIRT2615629	hsa-miR-216b	CLIP-seq
MIRT2615630	hsa-miR-2278	CLIP-seq
MIRT2615631	hsa-miR-27a	CLIP-seq
MIRT2615632	hsa-miR-27b	CLIP-seq
MIRT2615633	hsa-miR-3187-5p	CLIP-seq
MIRT2615634	hsa-miR-338-5p	CLIP-seq
MIRT2615635	hsa-miR-3618	CLIP-seq
MIRT2615636	hsa-miR-3663-3p	CLIP-seq
MIRT2615637	hsa-miR-376c	CLIP-seq
MIRT2615638	hsa-miR-3925-3p	CLIP-seq
MIRT2615639	hsa-miR-3929	CLIP-seq
MIRT2615640	hsa-miR-3936	CLIP-seq
MIRT2615641	hsa-miR-3945	CLIP-seq
MIRT2615642	hsa-miR-410	CLIP-seq
MIRT2615643	hsa-miR-424	CLIP-seq
MIRT2615644	hsa-miR-4253	CLIP-seq
MIRT2615645	hsa-miR-4267	CLIP-seq
MIRT2095430	hsa-miR-4269	CLIP-seq
MIRT2615646	hsa-miR-4328	CLIP-seq
MIRT2615647	hsa-miR-4419b	CLIP-seq
MIRT2615648	hsa-miR-4422	CLIP-seq
MIRT2095431	hsa-miR-4438	CLIP-seq
MIRT2615649	hsa-miR-4473	CLIP-seq
MIRT2615650	hsa-miR-4474-5p	CLIP-seq
MIRT2615651	hsa-miR-4478	CLIP-seq
MIRT2615652	hsa-miR-4524	CLIP-seq
MIRT2615653	hsa-miR-4531	CLIP-seq
MIRT2615654	hsa-miR-4663	CLIP-seq
MIRT2615655	hsa-miR-4803	CLIP-seq
MIRT2615656	hsa-miR-485-5p	CLIP-seq
MIRT2615657	hsa-miR-490-5p	CLIP-seq
MIRT2615658	hsa-miR-497	CLIP-seq
MIRT2615659	hsa-miR-500a	CLIP-seq
MIRT2615660	hsa-miR-503	CLIP-seq
MIRT2095432	hsa-miR-5095	CLIP-seq
MIRT2615661	hsa-miR-512-3p	CLIP-seq
MIRT2615662	hsa-miR-513a-5p	CLIP-seq
MIRT2615663	hsa-miR-520f	CLIP-seq
MIRT2615664	hsa-miR-548n	CLIP-seq
MIRT2615665	hsa-miR-552	CLIP-seq
MIRT2615666	hsa-miR-563	CLIP-seq
MIRT2615667	hsa-miR-612	CLIP-seq
MIRT2615668	hsa-miR-620	CLIP-seq
MIRT2615669	hsa-miR-627	CLIP-seq
MIRT2615670	hsa-miR-646	CLIP-seq
MIRT2615671	hsa-miR-766	CLIP-seq
MIRT2615672	hsa-miR-769-5p	CLIP-seq
MIRT2615673	hsa-miR-924	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0001974	Process	Blood vessel remodeling	IEA
GO:0001974	Process	Blood vessel remodeling	ISS
GO:0002040	Process	Sprouting angiogenesis	IEA
GO:0002040	Process	Sprouting angiogenesis	ISS
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005102	Function	Signaling receptor binding	IPI	22615920
GO:0005109	Function	Frizzled binding	IBA
GO:0005109	Function	Frizzled binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	NAS	24431302
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0008201	Function	Heparin binding	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0030177	Process	Positive regulation of Wnt signaling pathway	IDA	29769720
GO:0030177	Process	Positive regulation of Wnt signaling pathway	NAS	24431302
GO:0060070	Process	Canonical Wnt signaling pathway	IEA
GO:0060670	Process	Branching involved in labyrinthine layer morphogenesis	IEA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IBA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IEA
GO:2000052	Process	Positive regulation of non-canonical Wnt signaling pathway	IEA
GO:2000052	Process	Positive regulation of non-canonical Wnt signaling pathway	ISS
GO:2000096	Process	Positive regulation of Wnt signaling pathway, planar cell polarity pathway	TAS	24431302

MIM	HGNC	e!Ensembl
610574	20866	ENSG00000146374

Q9BXY4

Protein name

R-spondin-3 (Protein with TSP type-1 repeat) (hPWTSR) (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2)

Protein function

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled recep

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15913	Furin-like_2	41 → 142	Furin-like repeat, cysteine-rich	Domain
PF19028	TSP1_spondin	148 → 206	Spondin-like TSP1 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node (PubMed:12463421). Highly expressed in endothelial cells (PubMed:26766444). {ECO:0000269|PubMed:12463421, ECO:0000269|PubMed:26

Sequence

MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR
LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL
HLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREII
QHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLES
SKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH

Sequence length

272

Interactions

View interactions

	KEGG		Reactome
	Wnt signaling pathway		Regulation of FZD by ubiquitination RUNX1 regulates transcription of genes involved in WNT signaling

RSPO3 (R-spondin 3)