ZNF503 (zinc finger protein 503)

Gene

• Entrez ID: 84858
• Gene name: Zinc finger protein 503
• Gene symbol: ZNF503
• Synonyms (NCBI Gene): NOLZ-1, NOLZ1, Nlz2
• Chromosome: 10
• Chromosome location: 10q22.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019148	hsa-miR-335-5p	Microarray	18185580
MIRT049153	hsa-miR-92a-3p	CLASH	23622248
MIRT049153	hsa-miR-92a-3p	CLASH	23622248
MIRT049153	hsa-miR-92a-3p	CLASH	23622248
MIRT047261	hsa-miR-181b-5p	CLASH	23622248
MIRT043572	hsa-miR-331-3p	CLASH	23622248
MIRT042518	hsa-miR-423-3p	CLASH	23622248
MIRT722235	hsa-miR-153-5p	HITS-CLIP	19536157
MIRT722234	hsa-miR-7106-5p	HITS-CLIP	19536157
MIRT722233	hsa-miR-149-3p	HITS-CLIP	19536157
MIRT722232	hsa-miR-4728-5p	HITS-CLIP	19536157
MIRT722231	hsa-miR-6785-5p	HITS-CLIP	19536157
MIRT722230	hsa-miR-6883-5p	HITS-CLIP	19536157
MIRT722229	hsa-miR-6799-5p	HITS-CLIP	19536157
MIRT722228	hsa-miR-5087	HITS-CLIP	19536157
MIRT722227	hsa-miR-8068	HITS-CLIP	19536157
MIRT722226	hsa-miR-1273h-5p	HITS-CLIP	19536157
MIRT722225	hsa-miR-30b-3p	HITS-CLIP	19536157
MIRT722224	hsa-miR-3689a-3p	HITS-CLIP	19536157
MIRT722223	hsa-miR-3689b-3p	HITS-CLIP	19536157
MIRT722222	hsa-miR-3689c	HITS-CLIP	19536157
MIRT722221	hsa-miR-6779-5p	HITS-CLIP	19536157
MIRT722220	hsa-miR-6780a-5p	HITS-CLIP	19536157
MIRT722218	hsa-miR-3692-3p	HITS-CLIP	19536157
MIRT722235	hsa-miR-153-5p	HITS-CLIP	19536157
MIRT722234	hsa-miR-7106-5p	HITS-CLIP	19536157
MIRT722233	hsa-miR-149-3p	HITS-CLIP	19536157
MIRT722232	hsa-miR-4728-5p	HITS-CLIP	19536157
MIRT722231	hsa-miR-6785-5p	HITS-CLIP	19536157
MIRT722230	hsa-miR-6883-5p	HITS-CLIP	19536157
MIRT722229	hsa-miR-6799-5p	HITS-CLIP	19536157
MIRT722228	hsa-miR-5087	HITS-CLIP	19536157
MIRT722227	hsa-miR-8068	HITS-CLIP	19536157
MIRT722226	hsa-miR-1273h-5p	HITS-CLIP	19536157
MIRT722225	hsa-miR-30b-3p	HITS-CLIP	19536157
MIRT722224	hsa-miR-3689a-3p	HITS-CLIP	19536157
MIRT722223	hsa-miR-3689b-3p	HITS-CLIP	19536157
MIRT722222	hsa-miR-3689c	HITS-CLIP	19536157
MIRT722221	hsa-miR-6779-5p	HITS-CLIP	19536157
MIRT722220	hsa-miR-6780a-5p	HITS-CLIP	19536157
MIRT722218	hsa-miR-3692-3p	HITS-CLIP	19536157
MIRT1527107	hsa-miR-103b	CLIP-seq
MIRT1527108	hsa-miR-122	CLIP-seq
MIRT1527109	hsa-miR-1224-3p	CLIP-seq
MIRT1527110	hsa-miR-1253	CLIP-seq
MIRT1527111	hsa-miR-1260	CLIP-seq
MIRT1527112	hsa-miR-1260b	CLIP-seq
MIRT1527113	hsa-miR-1276	CLIP-seq
MIRT1527114	hsa-miR-1280	CLIP-seq
MIRT1527115	hsa-miR-129-5p	CLIP-seq
MIRT1527116	hsa-miR-1324	CLIP-seq
MIRT1527117	hsa-miR-134	CLIP-seq
MIRT1527118	hsa-miR-186	CLIP-seq
MIRT1527119	hsa-miR-194	CLIP-seq
MIRT1527120	hsa-miR-214	CLIP-seq
MIRT1527121	hsa-miR-3118	CLIP-seq
MIRT1527122	hsa-miR-3132	CLIP-seq
MIRT1527123	hsa-miR-3133	CLIP-seq
MIRT1527124	hsa-miR-3143	CLIP-seq
MIRT1527125	hsa-miR-3150a-3p	CLIP-seq
MIRT1527126	hsa-miR-3154	CLIP-seq
MIRT1527127	hsa-miR-3164	CLIP-seq
MIRT1527128	hsa-miR-3168	CLIP-seq
MIRT1527129	hsa-miR-3175	CLIP-seq
MIRT1527130	hsa-miR-3179	CLIP-seq
MIRT1527131	hsa-miR-338-5p	CLIP-seq
MIRT1527132	hsa-miR-3619-5p	CLIP-seq
MIRT1527133	hsa-miR-3656	CLIP-seq
MIRT1527134	hsa-miR-3657	CLIP-seq
MIRT1527135	hsa-miR-3670	CLIP-seq
MIRT1527136	hsa-miR-371-5p	CLIP-seq
MIRT1527137	hsa-miR-3908	CLIP-seq
MIRT1527138	hsa-miR-3935	CLIP-seq
MIRT1527139	hsa-miR-3942-5p	CLIP-seq
MIRT1527140	hsa-miR-4255	CLIP-seq
MIRT1527141	hsa-miR-4291	CLIP-seq
MIRT1527142	hsa-miR-4311	CLIP-seq
MIRT1527143	hsa-miR-4326	CLIP-seq
MIRT1527144	hsa-miR-4434	CLIP-seq
MIRT1527145	hsa-miR-4495	CLIP-seq
MIRT1527146	hsa-miR-4516	CLIP-seq
MIRT1527147	hsa-miR-4666-3p	CLIP-seq
MIRT1527148	hsa-miR-4703-5p	CLIP-seq
MIRT1527149	hsa-miR-4705	CLIP-seq
MIRT1527150	hsa-miR-4766-3p	CLIP-seq
MIRT1527151	hsa-miR-4796-3p	CLIP-seq
MIRT1527152	hsa-miR-4797-5p	CLIP-seq
MIRT1527153	hsa-miR-491-5p	CLIP-seq
MIRT1527154	hsa-miR-495	CLIP-seq
MIRT1527155	hsa-miR-513a-3p	CLIP-seq
MIRT1527156	hsa-miR-543	CLIP-seq
MIRT1527157	hsa-miR-548a-5p	CLIP-seq
MIRT1527158	hsa-miR-548ab	CLIP-seq
MIRT1527159	hsa-miR-548ak	CLIP-seq
MIRT1527160	hsa-miR-548b-5p	CLIP-seq
MIRT1527161	hsa-miR-548c-3p	CLIP-seq
MIRT1527162	hsa-miR-548c-5p	CLIP-seq
MIRT1527163	hsa-miR-548d-5p	CLIP-seq
MIRT1527164	hsa-miR-548h	CLIP-seq
MIRT1527165	hsa-miR-548i	CLIP-seq
MIRT1527166	hsa-miR-548j	CLIP-seq
MIRT1527167	hsa-miR-548k	CLIP-seq
MIRT1527168	hsa-miR-548l	CLIP-seq
MIRT1527169	hsa-miR-548w	CLIP-seq
MIRT1527170	hsa-miR-548y	CLIP-seq
MIRT1527171	hsa-miR-559	CLIP-seq
MIRT1527172	hsa-miR-583	CLIP-seq
MIRT1527173	hsa-miR-590-3p	CLIP-seq
MIRT1527174	hsa-miR-595	CLIP-seq
MIRT1527175	hsa-miR-599	CLIP-seq
MIRT1527176	hsa-miR-626	CLIP-seq
MIRT1527177	hsa-miR-639	CLIP-seq
MIRT1527178	hsa-miR-661	CLIP-seq
MIRT1527179	hsa-miR-758	CLIP-seq
MIRT1527180	hsa-miR-761	CLIP-seq
MIRT1527181	hsa-miR-802	CLIP-seq
MIRT1527182	hsa-miR-922	CLIP-seq
MIRT1527183	hsa-miR-939	CLIP-seq
MIRT1527120	hsa-miR-214	CLIP-seq
MIRT1527132	hsa-miR-3619-5p	CLIP-seq
MIRT1527133	hsa-miR-3656	CLIP-seq
MIRT1527141	hsa-miR-4291	CLIP-seq
MIRT1527178	hsa-miR-661	CLIP-seq
MIRT1527180	hsa-miR-761	CLIP-seq
MIRT1527182	hsa-miR-922	CLIP-seq
MIRT1527109	hsa-miR-1224-3p	CLIP-seq
MIRT2378632	hsa-miR-1245b-3p	CLIP-seq
MIRT1527111	hsa-miR-1260	CLIP-seq
MIRT1527112	hsa-miR-1260b	CLIP-seq
MIRT1527114	hsa-miR-1280	CLIP-seq
MIRT2378633	hsa-miR-1283	CLIP-seq
MIRT2378634	hsa-miR-1910	CLIP-seq
MIRT1527122	hsa-miR-3132	CLIP-seq
MIRT1527134	hsa-miR-3657	CLIP-seq
MIRT2378635	hsa-miR-374a	CLIP-seq
MIRT2378636	hsa-miR-374b	CLIP-seq
MIRT1527138	hsa-miR-3935	CLIP-seq
MIRT2378637	hsa-miR-4275	CLIP-seq
MIRT2378638	hsa-miR-4330	CLIP-seq
MIRT2378639	hsa-miR-513c	CLIP-seq
MIRT2378640	hsa-miR-514b-5p	CLIP-seq
MIRT2378641	hsa-miR-624	CLIP-seq
MIRT1527176	hsa-miR-626	CLIP-seq
MIRT1527177	hsa-miR-639	CLIP-seq
MIRT2378642	hsa-miR-944	CLIP-seq
MIRT2464306	hsa-miR-3690	CLIP-seq
MIRT2464307	hsa-miR-378	CLIP-seq
MIRT2464308	hsa-miR-378b	CLIP-seq
MIRT2464309	hsa-miR-378c	CLIP-seq
MIRT2464310	hsa-miR-378d	CLIP-seq
MIRT2464311	hsa-miR-378e	CLIP-seq
MIRT2464312	hsa-miR-378f	CLIP-seq
MIRT2464313	hsa-miR-378h	CLIP-seq
MIRT2464314	hsa-miR-378i	CLIP-seq
MIRT2464315	hsa-miR-422a	CLIP-seq
MIRT2464316	hsa-miR-4258	CLIP-seq
MIRT2464317	hsa-miR-4287	CLIP-seq
MIRT2464318	hsa-miR-4292	CLIP-seq
MIRT2464319	hsa-miR-4308	CLIP-seq
MIRT2464320	hsa-miR-4469	CLIP-seq
MIRT2464321	hsa-miR-4685-3p	CLIP-seq
MIRT1527115	hsa-miR-129-5p	CLIP-seq
MIRT1527117	hsa-miR-134	CLIP-seq
MIRT1527119	hsa-miR-194	CLIP-seq
MIRT1527121	hsa-miR-3118	CLIP-seq
MIRT1527127	hsa-miR-3164	CLIP-seq
MIRT1527154	hsa-miR-495	CLIP-seq
MIRT2670927	hsa-miR-579	CLIP-seq
MIRT1527179	hsa-miR-758	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 32353859, 33060197, 36217030
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	20735826
GO:0010629	Process	Negative regulation of gene expression	IDA	20735826
GO:0045892	Process	Negative regulation of DNA-templated transcription	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0061351	Process	Neural precursor cell proliferation	IEA
GO:0070315	Process	G1 to G0 transition involved in cell differentiation	IDA	20735826
GO:0070315	Process	G1 to G0 transition involved in cell differentiation	IEA

Other IDs

• MIM: 613902
• HGNC: 23589
• e!Ensembl: ENSG00000165655

Protein

• UniProt ID: Q96F45
• Protein name: Zinc finger protein 503
• Protein function: May function as a transcriptional repressor.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12402	nlz1	355 → 415	NocA-like zinc-finger protein 1	Family

• Sequence:

  MSTAPSLSALRSSKHSGGGGGGGGGGGADPAWTSALSGNSSGPGPGSSPAGSTKPFVHAV
  PPSDPLRQANRLPIKVLKMLTARTGHILHPEYLQPLPSTPVSPIELDAKKSPLALLAQTC
  SQIGKPDPSPSSKLSSVASNGGGAGGAGGGAAGDKDTKSGPLKLSDIGVEDKSSFKPYSK
  PGSDKKEPGGGGGGGGGGGGGGGGVSSEKSGFRVPSATCQPFTPRTGSPSSSASACSPGG
  MLSSAGGAPEGKDDKKDTDVGGGGKGTGGASAEGGPTGLAHGRISCGGGINVDVNQHPDG
  GPGGKALGSDCGGSSGSSSGSGPSAPTSSSVLGSGLVAPVSPYKPGQTVFPLPPAGMTYP
  GSLAGAYAGYPPQFLPHGVALDPTKPGSLVGAQLAAAAAGSLGCSKPAGSSPLAGASPPS
  VMTASLCRDPYCLSYHCASHLAGAAAASASCAHDPAAAAAALKSGYPLVYPTHPLHGVHS
  SLTAAAAAGATPPSLAGHPLYPYGFMLPNDPLPHICNWVSANGPCDKRFATSEELLSHLR
  THTAFPGTDKLLSGYPSSSSLASAAAAAMACHMHIPTSGAPGSPGTLALRSPHHALGLSS
  RYHPYSKSPLPTPGAPVPVPAATGPYYSPYALYGQRLTTASALGYQ

• Sequence length: 646

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BILIARY TRACT DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Carcinoma Non Small Cell Lung	Associate	31160893	★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Associate	33328429	★☆☆☆☆ Found in Text Mining only
Macular Degeneration	Inhibit	28880276	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	31160893	★☆☆☆☆ Found in Text Mining only
Precancerous Conditions	Associate	30598579	★☆☆☆☆ Found in Text Mining only