Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84817
Gene name Gene Name - the full gene name approved by the HGNC.	Thioredoxin domain containing 17
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TXNDC17
Synonyms (NCBI Gene) Gene synonyms aliases	TRP14, TXNL5
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p13.1

Show/Hide all(88)

miRTarBase ID	miRNA	Experiments	Reference
MIRT719816	hsa-miR-4328	HITS-CLIP	19536157
MIRT719815	hsa-miR-4729	HITS-CLIP	19536157
MIRT719814	hsa-miR-3143	HITS-CLIP	19536157
MIRT719813	hsa-miR-137	HITS-CLIP	19536157
MIRT719812	hsa-miR-5696	HITS-CLIP	19536157
MIRT719811	hsa-miR-302c-5p	HITS-CLIP	19536157
MIRT719810	hsa-miR-552-5p	HITS-CLIP	19536157
MIRT719816	hsa-miR-4328	HITS-CLIP	19536157
MIRT719815	hsa-miR-4729	HITS-CLIP	19536157
MIRT719814	hsa-miR-3143	HITS-CLIP	19536157
MIRT719813	hsa-miR-137	HITS-CLIP	19536157
MIRT719812	hsa-miR-5696	HITS-CLIP	19536157
MIRT719811	hsa-miR-302c-5p	HITS-CLIP	19536157
MIRT719810	hsa-miR-552-5p	HITS-CLIP	19536157
MIRT1465074	hsa-miR-28-3p	CLIP-seq
MIRT1465075	hsa-miR-3121-5p	CLIP-seq
MIRT1465076	hsa-miR-3122	CLIP-seq
MIRT1465077	hsa-miR-3153	CLIP-seq
MIRT1465078	hsa-miR-330-3p	CLIP-seq
MIRT1465079	hsa-miR-3617	CLIP-seq
MIRT1465080	hsa-miR-3689a-3p	CLIP-seq
MIRT1465081	hsa-miR-3689c	CLIP-seq
MIRT1465082	hsa-miR-3913-3p	CLIP-seq
MIRT1465083	hsa-miR-3913-5p	CLIP-seq
MIRT1465084	hsa-miR-4436a	CLIP-seq
MIRT1465085	hsa-miR-4452	CLIP-seq
MIRT1465086	hsa-miR-4639-5p	CLIP-seq
MIRT1465087	hsa-miR-4668-5p	CLIP-seq
MIRT1465088	hsa-miR-4728-5p	CLIP-seq
MIRT1465089	hsa-miR-4773	CLIP-seq
MIRT1465090	hsa-miR-582-5p	CLIP-seq
MIRT1465091	hsa-miR-641	CLIP-seq
MIRT2139917	hsa-miR-1184	CLIP-seq
MIRT2139918	hsa-miR-1205	CLIP-seq
MIRT2139919	hsa-miR-1286	CLIP-seq
MIRT2139920	hsa-miR-1976	CLIP-seq
MIRT2139921	hsa-miR-31	CLIP-seq
MIRT2139922	hsa-miR-3158-5p	CLIP-seq
MIRT1465078	hsa-miR-330-3p	CLIP-seq
MIRT2139923	hsa-miR-3690	CLIP-seq
MIRT1465082	hsa-miR-3913-3p	CLIP-seq
MIRT2139924	hsa-miR-3936	CLIP-seq
MIRT2139925	hsa-miR-4254	CLIP-seq
MIRT1465084	hsa-miR-4436a	CLIP-seq
MIRT2139926	hsa-miR-4436b-3p	CLIP-seq
MIRT1465085	hsa-miR-4452	CLIP-seq
MIRT2139927	hsa-miR-4693-5p	CLIP-seq
MIRT2139928	hsa-miR-4696	CLIP-seq
MIRT2139929	hsa-miR-4722-5p	CLIP-seq
MIRT2139930	hsa-miR-4761-3p	CLIP-seq
MIRT2139931	hsa-miR-544	CLIP-seq
MIRT2139932	hsa-miR-873	CLIP-seq
MIRT1465074	hsa-miR-28-3p	CLIP-seq
MIRT1465078	hsa-miR-330-3p	CLIP-seq
MIRT1465079	hsa-miR-3617	CLIP-seq
MIRT1465082	hsa-miR-3913-3p	CLIP-seq
MIRT1465084	hsa-miR-4436a	CLIP-seq
MIRT1465085	hsa-miR-4452	CLIP-seq
MIRT1465089	hsa-miR-4773	CLIP-seq
MIRT1465090	hsa-miR-582-5p	CLIP-seq
MIRT1465091	hsa-miR-641	CLIP-seq
MIRT2654007	hsa-miR-1197	CLIP-seq
MIRT2654008	hsa-miR-217	CLIP-seq
MIRT2654009	hsa-miR-548m	CLIP-seq
MIRT2139932	hsa-miR-873	CLIP-seq
MIRT2654007	hsa-miR-1197	CLIP-seq
MIRT2694538	hsa-miR-1207-5p	CLIP-seq
MIRT2694539	hsa-miR-1208	CLIP-seq
MIRT2139919	hsa-miR-1286	CLIP-seq
MIRT2694540	hsa-miR-192	CLIP-seq
MIRT2694541	hsa-miR-215	CLIP-seq
MIRT2654008	hsa-miR-217	CLIP-seq
MIRT1465074	hsa-miR-28-3p	CLIP-seq
MIRT2694542	hsa-miR-34b	CLIP-seq
MIRT2694543	hsa-miR-3614-5p	CLIP-seq
MIRT1465079	hsa-miR-3617	CLIP-seq
MIRT1465082	hsa-miR-3913-3p	CLIP-seq
MIRT2694544	hsa-miR-4318	CLIP-seq
MIRT1465084	hsa-miR-4436a	CLIP-seq
MIRT1465085	hsa-miR-4452	CLIP-seq
MIRT2694545	hsa-miR-4736	CLIP-seq
MIRT2694546	hsa-miR-4757-5p	CLIP-seq
MIRT2694547	hsa-miR-4763-3p	CLIP-seq
MIRT1465089	hsa-miR-4773	CLIP-seq
MIRT2654009	hsa-miR-548m	CLIP-seq
MIRT1465091	hsa-miR-641	CLIP-seq
MIRT2694548	hsa-miR-663b	CLIP-seq
MIRT2139932	hsa-miR-873	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004601	Function	Peroxidase activity	IDA	14607844
GO:0005515	Function	Protein binding	IPI	14607844, 21044950, 25416956, 32296183
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	14607844
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IMP	14607844
GO:0047134	Function	Protein-disulfide reductase activity	IBA	21873635
GO:0047134	Function	Protein-disulfide reductase activity	IDA	14607844, 15355959, 18579519
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0098869	Process	Cellular oxidant detoxification	IEA

MIM	HGNC	e!Ensembl
616967	28218	ENSG00000129235

Protein

UniProt ID

Q9BRA2

Protein name

Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5)

Protein function

Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activati

PDB

1WOU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06110	DUF953	8 → 122	Eukaryotic protein of unknown function (DUF953)	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed in cell lines. {ECO:0000269|PubMed:14607844}.

Sequence

MARYEEVSVSGFEEFHRAVEQHNGKTIFAYFTGSKDAGGKSWCPDCVQAEPVVREGLKHI
SEGCVFIYCQVGEKPYWKDPNNDFRKNLKVTAVPTLLKYGTPQKLVESECLQANLVEMLF
SED

Sequence length

123

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Esophagus neoplasm	Squamous cell carcinoma of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	21517111

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Neuroblastoma	Associate	28498513
Ovarian Neoplasms	Associate	25607466

TXNDC17 (thioredoxin domain containing 17)