NAA11 (N-alpha-acetyltransferase 11, NatA catalytic subunit)

Gene

• Entrez ID: 84779
• Gene name: N-alpha-acetyltransferase 11, NatA catalytic subunit
• Gene symbol: NAA11
• Synonyms (NCBI Gene): ARD1B, ARD2, hARD2
• Chromosome: 4
• Chromosome location: 4q21.21

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2576738	hsa-miR-3616-3p	CLIP-seq
MIRT2576739	hsa-miR-4253	CLIP-seq
MIRT2576740	hsa-miR-4761-3p	CLIP-seq
MIRT2576741	hsa-miR-583	CLIP-seq
MIRT2576742	hsa-miR-665	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004596	Function	Protein-N-terminal amino-acid acetyltransferase activity	IDA	16638120
GO:0004596	Function	Protein-N-terminal amino-acid acetyltransferase activity	IEA
GO:0005515	Function	Protein binding	IPI	16638120, 19480662, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	16638120
GO:0005794	Component	Golgi apparatus	IDA
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005929	Component	Cilium	IDA
GO:0006474	Process	N-terminal protein amino acid acetylation	IDA	16638120
GO:0008999	Function	Protein-N-terminal-alanine acetyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0016747	Function	Acyltransferase activity, transferring groups other than amino-acyl groups	IEA
GO:0031415	Component	NatA complex	IBA
GO:0031415	Component	NatA complex	IDA	16638120
GO:0031415	Component	NatA complex	IEA
GO:0031415	Component	NatA complex	IPI	16638120, 19480662
GO:0036064	Component	Ciliary basal body	IDA
GO:1990189	Function	Protein N-terminal-serine acetyltransferase activity	IBA
GO:1990189	Function	Protein N-terminal-serine acetyltransferase activity	IEA
GO:1990190	Function	Protein-N-terminal-glutamate acetyltransferase activity	IBA

Other IDs

• MIM: 619432
• HGNC: 28125
• e!Ensembl: ENSG00000156269

Protein

• UniProt ID: Q9BSU3
• Protein name: N-alpha-acetyltransferase 11 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog B) (hARD2) (NatA catalytic subunit Naa11)
• Protein function: Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00583	Acetyltransf_1	13 → 128	Acetyltransferase (GNAT) family	Family

• Tissue specificity: TISSUE SPECIFICITY: Present in several cell lines, with highest levels in MCF-7 cells (at protein level). {ECO:0000269|PubMed:16638120}.
• Sequence:

  MNIRNAQPDDLMNMQHCNLLCLPENYQMKYYLYHGLSWPQLSYIAEDEDGKIVGYVLAKM
  EEEPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKYVSLHVRKSNRPALH
  LYSNTLNFQISEVEPKYYADGEDAYAMKRDLSQMADELRRQMDLKKGGYVVLGSRENQET
  QGSTLSDSEEACQQKNPATEESGSDSKEPKESVESTNVQDSSESSDSTS

• Sequence length: 229

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANOREXIA NERVOSA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN SEROUS CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOURETTE SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Carcinoma Hepatocellular	Associate	20419844	★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Associate	34817046	★☆☆☆☆ Found in Text Mining only